{"id":"https://openalex.org/W1901654591","doi":"https://doi.org/10.1192/bjp.bp.106.026112","title":"Heroin-assisted treatment for opioid dependence","display_name":"Heroin-assisted treatment for opioid dependence","publication_year":2007,"publication_date":"2007-06-29","ids":{"openalex":"https://openalex.org/W1901654591","doi":"https://doi.org/10.1192/bjp.bp.106.026112","mag":"1901654591","pmid":"https://pubmed.ncbi.nlm.nih.gov/17602126"},"language":"en","primary_location":{"id":"doi:10.1192/bjp.bp.106.026112","doi":"https://doi.org/10.1192/bjp.bp.106.026112","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.106.026112","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8A7CFDCDF7E3863AC0242A8A13FFF54/S000712500017285Xa.pdf/div-class-title-heroin-assisted-treatment-for-opioid-dependence-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8A7CFDCDF7E3863AC0242A8A13FFF54/S000712500017285Xa.pdf/div-class-title-heroin-assisted-treatment-for-opioid-dependence-div.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111535683","display_name":"Christian Haasen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christian Haasen","raw_affiliation_strings":["Centre for Interdisciplinary Addiction Research, Department of Psychiatry, University Medical Centre Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. haasen@uke.uni-hamburg.de","Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Addiction Research, Department of Psychiatry, University Medical Centre Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. haasen@uke.uni-hamburg.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073079083","display_name":"Uwe Verthein","orcid":"https://orcid.org/0000-0002-5565-5536","observed_orcids":["https://orcid.org/0000-0002-5565-5536"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Verthein","raw_affiliation_strings":["Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000709185","display_name":"Peter Degkwitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Degkwitz","raw_affiliation_strings":["Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088126881","display_name":"Juergen Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juergen Berger","raw_affiliation_strings":["Institute for Medical Biometrics and Epidemiology, University Medical Centre Eppendorf, Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Biometrics and Epidemiology, University Medical Centre Eppendorf, Hamburg","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067159385","display_name":"Michael Reinhardt Krausz","orcid":"https://orcid.org/0000-0002-3509-7274","observed_orcids":["https://orcid.org/0000-0002-3509-7274"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Krausz","raw_affiliation_strings":["Centre for Interdisciplinary Addiction Research, University Medical Centre, Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Addiction Research, University Medical Centre, Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110050916","display_name":"Dieter Naber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Naber","raw_affiliation_strings":["Centre for Interdisciplinary Addiction Research, University Medical Centre, Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Addiction Research, University Medical Centre, Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111535683"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":{"value":4920,"currency":"USD","value_usd":4920},"apc_paid":null,"fwci":28.4704,"has_fulltext":true,"cited_by_count":264,"citation_normalized_percentile":{"value":0.99816619,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"191","issue":"1","first_page":"55","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11860","display_name":"HIV, Drug Use, Sexual Risk","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heroin-assisted-treatment","display_name":"heroin-assisted treatment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9760000109672546},{"id":"https://openalex.org/keywords/heroin-dependence","display_name":"heroin addiction","score":0.7279999852180481},{"id":"https://openalex.org/keywords/methadone-maintenance-treatment","display_name":"methadone maintenance treatment","score":0.9459999799728394},{"id":"https://openalex.org/keywords/treatment-retention","display_name":"treatment retention","score":0.8759999871253967},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5759999752044678},{"id":"https://openalex.org/keywords/illicit-drug-use","display_name":"illicit drug use","score":0.9190000295639038},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2778903686","wikidata":"https://www.wikidata.org/wiki/Q60168","display_name":"Heroin","level":3,"score":0.9463305473327637},{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.8310068845748901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6575289964675903},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6159220337867737},{"id":"https://openalex.org/C2778903061","wikidata":"https://www.wikidata.org/wiki/Q17156814","display_name":"Methadone maintenance","level":3,"score":0.5493341684341431},{"id":"https://openalex.org/C2909834198","wikidata":"https://www.wikidata.org/wiki/Q1639178","display_name":"Heroin dependence","level":4,"score":0.49398356676101685},{"id":"https://openalex.org/C2779418921","wikidata":"https://www.wikidata.org/wiki/Q1639178","display_name":"Opioid use disorder","level":4,"score":0.4885329008102417},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4441569447517395},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43525558710098267},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3542960286140442},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.23577550053596497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20901444554328918},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003932","descriptor_name":"Heroin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011613","descriptor_name":"Psychotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1192/bjp.bp.106.026112","doi":"https://doi.org/10.1192/bjp.bp.106.026112","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.106.026112","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8A7CFDCDF7E3863AC0242A8A13FFF54/S000712500017285Xa.pdf/div-class-title-heroin-assisted-treatment-for-opioid-dependence-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:17602126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17602126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of psychiatry : the journal of mental science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1192/bjp.bp.106.026112","doi":"https://doi.org/10.1192/bjp.bp.106.026112","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.106.026112","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8A7CFDCDF7E3863AC0242A8A13FFF54/S000712500017285Xa.pdf/div-class-title-heroin-assisted-treatment-for-opioid-dependence-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1901654591.pdf","grobid_xml":"https://content.openalex.org/works/W1901654591.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1558437381","https://openalex.org/W1600396548","https://openalex.org/W1852546349","https://openalex.org/W1968751484","https://openalex.org/W2020454958","https://openalex.org/W2021206500","https://openalex.org/W2034202363","https://openalex.org/W2043583313","https://openalex.org/W2044970527","https://openalex.org/W2054117065","https://openalex.org/W2064266716","https://openalex.org/W2100717894","https://openalex.org/W2108403589","https://openalex.org/W2128326642","https://openalex.org/W2156571510","https://openalex.org/W3163620136"],"related_works":["https://openalex.org/W2061832559","https://openalex.org/W2044970527","https://openalex.org/W2284024720","https://openalex.org/W1558437381","https://openalex.org/W2155960511","https://openalex.org/W2116367736","https://openalex.org/W2476328018","https://openalex.org/W4232924730","https://openalex.org/W1973722617","https://openalex.org/W2059827929"],"abstract_inverted_index":{"BACKGROUND:":[0],"Heroin-assisted":[1,146],"treatment":[2,30,147,180],"has":[3],"been":[4],"found":[5,133],"to":[6],"be":[7,177],"effective":[8,150],"for":[9,76,151,179],"people":[10,32,60,152],"with":[11,61,142,153],"severe":[12],"opioid":[13,154],"dependence":[14,63,155],"who":[15,35,42,156,165],"are":[16,43,166],"not":[17,48,167],"interested":[18],"in":[19,31,40,49,90,96,104,109,134,169],"or":[20,72,164],"do":[21],"poorly":[22],"on":[23,33,123,161],"methadone":[24,34,74,111,162],"maintenance.":[25],"AIMS:":[26],"To":[27],"study":[28],"heroin-assisted":[29],"continue":[36,157],"intravenous":[37,143,158],"heroin":[38,44,62,70,106,116,136,159],"and":[39,88,114,138],"those":[41],"dependent":[45],"but":[46],"currently":[47],"treatment.":[50,170],"METHOD:":[51],"In":[52],"an":[53,97],"open-label":[54],"multicentre":[55],"randomised":[56],"controlled":[57],"trial,":[58],"1015":[59],"received":[64],"a":[65,119,172],"variable":[66],"dose":[67],"of":[68,83],"injectable":[69],"(n=515)":[71],"oral":[73],"(n=500)":[75],"12":[77],"months.":[78],"Two":[79],"response":[80,122],"criteria,":[81],"improvement":[82],"physical":[84],"and/or":[85],"mental":[86],"health":[87],"decrease":[89],"illicit":[91],"drug":[92],"use,":[93],"were":[94,132,139],"evaluated":[95],"intent-to-treat":[98],"analysis.":[99],"RESULTS:":[100],"Retention":[101],"was":[102],"higher":[103,173],"the":[105,110,115,135],"(67.2%)":[107],"than":[108],"group":[112,117],"(40.0%)":[113],"showed":[118],"significantly":[120],"greater":[121],"both":[124],"primary":[125],"outcome":[126],"measures.":[127],"More":[128],"serious":[129],"adverse":[130],"events":[131],"group,":[137],"mainly":[140],"associated":[141],"use.":[144],"CONCLUSIONS:":[145],"is":[148],"more":[149],"while":[160],"maintenance":[163],"enrolled":[168],"Despite":[171],"risk,":[174],"it":[175],"should":[176],"considered":[178],"resistance":[181],"under":[182],"medical":[183],"supervision.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}