{"id":"https://openalex.org/W1905007679","doi":null,"title":"Purification and quantities of immunoglobulins of rheumatoid synovial tissues.","display_name":"Purification and quantities of immunoglobulins of rheumatoid synovial tissues.","publication_year":1980,"publication_date":"1980-09-01","ids":{"openalex":"https://openalex.org/W1905007679","mag":"1905007679","pmid":"https://pubmed.ncbi.nlm.nih.gov/7425534"},"language":"en","primary_location":{"id":"pmid:7425534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7425534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063822600","display_name":"Benjamin O. Anderson","orcid":"https://orcid.org/0000-0001-7217-7428","observed_orcids":["https://orcid.org/0000-0001-7217-7428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044453574","display_name":"Alice K. Jameson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Jameson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021136088","display_name":"M Lu-Steffes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Steffes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020177835","display_name":"Rasa R. Martincic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Martincic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11344097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"5","first_page":"432","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.9789999723434448},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.9520000219345093},{"id":"https://openalex.org/keywords/affinity-chromatography","display_name":"affinity chromatography","score":0.7739999890327454},{"id":"https://openalex.org/keywords/deae-cellulose","display_name":"DEAE-cellulose","score":0.7940000295639038},{"id":"https://openalex.org/keywords/immunoglobulin-m","display_name":"immunoglobulin M","score":0.781000018119812},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immunoglobulin-purification","display_name":"immunoglobulin purification","score":0.6800000071525574},{"id":"https://openalex.org/keywords/immunoglobulin-quantification","display_name":"immunoglobulin quantification","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7762511372566223},{"id":"https://openalex.org/C2779881004","wikidata":"https://www.wikidata.org/wiki/Q7451876","display_name":"Sepharose","level":3,"score":0.7248330116271973},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.70389324426651},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6630234122276306},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.5705902576446533},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4693616032600403},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3199647068977356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15444347262382507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08983111381530762},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08242601156234741}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7425534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7425534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Comparative Study"},{"id":"mag:1905007679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7425534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W25794465","https://openalex.org/W196311969","https://openalex.org/W1771132779","https://openalex.org/W2031920952","https://openalex.org/W2096205070","https://openalex.org/W2127497673","https://openalex.org/W2152247616","https://openalex.org/W2158393999","https://openalex.org/W2413150797"],"related_works":["https://openalex.org/W7097485136","https://openalex.org/W2330719380","https://openalex.org/W1978208898","https://openalex.org/W2033483768","https://openalex.org/W1989210654","https://openalex.org/W2053208493","https://openalex.org/W7033208604","https://openalex.org/W2092354936","https://openalex.org/W2412789732","https://openalex.org/W2055659578"],"abstract_inverted_index":{"Synovial":[0],"tissue":[1],"of":[2,16,30,49,100,113],"rheumatoid":[3],"arthritic":[4],"origin":[5],"was":[6],"incubateed":[7],"with":[8],"radio-labelled":[9],"amino":[10],"acids":[11],"and":[12,68,95],"the":[13,17,56,62,76],"immunoglobulin":[14,32,80],"fraction":[15],"products":[18],"isolated":[19],"using":[20],"either":[21],"a":[22,41],"diethylaminoethyl":[23],"(DEAE)-cellulose":[24],"column":[25,29,38],"or":[26],"an":[27],"affinity":[28,37,57,103],"antihuman":[31],"coupled":[33],"to":[34,64,91,115],"Sepharose.":[35],"The":[36,53,102],"method":[39],"provided":[40],"simple,":[42],"one-step":[43],"procedure":[44],"for":[45,85],"obtaining":[46],"quantitative":[47],"yields":[48],"substantially":[50],"pure":[51],"immunoglobulin.":[52],"elutions":[54,63],"from":[55],"columns":[58,104],"utilized":[59],"guanidine-HCl":[60],"allowing":[61],"be":[65,92,106],"performed":[66],"quickly":[67],"under":[69],"conditions":[70,84],"which":[71],"apparently":[72],"did":[73],"not":[74,93],"denature":[75],"immunoglobulins":[77],"except":[78],"perhaps":[79],"M.":[81],"Other":[82],"solvent":[83],"dissociating":[86],"antibody-antigen":[87],"complexes":[88],"were":[89],"shown":[90],"suitable":[94],"resulted":[96],"in":[97],"large":[98],"volumes":[99],"eluates.":[101],"could":[105],"reutilized":[107],"many":[108],"times":[109],"without":[110],"apparent":[111],"loss":[112],"capacity":[114],"bind":[116],"immunoglobulins.":[117]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
