{"id":"https://openalex.org/W1902532465","doi":null,"title":"Modulation of clinical drug resistance in a B cell lymphoma patient by the protein kinase inhibitor 7-hydroxystaurosporine: presentation of a novel therapeutic paradigm.","display_name":"Modulation of clinical drug resistance in a B cell lymphoma patient by the protein kinase inhibitor 7-hydroxystaurosporine: presentation of a novel therapeutic paradigm.","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W1902532465","mag":"1902532465","pmid":"https://pubmed.ncbi.nlm.nih.gov/10690518"},"language":"en","primary_location":{"id":"pmid:10690518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10690518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049385918","display_name":"Wyndham Hopkins Wilson","orcid":"https://orcid.org/0000-0002-2862-9711","observed_orcids":["https://orcid.org/0000-0002-2862-9711"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W H Wilson","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055705591","display_name":"Lynn R. Sorbara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Sorbara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079418869","display_name":"William Douglas Figg","orcid":"https://orcid.org/0000-0003-2428-5613","observed_orcids":["https://orcid.org/0000-0003-2428-5613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W D Figg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063472329","display_name":"Erik K. Mont","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E K Mont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111650985","display_name":"Edward A. Sausville","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Sausville","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091661843","display_name":"Katherine E Warren","orcid":"https://orcid.org/0000-0003-2173-4129","observed_orcids":["https://orcid.org/0000-0003-2173-4129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K E Warren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M Balis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110102534","display_name":"K D Bauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Bauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024701461","display_name":"Mark A. Raffeld","orcid":"https://orcid.org/0000-0002-4039-6957","observed_orcids":["https://orcid.org/0000-0002-4039-6957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Raffeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054111083","display_name":"Adrian Mario Senderowicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Senderowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064141830","display_name":"Anne P. Monks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Monks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7484,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94809597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"6","issue":"2","first_page":"415","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/7-hydroxystaurosporine","display_name":"7-hydroxystaurosporine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ucn-01","display_name":"UCN-01","score":0.9309999942779541},{"id":"https://openalex.org/keywords/plasmacytoid-lymphoma","display_name":"plasmacytoid lymphoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/large-cell-lymphoma","display_name":"large cell lymphoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7609999775886536},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.7620000243186951},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/protein-kinase-inhibitors","display_name":"protein kinase inhibitors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/epoch-chemotherapy","display_name":"EPOCH chemotherapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.7889999747276306},{"id":"https://openalex.org/keywords/immunoglobulin-gene-rearrangement","display_name":"immunoglobulin gene rearrangement","score":0.902999997138977},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.562801718711853},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5613082647323608},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5030178427696228},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.47256770730018616},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.45777982473373413},{"id":"https://openalex.org/C2781214270","wikidata":"https://www.wikidata.org/wiki/Q4692282","display_name":"Aggressive lymphoma","level":4,"score":0.43505001068115234},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4008041024208069},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36803674697875977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36647990345954895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35998374223709106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28985103964805603},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.24910441040992737},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.21151095628738403}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10690518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10690518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Case Reports"},{"id":"mag:1902532465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10690518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W140561711","https://openalex.org/W147398146","https://openalex.org/W203201669","https://openalex.org/W1538814462","https://openalex.org/W1559053841","https://openalex.org/W1862918409","https://openalex.org/W1870357416","https://openalex.org/W1970687636","https://openalex.org/W1992045438","https://openalex.org/W2034466202","https://openalex.org/W2052624241","https://openalex.org/W2069855944","https://openalex.org/W2078003307","https://openalex.org/W2078730133","https://openalex.org/W2081894694","https://openalex.org/W2097173890","https://openalex.org/W2101103624","https://openalex.org/W2122282190","https://openalex.org/W2142058281","https://openalex.org/W2154126059","https://openalex.org/W2156565205","https://openalex.org/W2245825568","https://openalex.org/W2276408020","https://openalex.org/W2322339599","https://openalex.org/W2337836213","https://openalex.org/W2394778384"],"related_works":["https://openalex.org/W22320562","https://openalex.org/W2168275772","https://openalex.org/W2170758544","https://openalex.org/W2394778384","https://openalex.org/W2071202158","https://openalex.org/W1527712367","https://openalex.org/W2407720616","https://openalex.org/W1019998367","https://openalex.org/W2023490489","https://openalex.org/W2619252664"],"abstract_inverted_index":{"Emerging":[0],"evidence":[1,125],"suggests":[2],"that":[3,24,61,243],"apoptosis":[4,27,233],"is":[5,18,31,224],"an":[6,207],"important":[7],"mechanism":[8],"of":[9,35,103,126,143,171,217,252,269],"tumor":[10],"cell":[11,84,238],"death":[12],"from":[13,113],"antineoplastic":[14],"therapy.":[15],"7-hydroxystaurosporine":[16],"(UCN-01)":[17],"a":[19,43,56,137,163,198,215,235,264],"novel":[20],"protein":[21],"kinase":[22],"inhibitor":[23],"increases":[25,231],"chemotherapy-induced":[26],"in":[28,32,86,141,148,159,178,210,234],"vitro":[29,211],"and":[30,52,80,89,111,162,230,261],"early":[33],"phases":[34],"clinical":[36],"development.":[37],"In":[38,221],"this":[39],"report,":[40],"we":[41],"present":[42],"68-year-old":[44],"patient":[45],"with":[46,50,66,168,226],"chemotherapy-resistant":[47],"lymphoma":[48,60,85,247],"treated":[49],"UCN-01":[51,195,223,244],"chemotherapy.":[53,75],"He":[54],"had":[55],"stage":[57],"IV":[58],"plasmacytoid":[59],"failed":[62],"to":[63,77,82,204,248],"enter":[64],"remission":[65],"high-dose":[67],"EPOCH":[68,101],"II":[69],"(etoposide,":[70],"prednisone,":[71],"vincristine,":[72],"cyclophosphamide,":[73],"doxorubicin)":[74],"Due":[76],"disease":[78],"progression":[79],"transformation":[81],"large":[83],"the":[87,149,169,179,246,249,257],"liver":[88],"bone":[90],"marrow,":[91],"he":[92,98],"received":[93,99],"UCN-01.":[94],"Four":[95],"weeks":[96],"later,":[97],"\"standard-dose\"":[100],"because":[102],"progression,":[104],"developed":[105],"severe":[106],"neutropenia":[107],"for":[108,131,200,259,267],"9":[109],"days,":[110],"expired":[112],"Candida":[114],"sepsis":[115],"on":[116],"day":[117],"23.":[118],"At":[119],"autopsy,":[120],"there":[121],"was":[122,175,190],"no":[123,152],"histological":[124],"residual":[127],"lymphoma,":[128],"although":[129],"PCR":[130,183],"immunoglobulin":[132,180],"gene":[133,181],"rearrangement":[134,182],"analysis":[135],"revealed":[136],"faint":[138],"clonal":[139],"band":[140],"two":[142],"six":[144],"nodes":[145],"but":[146],"none":[147],"liver.":[150],"Significantly,":[151],"B":[153,173],"cells":[154,174],"were":[155],"detected":[156],"by":[157,255],"immunohistochemistry":[158],"lymph":[160],"nodes,":[161],"polyclonal":[164],"ladder":[165],"pattern":[166],"associated":[167],"presence":[170],"normal":[172],"not":[176],"seen":[177],"assay.":[184],"Profound":[185],"peripheral":[186],"lymphopenia":[187],"(50":[188],"cells/microliter)":[189],"also":[191],"observed.":[192],"Pharmacokinetics":[193],"showed":[194],"salivary":[196],"concentrations,":[197,203],"surrogate":[199],"free":[201],"drug":[202,270],"be":[205],"within":[206],"effective":[208],"range":[209],"(45":[212],"nmol/L)":[213],"as":[214],"modulator":[216],"DNA-damaging":[218],"agent":[219],"cytotoxicity.":[220],"vitro,":[222],"synergistic":[225],"multiple":[227],"cytotoxic":[228,250],"agents":[229],"fludarabine-induced":[232],"human":[236],"breast":[237],"line.":[239],"These":[240],"results":[241],"suggest":[242],"sensitized":[245],"effects":[251],"EPOCH,":[253],"possibly":[254],"modulating":[256],"\"threshold\"":[258],"apoptosis,":[260],"may":[262],"illustrate":[263],"new":[265],"paradigm":[266],"reversal":[268],"resistance.":[271]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}