{"id":"https://openalex.org/W190443710","doi":null,"title":"FANCM AND FAAP24 MAINTAIN GENOMIC STABILITY THROUGH COOPERATIVE AND UNIQUE FUNCTIONS","display_name":"FANCM AND FAAP24 MAINTAIN GENOMIC STABILITY THROUGH COOPERATIVE AND UNIQUE FUNCTIONS","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W190443710","mag":"190443710"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1343","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102945222","display_name":"Yucai Wang","orcid":"https://orcid.org/0000-0002-1576-8341","observed_orcids":["https://orcid.org/0000-0002-1576-8341"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yucai Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1576-8341","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102945222"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fancm","display_name":"FANCM","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fanconi-anemia-pathway","display_name":"Fanconi anemia pathway","score":0.972000002861023},{"id":"https://openalex.org/keywords/interstrand-crosslink-repair","display_name":"interstrand crosslink repair","score":0.7749999761581421},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7129999995231628},{"id":"https://openalex.org/keywords/sister-chromatid-exchange","display_name":"sister chromatid exchange","score":0.6439999938011169},{"id":"https://openalex.org/keywords/fancd2-monoubiquitination","display_name":"FANCD2 monoubiquitination","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fa-core-complex","display_name":"FA core complex","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lesion-bypass","display_name":"lesion bypass","score":0.6489999890327454},{"id":"https://openalex.org/keywords/crossover-suppression","display_name":"crossover suppression","score":0.5329999923706055},{"id":"https://openalex.org/keywords/recombination-repair","display_name":"recombination repair","score":0.5709999799728394},{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4042740762233734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3893474340438843},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3376939594745636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3373830318450928}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1343","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:190443710","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1343&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1343","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/309","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W190443710.pdf","grobid_xml":"https://content.openalex.org/works/W190443710.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1970072945","https://openalex.org/W1973038715","https://openalex.org/W1977317997","https://openalex.org/W1979324654","https://openalex.org/W1984372057","https://openalex.org/W1986890123","https://openalex.org/W1990734482","https://openalex.org/W1995515648","https://openalex.org/W1998491954","https://openalex.org/W2004125597","https://openalex.org/W2004264651","https://openalex.org/W2009167909","https://openalex.org/W2010216792","https://openalex.org/W2010444982","https://openalex.org/W2015792141","https://openalex.org/W2022460501","https://openalex.org/W2024073282","https://openalex.org/W2024531751","https://openalex.org/W2028285902","https://openalex.org/W2028767678","https://openalex.org/W2030912934","https://openalex.org/W2034747770","https://openalex.org/W2039641528","https://openalex.org/W2042056279","https://openalex.org/W2042993247","https://openalex.org/W2043051674","https://openalex.org/W2044292152","https://openalex.org/W2045448966","https://openalex.org/W2052215590","https://openalex.org/W2056068841","https://openalex.org/W2062413735","https://openalex.org/W2084624885","https://openalex.org/W2086482792","https://openalex.org/W2087967916","https://openalex.org/W2088374322","https://openalex.org/W2096048754","https://openalex.org/W2101683085","https://openalex.org/W2108077889","https://openalex.org/W2109630092","https://openalex.org/W2111461823","https://openalex.org/W2111736994","https://openalex.org/W2112664493","https://openalex.org/W2114776482","https://openalex.org/W2114907977","https://openalex.org/W2116111997","https://openalex.org/W2126760394","https://openalex.org/W2128700722","https://openalex.org/W2128761982","https://openalex.org/W2132587601","https://openalex.org/W2135269077","https://openalex.org/W2140336382","https://openalex.org/W2141539652","https://openalex.org/W2159859860","https://openalex.org/W2167844213","https://openalex.org/W2345107231","https://openalex.org/W2410389862","https://openalex.org/W2465174048"],"related_works":["https://openalex.org/W2117459935","https://openalex.org/W8756019","https://openalex.org/W3015347908","https://openalex.org/W1970072945","https://openalex.org/W2058703060","https://openalex.org/W1979324654","https://openalex.org/W2756203475","https://openalex.org/W2114776482","https://openalex.org/W7017448945","https://openalex.org/W2050146059"],"abstract_inverted_index":{"Fanconi":[0],"anemia":[1],"(FA)":[2],"is":[3,35,261,311],"a":[4,252],"rare":[5],"recessive":[6],"genetic":[7,104],"disease":[8],"with":[9,266],"an":[10],"array":[11],"of":[12,29,78,102,136,200,207,241,263,278,284],"clinical":[13],"manifestations":[14],"including":[15],"multiple":[16],"congenital":[17],"abnormalities,":[18],"progressive":[19],"bone":[20],"marrow":[21],"failure":[22],"and":[23,47,52,75,98,120,131,138,149,169,176,194,211,223,243,289,314,319],"profound":[24],"cancer":[25],"susceptibility.":[26],"A":[27],"hallmark":[28],"cells":[30,60],"derived":[31],"from":[32,61],"FA":[33,72,142,201,208],"patients":[34],"hypersensitivity":[36],"to":[37,163,187,218,247,293],"DNA":[38,62,84,145,164],"interstrand":[39,63],"crosslinking":[40,165],"agents":[41,166],"such":[42],"as":[43,180,182],"mitomycin":[44],"C":[45],"(MMC)":[46],"cisplatin,":[48],"suggesting":[49,173],"that":[50,154,174,192],"FA-":[51],"FA-associated":[53],"proteins":[54],"play":[55],"important":[56],"roles":[57],"in":[58,70,128,185,231,245,255],"protecting":[59],"crosslink":[64],"(ICL)":[65],"damage.":[66,189,249],"Two":[67],"genes":[68],"involved":[69],"the":[71,99,134,155,198,269],"pathway,":[73],"FANCM":[74,137,175,193,242,272,281,318],"FAAP24,":[76],"are":[77,89],"particular":[79],"interest":[80],"because":[81],"they":[82],"contain":[83],"interacting":[85],"domains.":[86],"However,":[87],"there":[88],"no":[90],"definitive":[91],"patient":[92],"mutations":[93],"for":[94],"these":[95],"two":[96],"genes,":[97],"resulting":[100],"lack":[101],"human":[103,118],"model":[105],"system":[106],"renders":[107],"their":[108],"functional":[109],"studies":[110,303],"difficult.":[111],"In":[112,234],"this":[113],"study,":[114],"I":[115,152,190,236],"established":[116],"isogenic":[117],"FANCM-":[119],"FAAP24-null":[121],"mutants":[122],"through":[123,297],"homologous":[124],"replacement-mediated":[125],"gene":[126],"targeting":[127],"HCT-116":[129],"cells,":[130],"systematically":[132],"investigated":[133],"functions":[135,184,240],"FAAP24":[139,177,195,244,250],"inchromosome":[140],"stability,":[141],"pathway":[143,202],"activation,":[144],"damage":[146,295],"checkpoint":[147],"signaling,":[148],"ICL":[150,188,248,275,294],"repair.":[151,233],"found":[153],"FANCM-/-/FAAP24-/-":[156],"double":[157],"mutant":[158],"was":[159],"much":[160],"more":[161],"sensitive":[162],"than":[167],"FANCM-/-":[168],"FAAP24-/-":[170],"single":[171],"mutants,":[172],"possess":[178],"epistatic":[179],"well":[181],"unique":[183],"response":[186,246],"demonstrated":[191],"coordinately":[196,313],"support":[197],"activation":[199],"by":[203,228,317],"promoting":[204],"chromatin":[205],"localization":[206],"core":[209],"complex":[210],"FANCD2":[212],"monoubiqutination.":[213],"They":[214],"also":[215],"cooperatively":[216],"function":[217],"suppress":[219],"sister":[220],"chromatid":[221],"exchange":[222],"radial":[224],"chromosome":[225],"formation,":[226],"likely":[227],"limiting":[229],"crossovers":[230],"recombination":[232],"addition,":[235],"defined":[237],"novel":[238],"non-overlapping":[239],"plays":[251],"major":[253],"role":[254],"activating":[256],"ICL-induced":[257],"ATR-dependent":[258],"checkpoint,":[259],"which":[260],"independent":[262],"its":[264,298],"interaction":[265],"FANCM.":[267],"On":[268],"other":[270],"hand,":[271],"promotes":[273],"recombination-independent":[274],"repair":[276,287],"independently":[277,315],"FAAP24.":[279,320],"Mechanistically,":[280],"facilitates":[282],"recruitment":[283],"nucleotide":[285],"excision":[286],"machinery":[288],"lesion":[290],"bypass":[291],"factors":[292],"sites":[296],"translocase":[299],"activity.":[300],"Collectively,":[301],"my":[302],"provide":[304],"mechanistic":[305],"insights":[306],"into":[307],"how":[308],"genome":[309],"integrity":[310],"both":[312],"protected":[316]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
