{"id":"https://openalex.org/W1902434776","doi":null,"title":"Cancro do c\u00f3lon e recto","display_name":"Cancro do c\u00f3lon e recto","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W1902434776","mag":"1902434776"},"language":"es","primary_location":{"id":"pmh:oai:ubibliorum.ubi.pt:10400.6/844","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.6/844","pdf_url":"http://hdl.handle.net/10400.6/844","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.6/844","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049855195","display_name":"Pedro Miguel Gomes e S\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pedro Miguel Gomes e S\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049855195"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.2816999852657318,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.26489999890327454,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/colorectal-cancer-incidence","display_name":"colorectal cancer incidence","score":0.6179999709129333},{"id":"https://openalex.org/keywords/colorectal-cancer-mortality","display_name":"colorectal cancer mortality","score":0.9739999771118164},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.8519999980926514},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.5410000085830688},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.43799999356269836},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.9589999914169312},{"id":"https://openalex.org/keywords/advanced-colorectal-cancer","display_name":"advanced colorectal cancer","score":0.628000020980835},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46311819553375244}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ubibliorum.ubi.pt:10400.6/844","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.6/844","pdf_url":"http://hdl.handle.net/10400.6/844","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:1902434776","doi":null,"is_oa":false,"landing_page_url":"https://ubibliorum.ubi.pt/bitstream/10400.6/844/1/Disserta%c3%a7%c3%a3o%20de%20Mestrado%20-Cancro%20do%20c%c3%b3lon%20e%20recto.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ubibliorum.ubi.pt:10400.6/844","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.6/844","pdf_url":"http://hdl.handle.net/10400.6/844","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1902434776.pdf","grobid_xml":"https://content.openalex.org/works/W1902434776.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W591695177","https://openalex.org/W1492157159","https://openalex.org/W1514834090","https://openalex.org/W1571571428","https://openalex.org/W1602514656","https://openalex.org/W1605353467","https://openalex.org/W1925555331","https://openalex.org/W1947113137","https://openalex.org/W1956788036","https://openalex.org/W1965734230","https://openalex.org/W1978814685","https://openalex.org/W1993466050","https://openalex.org/W1993748871","https://openalex.org/W1996335419","https://openalex.org/W1997493715","https://openalex.org/W1997845311","https://openalex.org/W1998017088","https://openalex.org/W1998170462","https://openalex.org/W2001258296","https://openalex.org/W2001783446","https://openalex.org/W2004334734","https://openalex.org/W2009258616","https://openalex.org/W2010875436","https://openalex.org/W2014495259","https://openalex.org/W2016688090","https://openalex.org/W2018135173","https://openalex.org/W2027751334","https://openalex.org/W2047973495","https://openalex.org/W2048653865","https://openalex.org/W2051336007","https://openalex.org/W2054169477","https://openalex.org/W2063418762","https://openalex.org/W2068400261","https://openalex.org/W2077390904","https://openalex.org/W2077991158","https://openalex.org/W2079637644","https://openalex.org/W2086554912","https://openalex.org/W2091723114","https://openalex.org/W2106299982","https://openalex.org/W2118835794","https://openalex.org/W2118913969","https://openalex.org/W2122910319","https://openalex.org/W2123336903","https://openalex.org/W2124896165","https://openalex.org/W2127126695","https://openalex.org/W2138924822","https://openalex.org/W2143382094","https://openalex.org/W2145036053","https://openalex.org/W2148525099","https://openalex.org/W2161069925","https://openalex.org/W2164986143","https://openalex.org/W2166905446","https://openalex.org/W2170661469","https://openalex.org/W2171859697","https://openalex.org/W2171910021","https://openalex.org/W2185865975","https://openalex.org/W2261980809","https://openalex.org/W2316244438","https://openalex.org/W2318925269","https://openalex.org/W2350092907","https://openalex.org/W2415667260","https://openalex.org/W2460069449","https://openalex.org/W2614197161","https://openalex.org/W3090818122"],"related_works":["https://openalex.org/W2989227181","https://openalex.org/W3128282079","https://openalex.org/W3126553930","https://openalex.org/W2314549309","https://openalex.org/W3188567001","https://openalex.org/W6885090466","https://openalex.org/W2611158776","https://openalex.org/W1768841254","https://openalex.org/W2592827919","https://openalex.org/W3198161575"],"abstract_inverted_index":{"As":[0],"patologias":[1],"oncol\u00f3gicas":[2],"t\u00eam":[3,213,228],"cada":[4],"vez":[5],"mais":[6,210],"relevo":[7],"no":[8,20,55,177,200],"panorama":[9],"da":[10,82,139,234],"sa\u00fade":[11],"mundial,":[12],"acarretando":[13],"elevada":[14],"morbilidade/mortalidade":[15],"e,":[16],"tamb\u00e9m":[17],"elevados":[18],"custos":[19],"seu":[21],"diagn\u00f3stico":[22,162],"e":[23,31,143,164,245],"tratamento.":[24],"Nesse":[25],"contexto":[26],"o":[27,51,105,118,133,137,144,161,256],"cancro":[28],"do":[29,151,223],"c\u00f3lon":[30],"recto":[32],"(CCR)":[33],"assume":[34],"um":[35,232],"dos":[36,84,221],"pap\u00e9is":[37],"principais":[38],"devido":[39],"\u00e0":[40,59],"crescente":[41],"sua":[42],"incid\u00eancia":[43,60],"associada":[44],"a":[45,65,74,93,98,120,122,183,203,238,277],"uma":[46,247],"grande":[47],"mortalidade.":[48],"Portugal":[49],"ocupa":[50],"18\u00ba":[52],"lugar":[53],"europeu":[54],"que":[56,87,173,188,206,275],"se":[57,72,129,181,212,240],"refere":[58],"deste":[61],"cancro,":[62],"n\u00e3o":[63],"escapando":[64],"este":[66,264],"flagelo.":[67],"Na":[68],"\u00faltima":[69],"d\u00e9cada":[70],"tem":[71],"assistido":[73],"grandes":[75],"avan\u00e7os":[76],"na":[77,197,249,270],"compreens\u00e3o":[78],"desta":[79,166],"patologia":[80,94],"atrav\u00e9s":[81],"revela\u00e7\u00e3o":[83],"mecanismos":[85],"gen\u00e9ticos":[86],"lhe":[88],"est\u00e3o":[89],"subjacentes.":[90],"Actualmente":[91,168],"\u00e9":[92,158,199],"oncol\u00f3gica":[95],"melhor":[96],"compreendida":[97],"n\u00edvel":[99,204],"gen\u00e9tico,":[100],"servindo":[101],"de":[102,107,113,135,146,148,217,225,251,273],"base":[103],"para":[104,160,263],"entendimento":[106],"outros":[108,267],"cancros.":[109],"Existem":[110],"v\u00e1rios":[111,170],"factores":[112],"risco":[114],"perfeitamente":[115],"identificados,":[116],"nomeadamente":[117,220],"tabaco,":[119],"diabetes,":[121],"obesidade,":[123],"entre":[124],"outros,":[125],"sobre":[126],"os":[127],"quais":[128,185],"devem":[130,189],"actuar":[131],"com":[132],"intuito":[134],"prevenir":[136],"aparecimento":[138],"doen\u00e7a.":[140,167],"A":[141,215],"implementa\u00e7\u00e3o":[142],"cumprimento":[145],"programas":[147],"rastreio":[149],"nacionais":[150],"CCR":[152],"baseados":[153],"nas":[154],"\u201cguidelines\u201d":[155],"aceites":[156],"internacionalmente":[157],"essencial":[159],"precoce":[163],"preven\u00e7\u00e3o":[165],"existem":[169],"exames":[171],"complementares":[172],"podem":[174],"ser":[175,190],"usados":[176],"rastreio,":[178],"embora":[179],"ainda":[180],"continue":[182],"discutir":[184],"as":[186],"modalidades":[187],"usadas":[191],"como":[192,196],"abordagem":[193],"inicial.":[194],"Tal":[195],"carcinog\u00e9nese,":[198],"tratamento,":[201],"principalmente":[202],"farmacol\u00f3gico,":[205],"nos":[207],"\u00faltimos":[208],"anos":[209],"progressos":[211],"alcan\u00e7ado.":[214],"descoberta":[216],"novos":[218],"f\u00e1rmacos,":[219],"inibidores":[222],"factor":[224],"crescimento":[226],"epid\u00e9rmico,":[227],"proporcionado":[229],"aos":[230],"pacientes":[231],"aumento":[233],"sobrevida,":[235],"mesmo":[236],"quando":[237],"doen\u00e7a":[239],"encontra":[241],"numa":[242],"fase":[243,272],"avan\u00e7ada,":[244],"tamb\u00e9m,":[246],"melhoria":[248],"qualidade":[250],"vida.":[252],"Um":[253],"novo":[254],"f\u00e1rmaco,":[255],"Panitumumab,":[257],"aprovado":[258],"recentemente":[259],"ir\u00e1":[260],"certamente":[261],"contribuir":[262],"ganhos,":[265],"enquanto":[266],"f\u00e1rmacos":[268],"continuam":[269],"habitual":[271],"testes":[274],"antecedem":[276],"comercializa\u00e7\u00e3o.":[278]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}