{"id":"https://openalex.org/W19059775","doi":null,"title":"Etudes structure-fonction de lectines (DiscI et DiscII) de Dictyostelium discoideum","display_name":"Etudes structure-fonction de lectines (DiscI et DiscII) de Dictyostelium discoideum","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W19059775","mag":"19059775"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/832147","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/832147","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00385711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000380475","display_name":"Karoline S. Arag\u00e3o","orcid":"https://orcid.org/0009-0007-7640-5329","observed_orcids":["https://orcid.org/0009-0007-7640-5329"]},"institutions":[{"id":"https://openalex.org/I4210086338","display_name":"Centre de Recherches sur les Macromol\u00e9cules V\u00e9g\u00e9tales","ror":"https://ror.org/0003ege03","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210086338","https://openalex.org/I4210128300","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Karoline S. Arag\u00e3o","raw_affiliation_strings":["Centre de Recherches sur les Macromol\u00e9cules V\u00e9g\u00e9tales"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches sur les Macromol\u00e9cules V\u00e9g\u00e9tales","institution_ids":["https://openalex.org/I4210086338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000380475"],"corresponding_institution_ids":["https://openalex.org/I4210086338"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lectins","display_name":"lectins","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dictyostelium-discoideum","display_name":"Dictyostelium discoideum","score":0.972000002861023},{"id":"https://openalex.org/keywords/discoidin-domain","display_name":"discoidin domain","score":0.7310000061988831},{"id":"https://openalex.org/keywords/carbohydrate-lectin-interactions","display_name":"lectin-carbohydrate interaction","score":0.6470000147819519},{"id":"https://openalex.org/keywords/microcalorimetry","display_name":"microcalorimetry","score":0.6589999794960022},{"id":"https://openalex.org/keywords/x-ray-crystallography","display_name":"X-ray crystallography","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lectin-structure","display_name":"lectin structure","score":0.36899998784065247},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6359999775886536},{"id":"https://openalex.org/keywords/aggregation","display_name":"aggregation","score":0.32199999690055847},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2775969001","wikidata":"https://www.wikidata.org/wiki/Q134351","display_name":"Dictyostelium discoideum","level":3,"score":0.6924222707748413},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6722060441970825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5956632494926453},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.384633332490921},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3673660159111023},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.35659217834472656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22431021928787231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13012480735778809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/832147","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/832147","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00385711v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00385711","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimie [q-bio.BM]. Universit\u00e9 Joseph-Fourier - Grenoble I, 2008. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:19059775","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00385711","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-00385711v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00385711","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimie [q-bio.BM]. Universit\u00e9 Joseph-Fourier - Grenoble I, 2008. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W3911104","https://openalex.org/W128398215","https://openalex.org/W227712788","https://openalex.org/W569951484","https://openalex.org/W622460164","https://openalex.org/W979115662","https://openalex.org/W1483773410","https://openalex.org/W1491426643","https://openalex.org/W1496129393","https://openalex.org/W1529630921","https://openalex.org/W1533726483","https://openalex.org/W1550495386","https://openalex.org/W1572955611","https://openalex.org/W1578874979","https://openalex.org/W1579969375","https://openalex.org/W1582529739","https://openalex.org/W1606779508","https://openalex.org/W1780970402","https://openalex.org/W1891870091","https://openalex.org/W1928836998","https://openalex.org/W1936207504","https://openalex.org/W1964690379","https://openalex.org/W1965778925","https://openalex.org/W1966041739","https://openalex.org/W1967993480","https://openalex.org/W1969167814","https://openalex.org/W1970083218","https://openalex.org/W1970123832","https://openalex.org/W1970208847","https://openalex.org/W1971185254","https://openalex.org/W1972479717","https://openalex.org/W1975265168","https://openalex.org/W1981554936","https://openalex.org/W1983266482","https://openalex.org/W1984305420","https://openalex.org/W1985437385","https://openalex.org/W1986191025","https://openalex.org/W1988621302","https://openalex.org/W1990383451","https://openalex.org/W1992151914","https://openalex.org/W1994286350","https://openalex.org/W1995189079","https://openalex.org/W1995243908","https://openalex.org/W1996607909","https://openalex.org/W1997458323","https://openalex.org/W1998440525","https://openalex.org/W2001369616","https://openalex.org/W2001641653","https://openalex.org/W2002651802","https://openalex.org/W2004356660","https://openalex.org/W2005314771","https://openalex.org/W2008649826","https://openalex.org/W2010547921","https://openalex.org/W2012090457","https://openalex.org/W2016103528","https://openalex.org/W2016255772","https://openalex.org/W2016607365","https://openalex.org/W2019671439","https://openalex.org/W2019726270","https://openalex.org/W2020792055","https://openalex.org/W2025612977","https://openalex.org/W2028857471","https://openalex.org/W2029050128","https://openalex.org/W2029986004","https://openalex.org/W2032146098","https://openalex.org/W2032178469","https://openalex.org/W2035399581","https://openalex.org/W2036450478","https://openalex.org/W2038840577","https://openalex.org/W2039585575","https://openalex.org/W2041654633","https://openalex.org/W2045744003","https://openalex.org/W2047387450","https://openalex.org/W2050426579","https://openalex.org/W2051595973","https://openalex.org/W2052317605","https://openalex.org/W2054181212","https://openalex.org/W2055043387","https://openalex.org/W2055800251","https://openalex.org/W2057245021","https://openalex.org/W2059132659","https://openalex.org/W2059375062","https://openalex.org/W2059759326","https://openalex.org/W2060807817","https://openalex.org/W2062486325","https://openalex.org/W2062613923","https://openalex.org/W2065339207","https://openalex.org/W2067817921","https://openalex.org/W2072348008","https://openalex.org/W2074308942","https://openalex.org/W2074764651","https://openalex.org/W2076595001","https://openalex.org/W2080476827","https://openalex.org/W2083601141","https://openalex.org/W2084351422","https://openalex.org/W2084435672","https://openalex.org/W2085188889","https://openalex.org/W2085587941","https://openalex.org/W2085668729","https://openalex.org/W2086810146","https://openalex.org/W2087238009","https://openalex.org/W2087799413","https://openalex.org/W2088278594","https://openalex.org/W2088956519","https://openalex.org/W2089592322","https://openalex.org/W2093355482","https://openalex.org/W2094220579","https://openalex.org/W2095526534","https://openalex.org/W2095661528","https://openalex.org/W2096883384","https://openalex.org/W2099195012","https://openalex.org/W2101083650","https://openalex.org/W2102135397","https://openalex.org/W2107639405","https://openalex.org/W2108555933","https://openalex.org/W2108563067","https://openalex.org/W2109280121","https://openalex.org/W2112998064","https://openalex.org/W2114863423","https://openalex.org/W2118212170","https://openalex.org/W2120140131","https://openalex.org/W2120853801","https://openalex.org/W2124352852","https://openalex.org/W2124864045","https://openalex.org/W2125056252","https://openalex.org/W2125811479","https://openalex.org/W2126578659","https://openalex.org/W2129232972","https://openalex.org/W2131492616","https://openalex.org/W2132717858","https://openalex.org/W2134201060","https://openalex.org/W2139406125","https://openalex.org/W2144081223","https://openalex.org/W2144998676","https://openalex.org/W2148532133","https://openalex.org/W2148869329","https://openalex.org/W2152229185","https://openalex.org/W2155481598","https://openalex.org/W2163178337","https://openalex.org/W2163888944","https://openalex.org/W2169098832","https://openalex.org/W2185928127","https://openalex.org/W2187793044","https://openalex.org/W2280001637","https://openalex.org/W2292359171","https://openalex.org/W2413014697","https://openalex.org/W2472839243","https://openalex.org/W2563279134","https://openalex.org/W3151909901"],"related_works":["https://openalex.org/W6987456591","https://openalex.org/W2074764651","https://openalex.org/W1995189079","https://openalex.org/W4392541770","https://openalex.org/W199356763","https://openalex.org/W7100332084","https://openalex.org/W2082518451","https://openalex.org/W1582529739","https://openalex.org/W2315317661","https://openalex.org/W2295915717"],"abstract_inverted_index":{"Les":[0,143],"lectines":[1,58,173],"sont":[2],"des":[3,78,117,136,207,235,249],"prot\u00e9ines":[4],"qui":[5,59],"reconnaissent":[6,60],"les":[7,64,96,164,240],"glucides":[8],"complexes":[9],"de":[10,27,47,53,75,108,145,157,159,197,204,219,237,252,254],"mani\u00e8re":[11],"sp\u00e9cifique":[12,126],"et":[13,67,70,82,155,161,189,201,242,256],"r\u00e9versible.":[14],"L'amibe":[15],"Dictyostelium":[16],"discoideum":[17],"est":[18,100,129],"un":[19,210],"organisme":[20],"mod\u00e8le":[21],"eucaryote":[22],"tr\u00e8s":[23],"employ\u00e9":[24],"pour":[25],"l'\u00e9tude":[26,153],"nombreux":[28],"processus":[29,97],"biologiques":[30],"tel":[31],"la":[32,34,37,54,84,120,217],"phagocytose,":[33],"diff\u00e9renciation":[35],"ou":[36,226],"mort":[38],"cellulaire.":[39],"Lorsqu'elle":[40],"se":[41],"diff\u00e9rencie":[42],"suite":[43,215],"\u00e0":[44,139,199,209,216,258],"une":[45,168,246],"absence":[46],"nutriments,":[48],"elle":[49],"produit":[50],"au":[51],"cours":[52],"phase":[55],"d'agr\u00e9gation,":[56],"deux":[57,172],"le":[61],"Gal/GalNAc":[62,166],":":[63],"discoidines":[65],"(DiscI":[66],"DiscII).":[68],"DiscI":[69,160],"DiscII":[71,162],"pr\u00e9sentent":[72],"48%":[73],"d'identit\u00e9":[74],"s\u00e9quence,":[76],"forment":[77],"trim\u00e8res":[79],"en":[80,87,102,111,132],"solution":[81],"partagent":[83],"m\u00eame":[85],"organisation":[86],"domaine.":[88],"Un":[89],"domaine":[90,106,114],"discoidine":[91],"(domaine":[92],"DS)":[93],"impliqu\u00e9":[94],"dans":[95,148,181],"d'adh\u00e9sion":[98],"cellulaire":[99],"retrouv\u00e9":[101],"N-terminal":[103],"suivi":[104],"d'un":[105],"lectine":[107,115,121,125],"type":[109],"H":[110],"C-terminal.":[112],"Le":[113],"pr\u00e9sente":[116],"similarit\u00e9s":[118],"avec":[119,163],"d'escargot":[122],"HPA.":[123],"Cette":[124],"du":[127],"GalNAc":[128],"utilis\u00e9e":[130],"extensivement":[131],"histopathologie":[133],"comme":[134],"marqueur":[135],"cellules":[137],"tumorales":[138],"fort":[140],"caract\u00e8re":[141],"m\u00e9tastatique.":[142],"travaux":[144],"recherche":[146],"d\u00e9velopp\u00e9s":[147],"cette":[149],"th\u00e8se":[150],"portent":[151],"sur":[152],"structurale":[154],"fonctionnelle":[156],"l'interaction":[158],"sucres":[165,200],"selon":[167],"approche":[169],"pluridisciplinaire.":[170],"Ces":[171],"ont":[174,192],"\u00e9t\u00e9":[175,193],"clon\u00e9es,":[176],"exprim\u00e9es":[177],"sous":[178,223],"forme":[179,224],"recombinante":[180],"Escherichia":[182],"coli":[183],"avant":[184],"d'\u00eatre":[185],"purifi\u00e9es.":[186],"Leur":[187],"sp\u00e9cificit\u00e9":[188,255],"leur":[190,220],"affinit\u00e9":[191],"d\u00e9termin\u00e9es":[194],"par":[195,202,228],"l'utilisation":[196],"puces":[198],"microcalorim\u00e9trie":[203],"titration.":[205],"L'analyse":[206],"interactions":[208],"niveau":[211,259],"ol\u00e9culaire":[212],"s'est":[213],"r\u00e9alis\u00e9e":[214],"d\u00e9termination":[218],"structure":[221],"3-D":[222],"native":[225],"complex\u00e9e":[227],"cristallographie":[229],"aux":[230],"rayons":[231],"X.":[232],"La":[233],"comparaison":[234],"sites":[236],"liaison":[238],"entre":[239],"Discoidines":[241],"HPA":[243],"a":[244],"permis":[245],"meilleure":[247],"compr\u00e9hension":[248],"leurs":[250],"m\u00e9canismes":[251],"reconnaissance,":[253],"d'affinit\u00e9":[257],"mol\u00e9culaire.":[260]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}