{"id":"https://openalex.org/W189363407","doi":null,"title":"New tariquidar-like ABCB1 modulators in cancer chemotherapy:Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies","display_name":"New tariquidar-like ABCB1 modulators in cancer chemotherapy:Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies","publication_year":2010,"publication_date":"2010-07-19","ids":{"openalex":"https://openalex.org/W189363407","mag":"189363407"},"language":"en","primary_location":{"id":"pmh:oai:epub.uni-regensburg.de:15219","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","pdf_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058675509","display_name":"Peter H\u00f6cherl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter H\u00f6cherl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058675509"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.7789999842643738},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibitors","display_name":"P-glycoprotein inhibitors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tariquidar","display_name":"tariquidar","score":0.9309999942779541},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8799999952316284},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8880000114440918},{"id":"https://openalex.org/keywords/brain-penetration","display_name":"brain penetration","score":0.718999981880188},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9330000281333923},{"id":"https://openalex.org/keywords/valspodar","display_name":"valspodar","score":0.6320000290870667},{"id":"https://openalex.org/keywords/brain-to-plasma-ratio","display_name":"brain-to-plasma ratio","score":0.4449999928474426},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.31200000643730164},{"id":"https://openalex.org/keywords/cytochrome-p450-inhibition","display_name":"cytochrome P450 inhibition","score":0.7440000176429749},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.7559999823570251},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.5249999761581421},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.7981400489807129},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6310950517654419},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5420014262199402},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5374835729598999},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5266549587249756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48221075534820557},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.4696440100669861},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.44204604625701904},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4221251606941223},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.3555237948894501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2666386067867279},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23385843634605408},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21232756972312927},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1169452965259552},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:epub.uni-regensburg.de:15219","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","pdf_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-020492660","doi":null,"is_oa":false,"landing_page_url":"http://epub.uni-regensburg.de/15219/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"mag:189363407","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/15219/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:epub.uni-regensburg.de:15219","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","pdf_url":"https://epub.uni-regensburg.de/15219/1/Dissertation_Peter_Hoecherl.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W189363407.pdf","grobid_xml":"https://content.openalex.org/works/W189363407.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W8603682","https://openalex.org/W47078961","https://openalex.org/W53566393","https://openalex.org/W54720803","https://openalex.org/W102428806","https://openalex.org/W106690969","https://openalex.org/W120778686","https://openalex.org/W167845783","https://openalex.org/W274272304","https://openalex.org/W1485007245","https://openalex.org/W1491459594","https://openalex.org/W1511853133","https://openalex.org/W1513102809","https://openalex.org/W1519177607","https://openalex.org/W1526950891","https://openalex.org/W1529837192","https://openalex.org/W1560814177","https://openalex.org/W1587690368","https://openalex.org/W1593652087","https://openalex.org/W1594196316","https://openalex.org/W1598654033","https://openalex.org/W1623543107","https://openalex.org/W1668393581","https://openalex.org/W1798337468","https://openalex.org/W1807250678","https://openalex.org/W1834241234","https://openalex.org/W1910056530","https://openalex.org/W1934127833","https://openalex.org/W1961820026","https://openalex.org/W1964470226","https://openalex.org/W1964907928","https://openalex.org/W1968468357","https://openalex.org/W1968769447","https://openalex.org/W1970721581","https://openalex.org/W1973544766","https://openalex.org/W1976815300","https://openalex.org/W1977253304","https://openalex.org/W1977584573","https://openalex.org/W1978612710","https://openalex.org/W1980418252","https://openalex.org/W1983739049","https://openalex.org/W1984820569","https://openalex.org/W1984939118","https://openalex.org/W1988605167","https://openalex.org/W1989064705","https://openalex.org/W1991099559","https://openalex.org/W1992468039","https://openalex.org/W1992875306","https://openalex.org/W1993373855","https://openalex.org/W1995783411","https://openalex.org/W1997635067","https://openalex.org/W1997696660","https://openalex.org/W1999558499","https://openalex.org/W2004934711","https://openalex.org/W2005779465","https://openalex.org/W2006998103","https://openalex.org/W2007279146","https://openalex.org/W2012915029","https://openalex.org/W2013449127","https://openalex.org/W2014293907","https://openalex.org/W2014896707","https://openalex.org/W2018522485","https://openalex.org/W2020441233","https://openalex.org/W2021805364","https://openalex.org/W2025907258","https://openalex.org/W2026398446","https://openalex.org/W2028533496","https://openalex.org/W2030281462","https://openalex.org/W2033020367","https://openalex.org/W2033346155","https://openalex.org/W2034957642","https://openalex.org/W2034979953","https://openalex.org/W2035253718","https://openalex.org/W2037834300","https://openalex.org/W2038247317","https://openalex.org/W2040004169","https://openalex.org/W2041417130","https://openalex.org/W2041833179","https://openalex.org/W2044968828","https://openalex.org/W2045266358","https://openalex.org/W2047282772","https://openalex.org/W2048109742","https://openalex.org/W2048748629","https://openalex.org/W2049147399","https://openalex.org/W2050395817","https://openalex.org/W2050424784","https://openalex.org/W2051962690","https://openalex.org/W2055904567","https://openalex.org/W2057864075","https://openalex.org/W2058052390","https://openalex.org/W2060578335","https://openalex.org/W2061600887","https://openalex.org/W2064920658","https://openalex.org/W2065895412","https://openalex.org/W2066470751","https://openalex.org/W2066523050","https://openalex.org/W2069118421","https://openalex.org/W2070116427","https://openalex.org/W2072373055","https://openalex.org/W2075677078","https://openalex.org/W2076031566","https://openalex.org/W2079506644","https://openalex.org/W2083145519","https://openalex.org/W2083844992","https://openalex.org/W2091717171","https://openalex.org/W2092435069","https://openalex.org/W2093107388","https://openalex.org/W2094434087","https://openalex.org/W2096287682","https://openalex.org/W2098882527","https://openalex.org/W2099243119","https://openalex.org/W2101193630","https://openalex.org/W2101936797","https://openalex.org/W2105077123","https://openalex.org/W2105182686","https://openalex.org/W2107019456","https://openalex.org/W2107607807","https://openalex.org/W2108842980","https://openalex.org/W2110685305","https://openalex.org/W2111810662","https://openalex.org/W2111935912","https://openalex.org/W2114918609","https://openalex.org/W2118309500","https://openalex.org/W2120638480","https://openalex.org/W2120869872","https://openalex.org/W2123699472","https://openalex.org/W2125089526","https://openalex.org/W2125541186","https://openalex.org/W2125748363","https://openalex.org/W2126672062","https://openalex.org/W2128294490","https://openalex.org/W2128510659","https://openalex.org/W2128590097","https://openalex.org/W2128635872","https://openalex.org/W2132672867","https://openalex.org/W2133242849","https://openalex.org/W2133948037","https://openalex.org/W2134153749","https://openalex.org/W2135732933","https://openalex.org/W2137015675","https://openalex.org/W2138851039","https://openalex.org/W2138935969","https://openalex.org/W2143225906","https://openalex.org/W2147051864","https://openalex.org/W2147982205","https://openalex.org/W2150155770","https://openalex.org/W2150406132","https://openalex.org/W2150497755","https://openalex.org/W2151694718","https://openalex.org/W2152546397","https://openalex.org/W2153712534","https://openalex.org/W2155808778","https://openalex.org/W2157158547","https://openalex.org/W2157393167","https://openalex.org/W2157619122","https://openalex.org/W2158245905","https://openalex.org/W2158965810","https://openalex.org/W2160368116","https://openalex.org/W2162592548","https://openalex.org/W2163967054","https://openalex.org/W2165516338","https://openalex.org/W2165708803","https://openalex.org/W2166104595","https://openalex.org/W2167241428","https://openalex.org/W2168083203","https://openalex.org/W2169302611","https://openalex.org/W2169992673","https://openalex.org/W2171791920","https://openalex.org/W2273421669","https://openalex.org/W2417914911","https://openalex.org/W2993596412","https://openalex.org/W4292079585"],"related_works":["https://openalex.org/W7030488255","https://openalex.org/W1989064705","https://openalex.org/W2097897956","https://openalex.org/W7002508919","https://openalex.org/W3173465961","https://openalex.org/W1999558499","https://openalex.org/W2152546397","https://openalex.org/W2012431429","https://openalex.org/W2118937378","https://openalex.org/W2009281580"],"abstract_inverted_index":{"The":[0,119,224,242,276,503,585,607,633],"ABCB1":[1,45,462,471,486,620,626,642],"transporter":[2,142,487,514],"(P-glycoprotein),":[3],"an":[4,19,69,189,337,461],"ATP-driven":[5],"efflux":[6],"protein,":[7],"strongly":[8],"influences":[9],"the":[10,23,28,37,53,74,80,86,95,115,127,140,167,172,201,204,262,267,271,288,295,301,304,309,322,331,355,359,364,395,399,405,423,428,436,443,464,468,476,531,535,544,560,567,574,578,588,597,605,614,618,624,636,649],"absorption,":[11],"distribution":[12],"and":[13,82,160,171,209,222,240,257,512,524,601,622,644,655],"excretion":[14],"of":[15,22,30,44,52,56,65,76,90,162,169,203,233,245,261,274,282,294,303,312,328,333,372,377,388,425,453,467,470,478,537,546,566,573,587,617,628,640,653],"various":[16,296],"drugs.":[17],"As":[18,265],"essential":[20],"component":[21],"blood-brain":[24],"barrier,":[25],"P-glycoprotein":[26,98],"limits":[27],"penetration":[29],"potent":[31,91,430],"cytostatic":[32],"agents":[33],"(e.g.":[34],"paclitaxel)":[35],"into":[36,500],"central":[38],"nervous":[39],"system":[40],"(CNS).":[41],"Furthermore,":[42],"over-expression":[43],"transporters":[46],"in":[47,61,79,85,103,123,195,207,247,251,291,341,394,407,475,494,516,594],"tumor":[48,373,446,454],"cells":[49,111,138,351,391,490],"is":[50,68,327,593],"one":[51],"major":[54],"mechanisms":[55],"classical":[57],"multidrug":[58],"resistance":[59],"(MDR)":[60],"cancer.":[62],"Hence,":[63],"inhibition":[64,161],"P":[66],"glycoprotein":[67],"attractive":[70],"strategy":[71],"to":[72,145,199,284,300,368,530,550,647],"improve":[73,648],"therapy":[75,332],"both,":[77],"tumors":[78,480,548],"CNS":[81],"MDR":[83,479,656],"malignancies":[84,505],"periphery.\\nAccordingly,":[87],"a":[88,182,185,212,230,280,450],"series":[89],"inhibitors":[92],"derived":[93],"from":[94,385,604],"3rd":[96],"generation":[97,306],"modulator":[99,307],"tariquidar":[100,170,525],"was":[101,112,134,220,314,344,402,458,481],"investigated":[102,619],"vitro.":[104],"A":[105],"fluorescence-based":[106],"efflux-assay":[107],"using":[108],"human":[109],"Kb-V1":[110,489,547],"established":[113,221],"at":[114,148],"microtiter":[116],"plate":[117],"format.":[118],"obtained":[120,437],"data":[121,603],"were":[122,143,352,392,416,491,526,556],"good":[124],"agreement":[125],"with":[126,287,354,427,442,460,473,539,596,613],"validated":[128],"flow":[129],"cytometric":[130],"method":[131,225],"while":[132],"throughput":[133],"substantially":[135],"increased.":[136],"Additionally,":[137],"expressing":[139,390],"murine":[141,568],"generated":[144],"assure":[146],"activity":[147,627],"rodent":[149],"P-glycoprotein.":[150],"Further":[151],"biopharmaceutical":[152],"investigations":[153,555],"(concerning":[154],"toxicity,":[155],"stability,":[156],"plasma":[157,210,310],"albumin":[158],"binding":[159,591,609],"cytochrome":[163],"P450":[164],"isoenzymes)":[165],"confirmed":[166],"suitability":[168],"three":[173],"most":[174,429],"promising":[175],"derivatives":[176],"(bearing":[177],"polar":[178],"residues":[179],"such":[180],"as":[181,235,237],"methoxyethoxyethylamino":[183],"(ME27-4),":[184],"morpholino":[186],"(ME30-1)":[187],"or":[188,363,379,433],"ethoxyethyloxy":[190],"(ME33-1)":[191],"moiety)":[192],"for":[193,330,358,404,418,581],"further":[194],"vivo":[196,408],"studies.\\nIn":[197],"order":[198],"determine":[200],"concentration":[202,326],"selected":[205],"modulators":[206,268,431,472,576,621,643],"brain":[208,272,325,335],"samples,":[211],"solid-phase":[213],"extraction":[214],"procedure":[215],"followed":[216,496],"by":[217,279,375,497],"RP-HPLC":[218],"analysis":[219,572],"validated.":[223],"yielded":[226],"reproducible":[227,509],"high":[228,238,258,507],"recoveries,":[229],"low":[231],"limit":[232],"quantification":[234],"well":[236],"accuracy":[239],"precision.":[241],"concomitant":[243],"administration":[244],"paclitaxel":[246,313,324,426,457,474,540,551],"successive":[248,582],"bio-distribution":[249],"studies":[250],"NMRI":[252],"mice":[253,343],"revealed":[254,449],"favorable":[255],"bioavailability":[256],"metabolic":[259],"stability":[260],"tariquidar-like":[263,575],"compounds.":[264],"desired,":[266],"significantly":[269,541],"increased":[270,323],"AUC":[273,311],"paclitaxel.":[275],"observed":[277],"increase":[278],"factor":[281],"two":[283],"four":[285],"correlated":[286,441],"previously":[289],"determined":[290,445],"vitro":[292,495],"potency":[293],"inhibitors.":[297],"In":[298,518,528],"contrast":[299,529],"co-administration":[302,469],"2nd":[305],"valspodar,":[308],"unaffected,":[315],"indicating":[316],"lower":[317],"systemic":[318],"toxicity.\\nTo":[319],"investigate":[320],"if":[321],"relevance":[329],"malignant":[334],"tumors,":[336],"intracerebral":[338,386],"xenograft":[339],"model":[340],"nude":[342,501],"refined.":[345],"Human":[346],"U":[347,413],"118":[348],"MG":[349],"glioblastoma":[350],"transfected":[353],"genes":[356],"encoding":[357],"far-red":[360],"fluorescent":[361],"protein":[362],"luciferase2":[365,389],"(Luc2)":[366],"enzyme":[367],"facilitate":[369,635],"non-invasive":[370],"determination":[371],"burden":[374],"means":[376],"fluorescence":[378],"bioluminescence":[380],"imaging":[381],"(BLI).":[382],"Tumors":[383],"originating":[384],"injection":[387],"detectable":[393],"living":[396],"animal.":[397],"Unfortunately,":[398],"growth":[400,510,545],"behavior":[401],"unsuitable":[403],"intended":[406],"investigations.":[409],"Alternatively,":[410],"highly":[411],"tumorigenic":[412],"87-Luc2":[414],"xenografts":[415],"utilized":[417],"subsequent":[419,519],"treatment":[420,477,520],"experiments":[421,521],"evaluating":[422],"combination":[424,536],"ME33-1":[432,523],"tariquidar.":[434],"Since":[435],"light":[438],"signals":[439],"largely":[440,611],"histological":[444],"burden,":[447],"BLI":[448],"moderate":[451],"retardation":[452],"progression":[455],"when":[456],"combined":[459],"modulator.\\nFurthermore,":[463],"therapeutic":[465],"value":[466],"investigated.":[482,527],"For":[483],"this":[484],"purpose,":[485],"over-expressing":[488],"extensively":[492],"characterized":[493],"subcutaneous":[498],"implantation":[499],"mice.":[502],"resulting":[504],"showed":[506],"tumorigenicity,":[508],"kinetics":[511],"maintained":[513],"expression":[515],"vivo.":[517],"ME30-1,":[522],"other":[532],"modulators,":[533],"only":[534],"ME30-1":[538],"slowed":[542],"down":[543],"compared":[549],"mono-therapy.\\nAdditionally,":[552],"molecular":[553],"modeling":[554],"performed":[557],"based":[558,638],"on":[559],"very":[561],"recently":[562],"published":[563],"x-ray":[564],"structure":[565,637],"Abcb1a":[569],"transporter.":[570],"Conformational":[571],"provided":[577],"starting":[579],"conformation":[580],"docking":[583],"experiments.":[584],"location":[586],"subsequently":[589],"identified":[590],"region":[592],"accordance":[595],"suggested":[598],"transport":[599],"mechanism":[600],"experimental":[602],"literature.":[606],"proposed":[608],"modes":[610],"agree":[612],"inhibitory":[615],"potencies":[616],"explain":[623],"negligible":[625],"tariquidar-derived,":[629],"selective":[630],"ABCG2":[631],"modulators.":[632],"findings":[634],"design":[639],"optimized":[641],"may":[645],"contribute":[646],"adjuvant":[650],"cancer":[651],"chemotherapy":[652],"glioblastomas":[654],"tumors.":[657]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
