{"id":"https://openalex.org/W18974747","doi":"https://doi.org/10.3969/j.issn.1000-4432.2011.01.006","title":"Effect of quercetin on formation of choroidal neovascularization (CNV) in age-related macular degeneration(AMD).","display_name":"Effect of quercetin on formation of choroidal neovascularization (CNV) in age-related macular degeneration(AMD).","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W18974747","doi":"https://doi.org/10.3969/j.issn.1000-4432.2011.01.006","mag":"18974747","pmid":"https://pubmed.ncbi.nlm.nih.gov/21425492"},"language":"en","primary_location":{"id":"pmid:21425492","doi":"https://doi.org/10.3969/j.issn.1000-4432.2011.01.006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21425492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056935246","display_name":"Pei Zhuang","orcid":"https://orcid.org/0000-0002-8988-5735","observed_orcids":["https://orcid.org/0000-0002-8988-5735"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei Zhuang","raw_affiliation_strings":["Institute of Ocular Pharmacology, Texas A&M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ocular Pharmacology, Texas A&M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110926286","display_name":"Yi Shen","orcid":"https://orcid.org/0009-0004-7758-6633","observed_orcids":["https://orcid.org/0009-0004-7758-6633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023530149","display_name":"Bao Qin Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bao Qin Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wan Yu Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wan Yu Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005821761","display_name":"George C.Y. Chiou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George C Y Chiou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0296,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84267122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"1","first_page":"23","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.9940000176429749},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8100000023841858},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8949999809265137},{"id":"https://openalex.org/keywords/choroidal-circulation","display_name":"choroidal blood flow","score":0.9539999961853027},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.4339999854564667},{"id":"https://openalex.org/keywords/exudative-amd","display_name":"exudative AMD","score":0.7799999713897705},{"id":"https://openalex.org/keywords/laser-induced-cnv","display_name":"laser-induced CNV","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.8669319152832031},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7898480892181396},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.7225484251976013},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5252140164375305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5099059343338013},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.46247565746307373},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4466024339199066},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.43957632780075073},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4364369511604309},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.42853373289108276},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.410371333360672},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4018542170524597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35805752873420715},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.35209888219833374},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21912968158721924},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.19528648257255554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1641441285610199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1588229537010193},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.13242828845977783},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007452","descriptor_name":"Iodates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019810","descriptor_name":"Sodium Azide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:21425492","doi":"https://doi.org/10.3969/j.issn.1000-4432.2011.01.006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21425492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye science","raw_type":"Journal Article"},{"id":"mag:18974747","doi":"https://doi.org/10.3969/j.issn.1000-4432.2011.01.006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21425492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3149813528","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/98174A/201101/37552853.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555563","display_name":"\u773c\u79d1\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":"3005-9984","issn":["3005-9984","3005-9992"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u773c\u79d1\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029889091","https://openalex.org/W2946910782","https://openalex.org/W7100566332","https://openalex.org/W2052960966","https://openalex.org/W2060729901","https://openalex.org/W2359857185","https://openalex.org/W3087743559","https://openalex.org/W2042999089","https://openalex.org/W2516747190","https://openalex.org/W2141916939"],"abstract_inverted_index":{"PURPOSE:":[0],"Age-related":[1],"macular":[2],"degeneration":[3],"(AMD)":[4],"as":[5,31],"a":[6,145,211],"disease":[7],"entity":[8],"is":[9,57,64],"\"dry\"":[10],"at":[11,21],"early":[12],"stage":[13],"and":[14,26,118,182,200,203],"made":[15],"up":[16],"of":[17,51,61,69,74,81,127,155,185,195,217],"two":[18],"main":[19],"components":[20],"late":[22],"stage:":[23],"atrophic":[24],"AMD":[25,56],"exudative":[27],"AMD.":[28,77,218],"Quercetin":[29,150,191],"acts":[30],"an":[32],"anti-oxidant":[33],"to":[34,65,97,120],"protect":[35],"retinal":[36],"pigment":[37],"epithelial":[38],"cells":[39],"(RPE)":[40],"from":[41],"damaged":[42],"by":[43,84,88,137],"oxidative":[44,122],"stress,":[45],"but":[46],"its":[47],"effect":[48,68,126],"on":[49,71,129],"formation":[50,73,154,194],"choroidal":[52,100,159,205],"neovascularization":[53],"(CNV)":[54],"in":[55,76,103,109,133,162,180,198,201],"unclear.":[58],"The":[59,79,125,158],"aim":[60],"this":[62],"study":[63],"investigate":[66],"the":[67,72,99,153,193,215],"quercetin":[70,128,169,175],"CNV":[75,82,196],"METHODS:":[78],"development":[80],"induced":[83],"laser":[85],"was":[86,95,135,142,165],"detected":[87],"fluorescein":[89],"angiography":[90],"(FA).":[91],"Colored":[92],"microsphere":[93],"technique":[94],"used":[96],"determine":[98],"blood":[101,160,206],"flow":[102,161],"ocular":[104],"hypertensive":[105],"rabbit":[106,163],"eyes.":[107],"In":[108,171],"vitro":[110,172,202],"studies,":[111],"HUVECs":[112,134,140,181,186],"were":[113],"treated":[114],"with":[115],"NaIO3,":[116],"H2O2":[117],"NaN3":[119],"induce":[121],"cell":[123],"damages.":[124],"various":[130,177],"oxidations-induced":[131,178],"injuries":[132,179],"measured":[136],"MTT":[138],"assay.":[139,148],"migration":[141,184],"assessed":[143],"using":[144],"wound":[146,188],"healing":[147],"RESULTS:":[149],"significantly":[151,166],"inhibited":[152,183,192],"laser-induced":[156],"CNV.":[157],"eyes":[164],"increased":[167,204],"after":[168],"instillation.":[170],"results":[173],"showed":[174],"enhanced":[176],"during":[187],"healing.":[189],"CONCLUSION:":[190],"both":[197],"vivo":[199],"flow.":[207],"It":[208],"could":[209],"become":[210],"promising":[212],"candidate":[213],"for":[214],"treatment":[216]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
