{"id":"https://openalex.org/W1901908573","doi":"https://doi.org/10.1055/s-0037-1615058","title":"Increased Thromboxane Metabolites Excretion in Liver Cirrhosis","display_name":"Increased Thromboxane Metabolites Excretion in Liver Cirrhosis","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1901908573","doi":"https://doi.org/10.1055/s-0037-1615058","mag":"1901908573","pmid":"https://pubmed.ncbi.nlm.nih.gov/9569186"},"language":"en","primary_location":{"id":"doi:10.1055/s-0037-1615058","doi":"https://doi.org/10.1055/s-0037-1615058","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0037-1615058","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028571377","display_name":"Domenico Ferro","orcid":"https://orcid.org/0000-0001-5222-4477","observed_orcids":["https://orcid.org/0000-0001-5222-4477"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Ferro","raw_affiliation_strings":["From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","University of Rome \u201cLa Sapienza \u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"University of Rome \u201cLa Sapienza \u201d","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047687063","display_name":"Stefania Basili","orcid":"https://orcid.org/0000-0002-6987-1926","observed_orcids":["https://orcid.org/0000-0002-6987-1926"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Basili","raw_affiliation_strings":["From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","Internal Medicine and Medical Specialties"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Internal Medicine and Medical Specialties","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070911300","display_name":"Luigi Iuliano","orcid":"https://orcid.org/0000-0002-0027-9326","observed_orcids":["https://orcid.org/0000-0002-0027-9326"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Iuliano","raw_affiliation_strings":["From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","University of Rome \u201cLa Sapienza \u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"University of Rome \u201cLa Sapienza \u201d","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107911534","display_name":"Caterina Camastra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Camastra","raw_affiliation_strings":["From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","University of Rome \u201cLa Sapienza \u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"University of Rome \u201cLa Sapienza \u201d","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053376409","display_name":"Carlo Giammarresi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Giammarresi","raw_affiliation_strings":["From the Departments of Medicine, Universities of Chieti, Rome","University of Chieti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Universities of Chieti, Rome","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"University of Chieti","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090014153","display_name":"Stella Santarone","orcid":"https://orcid.org/0000-0002-5037-0515","observed_orcids":["https://orcid.org/0000-0002-5037-0515"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stella Santarone","raw_affiliation_strings":["From the Departments of Medicine, Universities of Chieti, Rome","University of Chieti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Universities of Chieti, Rome","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"University of Chieti","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057207523","display_name":"Bianca Rocca","orcid":"https://orcid.org/0000-0001-8304-6423","observed_orcids":["https://orcid.org/0000-0001-8304-6423"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bianca Rocca","raw_affiliation_strings":["From the Departments of Medicine, Rome Catholic University, Italy","Universit\u00e0 Cattolica del Sacro Cuore, Rome#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Rome Catholic University, Italy","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e0 Cattolica del Sacro Cuore, Rome#TAB#","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059461810","display_name":"Raffaele Landolfi","orcid":"https://orcid.org/0000-0002-7913-8576","observed_orcids":["https://orcid.org/0000-0002-7913-8576"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Landolfi","raw_affiliation_strings":["From the Departments of Medicine, Rome Catholic University, Italy","Universit\u00e0 Cattolica del Sacro Cuore, Rome#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Rome Catholic University, Italy","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e0 Cattolica del Sacro Cuore, Rome#TAB#","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109974847","display_name":"Giovanni Ciabattoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Ciabattoni","raw_affiliation_strings":["From the Departments of Medicine, Institute of Pharmacology, Catholic University of Rome, Italy","Universit\u00e0 Cattolica del Sacro Cuore, Rome#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Institute of Pharmacology, Catholic University of Rome, Italy","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e0 Cattolica del Sacro Cuore, Rome#TAB#","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113927893","display_name":"Corrado Cordova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Corrado Cordova","raw_affiliation_strings":["From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","University of Rome \u201cLa Sapienza \u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"University of Rome \u201cLa Sapienza \u201d","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076547685","display_name":"Francesco Violi","orcid":"https://orcid.org/0000-0002-6610-7068","observed_orcids":["https://orcid.org/0000-0002-6610-7068"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Violi","raw_affiliation_strings":["From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","Internal Medicine and Medical Specialties"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, \u201cLa Sapienza\u201d, Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Internal Medicine and Medical Specialties","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107860533","display_name":"Giovanni Davi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanni Dav\u00ec","raw_affiliation_strings":["From the Departments of Medicine, Universities of Chieti, Rome","Department of Medicine, University of Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Universities of Chieti, Rome","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Medicine, University of Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107860533"],"corresponding_institution_ids":["https://openalex.org/I39387349"],"apc_list":null,"apc_paid":null,"fwci":0.2473,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.58934049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"79","issue":"04","first_page":"747","last_page":"751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/thromboxane-metabolites","display_name":"thromboxane metabolites","score":0.8650000095367432},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.9229999780654907},{"id":"https://openalex.org/keywords/11-dehydrothromboxane-b2","display_name":"11-dehydrothromboxane B2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/thromboxane-synthesis","display_name":"thromboxane synthesis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hepatic-decompensation","display_name":"hepatic decompensation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/prothrombin-fragment-1-2","display_name":"prothrombin fragment 1+2","score":0.8999999761581421},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7628946304321289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5764365196228027},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5472755432128906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.508894681930542},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.48674488067626953},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.44129064679145813},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4289635121822357},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4253511428833008},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3961338698863983},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.365111768245697}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0037-1615058","doi":"https://doi.org/10.1055/s-0037-1615058","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0037-1615058","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:9569186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9569186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/245675","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000073000100011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322651","display_name":"Consiglio Nazionale delle Ricerche","ror":"https://ror.org/04zaypm56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W95067618","https://openalex.org/W265405240","https://openalex.org/W1710256526","https://openalex.org/W1978039741","https://openalex.org/W1996164449","https://openalex.org/W2003437266","https://openalex.org/W2009628393","https://openalex.org/W2014644245","https://openalex.org/W2015013806","https://openalex.org/W2028799952","https://openalex.org/W2032693555","https://openalex.org/W2035746389","https://openalex.org/W2047234648","https://openalex.org/W2053619102","https://openalex.org/W2060123467","https://openalex.org/W2063668704","https://openalex.org/W2065159753","https://openalex.org/W2091463103","https://openalex.org/W2100635240","https://openalex.org/W2123520002","https://openalex.org/W2155778635","https://openalex.org/W2173153796","https://openalex.org/W2319406102","https://openalex.org/W2417030366","https://openalex.org/W3169105340","https://openalex.org/W4250671816","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1514495514","https://openalex.org/W1995884538","https://openalex.org/W2074468494","https://openalex.org/W1997883635","https://openalex.org/W4233727563","https://openalex.org/W1995046607","https://openalex.org/W2018724834","https://openalex.org/W2397567751","https://openalex.org/W4246290699","https://openalex.org/W1974560148"],"abstract_inverted_index":{"An":[0],"augmented":[1],"systemic":[2,54],"production":[3],"of":[4,13,27,38,73,78,92,110,146,154,200,241,261,273,296,308],"thromboxane":[5,15,263,274],"(TX)":[6],"A2,":[7],"as":[8,56,58],"assessed":[9],"by":[10,82],"urinary":[11,107,239,306],"excretion":[12,108,144,152,240,307],"the":[14,25,76,90,119,129,143,147,165,201,213,284,294],"metabolites,":[16],"has":[17],"been":[18],"described":[19],"in":[20,33,75,86,118,126,164,171,212,216,265,321],"severe":[21],"liver":[22,34,83,266,280,297],"cirrhosis.":[23,267],"However,":[24],"significance":[26],"this":[28],"finding":[29],"remains":[30],"unclear":[31],"since":[32],"cirrhosis":[35],"a":[36,180,221,302],"number":[37],"phenomena":[39],"i.e.":[40],"altered":[41],"hepatic":[42],"TXA2":[43,51],"metabolism,":[44],"increased":[45,117,163,211,262,292],"intrasplenic":[46],"platelet":[47,323],"destruction,":[48],"may":[49],"affect":[50],"entry":[52],"into":[53],"circulation":[55],"well":[57],"its":[59],"metabolism.":[60],"In":[61],"order":[62],"to":[63,192,218,231,250,278,288],"further":[64,259],"clarify":[65],"this,":[66],"we":[67,269],"measured":[68],"both":[69],"major":[70],"enzymatic":[71,203],"metabolites":[72,204],"TXB2":[74],"urine":[77],"44":[79],"patients":[80,121,166,215],"affected":[81],"cirrhosis,":[84],"subdivided":[85],"three":[87,148],"classes":[88],"on":[89],"basis":[91],"Child-Pugh":[93],"criteria.":[94],"Urinary":[95],"11-dehydro-TXB2":[96,111],"and":[97,310],"2,3-dinor-TXB2":[98,289,309],"were":[99],"assayed":[100],"with":[101,128,173,179,220,293],"previously":[102],"validated":[103],"RIA":[104],"techniques.":[105],"The":[106,151,198,238],"rate":[109,153],"was":[112,157,205,244,290],"significantly":[113,159,206,245],"(p":[114,160,182,207,246],"=":[115,161,208,247],"0.0001)":[116,162],"cirrhotic":[120,214],"(673.5":[122],"pg/mg":[123,132,168,176,190,196,228,235],"cr,":[124,133,169,177,229,236],"median)":[125,134,170,230],"comparison":[127,172,217],"controls":[130,174],"(275":[131],"but":[135],"no":[136],"significant":[137,181,303],"difference":[138],"could":[139,317],"be":[140],"demonstrated":[141],"among":[142],"rates":[145],"patient":[149],"subgroups.":[150],"2,3":[155,242],"dinor-TXB2":[156,243],"also":[158],"(824":[167],"(175":[175],"median),":[178],"<":[183],"0.05)":[184],"increase":[185,223],"from":[186,224],"class":[187,193,225,232],"A":[188,226],"(381":[189],"cr)":[191],"C":[194,233],"(1337":[195],"cr).":[197],"sum":[199],"two":[202],"0.0001":[209],")":[210],"controls,":[219],"progressive":[222,279],"(1003":[227],"(2240":[234],"median).":[237],"0.008)":[248],"related":[249],"plasma":[251,311],"prothrombin":[252],"fragment":[253],"1+2":[254],"(F1+2).":[255],"This":[256],"study":[257],"provides":[258],"evidence":[260],"biosynthesis":[264],"Moreover,":[268],"demonstrate":[270],"intraliver":[271],"shift":[272],"metabolic":[275],"disposition,":[276],"due":[277],"decompensation,":[281],"because":[282],"only":[283],"fraction":[285],"undergoing":[286],"beta-oxidation":[287],"progressively":[291],"degree":[295],"failure.":[298],"We,":[299],"also,":[300],"find":[301],"correlation":[304],"between":[305],"F1+2,":[312],"suggesting":[313],"that":[314],"clotting":[315],"activation":[316],"partly":[318],"account":[319],"for":[320],"vivo":[322],"activation.":[324]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
