{"id":"https://openalex.org/W1895963467","doi":"https://doi.org/10.1146/annurev.pharmtox.41.1.317","title":"Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers","display_name":"Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W1895963467","doi":"https://doi.org/10.1146/annurev.pharmtox.41.1.317","mag":"1895963467","pmid":"https://pubmed.ncbi.nlm.nih.gov/11264460"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.pharmtox.41.1.317","doi":"https://doi.org/10.1146/annurev.pharmtox.41.1.317","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pharmtox.41.1.317","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005037936","display_name":"Hon Cheung Lee","orcid":"https://orcid.org/0000-0002-6993-0121","observed_orcids":["https://orcid.org/0000-0002-6993-0121"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hon Cheung Lee","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455;","Department of Pharmacology, University of Minnesota Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455;","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005037936"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":3.054,"has_fulltext":false,"cited_by_count":430,"citation_normalized_percentile":{"value":0.92592593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"41","issue":"1","first_page":"317","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-adp-ribose","display_name":"cyclic ADP-ribose","score":0.9869999885559082},{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adp-ribosyl-cyclase","display_name":"ADP-ribosyl cyclase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nad-metabolism","display_name":"NAD+ metabolism","score":0.6899999976158142},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6159999966621399},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/euglena","display_name":"Euglena","score":0.9750000238418579},{"id":"https://openalex.org/keywords/plant-gene-expression","display_name":"plant gene expression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/fertilisation-biology","display_name":"fertilisation (biology)","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":1.0},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.8982502222061157},{"id":"https://openalex.org/C2777336126","wikidata":"https://www.wikidata.org/wiki/Q2467043","display_name":"Cyclic ADP-ribose","level":5,"score":0.8720038533210754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6072579026222229},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.6052910685539246},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.5525830984115601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4723982512950897},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.41546687483787537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3934992849826813},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3282236158847809},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31646788120269775},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000246","descriptor_name":"Adenosine Diphosphate Ribose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.pharmtox.41.1.317","doi":"https://doi.org/10.1146/annurev.pharmtox.41.1.317","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pharmtox.41.1.317","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"pmid:11264460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11264460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of pharmacology and toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/171691","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/171691","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G198808630","display_name":"STRUCTURE-FUNCTION OF ADP-RIBOSYL CYCLASE AND HOMOLOGS","funder_award_id":"R01GM060333","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2684050290","display_name":"MECHANISM OF CALCIUM MOBILIZATION","funder_award_id":"R01HD017484","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7253384398","display_name":"Structure and Functions of CD38","funder_award_id":"R01GM061568","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":174,"referenced_works":["https://openalex.org/W199220195","https://openalex.org/W1483624903","https://openalex.org/W1488869774","https://openalex.org/W1514546358","https://openalex.org/W1517497728","https://openalex.org/W1528977425","https://openalex.org/W1536803321","https://openalex.org/W1538340522","https://openalex.org/W1544601757","https://openalex.org/W1548497076","https://openalex.org/W1561785493","https://openalex.org/W1562797648","https://openalex.org/W1566643819","https://openalex.org/W1577573703","https://openalex.org/W1577723740","https://openalex.org/W1579421676","https://openalex.org/W1591439195","https://openalex.org/W1615545200","https://openalex.org/W1658019904","https://openalex.org/W1676495195","https://openalex.org/W1746850292","https://openalex.org/W1888295889","https://openalex.org/W1895777307","https://openalex.org/W1902630152","https://openalex.org/W1918267618","https://openalex.org/W1963403501","https://openalex.org/W1964442923","https://openalex.org/W1965078524","https://openalex.org/W1967940275","https://openalex.org/W1969637387","https://openalex.org/W1976269779","https://openalex.org/W1976899888","https://openalex.org/W1979002457","https://openalex.org/W1979845008","https://openalex.org/W1981023326","https://openalex.org/W1981752474","https://openalex.org/W1986605032","https://openalex.org/W1986936050","https://openalex.org/W1990829674","https://openalex.org/W1990839195","https://openalex.org/W1991123763","https://openalex.org/W1991251241","https://openalex.org/W1991753089","https://openalex.org/W1992589123","https://openalex.org/W1995064239","https://openalex.org/W1998942070","https://openalex.org/W2000587392","https://openalex.org/W2000638509","https://openalex.org/W2001695130","https://openalex.org/W2002195659","https://openalex.org/W2003406255","https://openalex.org/W2004621033","https://openalex.org/W2004773321","https://openalex.org/W2006265135","https://openalex.org/W2006483772","https://openalex.org/W2008755938","https://openalex.org/W2009225669","https://openalex.org/W2012174792","https://openalex.org/W2012467728","https://openalex.org/W2013668456","https://openalex.org/W2014993252","https://openalex.org/W2015942983","https://openalex.org/W2016577440","https://openalex.org/W2017817071","https://openalex.org/W2018761751","https://openalex.org/W2019636677","https://openalex.org/W2019890971","https://openalex.org/W2020628351","https://openalex.org/W2023124110","https://openalex.org/W2025233098","https://openalex.org/W2026323342","https://openalex.org/W2026452617","https://openalex.org/W2026571586","https://openalex.org/W2028058416","https://openalex.org/W2029344008","https://openalex.org/W2030876482","https://openalex.org/W2032733531","https://openalex.org/W2034954660","https://openalex.org/W2039757972","https://openalex.org/W2040206752","https://openalex.org/W2040593177","https://openalex.org/W2040970860","https://openalex.org/W2041366867","https://openalex.org/W2041772438","https://openalex.org/W2043206126","https://openalex.org/W2043595657","https://openalex.org/W2046477201","https://openalex.org/W2048905982","https://openalex.org/W2049160993","https://openalex.org/W2049491065","https://openalex.org/W2050376414","https://openalex.org/W2051606662","https://openalex.org/W2052132908","https://openalex.org/W2053965162","https://openalex.org/W2054225000","https://openalex.org/W2054631039","https://openalex.org/W2058982726","https://openalex.org/W2059010267","https://openalex.org/W2061152555","https://openalex.org/W2061189653","https://openalex.org/W2061984547","https://openalex.org/W2063327869","https://openalex.org/W2063990725","https://openalex.org/W2064791032","https://openalex.org/W2064976108","https://openalex.org/W2066342307","https://openalex.org/W2066413495","https://openalex.org/W2067951047","https://openalex.org/W2069335961","https://openalex.org/W2070091424","https://openalex.org/W2070832223","https://openalex.org/W2073281086","https://openalex.org/W2074632454","https://openalex.org/W2074785948","https://openalex.org/W2074858432","https://openalex.org/W2074962841","https://openalex.org/W2075140618","https://openalex.org/W2075250269","https://openalex.org/W2075693778","https://openalex.org/W2075982463","https://openalex.org/W2076206499","https://openalex.org/W2076804771","https://openalex.org/W2078303408","https://openalex.org/W2081831622","https://openalex.org/W2082340361","https://openalex.org/W2084332777","https://openalex.org/W2085063650","https://openalex.org/W2085337050","https://openalex.org/W2085378902","https://openalex.org/W2086865536","https://openalex.org/W2087479677","https://openalex.org/W2087855975","https://openalex.org/W2088191066","https://openalex.org/W2088209808","https://openalex.org/W2088234206","https://openalex.org/W2090611949","https://openalex.org/W2093144498","https://openalex.org/W2093923609","https://openalex.org/W2109172777","https://openalex.org/W2111692871","https://openalex.org/W2112483397","https://openalex.org/W2113076389","https://openalex.org/W2117527010","https://openalex.org/W2120156727","https://openalex.org/W2122000530","https://openalex.org/W2125747114","https://openalex.org/W2126321136","https://openalex.org/W2133168959","https://openalex.org/W2138450406","https://openalex.org/W2138517958","https://openalex.org/W2140924908","https://openalex.org/W2148836983","https://openalex.org/W2157639361","https://openalex.org/W2157875108","https://openalex.org/W2160300777","https://openalex.org/W2162432548","https://openalex.org/W2164715751","https://openalex.org/W2166525973","https://openalex.org/W2168839532","https://openalex.org/W2171996036","https://openalex.org/W2184656895","https://openalex.org/W2186033591","https://openalex.org/W2187782459","https://openalex.org/W2267416220","https://openalex.org/W2281233611","https://openalex.org/W2342712812","https://openalex.org/W2394776735","https://openalex.org/W2396888550","https://openalex.org/W2409899947","https://openalex.org/W3166888799","https://openalex.org/W4229658362","https://openalex.org/W4235520986","https://openalex.org/W4240831657","https://openalex.org/W4250231884"],"related_works":["https://openalex.org/W2088191066","https://openalex.org/W2021779926","https://openalex.org/W2088892777","https://openalex.org/W133964533","https://openalex.org/W2038626940","https://openalex.org/W7096955023","https://openalex.org/W2070347001","https://openalex.org/W2015942983","https://openalex.org/W598707616","https://openalex.org/W4240831657"],"abstract_inverted_index":{"Cyclic":[0],"ADP-ribose":[1],"(cADPR)":[2],"and":[3,17,40,53,88,97,130,141],"nicotinic":[4],"acid":[5],"adenine":[6],"dinucleotide":[7],"phosphate":[8],"(NAADP)":[9],"are":[10],"two":[11,59,120],"Ca(2+)":[12,122,139,142],"messengers":[13,140],"derived":[14],"from":[15,28,92],"NAD":[16],"NADP,":[18],"respectively.":[19],"Although":[20],"NAADP":[21],"is":[22,33],"a":[23,70,82],"linear":[24],"molecule,":[25],"structurally":[26],"distinct":[27],"the":[29,48,115,132,135],"cyclic":[30],"cADPR,":[31],"it":[32],"synthesized":[34],"by":[35],"similar":[36],"enzymes,":[37],"ADP-ribosyl":[38],"cyclase":[39,49],"its":[41,54],"homolog,":[42],"CD38.":[43],"The":[44],"crystal":[45],"structure":[46],"of":[47,73,104,118,134,137],"has":[50],"been":[51,64,108],"solved":[52],"active":[55],"site":[56],"identified.":[57],"These":[58],"novel":[60,121],"nucleotides":[61],"have":[62,107],"now":[63],"shown":[65],"to":[66,94],"be":[67],"involved":[68],"in":[69,80,86,89,100,144],"wide":[71],"range":[72],"cellular":[74],"functions":[75,117],"including:":[76],"cell":[77],"cycle":[78],"regulation":[79],"Euglena,":[81],"protist;":[83],"gene":[84],"expression":[85],"plants;":[87],"animal":[90],"systems,":[91],"fertilization":[93],"neurotransmitter":[95],"release":[96],"long-term":[98],"depression":[99],"brain.":[101],"A":[102],"battery":[103],"pharmacological":[105],"reagents":[106],"developed,":[109],"providing":[110],"valuable":[111],"tools":[112],"for":[113],"elucidating":[114],"physiological":[116],"these":[119,127],"messengers.":[123],"This":[124],"article":[125],"reviews":[126],"recent":[128],"results":[129],"explores":[131],"implications":[133],"existence":[136],"multiple":[138],"stores":[143],"cells.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
