{"id":"https://openalex.org/W1904055835","doi":null,"title":"In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum: a morphologic study.","display_name":"In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum: a morphologic study.","publication_year":1979,"publication_date":"1979-04-01","ids":{"openalex":"https://openalex.org/W1904055835","mag":"1904055835","pmid":"https://pubmed.ncbi.nlm.nih.gov/434114","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042286"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2042286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042286","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042286","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072529872","display_name":"Kyoko Saida","orcid":"https://orcid.org/0000-0003-2911-8865","observed_orcids":["https://orcid.org/0000-0003-2911-8865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Saida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038444769","display_name":"Takahiko Saida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Saida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062436495","display_name":"Mark J. Brown","orcid":"https://orcid.org/0000-0002-3874-1352","observed_orcids":["https://orcid.org/0000-0002-3874-1352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111896171","display_name":"Donald H. Silberberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Silberberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.0297,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.99387806,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"95","issue":"1","first_page":"99","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.353300005197525,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galactocerebroside","display_name":"galactocerebroside","score":0.8799999952316284},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.8299999833106995},{"id":"https://openalex.org/keywords/intraneural-injection","display_name":"intraneural injection","score":0.7870000004768372},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.9430000185966492},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/myelin-phagocytosis","display_name":"myelin phagocytosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9739999771118164},{"id":"https://openalex.org/keywords/endoneurial-edema","display_name":"endoneurial edema","score":0.8259999752044678},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocyte-infiltration","display_name":"polymorphonuclear leukocyte infiltration","score":0.800000011920929},{"id":"https://openalex.org/keywords/experimental-allergic-neuritis","display_name":"experimental allergic neuritis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cobra-venom-factor","display_name":"cobra venom factor","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2781017270","wikidata":"https://www.wikidata.org/wiki/Q2756638","display_name":"Galactocerebroside","level":5,"score":0.8927010297775269},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7387540936470032},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.6299340128898621},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.622316300868988},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6017060279846191},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.5919846892356873},{"id":"https://openalex.org/C2776028648","wikidata":"https://www.wikidata.org/wiki/Q2307256","display_name":"Neuritis","level":2,"score":0.5739454627037048},{"id":"https://openalex.org/C2775850654","wikidata":"https://www.wikidata.org/wiki/Q763062","display_name":"Endoneurium","level":3,"score":0.5225945711135864},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.4860582649707794},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4528820812702179},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4265182316303253},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.38616782426834106},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2876296639442444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2789928615093231},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24504512548446655},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.2427181899547577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2348291277885437},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.15960153937339783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11251944303512573},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07185539603233337},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002554","descriptor_name":"Cerebrosides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005699","descriptor_name":"Galactosylceramides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2042286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042286","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:434114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/434114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:1904055835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/434114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2042286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042286","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1512511436","https://openalex.org/W1557680767","https://openalex.org/W1966064629","https://openalex.org/W1971353171","https://openalex.org/W1975253171","https://openalex.org/W1976508643","https://openalex.org/W1982155486","https://openalex.org/W1991094527","https://openalex.org/W1999315662","https://openalex.org/W2007484375","https://openalex.org/W2011144147","https://openalex.org/W2012907151","https://openalex.org/W2030021002","https://openalex.org/W2034318072","https://openalex.org/W2039116931","https://openalex.org/W2044158555","https://openalex.org/W2061019104","https://openalex.org/W2079622312","https://openalex.org/W2087251650","https://openalex.org/W2091671698","https://openalex.org/W2092210814","https://openalex.org/W2092307331","https://openalex.org/W2094365996","https://openalex.org/W2192379666","https://openalex.org/W2398609420","https://openalex.org/W2408852582","https://openalex.org/W2409703311","https://openalex.org/W2411986966","https://openalex.org/W2412101499","https://openalex.org/W2412289418","https://openalex.org/W2415275475","https://openalex.org/W2415806023","https://openalex.org/W2416300266","https://openalex.org/W4293775909"],"related_works":["https://openalex.org/W1974357433","https://openalex.org/W2009234156","https://openalex.org/W1965095812","https://openalex.org/W2114298309","https://openalex.org/W2124345384","https://openalex.org/W2409703311","https://openalex.org/W1966710505","https://openalex.org/W1980851023","https://openalex.org/W1965078160","https://openalex.org/W2074799982"],"abstract_inverted_index":{"Intraneural":[0],"injection":[1],"of":[2,20,74,88,122,136,163],"rabbit":[3,89],"anti-galactocerebroside":[4],"(anti-GC)":[5],"serum":[6,135],"produced":[7],"focaldemyelinative":[8],"lesions":[9],"in":[10,34,55,133,160,165],"rat":[11],"sciatic":[12],"nerves.":[13],"Recipient":[14],"rats":[15,123],"developed":[16],"a":[17],"sensory":[18],"motordeficit":[19],"the":[21,26,48,109,134,161],"toes":[22],"and":[23,45,61,79,104,118,142,156],"feet":[24],"on":[25],"side":[27],"injected":[28,119,125],"with":[29,96,126,138,148],"anti-GC":[30,90],"serum.":[31],"Schwann":[32],"cellabnormalities":[33],"recipient":[35],"nerves":[36,121],"were":[37,111],"apparent":[38],"by":[39,43,58,67,94],"20":[40],"minutes,":[41],"followed":[42],"myelinsplitting":[44],"vesiculation":[46],"over":[47],"next":[49],"8":[50],"hours.":[51],"Macrophages":[52],"first":[53],"appeared":[54],"moder-ate":[56],"numbers":[57],"15":[59],"hours,":[60],"degraded":[62],"myelin":[63,103],"was":[64,83,92,105],"completely":[65],"phagocvtized":[66],"5":[68],"days.An":[69],"acute":[70],"inflammatory":[71],"reaction":[72],"consisting":[73],"endoneurial":[75],"edema,":[76],"polymorphonuclearcell":[77],"infiltration,":[78],"fibrin":[80],"extravasation":[81],"also":[82,106],"prominent.":[84],"In":[85],"vivo":[86],"demyelinativeactivity":[87],"serums":[91,110],"removed":[93],"pre-incubation":[95],"GC":[97],"or":[98,152,169],"central":[99],"orperipheral":[100],"nervous":[101],"system":[102],"lost":[107],"when":[108],"heated":[112],"at":[113],"56C":[114],"for":[115],"30":[116],"minutes":[117],"into":[120],"previously":[124],"cobra":[127],"venomfactor.":[128],"Anti-GC":[129],"antibodies":[130],"are":[131],"present":[132],"rabbits":[137],"experimentalallergic":[139],"neuritis":[140],"(WNV-EAN)":[141],"encephalomyelitis":[143],"(WM-EAE)":[144],"produced,":[145],"respectively,by":[146],"immunization":[147],"whole":[149],"peripheral":[150],"nerve":[151],"brain":[153],"white":[154],"matter":[155],"may":[157],"play":[158],"arole":[159],"pathogenesis":[162],"demyelination":[164],"GC-induced":[166],"EAN,":[167],"WN-EAN,":[168],"WM-EAE.":[170]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}