{"id":"https://openalex.org/W189817824","doi":"https://doi.org/10.1007/978-1-59745-420-9_2","title":"The Basics of Oxidative Biochemistry","display_name":"The Basics of Oxidative Biochemistry","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W189817824","doi":"https://doi.org/10.1007/978-1-59745-420-9_2","mag":"189817824"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-420-9_2","doi":"https://doi.org/10.1007/978-1-59745-420-9_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-420-9_2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Stress in Aging","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2501476786","display_name":"Oxidative Stress in Aging"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083523538","display_name":"Satomi Miwa","orcid":"https://orcid.org/0000-0002-1239-1198","observed_orcids":["https://orcid.org/0000-0002-1239-1198"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Satomi Miwa","raw_affiliation_strings":["Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091138132","display_name":"Florian L. M\u00fcller","orcid":"https://orcid.org/0000-0001-7568-2948","observed_orcids":["https://orcid.org/0000-0001-7568-2948"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florian L. Muller","raw_affiliation_strings":["Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX","Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059093059","display_name":"Kenneth B. Beckman","orcid":"https://orcid.org/0000-0001-8876-0706","observed_orcids":["https://orcid.org/0000-0001-8876-0706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth B. Beckman","raw_affiliation_strings":["Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, CA","Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, CA","institution_ids":[]},{"raw_affiliation_string":"Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7038,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.83087793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"11","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.19020000100135803,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9279999732971191},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.777999997138977},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":1.0},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6790000200271606},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7940000295639038},{"id":"https://openalex.org/keywords/oxygen-chemistry","display_name":"oxygen chemistry","score":0.5669999718666077},{"id":"https://openalex.org/keywords/lipid-hydroperoxides","display_name":"lipid hydroperoxides","score":0.7979999780654907},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9160000085830688},{"id":"https://openalex.org/keywords/biotoxicity","display_name":"biotoxicity","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.9080616235733032},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8355956077575684},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.8170852661132812},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8087514042854309},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.7247523069381714},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6886422634124756},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.6734509468078613},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.596460223197937},{"id":"https://openalex.org/C2777103536","wikidata":"https://www.wikidata.org/wiki/Q7169514","display_name":"Peroxynitrous acid","level":5,"score":0.5530260801315308},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.48543983697891235},{"id":"https://openalex.org/C192937433","wikidata":"https://www.wikidata.org/wiki/Q2134627","display_name":"Reactive intermediate","level":3,"score":0.474619060754776},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4487175941467285},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4262143075466156},{"id":"https://openalex.org/C116119225","wikidata":"https://www.wikidata.org/wiki/Q7300316","display_name":"Reactive nitrogen","level":3,"score":0.41768038272857666},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3594895303249359},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3300136923789978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3180580735206604},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.15246257185935974},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.13905742764472961},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13222330808639526}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-420-9_2","doi":"https://doi.org/10.1007/978-1-59745-420-9_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-420-9_2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Stress in Aging","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":208,"referenced_works":["https://openalex.org/W116785906","https://openalex.org/W195366774","https://openalex.org/W1270671049","https://openalex.org/W1486525201","https://openalex.org/W1488265246","https://openalex.org/W1489524219","https://openalex.org/W1496181943","https://openalex.org/W1505281105","https://openalex.org/W1516318762","https://openalex.org/W1525139717","https://openalex.org/W1531710355","https://openalex.org/W1546262028","https://openalex.org/W1549189689","https://openalex.org/W1554017667","https://openalex.org/W1559531158","https://openalex.org/W1573826674","https://openalex.org/W1574445997","https://openalex.org/W1576198188","https://openalex.org/W1580575515","https://openalex.org/W1594934722","https://openalex.org/W1605366679","https://openalex.org/W1608856014","https://openalex.org/W1798026767","https://openalex.org/W1813230101","https://openalex.org/W1896619220","https://openalex.org/W1911972076","https://openalex.org/W1925799544","https://openalex.org/W1927592403","https://openalex.org/W1940436875","https://openalex.org/W1951528602","https://openalex.org/W1965668748","https://openalex.org/W1966571906","https://openalex.org/W1966582616","https://openalex.org/W1966685018","https://openalex.org/W1967305386","https://openalex.org/W1967305892","https://openalex.org/W1968991720","https://openalex.org/W1970094644","https://openalex.org/W1970184469","https://openalex.org/W1971308467","https://openalex.org/W1973535295","https://openalex.org/W1975044301","https://openalex.org/W1975621743","https://openalex.org/W1975984844","https://openalex.org/W1976842211","https://openalex.org/W1979048203","https://openalex.org/W1982900915","https://openalex.org/W1983078193","https://openalex.org/W1984501829","https://openalex.org/W1985977889","https://openalex.org/W1987777210","https://openalex.org/W1987981231","https://openalex.org/W1992412942","https://openalex.org/W1992630712","https://openalex.org/W1992678387","https://openalex.org/W1993058298","https://openalex.org/W1996833241","https://openalex.org/W1997382584","https://openalex.org/W1998596519","https://openalex.org/W2001157852","https://openalex.org/W2001426234","https://openalex.org/W2001735713","https://openalex.org/W2001923529","https://openalex.org/W2003337850","https://openalex.org/W2005381951","https://openalex.org/W2005709691","https://openalex.org/W2009494221","https://openalex.org/W2010077871","https://openalex.org/W2010094123","https://openalex.org/W2012473719","https://openalex.org/W2013805538","https://openalex.org/W2013866322","https://openalex.org/W2013970469","https://openalex.org/W2015090490","https://openalex.org/W2016403136","https://openalex.org/W2018732700","https://openalex.org/W2020428941","https://openalex.org/W2020914812","https://openalex.org/W2023194082","https://openalex.org/W2023419047","https://openalex.org/W2023586087","https://openalex.org/W2024893538","https://openalex.org/W2025152430","https://openalex.org/W2028164957","https://openalex.org/W2032784689","https://openalex.org/W2032949485","https://openalex.org/W2033718406","https://openalex.org/W2035396795","https://openalex.org/W2036282005","https://openalex.org/W2036969501","https://openalex.org/W2037426867","https://openalex.org/W2037526941","https://openalex.org/W2037542399","https://openalex.org/W2038345750","https://openalex.org/W2038949753","https://openalex.org/W2039105541","https://openalex.org/W2040402525","https://openalex.org/W2041489973","https://openalex.org/W2043956498","https://openalex.org/W2047672047","https://openalex.org/W2048048789","https://openalex.org/W2049151426","https://openalex.org/W2049207446","https://openalex.org/W2049713754","https://openalex.org/W2050878478","https://openalex.org/W2051802937","https://openalex.org/W2052078181","https://openalex.org/W2052252788","https://openalex.org/W2055055753","https://openalex.org/W2056840435","https://openalex.org/W2057180672","https://openalex.org/W2057818847","https://openalex.org/W2058106189","https://openalex.org/W2058137293","https://openalex.org/W2058821788","https://openalex.org/W2062431237","https://openalex.org/W2066541482","https://openalex.org/W2069225745","https://openalex.org/W2071074231","https://openalex.org/W2072978915","https://openalex.org/W2072999507","https://openalex.org/W2075584603","https://openalex.org/W2076485464","https://openalex.org/W2076510866","https://openalex.org/W2077466344","https://openalex.org/W2080911031","https://openalex.org/W2082466337","https://openalex.org/W2082631610","https://openalex.org/W2084016719","https://openalex.org/W2084054222","https://openalex.org/W2084473788","https://openalex.org/W2085356948","https://openalex.org/W2086605133","https://openalex.org/W2086896843","https://openalex.org/W2087269822","https://openalex.org/W2087561593","https://openalex.org/W2088658333","https://openalex.org/W2089307051","https://openalex.org/W2089571522","https://openalex.org/W2089926641","https://openalex.org/W2089958765","https://openalex.org/W2091194381","https://openalex.org/W2091485610","https://openalex.org/W2092300510","https://openalex.org/W2092551351","https://openalex.org/W2093057466","https://openalex.org/W2093929400","https://openalex.org/W2094026727","https://openalex.org/W2094655287","https://openalex.org/W2096136751","https://openalex.org/W2096318298","https://openalex.org/W2096942880","https://openalex.org/W2097996074","https://openalex.org/W2101032933","https://openalex.org/W2101147659","https://openalex.org/W2101882785","https://openalex.org/W2102619095","https://openalex.org/W2102934052","https://openalex.org/W2104052570","https://openalex.org/W2108448809","https://openalex.org/W2109384324","https://openalex.org/W2109439103","https://openalex.org/W2111682630","https://openalex.org/W2117102245","https://openalex.org/W2117966002","https://openalex.org/W2118524103","https://openalex.org/W2132673369","https://openalex.org/W2132826785","https://openalex.org/W2133874291","https://openalex.org/W2134428957","https://openalex.org/W2134515111","https://openalex.org/W2135257384","https://openalex.org/W2136573391","https://openalex.org/W2138122869","https://openalex.org/W2139344973","https://openalex.org/W2139837746","https://openalex.org/W2144229295","https://openalex.org/W2144714650","https://openalex.org/W2147080431","https://openalex.org/W2147785354","https://openalex.org/W2147849026","https://openalex.org/W2148557032","https://openalex.org/W2151561847","https://openalex.org/W2153781976","https://openalex.org/W2154828075","https://openalex.org/W2155666009","https://openalex.org/W2156107840","https://openalex.org/W2158496331","https://openalex.org/W2159130722","https://openalex.org/W2160666488","https://openalex.org/W2164066515","https://openalex.org/W2165072468","https://openalex.org/W2165448645","https://openalex.org/W2165877385","https://openalex.org/W2168721627","https://openalex.org/W2186103713","https://openalex.org/W2270686920","https://openalex.org/W2283573532","https://openalex.org/W2301670026","https://openalex.org/W2404667299","https://openalex.org/W2410297547","https://openalex.org/W2414123687","https://openalex.org/W2420714045","https://openalex.org/W4242270522","https://openalex.org/W4252784541","https://openalex.org/W4254547023","https://openalex.org/W4300198507","https://openalex.org/W6768902972"],"related_works":["https://openalex.org/W4248245537","https://openalex.org/W2055641262","https://openalex.org/W2951319095","https://openalex.org/W4242695476","https://openalex.org/W2115681584","https://openalex.org/W4232727838","https://openalex.org/W7128962591","https://openalex.org/W1027676165","https://openalex.org/W4404718980","https://openalex.org/W2087770120"],"abstract_inverted_index":{"Although":[0,163],"a":[1],"thorough":[2],"knowledge":[3],"of":[4,13,23,37,47,115,150],"oxygen":[5,15,50],"chemistry":[6],"is":[7,19,171],"necessary":[8],"to":[9,60,68,141,146,173,189],"understand":[10],"the":[11,21,34,65,69,142,147,151,160,176,182],"biochemistry":[12],"reactive":[14,49,54,113,154],"species,":[16,169],"that":[17,175],"topic":[18],"beyond":[20],"scope":[22],"this":[24,170],"book":[25,71],"(see":[26],"excellent":[27],"works":[28],"by":[29],"Sawyer":[30],"[1,":[31],"2]":[32],"and":[33,39,53,97,103,112,127,159,192],"outstanding":[35],"textbook":[36],"Halliwell":[38],"Gutteridge":[40],"[3],":[41],"Chapter":[42],"1).":[43],"A":[44],"large":[45],"number":[46],"different":[48],"species":[51,56],"(ROS)":[52],"nitrogen":[55],"are":[57,186],"now":[58],"known":[59,153,179],"exist":[61],"in":[62],"biological":[63,148],"systems,":[64],"most":[66],"relevant":[67,145,188],"present":[70],"being":[72],"superoxide":[73],"(O":[74],"2":[75,78,83,85,129,131],"/":[76],"HO":[77],"),":[79,86,111,132],"hydrogen":[80,157],"peroxide":[81],"(H":[82],"O":[84,130],"hydroxyl":[87,161],"radical":[88,108],"(OH),":[89],"organic":[90],"(lipid,":[91],"alkyl,":[92],"or":[93],"short":[94],"chain)":[95],"hydroperoxides":[96],"hydroperoxide":[98],"radicals":[99],"(ROOH,":[100],"ROO),":[101],"peroxynitrite":[102],"peroxynitrous":[104],"acid":[105],"(ONOO/ONOOH),":[106],"carbonate":[107],"(CO":[109],"3":[110],"aldehydes":[114],"varying":[116],"lengths.":[117],"Various":[118],"oxo-metal":[119],"complexes,":[120],"(such":[121],"as":[122],"those":[123],"formed":[124],"from":[125],"heme":[126],"H":[128],"may":[133],"also":[134],"be":[135],"relevant.":[136],"We":[137],"limit":[138],"our":[139],"discussion":[140],"chemical":[143],"properties":[144],"toxicity":[149],"best":[152],"species:":[155],"superoxide,":[156],"peroxide,":[158],"radical.":[162],"we":[164],"focus":[165],"on":[166],"these":[167],"three":[168],"not":[172,187],"say":[174],"many":[177],"other":[178],"ROS":[180],"(and":[181],"downstream":[183],"products":[184],"thereof)":[185],"oxidative":[190],"stress":[191],"aging.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}