{"id":"https://openalex.org/W189451180","doi":null,"title":"Immunoreactive insulin response to a single dose of glimepiride in lean type 2 diabetic subjects.","display_name":"Immunoreactive insulin response to a single dose of glimepiride in lean type 2 diabetic subjects.","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W189451180","mag":"189451180","pmid":"https://pubmed.ncbi.nlm.nih.gov/12568204"},"language":"en","primary_location":{"id":"pmid:12568204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12568204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51317819","display_name":"Institute of Medical Sciences","ror":"https://ror.org/04y75dx46","country_code":"IN","type":"education","lineage":["https://openalex.org/I51317819","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J Singh","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005","institution_ids":["https://openalex.org/I51317819","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109696816","display_name":"A. G. Unnikrishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A G Unnikrishnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087952690","display_name":"Neeraj Kumar Agrawal","orcid":"https://orcid.org/0000-0001-7322-4134","observed_orcids":["https://orcid.org/0000-0001-7322-4134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N K Agrawal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054825291","display_name":"Sanjeev Kumar Singh","orcid":"https://orcid.org/0000-0003-4153-6437","observed_orcids":["https://orcid.org/0000-0003-4153-6437","https://orcid.org/0000-0001-8001-3802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S K Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011313826","display_name":"J K Agrawal","orcid":"https://orcid.org/0000-0002-5096-6239","observed_orcids":["https://orcid.org/0000-0002-5096-6239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Agrawal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1566,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53941597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"50","issue":null,"first_page":"1232","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.8939999938011169},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9399999976158142},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.859000027179718},{"id":"https://openalex.org/keywords/homa","display_name":"HOMA","score":0.753000020980835},{"id":"https://openalex.org/keywords/blood-glucose-reduction","display_name":"blood glucose reduction","score":0.5640000104904175},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.609000027179718},{"id":"https://openalex.org/keywords/newly-diagnosed-diabetes","display_name":"newly diagnosed diabetes","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.9904574155807495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9195046424865723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7937418222427368},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.7404248118400574},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7123019099235535},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6320781111717224},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6210557818412781},{"id":"https://openalex.org/C2778854520","wikidata":"https://www.wikidata.org/wiki/Q418776","display_name":"Sulfonylurea","level":3,"score":0.6076688170433044},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5481600165367126},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.545864999294281},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5308146476745605}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012494","descriptor_name":"Sampling Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12568204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12568204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Comparative Study"},{"id":"mag:189451180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12568204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2128061198","https://openalex.org/W1991412148","https://openalex.org/W2015953629","https://openalex.org/W59245018","https://openalex.org/W2377728700","https://openalex.org/W2036713922","https://openalex.org/W1631085811","https://openalex.org/W2356122747","https://openalex.org/W2158275124","https://openalex.org/W1974459802"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,160],"best":[2],"method":[3],"for":[4,105,157],"glucose":[5,77,124],"lowering":[6],"in":[7,95,119,148],"lean":[8,43,149],"type":[9,44,150],"2":[10,45,151],"diabetes":[11],"remains":[12],"controversial":[13],"and":[14,63,69,74,102,115,121,136,146,171],"this":[15],"study":[16,20],"was":[17,111,164],"undertaken":[18],"to":[19,29,166],"the":[21,84,167,175],"24":[22,70,108,158],"hour":[23],"insulin":[24,64,86,96,144,182],"response":[25,128,163],"of":[26,61,162,174,179,181],"these":[27],"diabetics":[28,46],"glimepiride,":[30],"a":[31],"sulfonylurea":[32],"with":[33,131,138,154],"distinctive":[34],"properties.":[35],"METHODS:":[36],"Twenty":[37],"five":[38],"consecutive":[39],"newly":[40],"diagnosed":[41],"diet-unresponsive":[42],"(BMI":[47],"<":[48],"19":[49],"kg/m2)":[50],"without":[51],"any":[52],"vascular":[53],"complications":[54],"were":[55,66,79,88],"given":[56],"single":[57],"dose":[58],"(1":[59],"mg)":[60],"glimepiride":[62],"responses":[65],"measured":[67],"2,4,8,12":[68],"hours":[71,101],"later.":[72],"Pre":[73],"post-glimepiride":[75,85],"blood":[76,123],"levels":[78,87],"also":[80],"measured.":[81],"RESULTS:":[82],"All":[83],"significantly":[89],"higher":[90],"than":[91],"basal":[92],"values.":[93],"Increase":[94],"secretion":[97,145],"peaked":[98],"at":[99,106],"four":[100],"benefits":[103,155],"lasted":[104],"least":[107],"hours.":[109,159],"This":[110],"accompanied":[112],"by":[113],"clinically":[114],"statistically":[116],"significant":[117],"reductions":[118],"fasting":[120,139],"postprandial":[122],"levels.":[125],"Maximum":[126],"secretory":[127],"correlated":[129],"positively":[130],"beta":[132,168],"cell":[133,169],"function":[134],"(HOMA)":[135],"negatively":[137],"glucose.":[140],"CONCLUSIONS:":[141],"Glimepiride":[142],"improved":[143],"hyperglycemia":[147],"diabetic":[152],"subjects,":[153],"lasting":[156],"degree":[161],"proportional":[165],"reserve,":[170],"occurred":[172],"irrespective":[173],"presence":[176],"or":[177],"absence":[178],"markers":[180],"resistance.":[183]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}