{"id":"https://openalex.org/W190613686","doi":null,"title":"The role of sildenafil in the treatment of stroke.","display_name":"The role of sildenafil in the treatment of stroke.","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W190613686","mag":"190613686","pmid":"https://pubmed.ncbi.nlm.nih.gov/18600581"},"language":"en","primary_location":{"id":"pmid:18600581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18600581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076516816","display_name":"Martin M. Bednar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin M Bednar","raw_affiliation_strings":["Pfizer Inc, Pfizer Global Research and Development, 50 Pequot Avenue, MS 8260-2604, New London, CT 06320, USA. martin.m.bednar@pfizer.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Pfizer Global Research and Development, 50 Pequot Avenue, MS 8260-2604, New London, CT 06320, USA. martin.m.bednar@pfizer.com","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076516816"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":null,"apc_paid":null,"fwci":0.8484,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.67238347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"7","first_page":"754","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":1.0},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neurorestoration","display_name":"neurorestoration","score":0.878000020980835},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":1.0},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.847000002861023},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.6579999923706055},{"id":"https://openalex.org/keywords/brain-infarct-size","display_name":"brain infarct size","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7972427606582642},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.7504136562347412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7219706773757935},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6995411515235901},{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.6347212791442871},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5581223964691162},{"id":"https://openalex.org/C2776361831","wikidata":"https://www.wikidata.org/wiki/Q10681911","display_name":"Stroke recovery","level":3,"score":0.47839510440826416},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.4601055383682251},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4574756622314453},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4206351637840271},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.41358238458633423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3582085967063904},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15628939867019653},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.14771947264671326},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.12463408708572388},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08475455641746521},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068677","descriptor_name":"Sildenafil Citrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18600581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18600581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},{"id":"mag:190613686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18600581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1494919617","https://openalex.org/W1577111862","https://openalex.org/W1577381678","https://openalex.org/W1591263948","https://openalex.org/W1597878594","https://openalex.org/W1963966302","https://openalex.org/W1970674339","https://openalex.org/W1973363781","https://openalex.org/W1975319833","https://openalex.org/W1978654241","https://openalex.org/W1980499453","https://openalex.org/W1990281869","https://openalex.org/W1990589261","https://openalex.org/W1995792973","https://openalex.org/W2001908895","https://openalex.org/W2002956393","https://openalex.org/W2004284240","https://openalex.org/W2007737411","https://openalex.org/W2011751033","https://openalex.org/W2016283334","https://openalex.org/W2020311830","https://openalex.org/W2021246719","https://openalex.org/W2025108839","https://openalex.org/W2042335373","https://openalex.org/W2045682157","https://openalex.org/W2046770130","https://openalex.org/W2049172071","https://openalex.org/W2054482783","https://openalex.org/W2067856703","https://openalex.org/W2068239827","https://openalex.org/W2087048915","https://openalex.org/W2090146561","https://openalex.org/W2096597907","https://openalex.org/W2105711200","https://openalex.org/W2112515581","https://openalex.org/W2120752600","https://openalex.org/W2126631219","https://openalex.org/W2129974396","https://openalex.org/W2169079203","https://openalex.org/W2179702494","https://openalex.org/W2185032147","https://openalex.org/W2292308933","https://openalex.org/W2406062456","https://openalex.org/W2615043561"],"related_works":["https://openalex.org/W2887700965","https://openalex.org/W1966679068","https://openalex.org/W3205118406","https://openalex.org/W2002956393","https://openalex.org/W1990186655","https://openalex.org/W1973363781","https://openalex.org/W1995792973","https://openalex.org/W2684375425","https://openalex.org/W2031753070","https://openalex.org/W2299711865"],"abstract_inverted_index":{"The":[0,113],"structural":[1],"underpinning":[2],"responsible":[3],"for":[4,53,131],"neuroplasticity":[5],"and":[6,10,71,99,102,117],"neurorestoration":[7,60],"under":[8],"physiological":[9],"pathophysiological":[11],"conditions":[12],"is":[13,20,76,103,108],"only":[14],"beginning":[15],"to":[16,44],"be":[17],"elucidated.":[18],"It":[19],"evident":[21],"that":[22],"life-long":[23],"neurogenesis":[24],"occurs":[25],"in":[26,42,61,96],"the":[27,54,132],"human":[28],"brain,":[29],"with":[30,78],"experimental":[31],"data":[32],"supporting":[33],"its":[34],"upregulation":[35],"following":[36],"an":[37],"insult":[38],"(eg,":[39],"stroke)":[40],"and/or":[41],"response":[43],"pharmacological":[45],"therapy.":[46],"Sildenafil,":[47],"a":[48],"PDE5":[49],"inhibitor":[50],"currently":[51],"marketed":[52],"treatment":[55,133],"of":[56,64,120,122,134],"erectile":[57],"dysfunction,":[58],"enhances":[59],"rat":[62],"models":[63],"stroke,":[65],"as":[66,126],"measured":[67],"by":[68],"neurogenesis,":[69],"synaptogenesis":[70],"angiogenesis.":[72],"This":[73,89],"neurorestorative":[74,90,123],"effect":[75,84,91],"associated":[77],"improved":[79],"outcome":[80],"despite":[81],"no":[82],"observed":[83,95],"on":[85],"brain":[86],"infarct":[87],"size.":[88],"has":[92],"also":[93],"been":[94],"both":[97],"young":[98],"old":[100],"animals,":[101],"demonstrable":[104],"even":[105],"if":[106],"therapy":[107],"initiated":[109],"1":[110],"week":[111],"post-stroke.":[112],"extended":[114],"therapeutic":[115],"window":[116],"novel":[118],"mechanism":[119],"action":[121],"therapies,":[124],"such":[125],"sildenafil,":[127],"warrant":[128],"further":[129],"investigation":[130],"stroke.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}