{"id":"https://openalex.org/W1902581652","doi":null,"title":"17beta-estradiol regulation of human growth hormone (hGH), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) axis in hypoestrogenic, hypergonadotropic women.","display_name":"17beta-estradiol regulation of human growth hormone (hGH), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) axis in hypoestrogenic, hypergonadotropic women.","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W1902581652","mag":"1902581652","pmid":"https://pubmed.ncbi.nlm.nih.gov/16821205"},"language":"en","primary_location":{"id":"pmid:16821205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16821205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrynologia Polska","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ruj.uj.edu.pl/xmlui/handle/item/155188","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070586291","display_name":"Tomasz Milewicz","orcid":"https://orcid.org/0000-0003-2452-0193","observed_orcids":["https://orcid.org/0000-0003-2452-0193"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]},{"id":"https://openalex.org/I4210090147","display_name":"Uniwersytecki Szpital Dzieci\u0119cy","ror":"https://ror.org/009x1kj44","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I126596746","https://openalex.org/I4210090147"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Milewicz","raw_affiliation_strings":["Department of Gynecological Endocrinology Jagiellonian University, and Department of Clinical Biochemistry, Universtiy Children Hospital, Cracow, Poland. momilewi@cyf-kr.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecological Endocrinology Jagiellonian University, and Department of Clinical Biochemistry, Universtiy Children Hospital, Cracow, Poland. momilewi@cyf-kr.edu.pl","institution_ids":["https://openalex.org/I126596746","https://openalex.org/I4210090147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068599995","display_name":"J\u00f3zef Krzysiek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00f3zef Krzysiek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064863834","display_name":"Krystyna Sztefko","orcid":"https://orcid.org/0000-0002-0455-0662","observed_orcids":["https://orcid.org/0000-0002-0455-0662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystyna Sztefko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036029646","display_name":"Stanis\u0142aw Radowicki","orcid":"https://orcid.org/0000-0003-3376-0471","observed_orcids":["https://orcid.org/0000-0003-3376-0471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanis\u0142aw Radowicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111962542","display_name":"Magdalena Krzyczkowska-Sendrakowska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Krzyczkowska-Sendrakowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"6","first_page":"876","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9639999866485596},{"id":"https://openalex.org/keywords/human-growth-hormone","display_name":"human growth hormone","score":0.8899999856948853},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8970000147819519},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3","display_name":"insulin-like growth factor binding protein-3","score":0.9599999785423279},{"id":"https://openalex.org/keywords/premature-ovarian-failure","display_name":"premature ovarian failure","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hypergonadotropic-hypogonadism","display_name":"hypergonadotropic hypogonadism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ovarian-function","display_name":"ovarian function","score":0.414000004529953},{"id":"https://openalex.org/keywords/growth-hormone-axis","display_name":"growth hormone axis","score":0.5440000295639038},{"id":"https://openalex.org/keywords/igf-i-igfbp-3-ratio","display_name":"IGF-I/IGFBP-3 ratio","score":0.7400000095367432},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.5189999938011169},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.7590000033378601},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.5630000233650208},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7608605027198792},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7228286266326904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6616470813751221},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.526605486869812},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4422450363636017},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16401827335357666}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016649","descriptor_name":"Primary Ovarian Insufficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16821205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16821205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrynologia Polska","raw_type":"Comparative Study"},{"id":"pmh:oai:ruj.uj.edu.pl:item/155188","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25779/20601","pdf_url":"https://ruj.uj.edu.pl/xmlui/handle/item/155188","source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ruj.uj.edu.pl:item/155188","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/endokrynologia_polska/article/view/25779/20601","pdf_url":"https://ruj.uj.edu.pl/xmlui/handle/item/155188","source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1902581652.pdf","grobid_xml":"https://content.openalex.org/works/W1902581652.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W265898859","https://openalex.org/W1963723296","https://openalex.org/W1966341815","https://openalex.org/W1980701912","https://openalex.org/W1985702136","https://openalex.org/W1987910229","https://openalex.org/W1992460416","https://openalex.org/W1996121105","https://openalex.org/W1997993870","https://openalex.org/W2000269528","https://openalex.org/W2014248907","https://openalex.org/W2014358951","https://openalex.org/W2018804468","https://openalex.org/W2031397997","https://openalex.org/W2039621194","https://openalex.org/W2049144714","https://openalex.org/W2050386090","https://openalex.org/W2062970399","https://openalex.org/W2062999270","https://openalex.org/W2064869610","https://openalex.org/W2067385360","https://openalex.org/W2079821269","https://openalex.org/W2086223474","https://openalex.org/W2090171857","https://openalex.org/W2092035265","https://openalex.org/W2094667589","https://openalex.org/W2099600128","https://openalex.org/W2108372662","https://openalex.org/W2124294030","https://openalex.org/W2124833005","https://openalex.org/W2395314500","https://openalex.org/W2474618833","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7139431589","https://openalex.org/W36385595","https://openalex.org/W2099252082","https://openalex.org/W2064869610","https://openalex.org/W1975217105","https://openalex.org/W2084596533","https://openalex.org/W2027007779","https://openalex.org/W1995950849","https://openalex.org/W1966341815","https://openalex.org/W1976923590"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Ovarian":[1],"hormonal":[2],"function":[3],"may":[4,424],"be":[5,425],"as":[6,13,111,113,225,342,344,426,436],"important":[7,427],"contributing":[8],"factor":[9],"to":[10,31,172,201,329,429],"hGH-IGF-I-IGFBP-3":[11],"axis":[12],"age.":[14],"AIM:":[15],"To":[16],"examine":[17],"plasma":[18,103,161,208,275,434],"hGH,":[19,104],"IGF-1":[20],"and":[21,35,97,109,117,151,178,245,265,277,286,299,311,364,385,411],"IGFBP-3":[22,191,209,386,402],"levels":[23,279,331],"in":[24,146,154,164,175,184,195,213,219,226,237,242,252,262,270,283,307,332,356,359,367,379,382,395,398,408,415,438],"women":[25,41,63,83],"with":[26,42,182],"premature":[27,43],"ovarian":[28,44],"failure":[29,45],"compared":[30,181,200],"healthy":[32],"normal":[33],"controls":[34,78],"postmenopausal":[36],"ones.":[37],"PATIENTS:":[38],"Group":[39,57,75],"A-15":[40],"(POF)":[46],"(mean:":[47,64,84],"age":[48,65,85,300,320,437],"38.9+/-5.2":[49],"years,":[50],"FSH":[51,68,88,116,278],"101.4+/-29.0":[52],"IU/l;":[53,70,90],"17beta-estradiol":[54,71,91],"22.5+/-14.6":[55],"ng/l).":[56,74,93],"B":[58,148,177,197,287,312,362,384,417],"consisted":[59],"of":[60,339,353,376,392,418],"15":[61,80],"menopausal":[62],"54.7+/-2.7":[66],"years;":[67,87],"81.9+/-32.1":[69],"17.1+/-":[72],"8.0":[73],"C":[76,156,203,221,246,272,293,334],"-":[77,79],"normally":[81],"menstruating":[82],"37.1+/-9.0":[86],"6.2+/-1.0":[89],"144.8+/-117.1":[92],"METHODS:":[94],"Body":[95],"mass":[96],"BMI":[98],"were":[99,119,235,247,280,295,347],"measured.":[100],"Basic":[101],"fasting":[102],"IGF-I,":[105],"IGFBP-3,":[106],"insulin,":[107],"testosterone":[108],"LH":[110,276],"well":[112,343],"prolactin":[114],"(PRL),":[115],"estradiol":[118,258],"assessed":[120],"by":[121],"RIA":[122],"kits.":[123],"Statistical":[124],"analysis.":[125],"Shapiro-Wilk":[126],"test,":[127],"Mann-Whitney":[128],"u-test,":[129],"Spearman":[130],"rang":[131],"correlation":[132],"coefficient,":[133],"stepwise":[134],"multiple":[135],"regression.":[136],"RESULTS:":[137],"Mean":[138,274],"serum":[139,190],"IGF-I":[140,162,298,357,380,396],"level":[141,163,192,210,259,326,358,381,397,435],"was":[142,167,193,216,260,269,327,387,403],"the":[143,152,308,354,360,377,393,419],"lowest":[144,188,256],"(p<0.005)":[145,189,222],"group":[147,155,165,176,185,196,202,214,220,227,243,253,271,289,292,333,361,368,383,399,409,416],"(172.0+/-54.6":[149],"microg/l)":[150,171,199,212],"highest":[153,268],"(273.6+/-109.0":[157],"microg/l).":[158,205],"The":[159,187,206,255,267,303,316],"mean":[160,207,238,257],"A":[166,215,244,264,285,310,369,410],"similar":[168],"(NS)":[169],"(208.3+/-66.5":[170],"that":[173,183],"found":[174,194,261],"lower":[179,217],"(p<0.02)":[180],"C.":[186,290,400],"(3.1+/-0.7":[198],"(4.4+/-0.3":[204],"(3.1+/-1.0":[211],"than":[218,250],"but":[223],"identical":[224],"B.":[228,254,266],"No":[229],"statistically":[230],"significant":[231],"differences":[232],"between":[233,297],"groups":[234,263,284,309,340],"observed":[236],"hGH":[239,330,420],"levels.":[240],"Women":[241],"younger":[248],"(p<0.001)":[249,282],"those":[251],"(p<0.001).":[273],"higher":[281],"vs":[288],"In":[291,337],"there":[294],"links":[296],"(r=-0.60;":[301],"p=0.014)":[302],"IGF-I/age":[304],"relation":[305],"disappeared":[306],"(rA=-0.26;":[313],"rB=0.10;":[314],"NS).":[315],"same":[317],"regards":[318],"IGFBP-3/":[319],"link":[321],"(rA=-0.44,":[322],"NS;":[323],"rB=0,31;NS).":[324],"Estradiol":[325],"related":[328],"(r=-0.54;":[335],"p<0.05).":[336],"none":[338],"hGH/IGF-1":[341],"IGFBP-3/hGH":[345],"relations":[346],"found.":[348],"Prolactin":[349],"accounted":[350,372],"for":[351,365,373,389,405,412],"69%":[352],"variance":[355,378,394],"(p=0.003)":[363],"24%":[366],"(NS).":[370],"Testosterone":[371],"88%":[374],"(p=0.004)":[375],"responsible":[388,404],"86%":[390],"(p=0.038)":[391],"Again":[401],"47%":[406],"(p=0.023)":[407],"49%":[413],"(p=0.04)":[414],"variance.":[421],"CONCLUSIONS:":[422],"17b-estradiol":[423],"contributor":[428],"insulin-like":[430],"growth":[431],"factor-I":[432],"(IGF-I)":[433],"hypoestrogenic,":[439],"hypogonadotropic":[440],"women.":[441]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
