{"id":"https://openalex.org/W1905596132","doi":null,"title":"Compensatory Mechanisms and T Cell Migration In Mouse Models of Dopaminergic Loss","display_name":"Compensatory Mechanisms and T Cell Migration In Mouse Models of Dopaminergic Loss","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1905596132","mag":"1905596132"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unmc.edu:etd-1039","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/etd/39","pdf_url":"https://digitalcommons.unmc.edu/etd/39","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses & Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.unmc.edu/etd/39","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034159409","display_name":"Kristi M. Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristi M. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034159409"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.9570000171661377},{"id":"https://openalex.org/keywords/compensatory-mechanisms","display_name":"compensatory mechanisms","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.949999988079071},{"id":"https://openalex.org/keywords/dopamine-replacement-therapy","display_name":"dopamine replacement therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mptp-model","display_name":"MPTP model","score":0.7509999871253967},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.6200000047683716},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.7200000286102295},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.8410000205039978},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.7440000176429749},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.9261233806610107},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.789456844329834},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.7606954574584961},{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.7453768253326416},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.6712977886199951},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6429466605186462},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6127119064331055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5593083500862122},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.5519895553588867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5270776152610779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46795761585235596},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.4530784487724304},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35820090770721436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20893704891204834},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.1684364378452301},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15751326084136963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13837343454360962}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unmc.edu:etd-1039","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/etd/39","pdf_url":"https://digitalcommons.unmc.edu/etd/39","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses & Dissertations","raw_type":"text"},{"id":"mag:1905596132","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1039&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unmc.edu:etd-1039","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/etd/39","pdf_url":"https://digitalcommons.unmc.edu/etd/39","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses & Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1905596132.pdf","grobid_xml":"https://content.openalex.org/works/W1905596132.grobid-xml"},"referenced_works_count":232,"referenced_works":["https://openalex.org/W16957298","https://openalex.org/W62603772","https://openalex.org/W99762335","https://openalex.org/W109224225","https://openalex.org/W139322991","https://openalex.org/W141718882","https://openalex.org/W167486056","https://openalex.org/W180927739","https://openalex.org/W1238819995","https://openalex.org/W1485816512","https://openalex.org/W1494364449","https://openalex.org/W1509596990","https://openalex.org/W1511809726","https://openalex.org/W1512374667","https://openalex.org/W1522510037","https://openalex.org/W1523338791","https://openalex.org/W1531344161","https://openalex.org/W1539334271","https://openalex.org/W1546232808","https://openalex.org/W1546697179","https://openalex.org/W1553317920","https://openalex.org/W1554054932","https://openalex.org/W1604776255","https://openalex.org/W1653051905","https://openalex.org/W1843290366","https://openalex.org/W1892508608","https://openalex.org/W1905324622","https://openalex.org/W1934778253","https://openalex.org/W1964622038","https://openalex.org/W1966100398","https://openalex.org/W1967640115","https://openalex.org/W1968013520","https://openalex.org/W1969542015","https://openalex.org/W1969800514","https://openalex.org/W1971033959","https://openalex.org/W1971305213","https://openalex.org/W1971305731","https://openalex.org/W1974904670","https://openalex.org/W1975980701","https://openalex.org/W1976749972","https://openalex.org/W1977034183","https://openalex.org/W1977215237","https://openalex.org/W1977994862","https://openalex.org/W1979883589","https://openalex.org/W1980947632","https://openalex.org/W1981126128","https://openalex.org/W1982320234","https://openalex.org/W1982657635","https://openalex.org/W1982686540","https://openalex.org/W1984940197","https://openalex.org/W1986300349","https://openalex.org/W1986641407","https://openalex.org/W1987167495","https://openalex.org/W1990714772","https://openalex.org/W1990872391","https://openalex.org/W1992424600","https://openalex.org/W1992743838","https://openalex.org/W1994331976","https://openalex.org/W1994697178","https://openalex.org/W1995176369","https://openalex.org/W1996133810","https://openalex.org/W1996630962","https://openalex.org/W1997460269","https://openalex.org/W1998270315","https://openalex.org/W1998488298","https://openalex.org/W1999746084","https://openalex.org/W2000631088","https://openalex.org/W2001343425","https://openalex.org/W2001405298","https://openalex.org/W2001593633","https://openalex.org/W2002328113","https://openalex.org/W2003915808","https://openalex.org/W2003943670","https://openalex.org/W2004689504","https://openalex.org/W2004747758","https://openalex.org/W2004983430","https://openalex.org/W2005447847","https://openalex.org/W2005890826","https://openalex.org/W2006249161","https://openalex.org/W2006634467","https://openalex.org/W2009205613","https://openalex.org/W2009327298","https://openalex.org/W2012199003","https://openalex.org/W2012947001","https://openalex.org/W2014182955","https://openalex.org/W2016174853","https://openalex.org/W2017329102","https://openalex.org/W2017651145","https://openalex.org/W2018212332","https://openalex.org/W2021429544","https://openalex.org/W2021893363","https://openalex.org/W2022614058","https://openalex.org/W2022911097","https://openalex.org/W2024054612","https://openalex.org/W2024454234","https://openalex.org/W2026393786","https://openalex.org/W2027612709","https://openalex.org/W2028948697","https://openalex.org/W2030500478","https://openalex.org/W2030536065","https://openalex.org/W2031012856","https://openalex.org/W2031590292","https://openalex.org/W2031740174","https://openalex.org/W2032777075","https://openalex.org/W2033068332","https://openalex.org/W2033206554","https://openalex.org/W2033521385","https://openalex.org/W2035645280","https://openalex.org/W2036201815","https://openalex.org/W2036596102","https://openalex.org/W2037892935","https://openalex.org/W2042408279","https://openalex.org/W2042630261","https://openalex.org/W2043209647","https://openalex.org/W2043547635","https://openalex.org/W2045950884","https://openalex.org/W2046807021","https://openalex.org/W2048020246","https://openalex.org/W2048833489","https://openalex.org/W2049209128","https://openalex.org/W2050885181","https://openalex.org/W2052615066","https://openalex.org/W2052805851","https://openalex.org/W2054264241","https://openalex.org/W2055831519","https://openalex.org/W2056100616","https://openalex.org/W2057598453","https://openalex.org/W2058126826","https://openalex.org/W2060817628","https://openalex.org/W2061154270","https://openalex.org/W2061653201","https://openalex.org/W2062186304","https://openalex.org/W2063607820","https://openalex.org/W2064645845","https://openalex.org/W2065260015","https://openalex.org/W2065271393","https://openalex.org/W2065726682","https://openalex.org/W2066027939","https://openalex.org/W2067147530","https://openalex.org/W2068868710","https://openalex.org/W2071795725","https://openalex.org/W2072787449","https://openalex.org/W2073450860","https://openalex.org/W2073784532","https://openalex.org/W2074668650","https://openalex.org/W2075849062","https://openalex.org/W2076237842","https://openalex.org/W2077332064","https://openalex.org/W2078827060","https://openalex.org/W2079585728","https://openalex.org/W2081323923","https://openalex.org/W2082622527","https://openalex.org/W2083268412","https://openalex.org/W2084374696","https://openalex.org/W2085518524","https://openalex.org/W2086539844","https://openalex.org/W2087848764","https://openalex.org/W2088318694","https://openalex.org/W2088949976","https://openalex.org/W2089353787","https://openalex.org/W2090092419","https://openalex.org/W2092232838","https://openalex.org/W2100637804","https://openalex.org/W2102321124","https://openalex.org/W2103477671","https://openalex.org/W2104125861","https://openalex.org/W2105672563","https://openalex.org/W2106689521","https://openalex.org/W2107251840","https://openalex.org/W2107525024","https://openalex.org/W2109608980","https://openalex.org/W2110202583","https://openalex.org/W2111443698","https://openalex.org/W2113083939","https://openalex.org/W2114206069","https://openalex.org/W2114264728","https://openalex.org/W2116309538","https://openalex.org/W2116491528","https://openalex.org/W2116828514","https://openalex.org/W2117047064","https://openalex.org/W2117053539","https://openalex.org/W2117506912","https://openalex.org/W2117755788","https://openalex.org/W2121833804","https://openalex.org/W2123706258","https://openalex.org/W2124117567","https://openalex.org/W2124659766","https://openalex.org/W2126009024","https://openalex.org/W2126162679","https://openalex.org/W2127235616","https://openalex.org/W2127508962","https://openalex.org/W2128631317","https://openalex.org/W2132550836","https://openalex.org/W2133759882","https://openalex.org/W2134330719","https://openalex.org/W2134692767","https://openalex.org/W2136243788","https://openalex.org/W2139321499","https://openalex.org/W2139408348","https://openalex.org/W2140595333","https://openalex.org/W2141480293","https://openalex.org/W2145818538","https://openalex.org/W2146127468","https://openalex.org/W2147242210","https://openalex.org/W2152301173","https://openalex.org/W2152717528","https://openalex.org/W2153164431","https://openalex.org/W2154457951","https://openalex.org/W2154761542","https://openalex.org/W2155737332","https://openalex.org/W2159312863","https://openalex.org/W2159375447","https://openalex.org/W2160733114","https://openalex.org/W2162298596","https://openalex.org/W2162786497","https://openalex.org/W2163020124","https://openalex.org/W2163380380","https://openalex.org/W2163818378","https://openalex.org/W2164250102","https://openalex.org/W2169295394","https://openalex.org/W2181519063","https://openalex.org/W2181595468","https://openalex.org/W2191356548","https://openalex.org/W2206687388","https://openalex.org/W2319017141","https://openalex.org/W2328099797","https://openalex.org/W2397611693","https://openalex.org/W2406590825","https://openalex.org/W2409678956","https://openalex.org/W2409911932","https://openalex.org/W2411618542","https://openalex.org/W2460367034"],"related_works":["https://openalex.org/W2181595468","https://openalex.org/W1971408164","https://openalex.org/W964958901","https://openalex.org/W2341507786","https://openalex.org/W7064940528","https://openalex.org/W1982686540","https://openalex.org/W1974904670","https://openalex.org/W2072963708","https://openalex.org/W2070273811","https://openalex.org/W2072043358"],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease":[1],"(PD)":[2],"is":[3,17,83,119,137],"the":[4,20,30,36,51,125,153,158,174,188,194,280,301,340],"most":[5,12],"common":[6,13],"neurodegenerative":[7,14],"movement":[8,53],"disorder":[9,54],"and":[10,26,33,49,124,150,184,266,275],"second":[11],"disorder.":[15],"PD":[16,69,81,94,131,318],"characterized":[18],"by":[19,50,338],"selective":[21],"loss":[22,39,292],"of":[23,40,60,68,80,101,144,146,162,166,176,190,214,227,279,343],"dopaminergic":[24,41,61,102,206,257,291,302],"neurons":[25,42,62,103,192,201,217],"dopamine":[27,147,167,228,239,243],"neurotransmitter":[28],"within":[29],"substantia":[31,195],"nigra":[32],"termini":[34],"in":[35,47,74,112,129,173,180,187,193,199,241,277],"striatum.":[37],"Progressive":[38],"occurs":[43],"over":[44],"many":[45],"years":[46],"PD,":[48,163],"time":[52],"symptoms":[55,91],"manifest,":[56],"up":[57],"to":[58,85,218,237,253,262,293,300],"50-70%":[59],"have":[63,71,254],"been":[64,72],"lost.":[65],"Several":[66],"aspects":[67],"pathology":[70],"described":[73],"detail,":[75],"but":[76,209],"a":[77,110,211,224,242,314],"better":[78],"understanding":[79],"progression":[82],"needed":[84],"develop":[86],"more":[87,335],"efficient":[88],"treatments.":[89],"Motor":[90],"associated":[92,204],"with":[93,205],"do":[95],"not":[96,203],"manifest":[97],"until":[98],"significant":[99,269],"numbers":[100],"are":[104],"lost,":[105],"suggesting":[106],"compensatory":[107,234,311],"mechanisms":[108,123,312],"play":[109,128],"role":[111,126],"maintaining":[113],"normal":[114,307],"motor":[115,182,264,284],"function.":[116],"However,":[117],"little":[118],"known":[120],"about":[121],"these":[122],"they":[127],"delaying":[130],"symptom":[132],"onset.":[133],"Only":[134],"palliative":[135],"treatment":[136,155,319],"now":[138],"available":[139],"for":[140,306,317],"PD.":[141],"This":[142],"consists":[143],"principally":[145],"replacement":[148,168,229],"therapy":[149,230],"L-DOPA":[151,170],"considered":[152],"gold":[154],"standard.":[156],"In":[157],"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine":[159],"(MPTP)":[160],"model":[161],"chronic":[164],"administration":[165],"drugs,":[169],"or":[171,282,297],"BL-1023":[172],"absence":[175],"further":[177],"degeneration,":[178],"resulted":[179],"improved":[181],"function":[183],"consistent":[185],"increases":[186],"number":[189],"TH+":[191,200],"nigra.":[196],"The":[197],"increase":[198],"was":[202,260],"neurogenic":[207],"activity,":[208],"rather":[210],"phenotypic":[212],"shift":[213],"GAD67+":[215],"GABAergic":[216],"express":[219],"TH.":[220],"These":[221,286],"data":[222,287],"represent":[223,313],"novel":[225,315],"effect":[226],"as":[231,324,326],"triggering":[232],"putative":[233],"mechanisms,":[235],"presumably":[236],"restore":[238],"levels":[240],"depleted":[244],"environment.":[245],"An":[246],"interleukin-23":[247],"(IL-23)":[248],"knock-out":[249,274],"mouse":[250],"strain":[251],"proven":[252],"significantly":[255],"reduced":[256],"neuron":[258],"population":[259],"used":[261],"test":[263],"control":[265],"behavior.":[267],"No":[268],"differences":[270],"were":[271],"observed":[272],"between":[273],"wild-type":[276],"any":[278],"forced":[281],"unforced":[283],"tests.":[285],"suggest":[288],"either":[289],"insufficient":[290],"afford":[294],"functional":[295],"alterations":[296],"that":[298,320],"compensation":[299],"signaling":[303],"pathway":[304,316],"allowed":[305],"functioning.":[308],"Taken":[309],"together,":[310],"include":[321],"symptomatic":[322],"benefits":[323],"well":[325],"potential":[327],"regenerative":[328],"strategies.":[329],"Targeting":[330],"such":[331],"pathways":[332],"may":[333],"provide":[334],"effective":[336],"therapeutics":[337],"avoiding":[339],"secondary":[341],"toxicities":[342],"current":[344],"pharmaceuticals.":[345]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
