{"id":"https://openalex.org/W1899240663","doi":null,"title":"Bone Health, Osteoporosis and Fracture Risk in Neurofibromatosis 1 - An Emphasis on Osteoclasts","display_name":"Bone Health, Osteoporosis and Fracture Risk in Neurofibromatosis 1 - An Emphasis on Osteoclasts","publication_year":2012,"publication_date":"2012-06-29","ids":{"openalex":"https://openalex.org/W1899240663","mag":"1899240663"},"language":"en","primary_location":{"id":"pmh:oai:utupub.fi:11111/27501","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27501","pdf_url":"https://www.utupub.fi/bitstreams/bbf71f83-04e4-4749-bfdd-38bdb100a4c4/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/77141","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.utupub.fi/bitstreams/bbf71f83-04e4-4749-bfdd-38bdb100a4c4/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023592947","display_name":"Eetu Heerv\u00e4","orcid":"https://orcid.org/0000-0002-6134-1170","observed_orcids":["https://orcid.org/0000-0002-6134-1170"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eetu Heerv\u00e4","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6134-1170","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023592947"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.7730000019073486},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9810000061988831},{"id":"https://openalex.org/keywords/osteoclast-precursors","display_name":"osteoclast precursors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6470000147819519},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8460000157356262},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9539999961853027},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clodronate","display_name":"clodronate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.4650000035762787},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7862361669540405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5894078016281128},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.5821078419685364},{"id":"https://openalex.org/C177454536","wikidata":"https://www.wikidata.org/wiki/Q578290","display_name":"Emphasis (telecommunications)","level":2,"score":0.5280417203903198},{"id":"https://openalex.org/C2778976249","wikidata":"https://www.wikidata.org/wiki/Q17005820","display_name":"Bone health","level":4,"score":0.48737460374832153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3172859847545624},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18355602025985718},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.18058764934539795},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14558136463165283},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07566177845001221}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:utupub.fi:11111/27501","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27501","pdf_url":"https://www.utupub.fi/bitstreams/bbf71f83-04e4-4749-bfdd-38bdb100a4c4/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/77141","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.doria.fi:10024/77141","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/77141","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis (article-based)"},{"id":"pmh:oai:www.utupub.fi:10024/77141","doi":null,"is_oa":false,"landing_page_url":"http://www.utupub.fi/handle/10024/77141","pdf_url":null,"source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"mag:1899240663","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/bitstream/10024/77141/1/AnnalesD1013Heerv%c3%a4.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utupub.fi:11111/27501","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27501","pdf_url":"https://www.utupub.fi/bitstreams/bbf71f83-04e4-4749-bfdd-38bdb100a4c4/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/77141","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"},{"id":"https://openalex.org/F4320327286","display_name":"Turun Yliopistollinen Keskussairaala","ror":"https://ror.org/05dbzj528"},{"id":"https://openalex.org/F4320331826","display_name":"Turun Yliopistos\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02kjggt26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1899240663.pdf","grobid_xml":"https://content.openalex.org/works/W1899240663.grobid-xml"},"referenced_works_count":218,"referenced_works":["https://openalex.org/W7911550","https://openalex.org/W153242516","https://openalex.org/W175660244","https://openalex.org/W1480506159","https://openalex.org/W1480704041","https://openalex.org/W1493278628","https://openalex.org/W1495338768","https://openalex.org/W1521657513","https://openalex.org/W1535833444","https://openalex.org/W1860190162","https://openalex.org/W1907091025","https://openalex.org/W1964981296","https://openalex.org/W1965511198","https://openalex.org/W1966179399","https://openalex.org/W1966390646","https://openalex.org/W1969142291","https://openalex.org/W1970155584","https://openalex.org/W1972597519","https://openalex.org/W1972625766","https://openalex.org/W1972844451","https://openalex.org/W1975951043","https://openalex.org/W1976334274","https://openalex.org/W1981018937","https://openalex.org/W1982232165","https://openalex.org/W1983068219","https://openalex.org/W1984410056","https://openalex.org/W1984758838","https://openalex.org/W1984789741","https://openalex.org/W1985416532","https://openalex.org/W1985746223","https://openalex.org/W1986533422","https://openalex.org/W1990427118","https://openalex.org/W1990654348","https://openalex.org/W1992149466","https://openalex.org/W1992695399","https://openalex.org/W1993215772","https://openalex.org/W1993522852","https://openalex.org/W1993701679","https://openalex.org/W1993741449","https://openalex.org/W1993815111","https://openalex.org/W1995607634","https://openalex.org/W1997887695","https://openalex.org/W1997889859","https://openalex.org/W2001167820","https://openalex.org/W2001577233","https://openalex.org/W2002062088","https://openalex.org/W2002066999","https://openalex.org/W2002266390","https://openalex.org/W2004805025","https://openalex.org/W2005041472","https://openalex.org/W2005508652","https://openalex.org/W2005779589","https://openalex.org/W2005879837","https://openalex.org/W2006006929","https://openalex.org/W2006668750","https://openalex.org/W2006689445","https://openalex.org/W2006997764","https://openalex.org/W2007012469","https://openalex.org/W2007853357","https://openalex.org/W2009678900","https://openalex.org/W2009933339","https://openalex.org/W2010652648","https://openalex.org/W2011328374","https://openalex.org/W2015859735","https://openalex.org/W2016846444","https://openalex.org/W2017030320","https://openalex.org/W2018691087","https://openalex.org/W2019582558","https://openalex.org/W2020350757","https://openalex.org/W2020370649","https://openalex.org/W2020378019","https://openalex.org/W2020644044","https://openalex.org/W2020898706","https://openalex.org/W2021176678","https://openalex.org/W2021308032","https://openalex.org/W2021696992","https://openalex.org/W2022112190","https://openalex.org/W2022562215","https://openalex.org/W2023541575","https://openalex.org/W2024098071","https://openalex.org/W2024795024","https://openalex.org/W2027575976","https://openalex.org/W2027964881","https://openalex.org/W2032719886","https://openalex.org/W2033366545","https://openalex.org/W2033586513","https://openalex.org/W2034131055","https://openalex.org/W2036179014","https://openalex.org/W2036594607","https://openalex.org/W2037345665","https://openalex.org/W2037609465","https://openalex.org/W2037920362","https://openalex.org/W2039117920","https://openalex.org/W2040053082","https://openalex.org/W2041138285","https://openalex.org/W2044102675","https://openalex.org/W2048140690","https://openalex.org/W2048190193","https://openalex.org/W2048299560","https://openalex.org/W2050724926","https://openalex.org/W2052672099","https://openalex.org/W2053372607","https://openalex.org/W2053723553","https://openalex.org/W2054797498","https://openalex.org/W2057399298","https://openalex.org/W2059815518","https://openalex.org/W2059986841","https://openalex.org/W2060314412","https://openalex.org/W2062976959","https://openalex.org/W2063057728","https://openalex.org/W2066209628","https://openalex.org/W2066278568","https://openalex.org/W2067014899","https://openalex.org/W2067122321","https://openalex.org/W2067323805","https://openalex.org/W2067897112","https://openalex.org/W2068947159","https://openalex.org/W2069798869","https://openalex.org/W2070212339","https://openalex.org/W2070381129","https://openalex.org/W2071412715","https://openalex.org/W2071502548","https://openalex.org/W2073382359","https://openalex.org/W2074145013","https://openalex.org/W2075856022","https://openalex.org/W2076107807","https://openalex.org/W2079027396","https://openalex.org/W2080401999","https://openalex.org/W2081285803","https://openalex.org/W2082942825","https://openalex.org/W2084086973","https://openalex.org/W2084612017","https://openalex.org/W2087285213","https://openalex.org/W2087289859","https://openalex.org/W2088004537","https://openalex.org/W2089678050","https://openalex.org/W2090210600","https://openalex.org/W2091031576","https://openalex.org/W2095530149","https://openalex.org/W2096804803","https://openalex.org/W2097592282","https://openalex.org/W2098528749","https://openalex.org/W2100217829","https://openalex.org/W2100380960","https://openalex.org/W2100465512","https://openalex.org/W2100894820","https://openalex.org/W2102312968","https://openalex.org/W2103344965","https://openalex.org/W2105518445","https://openalex.org/W2106504381","https://openalex.org/W2108275539","https://openalex.org/W2112590956","https://openalex.org/W2113932898","https://openalex.org/W2113958163","https://openalex.org/W2114527338","https://openalex.org/W2115631195","https://openalex.org/W2116605720","https://openalex.org/W2116822992","https://openalex.org/W2118576106","https://openalex.org/W2118689243","https://openalex.org/W2119008404","https://openalex.org/W2119320536","https://openalex.org/W2120433336","https://openalex.org/W2122467899","https://openalex.org/W2123346255","https://openalex.org/W2124802112","https://openalex.org/W2125658915","https://openalex.org/W2125723268","https://openalex.org/W2128127815","https://openalex.org/W2128241866","https://openalex.org/W2128874562","https://openalex.org/W2130848213","https://openalex.org/W2131350538","https://openalex.org/W2132608007","https://openalex.org/W2133188589","https://openalex.org/W2134565188","https://openalex.org/W2134843423","https://openalex.org/W2136069822","https://openalex.org/W2136358316","https://openalex.org/W2137036286","https://openalex.org/W2137559175","https://openalex.org/W2138616826","https://openalex.org/W2138640863","https://openalex.org/W2139425782","https://openalex.org/W2139494523","https://openalex.org/W2139996507","https://openalex.org/W2144207870","https://openalex.org/W2144501719","https://openalex.org/W2145065899","https://openalex.org/W2146326641","https://openalex.org/W2147849339","https://openalex.org/W2149346727","https://openalex.org/W2149551358","https://openalex.org/W2151147342","https://openalex.org/W2152280563","https://openalex.org/W2154040794","https://openalex.org/W2154348064","https://openalex.org/W2159096148","https://openalex.org/W2159099714","https://openalex.org/W2159552471","https://openalex.org/W2159562139","https://openalex.org/W2160005424","https://openalex.org/W2160721372","https://openalex.org/W2165705973","https://openalex.org/W2166041703","https://openalex.org/W2166436452","https://openalex.org/W2169061872","https://openalex.org/W2170946947","https://openalex.org/W2171756643","https://openalex.org/W2172119280","https://openalex.org/W2275355856","https://openalex.org/W2319095730","https://openalex.org/W2335178464","https://openalex.org/W2414375923","https://openalex.org/W2466365686","https://openalex.org/W2649968629","https://openalex.org/W2655108626","https://openalex.org/W2730956153"],"related_works":["https://openalex.org/W2037156682","https://openalex.org/W2079594150","https://openalex.org/W2292519221","https://openalex.org/W1966646981","https://openalex.org/W1983991575","https://openalex.org/W3128791227","https://openalex.org/W4403149223","https://openalex.org/W2009029265","https://openalex.org/W1997036108","https://openalex.org/W2253023023"],"abstract_inverted_index":{"Neurofibromatosis":[0],"1":[1],"(NF1)":[2],"is":[3,51,77,94],"an":[4],"autosomal":[5],"dominant":[6],"hereditary":[7],"syndrome,":[8],"affecting":[9],"skin,":[10],"neural":[11],"tissues":[12],"and":[13,28,34,44,61,72,84,103,131,134,147,152,186,211,228,243],"skeleton.":[14],"Hallmarks":[15],"of":[16,66,89,97,170,183,191,207,225,240],"NF1":[17,129,140,185,201,236,255,260],"include":[18],"benign":[19],"cutaneous":[20],"neurofibroma":[21],"tumors,":[22],"pigmentation":[23],"lesions":[24],"on":[25],"the":[26,30,90,164,168,204,226],"skin":[27],"in":[29,48,79,136,177,213,222,249,254,258,280],"iris,":[31],"learning":[32],"disabilities":[33],"predisposition":[35],"to":[36,69,138,154,158,166,174,216,275],"selected":[37,229],"malignancies.":[38],"Low":[39],"bone":[40,58,99,105,247],"mineral":[41,59],"density":[42,60],"(BMD)":[43],"osteopenia/osteoporosis":[45],"are":[46,111,142],"common":[47],"NF1.":[49],"Osteoporosis":[50,76],"a":[52,95],"systemic":[53],"disorder":[54],"characterized":[55],"by":[56,81,101,107],"low":[57],"increased":[62,145,238,246],"fracture":[63,74],"risk.":[64,75],"Treatment":[65],"osteoporosis":[67,219],"aims":[68],"prevent":[70],"falls":[71],"decrease":[73],"diagnosed":[78],"adults":[80],"measuring":[82],"BMD":[83,251,267],"evaluating":[85],"clinical":[86],"risk":[87],"factors":[88],"patient.":[91],"Bone":[92],"turnover":[93,248],"process":[96],"old":[98],"resorbed":[100],"osteoclasts":[102,110,141,178,193,202],"new":[104],"formed":[106],"osteoblasts.":[108],"Multinuclear":[109],"derived":[112,179],"from":[113,120,127,180],"osteoclast":[114],"progenitors,":[115],"which":[116],"can":[117],"be":[118],"isolated":[119,126],"peripheral":[121],"blood.":[122],"Osteoclast":[123],"progenitors":[124],"were":[125,232],"17":[128],"patients":[130,261,281],"healthy":[132],"controls,":[133],"cultured":[135],"vitro":[137,214],"osteoclasts.":[139,160],"hyperactive,":[143],"displaying":[144],"differentiation":[146],"resorption":[148],"capacity,":[149],"abnormal":[150],"morphology":[151],"tolerance":[153],"serum":[155,241],"deprivation":[156],"compared":[157,215],"control":[159,187,192],"These":[161],"findings":[162],"expanded":[163],"study":[165],"evaluate":[167],"effects":[169],"bisphosphonates,":[171],"drugs":[172],"designed":[173],"treat":[175],"osteoporosis,":[176],"blood":[181],"samples":[182],"20":[184],"persons.":[188],"The":[189],"number":[190],"was":[194,220,278],"expectedly":[195],"reduced":[196],"after":[197,264],"bisphosphonate":[198],"treatment.":[199],"However,":[200],"tolerated":[203],"apoptotic":[205],"effect":[206],"alendronate,":[208],"zoledronic":[209],"acid":[210],"clodronate":[212],"controls.":[217],"NF1-related":[218,271],"found":[221,279],"~20":[223],"%":[224],"patients,":[227],"laboratory":[230],"parameters":[231],"measured.":[233],"Patients":[234,269],"with":[235,270],"have":[237],"levels":[239],"CTX":[242],"PINP,":[244],"reflecting":[245],"vivo.":[250],"decreases":[252],"progressively":[253],"as":[256],"evaluated":[257],"19":[259],"12":[262],"years":[263],"their":[265],"initial":[266],"measurement.":[268],"osteopenia":[272],"often":[273],"progress":[274],"osteoporosis.":[276],"This":[277],"aged":[282],"37-76.":[283]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}