{"id":"https://openalex.org/W189554700","doi":null,"title":"Mitochondrial trafficking in healthy and injured neurons","display_name":"Mitochondrial trafficking in healthy and injured neurons","publication_year":2005,"publication_date":"2005-12-14","ids":{"openalex":"https://openalex.org/W189554700","mag":"189554700"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10356","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","pdf_url":"http://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110034119","display_name":"Diane T. W. Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Diane T. W. Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110034119"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1032,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3701011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-trafficking","display_name":"mitochondrial trafficking","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mitochondrial-transport","display_name":"mitochondrial transport","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.7099999785423279},{"id":"https://openalex.org/keywords/synaptic-development","display_name":"synaptic development","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.5619999766349792},{"id":"https://openalex.org/keywords/axonal-transport","display_name":"axonal transport","score":0.6039999723434448},{"id":"https://openalex.org/keywords/dendritic-mitochondria","display_name":"dendritic mitochondria","score":0.7990000247955322},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.671999990940094},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.906000018119812},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/huntingtin-aggregates","display_name":"huntingtin aggregates","score":0.8820000290870667},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6169999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.3869999945163727},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7897891402244568},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.6921616196632385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6196796298027039},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5892582535743713},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5329082608222961},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4919252395629883},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4584043622016907},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.4529385566711426},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.4406340420246124},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.4383348226547241},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.16610383987426758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12287801504135132},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10510614514350891},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.10199758410453796}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10356","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","pdf_url":"http://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:189554700","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10356/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10356","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","pdf_url":"http://d-scholarship.pitt.edu/10356/1/Chang-DTW-Dec05.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W189554700.pdf","grobid_xml":"https://content.openalex.org/works/W189554700.grobid-xml"},"referenced_works_count":274,"referenced_works":["https://openalex.org/W964655","https://openalex.org/W14527431","https://openalex.org/W69871636","https://openalex.org/W87986886","https://openalex.org/W605033683","https://openalex.org/W1263541778","https://openalex.org/W1480948328","https://openalex.org/W1481609997","https://openalex.org/W1485297825","https://openalex.org/W1504584187","https://openalex.org/W1514558092","https://openalex.org/W1518489158","https://openalex.org/W1522554854","https://openalex.org/W1539166295","https://openalex.org/W1543142265","https://openalex.org/W1554250492","https://openalex.org/W1564601025","https://openalex.org/W1571022725","https://openalex.org/W1572679174","https://openalex.org/W1577778731","https://openalex.org/W1584917605","https://openalex.org/W1599277155","https://openalex.org/W1599549671","https://openalex.org/W1601800012","https://openalex.org/W1643772655","https://openalex.org/W1652058896","https://openalex.org/W1661937675","https://openalex.org/W1686385174","https://openalex.org/W1836007821","https://openalex.org/W1868333091","https://openalex.org/W1930159471","https://openalex.org/W1935060748","https://openalex.org/W1953513934","https://openalex.org/W1959238069","https://openalex.org/W1964151230","https://openalex.org/W1965819088","https://openalex.org/W1966798559","https://openalex.org/W1967497524","https://openalex.org/W1968112618","https://openalex.org/W1968177047","https://openalex.org/W1970356391","https://openalex.org/W1971424120","https://openalex.org/W1972771185","https://openalex.org/W1973552449","https://openalex.org/W1973760882","https://openalex.org/W1974396693","https://openalex.org/W1974750801","https://openalex.org/W1974963742","https://openalex.org/W1975321314","https://openalex.org/W1975428625","https://openalex.org/W1975828956","https://openalex.org/W1977383752","https://openalex.org/W1981095308","https://openalex.org/W1981168617","https://openalex.org/W1981270258","https://openalex.org/W1982176321","https://openalex.org/W1982520634","https://openalex.org/W1982734478","https://openalex.org/W1983804222","https://openalex.org/W1985364907","https://openalex.org/W1985730861","https://openalex.org/W1985798624","https://openalex.org/W1989396363","https://openalex.org/W1989507218","https://openalex.org/W1990406694","https://openalex.org/W1991802156","https://openalex.org/W1992746109","https://openalex.org/W1993250284","https://openalex.org/W1993551687","https://openalex.org/W1993772997","https://openalex.org/W1995167983","https://openalex.org/W2001066986","https://openalex.org/W2001287092","https://openalex.org/W2001973412","https://openalex.org/W2002849044","https://openalex.org/W2004427197","https://openalex.org/W2004976934","https://openalex.org/W2004981183","https://openalex.org/W2006298998","https://openalex.org/W2012997203","https://openalex.org/W2013473672","https://openalex.org/W2013555714","https://openalex.org/W2017881592","https://openalex.org/W2018298525","https://openalex.org/W2019986722","https://openalex.org/W2020405906","https://openalex.org/W2021198811","https://openalex.org/W2023874952","https://openalex.org/W2023991572","https://openalex.org/W2024006352","https://openalex.org/W2024434386","https://openalex.org/W2024656201","https://openalex.org/W2025626596","https://openalex.org/W2025764899","https://openalex.org/W2026228428","https://openalex.org/W2027397876","https://openalex.org/W2028135977","https://openalex.org/W2028177630","https://openalex.org/W2028248935","https://openalex.org/W2028309418","https://openalex.org/W2028897118","https://openalex.org/W2030113770","https://openalex.org/W2032205778","https://openalex.org/W2034531487","https://openalex.org/W2034780161","https://openalex.org/W2035089473","https://openalex.org/W2035750459","https://openalex.org/W2037921808","https://openalex.org/W2040503127","https://openalex.org/W2041061895","https://openalex.org/W2041255615","https://openalex.org/W2041581676","https://openalex.org/W2042409437","https://openalex.org/W2042559199","https://openalex.org/W2043479012","https://openalex.org/W2043899474","https://openalex.org/W2045085957","https://openalex.org/W2045576314","https://openalex.org/W2045912466","https://openalex.org/W2046470310","https://openalex.org/W2048320127","https://openalex.org/W2049494624","https://openalex.org/W2050297509","https://openalex.org/W2054247106","https://openalex.org/W2054859849","https://openalex.org/W2055308573","https://openalex.org/W2056857556","https://openalex.org/W2057147625","https://openalex.org/W2057250794","https://openalex.org/W2057315336","https://openalex.org/W2057332354","https://openalex.org/W2060811345","https://openalex.org/W2061091844","https://openalex.org/W2061896556","https://openalex.org/W2061965391","https://openalex.org/W2063020331","https://openalex.org/W2063683201","https://openalex.org/W2064317688","https://openalex.org/W2064347675","https://openalex.org/W2066575706","https://openalex.org/W2067709327","https://openalex.org/W2068339776","https://openalex.org/W2070923033","https://openalex.org/W2072261604","https://openalex.org/W2072463822","https://openalex.org/W2073095545","https://openalex.org/W2073988218","https://openalex.org/W2076658236","https://openalex.org/W2077122729","https://openalex.org/W2077529180","https://openalex.org/W2077814219","https://openalex.org/W2078023075","https://openalex.org/W2079167667","https://openalex.org/W2080611091","https://openalex.org/W2080778713","https://openalex.org/W2081253095","https://openalex.org/W2081438789","https://openalex.org/W2082328015","https://openalex.org/W2082588556","https://openalex.org/W2085058400","https://openalex.org/W2086262835","https://openalex.org/W2086313318","https://openalex.org/W2088481798","https://openalex.org/W2088661320","https://openalex.org/W2089553250","https://openalex.org/W2090429649","https://openalex.org/W2092146469","https://openalex.org/W2093384103","https://openalex.org/W2094247127","https://openalex.org/W2095099413","https://openalex.org/W2095841601","https://openalex.org/W2098024573","https://openalex.org/W2098163379","https://openalex.org/W2098599651","https://openalex.org/W2098992864","https://openalex.org/W2099685145","https://openalex.org/W2099733934","https://openalex.org/W2099890622","https://openalex.org/W2099949096","https://openalex.org/W2099997349","https://openalex.org/W2100103422","https://openalex.org/W2100728233","https://openalex.org/W2101051879","https://openalex.org/W2101119157","https://openalex.org/W2102430316","https://openalex.org/W2104048407","https://openalex.org/W2106258762","https://openalex.org/W2106379738","https://openalex.org/W2106545408","https://openalex.org/W2107792324","https://openalex.org/W2107846158","https://openalex.org/W2108102646","https://openalex.org/W2109692759","https://openalex.org/W2110048005","https://openalex.org/W2110997472","https://openalex.org/W2111335223","https://openalex.org/W2111501638","https://openalex.org/W2111757377","https://openalex.org/W2112729781","https://openalex.org/W2113149589","https://openalex.org/W2113302824","https://openalex.org/W2113630941","https://openalex.org/W2116449089","https://openalex.org/W2116650656","https://openalex.org/W2116673443","https://openalex.org/W2117138295","https://openalex.org/W2119683782","https://openalex.org/W2120293274","https://openalex.org/W2122219869","https://openalex.org/W2122737933","https://openalex.org/W2123673927","https://openalex.org/W2124486024","https://openalex.org/W2125206853","https://openalex.org/W2125744986","https://openalex.org/W2126274369","https://openalex.org/W2127806759","https://openalex.org/W2128300032","https://openalex.org/W2128347259","https://openalex.org/W2132379826","https://openalex.org/W2132594134","https://openalex.org/W2133383948","https://openalex.org/W2134022293","https://openalex.org/W2135621635","https://openalex.org/W2136372119","https://openalex.org/W2138803210","https://openalex.org/W2138823723","https://openalex.org/W2139861422","https://openalex.org/W2140899105","https://openalex.org/W2141866767","https://openalex.org/W2142003218","https://openalex.org/W2142716581","https://openalex.org/W2143196520","https://openalex.org/W2144588131","https://openalex.org/W2144662987","https://openalex.org/W2144687501","https://openalex.org/W2144846851","https://openalex.org/W2144918294","https://openalex.org/W2145482520","https://openalex.org/W2146771791","https://openalex.org/W2147551208","https://openalex.org/W2149967205","https://openalex.org/W2150852495","https://openalex.org/W2151538478","https://openalex.org/W2151766741","https://openalex.org/W2152913938","https://openalex.org/W2153456027","https://openalex.org/W2153578959","https://openalex.org/W2155643523","https://openalex.org/W2155916251","https://openalex.org/W2156682516","https://openalex.org/W2156974283","https://openalex.org/W2157299674","https://openalex.org/W2159000703","https://openalex.org/W2159650080","https://openalex.org/W2161164503","https://openalex.org/W2162653594","https://openalex.org/W2164174765","https://openalex.org/W2165601218","https://openalex.org/W2165741741","https://openalex.org/W2166131777","https://openalex.org/W2166149507","https://openalex.org/W2167512703","https://openalex.org/W2170965874","https://openalex.org/W2170998869","https://openalex.org/W2171776741","https://openalex.org/W2271928871","https://openalex.org/W2320650792","https://openalex.org/W2338434618","https://openalex.org/W2418136227","https://openalex.org/W2460929941","https://openalex.org/W3148499377","https://openalex.org/W3216995939","https://openalex.org/W4296930909","https://openalex.org/W4301193148"],"related_works":["https://openalex.org/W2146367213","https://openalex.org/W1969853133","https://openalex.org/W1984510450","https://openalex.org/W2047460306","https://openalex.org/W3027297478","https://openalex.org/W48009639","https://openalex.org/W2012478814","https://openalex.org/W2058117278","https://openalex.org/W4392970982","https://openalex.org/W2309134460"],"abstract_inverted_index":{"Mitochondria":[0],"are":[1,8,17,113,175,191,318],"the":[2,105,116],"primary":[3],"generators":[4],"of":[5,11,31,39,75,118,184,252,280,285,294,308,343],"ATP":[6,149],"and":[7,48,70,81,90,93,129,150,169,181,187,213,227,265,282,297,312,324,336],"important":[9,66],"regulators":[10],"intracellular":[12],"calcium":[13],"homeostasis.":[14],"These":[15,219],"organelles":[16],"dynamically":[18],"transported":[19],"along":[20],"lengthy":[21],"neuronal":[22,69,80],"processes,":[23],"presumably":[24],"for":[25,67,85,154,177,224],"appropriate":[26],"distribution":[27,313],"to":[28,54,60,79,138,147,164,278],"cellular":[29],"regions":[30,293],"increased":[32],"need":[33],"such":[34],"as":[35,238],"synapses.":[36],"The":[37,156],"removal":[38],"damaged":[40],"mitochondria":[41,86,146,287],"that":[42,173,188,201,249,317,328,337],"produce":[43],"harmful":[44],"reactive":[45],"oxygen":[46],"species":[47],"promote":[49],"apoptosis":[50],"is":[51,64,206,331],"also":[52,199],"thought":[53],"be":[55],"mediated":[56],"by":[57,115,193,210,259,288],"mitochondrial":[58,71,82,95,111,127,140,160,179,202,236,275,295,309,329],"transport":[59,237,258],"autophagosomes.":[61],"Mitochondrial":[62],"trafficking":[63,161,189,276],"therefore":[65],"maintaining":[68],"health":[72],"while":[73],"cessation":[74],"movement":[76,128,203,330],"may":[77],"lead":[78],"dysfunctions.The":[83],"demands":[84],"differ":[87],"between":[88],"developing":[89],"mature":[91,133],"neurons,":[92],"separate":[94],"recruitment":[96,183],"signals":[97],"have":[98],"been":[99],"identified":[100],"in":[101,121,132,195,204,217,230,243,270,291,314,333],"each":[102],"case.":[103],"In":[104],"first":[106],"aim,":[107],"we":[108],"examined":[109,234],"how":[110],"dynamics":[112],"affected":[114],"development":[117],"synaptic":[119,143,165,196],"connections":[120],"cortical":[122,271,315],"neurons.":[123],"We":[124,171,198,326],"revealed":[125],"reduced":[126,274],"elongated":[130],"morphology":[131,311],"neurons":[134,272,316,335,339],"which":[135],"probably":[136],"serve":[137],"optimize":[139],"contact":[141],"with":[142],"sites.Synapses":[144],"require":[145],"supply":[148],"regulate":[151],"local":[152],"[Ca2+]i":[153],"neurotransmission.":[155],"second":[157],"aim":[158,233],"investigated":[159],"patterns":[162,190],"relative":[163],"sites":[166,279],"on":[167],"axons":[168],"dendrites.":[170],"demonstrated":[172,273],"synapses":[174],"targets":[176],"long-term":[178],"localization":[180],"dynamic":[182,332],"moving":[185,286],"mitochondria,":[186],"influenced":[192],"changes":[194],"activity.":[197],"found":[200],"dendrites":[205],"more":[207],"severely":[208],"impaired":[209,235,344],"neurotoxic":[211],"glutamate":[212],"zinc":[214],"exposures":[215],"than":[216],"axons.":[218],"findings":[220],"suggest":[221],"a":[222],"mechanism":[223,242],"postsynaptic":[225],"dysfunction":[226],"dendritic":[228],"degeneration":[229],"excitotoxicity.The":[231],"third":[232],"an":[239],"early":[240],"pathogenic":[241],"Huntington's":[244],"disease.":[245],"Recent":[246],"studies":[247,269],"indicate":[248],"aggregates":[250,281,289],"composed":[251],"mutant":[253],"huntingtin":[254],"fragments":[255],"hinder":[256],"axonal":[257],"sequestering":[260],"wildtype":[261],"huntingtin,":[262],"cytoskeletal":[263],"components":[264],"molecular":[266],"motors.":[267],"Our":[268],"specifically":[277],"impeded":[283],"passage":[284],"resulting":[290],"discrete":[292],"accumulation":[296],"immobilization.In":[298],"summary,":[299],"this":[300],"dissertation":[301],"provides":[302],"new":[303],"insight":[304],"into":[305],"our":[306],"understanding":[307],"trafficking,":[310],"developing,":[319],"synaptically":[320],"mature,":[321],"acutely":[322],"injured,":[323],"diseased.":[325],"conclude":[327],"healthy":[334],"injured":[338],"exhibit":[340],"different":[341],"manifestations":[342],"movement.":[345]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
