{"id":"https://openalex.org/W189695663","doi":null,"title":"Distal deletion of chromosome Ip in ductal carcinoma of the breast.","display_name":"Distal deletion of chromosome Ip in ductal carcinoma of the breast.","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W189695663","mag":"189695663","pmid":"https://pubmed.ncbi.nlm.nih.gov/2545098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1683390"},"language":"en","primary_location":{"id":"pmid:2545098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2545098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1683390/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020769869","display_name":"Maurizio Genuardi","orcid":"https://orcid.org/0000-0002-7410-8351","observed_orcids":["https://orcid.org/0000-0002-7410-8351"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Genuardi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064016000","display_name":"H Tsihira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Tsihira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D E Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109939852","display_name":"G F Saunders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G F Saunders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0368,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.97204759,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"45","issue":"1","first_page":"73","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.4683000147342682,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.4683000147342682,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.3905999958515167,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.08320000022649765,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosome-1p","display_name":"chromosome 1p","score":0.8180000185966492},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.8040000200271606},{"id":"https://openalex.org/keywords/family-history-of-breast-cancer","display_name":"family history of breast cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/early-onset-breast-cancer","display_name":"early-onset breast cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/multiple-primary-neoplasms","display_name":"multiple primary neoplasms","score":0.8489999771118164},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.9794535636901855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.719146728515625},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6210169792175293},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5544042587280273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4855770468711853},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.4830961227416992},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4631710648536682},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.42058032751083374},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4117526412010193},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4087139070034027},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32867759466171265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24468347430229187},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.20600146055221558},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.1725257933139801}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:2545098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2545098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1683390","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1683390/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"pmh:oai:flore.unifi.it:2158/649707","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/649707","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:189695663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2545098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1683390","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1683390/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W154319537","https://openalex.org/W208821361","https://openalex.org/W1504841439","https://openalex.org/W1536196786","https://openalex.org/W1571407558","https://openalex.org/W1599207756","https://openalex.org/W1964619416","https://openalex.org/W1971074898","https://openalex.org/W1974488887","https://openalex.org/W1974609731","https://openalex.org/W1976125993","https://openalex.org/W1984762045","https://openalex.org/W1988433137","https://openalex.org/W1989752636","https://openalex.org/W1993125488","https://openalex.org/W1995259307","https://openalex.org/W1998291209","https://openalex.org/W2001178411","https://openalex.org/W2003522028","https://openalex.org/W2006874765","https://openalex.org/W2012458402","https://openalex.org/W2014669590","https://openalex.org/W2015085861","https://openalex.org/W2019769423","https://openalex.org/W2024002073","https://openalex.org/W2024247791","https://openalex.org/W2024378792","https://openalex.org/W2026421952","https://openalex.org/W2028400858","https://openalex.org/W2034440981","https://openalex.org/W2037749822","https://openalex.org/W2038982749","https://openalex.org/W2040834490","https://openalex.org/W2052878543","https://openalex.org/W2056560598","https://openalex.org/W2066055108","https://openalex.org/W2066328877","https://openalex.org/W2070452292","https://openalex.org/W2071456395","https://openalex.org/W2071588912","https://openalex.org/W2073331514","https://openalex.org/W2077858999","https://openalex.org/W2079368868","https://openalex.org/W2086322317","https://openalex.org/W2088073190","https://openalex.org/W2088706525","https://openalex.org/W2090631526","https://openalex.org/W2099742439","https://openalex.org/W2141393790","https://openalex.org/W2147650665","https://openalex.org/W2235193338","https://openalex.org/W2337585549","https://openalex.org/W2460265222","https://openalex.org/W4290309780"],"related_works":["https://openalex.org/W1910646251","https://openalex.org/W1998291209","https://openalex.org/W7095670739","https://openalex.org/W3032039860","https://openalex.org/W2030625872","https://openalex.org/W2075235789","https://openalex.org/W2076709640","https://openalex.org/W2098034673","https://openalex.org/W6983251021","https://openalex.org/W1990120418"],"abstract_inverted_index":{"By":[0],"use":[1],"of":[2,34,40,61,76,85,91,105,117,135,138,148,158,168,186,189],"recombinant":[3],"DNA":[4,16,25],"probes":[5],"that":[6,156],"correspond":[7],"to":[8,42],"genetic":[9,176],"loci":[10,67],"residing":[11],"on":[12,58,164],"human":[13],"chromosome":[14,65,169],"1,":[15],"samples":[17],"from":[18,26],"37":[19],"ductal":[20,187],"breast":[21,106],"carcinomas":[22],"and":[23,78,120,150],"constitutional":[24],"the":[27,47,52,83,86,136,165,184,190],"same":[28],"individuals":[29],"were":[30,144],"tested":[31],"for":[32],"loss":[33,90,147],"heterozygosity.":[35],"A":[36],"high":[37],"frequency":[38,75],"(41%)":[39],"reduction":[41],"homozygosity":[43],"was":[44,68,79,95],"detected":[45],"with":[46,100,111,123,133,174],"probe":[48],"p1-79,":[49],"which":[50],"recognizes":[51],"highly":[53],"polymorphic":[54],"locus":[55],"D1Z2,":[56],"localized":[57],"1p36.":[59],"Loss":[60],"heterozygosity":[62,92,149],"at":[63,93],"other":[64,175],"1":[66],"much":[69],"less":[70],"common,":[71],"not":[72],"exceeding":[73],"a":[74,101,159,180],"10%,":[77],"never":[80],"observed":[81,145],"in":[82,98,109,121,131,183],"absence":[84],"D1Z2":[87,94],"loss.":[88],"Somatic":[89],"more":[96],"frequent":[97],"patients":[99,110,132],"strong":[102],"family":[103],"history":[104],"cancer":[107],"(60%),":[108],"early":[112],"diagnosis":[113],"(before":[114],"45":[115],"years":[116],"age)":[118],"(70%),":[119],"those":[122],"multiple":[124],"tumors":[125,140],"or":[126,172],"tumor":[127,160],"foci":[128],"(50%)":[129],"than":[130],"none":[134],"characteristics":[137],"hereditary":[139],"(21%).":[141],"No":[142],"associations":[143],"between":[146],"prognostic":[151],"factors.":[152],"These":[153],"results":[154],"suggest":[155],"inactivation":[157],"suppressor":[161],"gene":[162],"located":[163],"distal":[166],"portion":[167],"1p,":[170],"alone":[171],"combined":[173],"changes,":[177],"may":[178],"represent":[179],"fundamental":[181],"step":[182],"pathogenesis":[185],"carcinoma":[188],"breast.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}