{"id":"https://openalex.org/W1900438073","doi":null,"title":"Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.","display_name":"Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W1900438073","mag":"1900438073","pmid":"https://pubmed.ncbi.nlm.nih.gov/10473095"},"language":"en","primary_location":{"id":"pmid:10473095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10473095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110869","display_name":"Parker Hughes Cancer Center","ror":"https://ror.org/01ahys275","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Sun","raw_affiliation_strings":["Parker Hughes Cancer Center and Children's Cancer Group ALL Biology Reference Laboratory, Hughes Institute, St. Paul, Minnesota 55113, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parker Hughes Cancer Center and Children's Cancer Group ALL Biology Reference Laboratory, Hughes Institute, St. Paul, Minnesota 55113, USA","institution_ids":["https://openalex.org/I4210110869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113506182","display_name":"Mya Lisa Crotty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Crotty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008518579","display_name":"Martha G. Sensel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sensel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112213826","display_name":"Harland N. Sather","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Sather","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087262757","display_name":"Christopher S. Navara","orcid":"https://orcid.org/0000-0001-5915-0327","observed_orcids":["https://orcid.org/0000-0001-5915-0327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Navara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078116164","display_name":"Joseph Nachman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Nachman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034653175","display_name":"Peter G. Steinherz","orcid":"https://orcid.org/0000-0002-5211-0522","observed_orcids":["https://orcid.org/0000-0002-5211-0522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P G Steinherz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033167405","display_name":"Paul S. Gaynon","orcid":"https://orcid.org/0000-0002-1582-2862","observed_orcids":["https://orcid.org/0000-0002-1582-2862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P S Gaynon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048397868","display_name":"Nita L. Seibel","orcid":"https://orcid.org/0000-0001-6259-7955","observed_orcids":["https://orcid.org/0000-0001-6259-7955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Seibel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110121737","display_name":"Alexei O. Vassilev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Vassilev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019914745","display_name":"Gregory H. Reaman","orcid":"https://orcid.org/0000-0002-6698-4503","observed_orcids":["https://orcid.org/0000-0002-6698-4503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G H Reaman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091381226","display_name":"Fatih Mehmet Uckun","orcid":"https://orcid.org/0000-0001-9334-183X","observed_orcids":["https://orcid.org/0000-0001-9334-183X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M Uckun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.7003,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.97840036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"8","first_page":"2112","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.949999988079071},{"id":"https://openalex.org/keywords/dominant-negative-isoform","display_name":"dominant-negative isoform","score":0.968999981880188},{"id":"https://openalex.org/keywords/transcription-factor-isoforms","display_name":"transcription factor isoforms","score":0.5529999732971191},{"id":"https://openalex.org/keywords/subcellular-compartmentalization","display_name":"subcellular compartmentalization","score":0.7379999756813049},{"id":"https://openalex.org/keywords/transcription-activation-domain","display_name":"transcription activation domain","score":0.7739999890327454},{"id":"https://openalex.org/keywords/leukemia-cell-lines","display_name":"leukemia cell lines","score":0.5649999976158142},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7355743050575256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7217409014701843},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.595531165599823},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5748642683029175},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4657500684261322},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.435200035572052},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40418243408203125},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3567996025085449},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32877856492996216},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31497228145599365}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051740","descriptor_name":"Ikaros Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10473095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10473095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:1900438073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10473095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4254236046","display_name":"CHILDRENS CANCER GROUP CHAIRMANS AWARD","funder_award_id":"U10CA013539","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W45030491","https://openalex.org/W81453212","https://openalex.org/W1508716863","https://openalex.org/W1816156148","https://openalex.org/W1883290480","https://openalex.org/W1982295124","https://openalex.org/W1989695798","https://openalex.org/W1993243592","https://openalex.org/W2013083986","https://openalex.org/W2032205265","https://openalex.org/W2039186983","https://openalex.org/W2059333381","https://openalex.org/W2070994243","https://openalex.org/W2091253809","https://openalex.org/W2125378951","https://openalex.org/W2169923455"],"related_works":["https://openalex.org/W1989695798","https://openalex.org/W2552924338","https://openalex.org/W1523891193","https://openalex.org/W2329365382","https://openalex.org/W2983610050","https://openalex.org/W2237420558","https://openalex.org/W2005120017","https://openalex.org/W2029681705","https://openalex.org/W2060739922","https://openalex.org/W2464532039"],"abstract_inverted_index":{"Ikaros,":[0],"a":[1,141],"zinc":[2,27,132,166],"finger-containing":[3],"DNA-binding":[4],"protein,":[5],"is":[6],"required":[7],"for":[8],"normal":[9],"lymphocyte":[10],"development.":[11],"Germ-line":[12],"mutant":[13],"mice":[14],"that":[15,102,128],"express":[16,178],"only":[17],"non-DNA":[18],"binding":[19,93],"dominant-negative":[20,73,121,183],"\"leukemogenic\"":[21],"Ikaros":[22,38,76,122,184],"isoforms":[23,74,123],"lacking":[24],"critical":[25,130],"NH2-terminal":[26,131],"fingers":[28,167],"develop":[29],"an":[30,146],"aggressive":[31],"form":[32],"of":[33,55,72,75,115,136,149,168,181],"T-cell":[34,48],"leukemia.":[35],"We":[36],"studied":[37],"gene":[39],"expression":[40,71],"in":[41,95],"leukemic":[42,111],"cells":[43,86,112],"from":[44,84,113],"18":[45,57],"children":[46,175],"with":[47,77,118,176],"acute":[49],"lymphoblastic":[50],"leukemia":[51],"(T-ALL).":[52],"In":[53,134],"each":[54],"the":[56,91,157,164],"T-ALL":[58,119,177],"cases":[59],"as":[60,62,108,110],"well":[61,109],"JK-E6-1":[63,103],"and":[64,99,104,126,161,172],"MOLT-3":[65,105],"cell":[66,106],"lines,":[67],"we":[68,139],"found":[69],"high-level":[70],"abnormal":[78],"subcellular":[79],"compartmentalization":[80],"patterns.":[81],"Nuclear":[82],"extracts":[83],"these":[85],"failed":[87],"to":[88,90,145,156,163],"bind":[89],"IKAROS-specific":[92],"sequence":[94],"DNA.":[96],"PCR":[97],"cloning":[98],"sequencing":[100],"confirmed":[101],"lines":[107],"9":[114],"10":[116,137,150],"patients":[117],"expressed":[120],"Ik-4,":[124,170],"Ik-7,":[125,171],"Ik-8":[127],"lack":[129],"fingers.":[133],"6":[135],"patients,":[138],"detected":[140],"specific":[142],"mutation":[143],"leading":[144],"in-frame":[147],"deletion":[148],"amino":[151],"acids":[152],"(delta":[153],"KSSMPQKFLG)":[154],"upstream":[155],"transcription":[158],"activation":[159],"domain":[160],"adjacent":[162],"COOH-terminal":[165],"Ik-2,":[169],"Ik-8.":[173],"Thus,":[174],"high":[179],"levels":[180],"dysfunctional":[182],"isoforms.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}