{"id":"https://openalex.org/W1900387805","doi":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","title":"TYRO3-mediated regulation of MITF: a novel target in melanoma?","display_name":"TYRO3-mediated regulation of MITF: a novel target in melanoma?","publication_year":2009,"publication_date":"2009-10-20","ids":{"openalex":"https://openalex.org/W1900387805","doi":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","mag":"1900387805","pmid":"https://pubmed.ncbi.nlm.nih.gov/19843245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159175"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-148x.2009.00649.x","doi":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-148X.2009.00649.x","source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-148X.2009.00649.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028439777","display_name":"Udo Rudloff","orcid":"https://orcid.org/0000-0003-2137-9040","observed_orcids":["https://orcid.org/0000-0003-2137-9040"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Udo Rudloff","raw_affiliation_strings":["e-mail: [email protected]","e\u2010mail: samuelsy@mail.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"e-mail: [email protected]","institution_ids":[]},{"raw_affiliation_string":"e\u2010mail: samuelsy@mail.nih.gov","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042139239","display_name":"Yardena Samuels","orcid":"https://orcid.org/0000-0002-3349-7266","observed_orcids":["https://orcid.org/0000-0002-3349-7266"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yardena Samuels","raw_affiliation_strings":["e-mail: [email protected]","e\u2010mail: samuelsy@mail.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"e-mail: [email protected]","institution_ids":[]},{"raw_affiliation_string":"e\u2010mail: samuelsy@mail.nih.gov","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028439777","https://openalex.org/A5042139239"],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.1341,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.49061589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"1","first_page":"9","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyro3","display_name":"Tyro3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.9879999756813049},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plx4720","display_name":"PLX4720","score":0.8859999775886536},{"id":"https://openalex.org/keywords/braf-inhibitor-resistance","display_name":"BRAF inhibitor resistance","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.8940398097038269},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6347212791442871},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6235635876655579},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.6185624003410339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5969433188438416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5719746351242065},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5039116740226746},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4773326516151428},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4396989643573761},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38368460536003113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30089902877807617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24293193221092224},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.24219673871994019},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.20994162559509277},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1779969334602356}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1755-148x.2009.00649.x","doi":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-148X.2009.00649.x","source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},{"id":"pmid:19843245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19843245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment cell & melanoma research","raw_type":"News"},{"id":"pmh:oai:europepmc.org:2164796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3159175","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159175","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pigment Cell Melanoma Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1755-148x.2009.00649.x","doi":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2009.00649.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-148X.2009.00649.x","source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1075220770","display_name":"Mutational analysis of signal transducing gene families in malignant melanoma","funder_award_id":"Z01HG200337","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5294359063","display_name":null,"funder_award_id":"Z99 HG999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1900387805.pdf","grobid_xml":"https://content.openalex.org/works/W1900387805.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1989121777","https://openalex.org/W2015009944","https://openalex.org/W2058680810","https://openalex.org/W2067937212","https://openalex.org/W2073620629","https://openalex.org/W2085002165","https://openalex.org/W2099289479","https://openalex.org/W2135492013","https://openalex.org/W2146012957"],"related_works":["https://openalex.org/W1217284267","https://openalex.org/W2323386707","https://openalex.org/W2129245282","https://openalex.org/W2053969391","https://openalex.org/W2032211985","https://openalex.org/W1999983570","https://openalex.org/W2164850852","https://openalex.org/W2020937386","https://openalex.org/W109728801","https://openalex.org/W4301382142"],"abstract_inverted_index":{"primary":[0,31],"melanoma":[1],"cells":[2,16],"with":[3],"the":[4,23],"B-RAF":[5],"selective":[6],"inhibitor":[7],"PLX4720.The":[8],"authors":[9,20],"found":[10],"a":[11],"profound":[12],"cross-resistance":[13],"of":[14,25],"these":[15],"to":[17],"drug":[18],"treatment.The":[19],"then":[21],"investigated":[22],"effect":[24],"PLX4720":[26],"treatment":[27],"on":[28],"MEK":[29],"resistant":[30],"alleles":[32,38],"(AZD6244":[33],"binding":[34],"mutants)":[35],"and":[36],"secondary":[37],"(P124L,":[39]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}