{"id":"https://openalex.org/W189580784","doi":null,"title":"Molecular features of hypothalamic plaques in Alzheimer's disease.","display_name":"Molecular features of hypothalamic plaques in Alzheimer's disease.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W189580784","mag":"189580784","pmid":"https://pubmed.ncbi.nlm.nih.gov/1653521","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886221"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000374325","display_name":"David G. Standaert","orcid":"https://orcid.org/0000-0003-2921-8348","observed_orcids":["https://orcid.org/0000-0003-2921-8348"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D G Standaert","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089227604","display_name":"V. M.-Y. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V M Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064906147","display_name":"Barry Greenberg","orcid":"https://orcid.org/0000-0002-6605-9385","observed_orcids":["https://orcid.org/0000-0002-6605-9385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B D Greenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068031285","display_name":"David E. Lowery","orcid":"https://orcid.org/0000-0001-5111-4719","observed_orcids":["https://orcid.org/0000-0001-5111-4719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Lowery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Q Trojanowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7103,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.6248489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"139","issue":"3","first_page":"681","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7670000195503235},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9440000057220459},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9259999990463257},{"id":"https://openalex.org/keywords/diffuse-plaques","display_name":"diffuse plaques","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.5899999737739563},{"id":"https://openalex.org/keywords/neurofilaments","display_name":"neurofilaments","score":0.8629999756813049},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuropil","display_name":"neuropil","score":0.515999972820282},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.550000011920929},{"id":"https://openalex.org/keywords/cortical-pathology","display_name":"cortical pathology","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.666672945022583},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6627188920974731},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.6179904937744141},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6128969788551331},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5585640072822571},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5568646192550659},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5421058535575867},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.49498242139816284},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4751948118209839},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.4667162299156189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45351260900497437},{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.43574416637420654},{"id":"https://openalex.org/C2993858690","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal cortex","level":2,"score":0.41126927733421326},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4098367691040039},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3761456608772278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3028715252876282},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.25586262345314026},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19048994779586792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13695508241653442},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11627188324928284}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1653521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1653521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:189580784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1653521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4361383882","display_name":"Molecular substrates of aging and neuron death","funder_award_id":"P01AG009215","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W53370629","https://openalex.org/W77889792","https://openalex.org/W84909961","https://openalex.org/W144212950","https://openalex.org/W299188937","https://openalex.org/W1480496318","https://openalex.org/W1487346158","https://openalex.org/W1488741626","https://openalex.org/W1601155059","https://openalex.org/W1771725737","https://openalex.org/W1966614543","https://openalex.org/W1967024359","https://openalex.org/W1970269823","https://openalex.org/W1975536870","https://openalex.org/W1981063463","https://openalex.org/W1983882084","https://openalex.org/W1989210395","https://openalex.org/W1990836357","https://openalex.org/W1992598058","https://openalex.org/W1995515835","https://openalex.org/W2007824057","https://openalex.org/W2011279980","https://openalex.org/W2022446410","https://openalex.org/W2028509230","https://openalex.org/W2028880021","https://openalex.org/W2030100345","https://openalex.org/W2032920422","https://openalex.org/W2035720621","https://openalex.org/W2037587061","https://openalex.org/W2038086035","https://openalex.org/W2038708976","https://openalex.org/W2041436943","https://openalex.org/W2045466989","https://openalex.org/W2052559661","https://openalex.org/W2056046302","https://openalex.org/W2057662501","https://openalex.org/W2058859054","https://openalex.org/W2060792213","https://openalex.org/W2064093411","https://openalex.org/W2064148637","https://openalex.org/W2069682857","https://openalex.org/W2073391734","https://openalex.org/W2078879794","https://openalex.org/W2081881251","https://openalex.org/W2082449919","https://openalex.org/W2086660887","https://openalex.org/W2086780496","https://openalex.org/W2091008378","https://openalex.org/W2140746923","https://openalex.org/W2155571475","https://openalex.org/W2166249172","https://openalex.org/W2171074844","https://openalex.org/W2171405125","https://openalex.org/W2401927203","https://openalex.org/W2413876480","https://openalex.org/W2431784433"],"related_works":["https://openalex.org/W2112139446","https://openalex.org/W2093899542","https://openalex.org/W1866663684","https://openalex.org/W1976360668","https://openalex.org/W1986327756","https://openalex.org/W7046550140","https://openalex.org/W1980943948","https://openalex.org/W6989634141","https://openalex.org/W7036909418","https://openalex.org/W1992485911"],"abstract_inverted_index":{"The":[0,13],"pathology":[1],"of":[2,24,43,60,75,86,99,137,159],"Alzheimer's":[3],"disease":[4],"(AD)":[5],"involves":[6],"subcortical":[7],"as":[8,10],"well":[9],"cortical":[11,149],"structures.":[12],"authors":[14,39],"have":[15],"used":[16],"immunohistochemical":[17],"methods":[18],"to":[19,32,54,96],"study":[20],"the":[21,28,38,47,55,61,73,82,100,117,134,140,156],"molecular":[22,129],"composition":[23],"AD":[25,48,87,138],"plaques":[26,45,69,80,90],"in":[27,46,72,81,133,139,146],"hypothalamus.":[29],"In":[30],"contrast":[31],"previous":[33],"studies":[34],"using":[35],"histochemical":[36],"methods,":[37],"observed":[40,145],"large":[41],"numbers":[42],"diffuse":[44],"hypothalamus":[49,74,141],"labeled":[50],"with":[51,143],"an":[52],"antiserum":[53],"beta-amyloid,":[56],"or":[57,109,119],"A4":[58],"peptide,":[59],"beta-amyloid":[62],"precursor":[63],"proteins":[64],"(beta":[65],"APPs),":[66],"whereas":[67],"A4-immunoreactive":[68],"were":[70],"uncommon":[71],"patients":[76],"without":[77],"AD.":[78,160],"Unlike":[79],"cortex":[83],"and":[84,113,130,148],"hippocampus":[85],"patients,":[88],"hypothalamic":[89],"did":[91,104,114],"not":[92,115],"contain":[93,106],"epitopes":[94],"corresponding":[95],"other":[97],"regions":[98],"beta":[101],"APPs,":[102],"nor":[103],"they":[105],"tau-,":[107],"neurofilament-,":[108],"microtubule-associated":[110],"protein-reactive":[111],"epitopes,":[112],"disrupt":[116],"neuropil":[118],"produce":[120],"astrogliosis.":[121],"These":[122],"findings":[123],"demonstrate":[124],"that":[125],"there":[126],"are":[127],"substantial":[128],"cellular":[131],"differences":[132],"pathologic":[135],"features":[136],"compared":[142],"those":[144],"hippocampal":[147],"structures,":[150],"which":[151],"may":[152],"provide":[153],"insight":[154],"into":[155],"pathogenetic":[157],"mechanisms":[158]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
