{"id":"https://openalex.org/W190645136","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb256","title":"Anti\u2010obesity effect of Actiponin supplementation in obese Korean subjects: A 12 week, randomized, double\u2010blind, placebo\u2010controlled clinical trial","display_name":"Anti\u2010obesity effect of Actiponin supplementation in obese Korean subjects: A 12 week, randomized, double\u2010blind, placebo\u2010controlled clinical trial","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W190645136","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb256","mag":"190645136"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.25.1_supplement.lb256","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb256","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.lb256","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061970066","display_name":"Soo\u2010Hyun Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo\u2010Hyun Park","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027723049","display_name":"Hyang\u2010Im Back","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyang\u2010Im Back","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008775426","display_name":"Sun\u2010Young Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun\u2010Young Kim","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eun\u2010Ok Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun\u2010Ok Park","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033874007","display_name":"Mira Oh","orcid":"https://orcid.org/0000-0002-2375-9971","observed_orcids":["https://orcid.org/0000-0002-2375-9971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mi\u2010Ra Oh","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081300522","display_name":"Min\u2010Gul Kim","orcid":"https://orcid.org/0000-0001-7269-9533","observed_orcids":["https://orcid.org/0000-0001-7269-9533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min\u2010Gul Kim","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012301271","display_name":"Eunkyung Choi","orcid":"https://orcid.org/0000-0003-4823-2532","observed_orcids":["https://orcid.org/0000-0003-4823-2532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun\u2010Kyung Choi","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044933539","display_name":"Su\u2010Jin Jung","orcid":"https://orcid.org/0000-0003-1103-7477","observed_orcids":["https://orcid.org/0000-0003-1103-7477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Su Jin Jung","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079056450","display_name":"Il Han Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Il Han Yu","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036125990","display_name":"Hye Mi Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hye Mi Kim","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058495015","display_name":"Tae\u2010Lin Huh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae\u2010Lin Huh","raw_affiliation_strings":["Kyungpook National University Technobuilding Daegu Republic of Korea Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyungpook National University Technobuilding Daegu Republic of Korea Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091527262","display_name":"Youn\u2010Soo Cha","orcid":"https://orcid.org/0000-0001-5579-650X","observed_orcids":["https://orcid.org/0000-0001-5579-650X"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youn\u2010Soo Cha","raw_affiliation_strings":["Department of Food Science and Human Nutrition Chonbuk National University Hospital Jeonju Jeonbuk 561\u2010172 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition Chonbuk National University Hospital Jeonju Jeonbuk 561\u2010172 Republic of Korea","institution_ids":["https://openalex.org/I4210131908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050666299","display_name":"Soo\u2010Wan Chae","orcid":"https://orcid.org/0000-0003-3660-8272","observed_orcids":["https://orcid.org/0000-0003-3660-8272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo\u2010Wan Chae","raw_affiliation_strings":["Clinical Trial Center for Functional Foods"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gynostemma-pentaphyllum","display_name":"Gynostemma pentaphyllum","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anti-obesity-effect","display_name":"anti-obesity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.878000020980835},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8790000081062317},{"id":"https://openalex.org/keywords/abdominal-fat-distribution","display_name":"abdominal fat distribution","score":0.8560000061988831},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.5410000085830688},{"id":"https://openalex.org/keywords/korean-adults","display_name":"Korean adults","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8562052845954895},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8195741176605225},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6631725430488586},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6621840000152588},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5924593806266785},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.511625349521637},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44245606660842896},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4337582290172577},{"id":"https://openalex.org/C2777693730","wikidata":"https://www.wikidata.org/wiki/Q1140549","display_name":"Abdominal obesity","level":4,"score":0.4314831495285034},{"id":"https://openalex.org/C2778713507","wikidata":"https://www.wikidata.org/wiki/Q134253","display_name":"Gynostemma pentaphyllum","level":3,"score":0.4253404140472412},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41591835021972656},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.191878080368042},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.25.1_supplement.lb256","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb256","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.lb256","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1831870119","https://openalex.org/W3186025610","https://openalex.org/W2979937158","https://openalex.org/W2991540172","https://openalex.org/W4210763167","https://openalex.org/W3204146697","https://openalex.org/W1988319187","https://openalex.org/W2782530208","https://openalex.org/W3044656815","https://openalex.org/W2071605031"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,117,120,140,148],"effects":[3],"of":[4,10,86,123,167],"Actiponin":[5,75,111,141,174],",":[6],"a":[7,74],"modified":[8],"extract":[9],"Gynostemma":[11],"pentaphyllum":[12],"plant,":[13],"on":[14,180],"anti\u2010obesity":[15],"effect":[16,179],"in":[17,57,139],"human,":[18],"we":[19],"carried":[20],"out":[21],"12":[22,121],"week,":[23],"randomized,":[24],"double\u2010blind,":[25],"placebo\u2010controlled":[26],"clinical":[27],"trial":[28],"for":[29],"obese":[30],"Korean":[31],"subjects.":[32],"Obese":[33],"subjects":[34,61,109],"[both":[35],"BMI":[36,132],"\u2265":[37,43,46],"25":[38],"kg/m":[39,136],"2":[40,137],"and":[41,98,105],"WHR":[42,45],"0.90(men),":[44],"0.85(women)]":[47],"who":[48],"were":[49,55,70],"not":[50],"diagnosed":[51],"with":[52],"any":[53],"disease":[54],"included":[56,84],"this":[58],"study.":[59,118],"Eighty":[60],"(40.08":[62],"\u00b1":[63,67],"10.60":[64],"years,":[65],"164.3":[66],"8.8":[68],"cm)":[69],"randomly":[71],"divided":[72],"into":[73],"(n=40,":[76],"450":[77],"mg/day)":[78],"or":[79],"Placebo":[80,114,149],"group":[81,142,150],"(n=40).":[82],"Outcomes":[83],"measures":[85],"efficacy":[87],"(Anthropometric":[88],"parameter,":[89],"abdominal":[90],"fat":[91,126,129],"distribution":[92],"by":[93],"computerized":[94],"tomography,":[95],"blood":[96],"components)":[97],"safety":[99,168],"(adverse":[100],"events,":[101],"laboratory":[102],"test,":[103],"electrocardiogram,":[104],"vital":[106],"sign).":[107],"Seventy\u2010four":[108],"(36":[110],"group,":[112],"38":[113],"group)":[115],"finished":[116],"After":[119],"weeks":[122],"supplementation,":[124],"body":[125,128],"mass,":[127],"percent,":[130],"weight,":[131],"(body":[133],"mass":[134],"index,":[135],")":[138],"was":[143,162],"significantly":[144],"reduced":[145],"compared":[146],"to":[147],"(":[151],"P":[152,154,156,158],"<0.001,":[153,155],"<0.05,":[157],"<0.05).":[159],"Also":[160],"there":[161],"no":[163],"clinically":[164],"significant":[165],"change":[166],"parameter.":[169],"These":[170],"results":[171],"suggested":[172],"that":[173],"supplementation":[175],"may":[176],"have":[177],"positive":[178],"anti\u2010obesity.":[181]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}