{"id":"https://openalex.org/W1897666136","doi":"https://doi.org/10.1164/arrd.1983.128.1.45","title":"Relationship between Central Nervous System Hydrogen Ion Regulation and Amino Acid Metabolism in Hypercapnia","display_name":"Relationship between Central Nervous System Hydrogen Ion Regulation and Amino Acid Metabolism in Hypercapnia","publication_year":1983,"publication_date":"1983-07-01","ids":{"openalex":"https://openalex.org/W1897666136","doi":"https://doi.org/10.1164/arrd.1983.128.1.45","mag":"1897666136","pmid":"https://pubmed.ncbi.nlm.nih.gov/2862818"},"language":"en","primary_location":{"id":"doi:10.1164/arrd.1983.128.1.45","doi":"https://doi.org/10.1164/arrd.1983.128.1.45","is_oa":false,"landing_page_url":"https://doi.org/10.1164/arrd.1983.128.1.45","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008480966","display_name":"B. Hoop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Hoop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110070460","display_name":"Vivian E. Shih","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. E. Shih","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111095850","display_name":"H. Kazemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Kazemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.208,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.33548387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"128","issue":"1","first_page":"45","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.8149999976158142},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.972000002861023},{"id":"https://openalex.org/keywords/medulla-oblongata","display_name":"medulla oblongata","score":0.9409999847412109},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.984000027179718},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ammonia-metabolism","display_name":"ammonia metabolism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/carbon-dioxide","display_name":"carbon dioxide","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.6910170316696167},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6027059555053711},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5736235976219177},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.5269356966018677},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5155272483825684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.466999888420105},{"id":"https://openalex.org/C2780847362","wikidata":"https://www.wikidata.org/wiki/Q3518755","display_name":"Hydrogen ion","level":3,"score":0.4178515672683716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33180636167526245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2913430333137512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28843557834625244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703387439250946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21147167682647705},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.182303786277771},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06877568364143372}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1164/arrd.1983.128.1.45","doi":"https://doi.org/10.1164/arrd.1983.128.1.45","is_oa":false,"landing_page_url":"https://doi.org/10.1164/arrd.1983.128.1.45","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:2862818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2862818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},{"id":"pmid:6870069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6870069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W202004645","https://openalex.org/W433088743","https://openalex.org/W1592565027","https://openalex.org/W1984089779","https://openalex.org/W2029919028","https://openalex.org/W2042848772","https://openalex.org/W2152965622","https://openalex.org/W2165904973","https://openalex.org/W2218734770","https://openalex.org/W2230405938","https://openalex.org/W2287740762","https://openalex.org/W2415387928","https://openalex.org/W2416729317","https://openalex.org/W2418421252"],"related_works":["https://openalex.org/W2230405938","https://openalex.org/W2398469977","https://openalex.org/W2087268864","https://openalex.org/W2047487540","https://openalex.org/W2071418485","https://openalex.org/W2160307809","https://openalex.org/W1972343289","https://openalex.org/W170083205","https://openalex.org/W1993576218","https://openalex.org/W2248696142"],"abstract_inverted_index":{"Resting":[0],"level":[1],"of":[2,35,38,47,64,77,84,105,129,140,146,160],"ventilation":[3],"is":[4,153],"affected":[5],"by":[6,13,71,143],"change":[7],"in":[8,18,55,113],"hydrogen":[9,100,164],"ion":[10,101,165],"[H+]":[11,27],"and":[12,21,28,42,51,89,99,162],"certain":[14],"amino":[15,29,49,91],"acid":[16,30,88],"neurotransmitters":[17,86],"the":[19,33,85,114,133,136],"brain":[20],"cerebral":[22],"fluids.":[23],"Hypercapnia":[24],"alters":[25],"both":[26],"content.":[31],"Therefore,":[32],"effect":[34],"90":[36,127],"min":[37,128],"hypercapnia":[39],"on":[40],"blood":[41],"cerebrospinal":[43],"fluid":[44],"(CSF)":[45],"contents":[46],"selected":[48],"acids":[50],"ammonia":[52,66,111],"was":[53,67],"studied":[54],"anesthetized":[56],"mongrel":[57],"dogs":[58],"using":[59],"13N-labeled":[60],"ammonia.":[61],"Metabolic":[62],"turnover":[63],"CSF":[65,74,97,106,137],"not":[68],"significantly":[69],"altered":[70],"hypercapnia,":[72,130],"but":[73],"equilibrium":[75],"concentration":[76],"metabolized":[78,112],"ammonia,":[79],"i.e.,":[80],"glutamine,":[81],"a":[82,144,154],"precursor":[83],"glutamic":[87],"gamma":[90],"butyric":[92],"acid,":[93],"varied":[94],"linearly":[95],"with":[96],"bicarbonate":[98],"concentration.":[102],"The":[103],"percentage":[104],"glutamine":[107,141,161],"derived":[108],"from":[109,120],"tracer-labeled":[110],"central":[115],"nervous":[116],"system":[117],"(CNS)":[118],"rose":[119],"30%":[121],"at":[122,132],"normocapnia":[123],"to":[124],"60%":[125],"after":[126],"whereas":[131],"same":[134],"time,":[135],"transfer":[138,159],"rate":[139],"increased":[142],"factor":[145],"2.":[147],"These":[148],"observations":[149],"show":[150],"that":[151],"there":[152],"significant":[155],"correlation":[156],"between":[157],"CNS":[158,163],"regulation":[166],"during":[167],"hypercapnia.":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}