{"id":"https://openalex.org/W1897271857","doi":"https://doi.org/10.5607/en.2015.24.3.197","title":"Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells","display_name":"Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells","publication_year":2015,"publication_date":"2015-09-24","ids":{"openalex":"https://openalex.org/W1897271857","doi":"https://doi.org/10.5607/en.2015.24.3.197","mag":"1897271857","pmid":"https://pubmed.ncbi.nlm.nih.gov/26412968","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4580746"},"language":"en","primary_location":{"id":"doi:10.5607/en.2015.24.3.197","doi":"https://doi.org/10.5607/en.2015.24.3.197","is_oa":true,"landing_page_url":"https://doi.org/10.5607/en.2015.24.3.197","pdf_url":"https://www.en-journal.org/journal/download_pdf.php?uid=271","source":{"id":"https://openalex.org/S4210220946","display_name":"Experimental Neurobiology","issn_l":"1226-2560","issn":["1226-2560","2093-8144"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","kci-registered","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.en-journal.org/journal/download_pdf.php?uid=271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110171978","display_name":"So-Young Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So-Young Yoon","raw_affiliation_strings":["Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul 03722, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul 03722, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079280873","display_name":"Young J. Oh","orcid":"https://orcid.org/0000-0002-0422-4525","observed_orcids":["https://orcid.org/0000-0002-0422-4525"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young J. Oh","raw_affiliation_strings":["Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul 03722, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul 03722, Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079280873"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":null,"apc_paid":null,"fwci":1.175,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77860127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"3","first_page":"197","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.40450000762939453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mpp","display_name":"MPP+","score":0.921999990940094},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mn9d-cells","display_name":"MN9D cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/glucose-levels","display_name":"glucose concentration","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cell-death-mode","display_name":"cell death mode","score":0.9200000166893005},{"id":"https://openalex.org/keywords/caspase-independent-cell-death","display_name":"caspase-independent cell death","score":0.8119999766349792},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9409999847412109},{"id":"https://openalex.org/keywords/jnk-activation","display_name":"JNK activation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.628000020980835},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.8985823392868042},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7943775057792664},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6917184591293335},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6400142908096313},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.5669988989830017},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5476332306861877},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5172746777534485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49589285254478455},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4929980933666229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4866541028022766},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4649357497692108},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4440196752548218},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4338533282279968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359171748161316},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3244304060935974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3103005290031433},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23709431290626526},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.11951056122779846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.047891587018966675},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5607/en.2015.24.3.197","doi":"https://doi.org/10.5607/en.2015.24.3.197","is_oa":true,"landing_page_url":"https://doi.org/10.5607/en.2015.24.3.197","pdf_url":"https://www.en-journal.org/journal/download_pdf.php?uid=271","source":{"id":"https://openalex.org/S4210220946","display_name":"Experimental Neurobiology","issn_l":"1226-2560","issn":["1226-2560","2093-8144"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","kci-registered","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurobiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3555568","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4580746","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4580746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4580746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Neurobiol","raw_type":"Text"},{"id":"pmid:26412968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26412968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental neurobiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5607/en.2015.24.3.197","doi":"https://doi.org/10.5607/en.2015.24.3.197","is_oa":true,"landing_page_url":"https://doi.org/10.5607/en.2015.24.3.197","pdf_url":"https://www.en-journal.org/journal/download_pdf.php?uid=271","source":{"id":"https://openalex.org/S4210220946","display_name":"Experimental Neurobiology","issn_l":"1226-2560","issn":["1226-2560","2093-8144"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","kci-registered","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurobiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8730452752","display_name":null,"funder_award_id":"A111382","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"}],"funders":[{"id":"https://openalex.org/F4320322034","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/00vxgjw72"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1897271857.pdf","grobid_xml":"https://content.openalex.org/works/W1897271857.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W1946523045","https://openalex.org/W1964230438","https://openalex.org/W1977434420","https://openalex.org/W1981819503","https://openalex.org/W1998225973","https://openalex.org/W2018679722","https://openalex.org/W2030536065","https://openalex.org/W2033126835","https://openalex.org/W2040558323","https://openalex.org/W2043075342","https://openalex.org/W2054526986","https://openalex.org/W2061598644","https://openalex.org/W2063767510","https://openalex.org/W2071965727","https://openalex.org/W2117724384","https://openalex.org/W2118566161","https://openalex.org/W2139053076","https://openalex.org/W2140283306","https://openalex.org/W2150881749","https://openalex.org/W2156355403","https://openalex.org/W2169905941"],"related_works":["https://openalex.org/W2271976771","https://openalex.org/W30214730","https://openalex.org/W2165817768","https://openalex.org/W2118566161","https://openalex.org/W1974752045","https://openalex.org/W1999809783","https://openalex.org/W2067428096","https://openalex.org/W2156355403","https://openalex.org/W2001145883","https://openalex.org/W2059485051"],"abstract_inverted_index":{"We":[0,165],"previously":[1],"demonstrated":[2],"that":[3,57,124,186],"1-methyl-4-phenylpyridinium":[4],"(MPP(+))":[5],"causes":[6],"caspase-independent,":[7],"non-apoptotic":[8],"death":[9,34,63,86,146,174,191],"of":[10,21,36,51,82,118,172,178],"dopaminergic":[11],"(DA)":[12],"neuronal":[13],"cells.":[14],"Here,":[15],"we":[16,55,122],"specifically":[17],"examined":[18],"whether":[19],"change":[20],"glucose":[22,52,74,77,112,128,133,150,200],"concentration":[23,75],"in":[24,46,104,175],"culture":[25],"medium":[26,47,105],"may":[27],"play":[28],"a":[29,60,187],"role":[30],"for":[31],"determining":[32],"cell":[33,62,97,145,173,190],"modes":[35],"DA":[37,179],"neurons":[38],"following":[39,155],"MPP(+)":[40,79,125,196],"treatment.":[41],"By":[42],"incubating":[43],"MN9D":[44,101],"cells":[45,58,102],"containing":[48,106],"varying":[49],"concentrations":[50],"(5~35":[53],"mM),":[54],"found":[56],"underwent":[59],"distinct":[61,189],"as":[64,94,96],"determined":[65],"by":[66,195],"morphological":[67],"and":[68,91,139],"biochemical":[69],"criteria.":[70],"At":[71],"5~10":[72],"mM":[73,110],"(low":[76],"levels),":[78],"induced":[80],"typical":[81],"the":[83,168],"apoptotic":[84],"dell":[85],"accompanied":[87],"with":[88,157],"caspase":[89,160],"activation":[90],"DNA":[92],"fragmentation":[93],"well":[95],"shrinkage.":[98],"In":[99],"contrast,":[100],"cultivated":[103],"more":[107],"than":[108],"17.5":[109],"(high":[111],"levels)":[113],"did":[114],"not":[115,131],"demonstrate":[116],"any":[117],"these":[119],"changes.":[120],"Subsequently,":[121],"observed":[123],"at":[126,148],"low":[127,149],"levels":[129,134,151],"but":[130],"high":[132],"led":[135],"to":[136],"ROS":[137,158],"generation":[138],"subsequent":[140],"JNK":[141,163],"activation.":[142],"Therefore,":[143],"MPP(+)-induced":[144],"only":[147],"was":[152],"significantly":[153],"ameliorated":[154],"co-treatment":[156],"scavenger,":[159],"inhibitor":[161],"or":[162],"inhibitor.":[164],"basically":[166],"confirmed":[167],"quite":[169],"similar":[170],"pattern":[171],"primary":[176],"cultures":[177],"neurons.":[180],"Taken":[181],"together,":[182],"our":[183],"results":[184],"suggest":[185],"biochemically":[188],"mode":[192],"is":[193],"recruited":[194],"depending":[197],"on":[198],"extracellular":[199],"levels.":[201]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}