{"id":"https://openalex.org/W1903353148","doi":null,"title":"Genistein potentiates the radiation effect on prostate carcinoma cells.","display_name":"Genistein potentiates the radiation effect on prostate carcinoma cells.","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W1903353148","mag":"1903353148","pmid":"https://pubmed.ncbi.nlm.nih.gov/11234894"},"language":"en","primary_location":{"id":"pmid:11234894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11234894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080528828","display_name":"Gilda Gali Hillman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I2801460292","display_name":"Harper University Hospital","ror":"https://ror.org/00sxe0e68","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109","https://openalex.org/I2801460292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G G Hillman","raw_affiliation_strings":["Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA. hillmang@karmanos.org","Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA. hillmang@karmanos.org","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I2801460292","https://openalex.org/I4210090317"]},{"raw_affiliation_string":"Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I2801460292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017339790","display_name":"Jeffrey D. Forman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Forman","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":null,"display_name":"O Kucuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Kucuk","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043032824","display_name":"Mark Yudelev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Yudelev","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109231212","display_name":"Richard L. Maughan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R L Maughan","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038246064","display_name":"Johanna Rubio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Rubio","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024252101","display_name":"Andrey Layer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Layer","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111503382","display_name":"Samuel Tekyi\u2010Mensah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Tekyi-Mensah","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016774003","display_name":"Judith Abrams","orcid":"https://orcid.org/0000-0001-9171-6458","observed_orcids":["https://orcid.org/0000-0001-9171-6458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Abrams","raw_affiliation_strings":["Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109278193","display_name":"Fazlul H. Sarkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F H Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4582,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.91689393,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"2","first_page":"382","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neutron-radiation","display_name":"neutron radiation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/photon-radiation","display_name":"photon radiation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.8360000252723694},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.875},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.7789999842643738},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.7009999752044678},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.8598248958587646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5532872676849365},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5246624946594238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4445742070674896},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4429967403411865},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4383714497089386},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43557465076446533},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4211330711841583},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.42087388038635254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37195008993148804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3495488166809082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3209354281425476},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2981783449649811},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22137489914894104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14118018746376038}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11234894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11234894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:1903353148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11234894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1520696669","https://openalex.org/W1557552990","https://openalex.org/W1676540962","https://openalex.org/W1926564796","https://openalex.org/W1947279451","https://openalex.org/W1966902465","https://openalex.org/W1969327970","https://openalex.org/W1972001819","https://openalex.org/W1976766196","https://openalex.org/W1976999762","https://openalex.org/W1986358472","https://openalex.org/W1989345460","https://openalex.org/W1991432037","https://openalex.org/W2005289060","https://openalex.org/W2009526752","https://openalex.org/W2014676294","https://openalex.org/W2024138588","https://openalex.org/W2031586124","https://openalex.org/W2036843530","https://openalex.org/W2037250108","https://openalex.org/W2057184021","https://openalex.org/W2069701115","https://openalex.org/W2072650440","https://openalex.org/W2073412226","https://openalex.org/W2111077139","https://openalex.org/W2123927174","https://openalex.org/W2131032307","https://openalex.org/W2143965341","https://openalex.org/W2150726070","https://openalex.org/W2163413812","https://openalex.org/W2170506785","https://openalex.org/W2318098003"],"related_works":["https://openalex.org/W2142716359","https://openalex.org/W2147301416","https://openalex.org/W4388171703","https://openalex.org/W2153734946","https://openalex.org/W2398849335","https://openalex.org/W2519367728","https://openalex.org/W2253208760","https://openalex.org/W2052628987","https://openalex.org/W7099229135","https://openalex.org/W7221630326"],"abstract_inverted_index":{"We":[0,84],"have":[1,39],"shown":[2],"previously":[3],"that":[4,86,169],"genistein,":[5],"the":[6,12,23,31,42,94,131,137,154,188,203,217],"major":[7],"isoflavone":[8],"in":[9,19,55,100,103,122,130,178],"soybean,":[10],"inhibited":[11],"growth":[13],"of":[14,33,44,59,96,108,133,139,142,153,180,190,211,219],"human":[15],"prostate":[16,36,52,97,221],"cancer":[17],"cells":[18,54,99],"vitro":[20],"by":[21],"affecting":[22],"cell":[24,76,79,125,181],"cycle":[25],"and":[26,48,78,127,135,183],"inducing":[27],"apoptosis.":[28],"To":[29],"augment":[30,187],"effect":[32,138,152,189],"radiation":[34,50,63,164,173,215],"for":[35,93,216],"carcinoma,":[37],"we":[38],"now":[40],"tested":[41],"combination":[43],"genistein":[45,66,162,170,213],"with":[46,112,161,172,214],"photon":[47,60,145,198],"neutron":[49,62,149],"on":[51,73],"carcinoma":[53,98],"vitro.":[56],"The":[57,151],"effects":[58],"or":[61,65,68,146,163],"alone":[64,67],"both":[69],"combined":[70,155,171],"were":[71,88],"evaluated":[72],"DNA":[74,123,175],"synthesis,":[75,124,176],"growth,":[77,126],"ability":[80],"to":[81,201],"form":[82],"colonies.":[83],"found":[85],"neutrons":[87,191],"more":[89,158],"effective":[90],"than":[91,160,197],"photons":[92],"killing":[95],"vitro,":[101],"resulting":[102,177],"a":[104,119,209],"relative":[105],"biological":[106],"effectiveness":[107],"2.6":[109],"when":[110],"compared":[111],"photons.":[113],"Genistein":[114,185],"at":[115,192],"15":[116],"microM":[117],"caused":[118],"significant":[120],"inhibition":[121,179],"colony":[128],"formation":[129],"range":[132],"40-60%":[134],"potentiated":[136],"low":[140],"doses":[141,193,199],"200-300":[143],"cGy":[144,148],"100-150":[147],"radiation.":[150],"treatment":[156,218],"was":[157],"pronounced":[159],"alone.":[165],"Our":[166],"data":[167],"indicate":[168],"inhibits":[174],"division":[182],"growth.":[184],"can":[186],"approximately":[194],"2-fold":[195],"lower":[196],"required":[200],"observe":[202],"same":[204],"efficacy.":[205],"These":[206],"studies":[207],"suggest":[208],"potential":[210],"combining":[212],"localized":[220],"carcinoma.":[222]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}