{"id":"https://openalex.org/W1898707643","doi":"https://doi.org/10.1128/jvi.73.9.7271-7277.1999","title":"Inhibition of Epstein-Barr Virus Replication by a Benzimidazole l -Riboside: Novel Antiviral Mechanism of 5,6-Dichloro-2-(Isopropylamino)-1-\u03b2- l -Ribofuranosyl-1H-Benzimidazole","display_name":"Inhibition of Epstein-Barr Virus Replication by a Benzimidazole l -Riboside: Novel Antiviral Mechanism of 5,6-Dichloro-2-(Isopropylamino)-1-\u03b2- l -Ribofuranosyl-1H-Benzimidazole","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W1898707643","doi":"https://doi.org/10.1128/jvi.73.9.7271-7277.1999","mag":"1898707643","pmid":"https://pubmed.ncbi.nlm.nih.gov/10438815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/104252"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.73.9.7271-7277.1999","doi":"https://doi.org/10.1128/jvi.73.9.7271-7277.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.73.9.7271-7277.1999","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/104252","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055722265","display_name":"Valerie L. Zacny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie L. Zacny","raw_affiliation_strings":["<!--label omitted: 1-->Lineberger Comprehensive Cancer Center1 and","<!--label omitted: 2-->Departments of Microbiology and Immunology2 and","Departments of Microbiology and Immunology2 and","Lineberger Comprehensive Cancer Center1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lineberger Comprehensive Cancer Center1 and","institution_ids":["https://openalex.org/I4390039329"]},{"raw_affiliation_string":"<!--label omitted: 2-->Departments of Microbiology and Immunology2 and","institution_ids":[]},{"raw_affiliation_string":"Departments of Microbiology and Immunology2 and","institution_ids":[]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center1 and","institution_ids":["https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032791330","display_name":"Edward Gershburg","orcid":"https://orcid.org/0000-0003-3584-9947","observed_orcids":["https://orcid.org/0000-0003-3584-9947"]},"institutions":[{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduard Gershburg","raw_affiliation_strings":["<!--label omitted: 1-->Lineberger Comprehensive Cancer Center1 and","Lineberger Comprehensive Cancer Center1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lineberger Comprehensive Cancer Center1 and","institution_ids":["https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center1 and","institution_ids":["https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108353480","display_name":"Michelle G. Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle G. Davis","raw_affiliation_strings":["<!--label omitted: 3-->Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093","Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093","institution_ids":[]},{"raw_affiliation_string":"Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038217140","display_name":"Karen K. Biron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen K. Biron","raw_affiliation_strings":["<!--label omitted: 3-->Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093","Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093","institution_ids":[]},{"raw_affiliation_string":"Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277093","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075719027","display_name":"Joseph Stephen Pagano","orcid":"https://orcid.org/0009-0000-6711-7092","observed_orcids":["https://orcid.org/0009-0000-6711-7092"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S. Pagano","raw_affiliation_strings":["<!--label omitted: 1-->Lineberger Comprehensive Cancer Center1 and","<!--label omitted: 2-->Departments of Microbiology and Immunology2 and","<!--label omitted: 4-->Medicine,4 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and","Departments of Microbiology and Immunology2 and","Lineberger Comprehensive Cancer Center1 and","Medicine,4 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lineberger Comprehensive Cancer Center1 and","institution_ids":["https://openalex.org/I4390039329"]},{"raw_affiliation_string":"<!--label omitted: 2-->Departments of Microbiology and Immunology2 and","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 4-->Medicine,4 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Departments of Microbiology and Immunology2 and","institution_ids":[]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center1 and","institution_ids":["https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Medicine,4 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0648,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.86137025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"73","issue":"9","first_page":"7271","last_page":"7277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.652999997138977},{"id":"https://openalex.org/keywords/lytic-replication","display_name":"lytic replication","score":0.8349999785423279},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.746999979019165},{"id":"https://openalex.org/keywords/burkitt-lymphoma-cells","display_name":"Burkitt lymphoma cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/latent-infection","display_name":"latent infection","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7898471355438232},{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.7507073879241943},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.6349872946739197},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.5596797466278076},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5522227883338928},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5515876412391663},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5438026785850525},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.462371826171875},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.4368545413017273},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.42963969707489014},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31532859802246094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2018585503101349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12341564893722534},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004004","descriptor_name":"Dichlororibofuranosylbenzimidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004004","descriptor_name":"Dichlororibofuranosylbenzimidazole","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.73.9.7271-7277.1999","doi":"https://doi.org/10.1128/jvi.73.9.7271-7277.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.73.9.7271-7277.1999","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1254836","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/104252","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:104252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/104252","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:10438815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10438815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1254836","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/104252","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7016388848","display_name":null,"funder_award_id":"CA 19014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880694","display_name":"Viral Oncogenesis, Latency, and Replication","funder_award_id":"P01CA019014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W81590852","https://openalex.org/W159156145","https://openalex.org/W584325581","https://openalex.org/W1482180607","https://openalex.org/W1502391241","https://openalex.org/W1507636017","https://openalex.org/W1512885164","https://openalex.org/W1534625428","https://openalex.org/W1589968725","https://openalex.org/W1605243519","https://openalex.org/W1668568220","https://openalex.org/W1720083525","https://openalex.org/W1760923416","https://openalex.org/W1801060758","https://openalex.org/W1805559261","https://openalex.org/W1890864184","https://openalex.org/W1926456818","https://openalex.org/W1968014896","https://openalex.org/W1969924906","https://openalex.org/W1972118816","https://openalex.org/W1974350561","https://openalex.org/W1976215254","https://openalex.org/W1976648018","https://openalex.org/W1981435401","https://openalex.org/W1984643643","https://openalex.org/W1986791214","https://openalex.org/W1996440858","https://openalex.org/W2001352041","https://openalex.org/W2008185754","https://openalex.org/W2015896032","https://openalex.org/W2033630367","https://openalex.org/W2045360603","https://openalex.org/W2048028918","https://openalex.org/W2056875236","https://openalex.org/W2057069454","https://openalex.org/W2062434608","https://openalex.org/W2062924063","https://openalex.org/W2064567786","https://openalex.org/W2072945014","https://openalex.org/W2073703630","https://openalex.org/W2077910054","https://openalex.org/W2081499148","https://openalex.org/W2084278918","https://openalex.org/W2087064620","https://openalex.org/W2090162429","https://openalex.org/W2095356884","https://openalex.org/W2095953096","https://openalex.org/W2100161576","https://openalex.org/W2103922065","https://openalex.org/W2110131180","https://openalex.org/W2111311719","https://openalex.org/W2111973961","https://openalex.org/W2113209260","https://openalex.org/W2119535180","https://openalex.org/W2127791051","https://openalex.org/W2129639254","https://openalex.org/W2131230225","https://openalex.org/W2134971124","https://openalex.org/W2140225836","https://openalex.org/W2150946329","https://openalex.org/W2159163386","https://openalex.org/W2160645346","https://openalex.org/W2160858666","https://openalex.org/W2166025376","https://openalex.org/W2167561115","https://openalex.org/W2167835886","https://openalex.org/W2168602825","https://openalex.org/W2169249442","https://openalex.org/W2257569374","https://openalex.org/W2331222889","https://openalex.org/W2950125885","https://openalex.org/W4249086574"],"related_works":["https://openalex.org/W2106227497","https://openalex.org/W2096682430","https://openalex.org/W2413887371","https://openalex.org/W2055397341","https://openalex.org/W2327853461","https://openalex.org/W7096078036","https://openalex.org/W1985760862","https://openalex.org/W2086497828","https://openalex.org/W1863834332","https://openalex.org/W1507636017"],"abstract_inverted_index":{"Although":[0],"a":[1,43,81,206],"number":[2],"of":[3,8,31,46,53,60,68,77,94,98,137,150,155,166,209,220],"antiviral":[4,47],"drugs":[5,24],"inhibit":[6],"replication":[7,19,57,76],"Epstein-Barr":[9],"virus":[10],"(EBV)":[11],"in":[12,20,71,80,105,158],"cell":[13,84],"culture,":[14],"and":[15,101,217],"acyclovir":[16],"(ACV)":[17],"suppresses":[18],"vivo,":[21],"currently":[22],"available":[23],"have":[25],"not":[26,59,146],"proven":[27],"effective":[28],"for":[29,189,201],"treatment":[30],"EBV-associated":[32],"diseases":[33],"other":[34,61],"than":[35],"oral":[36],"hairy":[37],"leukoplakia.":[38],"Benzimidazole":[39],"riboside":[40],"compounds":[41,48,70,132],"represent":[42],"new":[44],"class":[45,73],"that":[49,133],"are":[50],"potent":[51,207],"inhibitors":[52,136],"human":[54],"cytomegalovirus":[55],"(HCMV)":[56],"but":[58],"herpesviruses.":[62],"Here":[63],"we":[64],"characterize":[65],"the":[66,121,148,159,164,179,215,218,221],"effects":[67],"two":[69],"this":[72],"against":[74],"lytic":[75,99],"EBV":[78,95,156,168,223],"induced":[79,160],"Burkitt":[82],"lymphoma":[83],"line":[85],"latently":[86,106],"infected":[87,107],"with":[88,198],"EBV.":[89,210],"We":[90],"analyzed":[91],"linear":[92,167],"forms":[93,103,154],"genomes,":[96],"indicative":[97],"replication,":[100],"episomal":[102],"present":[104],"cells":[108],"by":[109,114,126],"terminal":[110],"probe":[111],"analysis":[112],"followed":[113],"Southern":[115],"blot":[116],"hybridization":[117],"as":[118,120,135,170,172],"well":[119,171],"high-molecular-weight":[122,151],"unprocessed":[123],"viral":[124,174],"DNA":[125,139,157,169,175],"pulsed-field":[127],"gel":[128],"electrophoresis.":[129],"D-Ribofuranosyl":[130],"benzimidazole":[131],"act":[134],"HCMV":[138],"maturation,":[140],"including":[141],"BDCRB":[142],"(5,":[143],"6-dichloro-2-bromo-1-beta-D-ribofuranosyl-1H-benzimidazole),":[144],"did":[145],"affect":[147],"accumulation":[149,219],"or":[152],"monomeric":[153],"cells.":[161],"In":[162,211],"contrast,":[163],"generation":[165],"precursor":[173],"was":[176,191],"sensitive":[177],"to":[178,193],"L-riboside":[180],"1263W94":[181,190,204,213],"[5,":[182],"6-dichloro-2-(isopropylamino)-1-beta-L-ribofuranosyl-1H-benzimidazole].":[183],"The":[184],"50%":[185],"inhibitory":[186],"concentration":[187],"range":[188],"0.15":[192],"1.":[194],"1":[195],"microM,":[196],"compared":[197],"10":[199],"microM":[200],"ACV.":[202],"Thus,":[203],"is":[205],"inhibitor":[208],"addition,":[212],"inhibited":[214],"phosphorylation":[216],"essential":[222],"replicative":[224],"cofactor,":[225],"early":[226],"antigen":[227],"D.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}