{"id":"https://openalex.org/W1893621176","doi":"https://doi.org/10.1002/9780470015902.a0000561","title":"Drosophilaas an Experimental Organism for Functional Genomics","display_name":"Drosophilaas an Experimental Organism for Functional Genomics","publication_year":2012,"publication_date":"2012-03-15","ids":{"openalex":"https://openalex.org/W1893621176","doi":"https://doi.org/10.1002/9780470015902.a0000561","mag":"1893621176"},"language":"en","primary_location":{"id":"doi:10.1002/9780470015902.a0000561","doi":"https://doi.org/10.1002/9780470015902.a0000561","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470015902.a0000561","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Life Sciences","raw_type":"other"},"volume":{"id":"https://openalex.org/W1905439276","display_name":"Encyclopedia of Life Sciences"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072772917","display_name":"Julian A. T. Dow","orcid":"https://orcid.org/0000-0002-9595-5146","observed_orcids":["https://orcid.org/0000-0002-9595-5146"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julian AT Dow","raw_affiliation_strings":["University of Glasgow, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Glasgow, Scotland, UK","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072772917"],"corresponding_institution_ids":["https://openalex.org/I7882870"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12606","display_name":"Diptera species taxonomy and behavior","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":1.0},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"functional genomics","score":0.9869999885559082},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.5989999771118164},{"id":"https://openalex.org/keywords/genetic-tools","display_name":"genetic instruments","score":0.6159999966621399},{"id":"https://openalex.org/keywords/transgenic-flies","display_name":"transgenic flies","score":0.7129999995231628},{"id":"https://openalex.org/keywords/anopheles-gambiae","display_name":"Anopheles gambiae","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mosquito-vectors","display_name":"mosquito vectors","score":0.46799999475479126},{"id":"https://openalex.org/keywords/disease-vectors","display_name":"disease vectors","score":0.5400000214576721},{"id":"https://openalex.org/keywords/tissue-interactions","display_name":"tissue interactions","score":0.45500001311302185},{"id":"https://openalex.org/keywords/developmental-biology","display_name":"developmental biology","score":0.49399998784065247},{"id":"https://openalex.org/keywords/genetically-encoded-biosensors","display_name":"genetically encoded biosensors","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.8826628923416138},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.8145935535430908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7774873971939087},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.7398452162742615},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.7048488855361938},{"id":"https://openalex.org/C2776802408","wikidata":"https://www.wikidata.org/wiki/Q135237","display_name":"Anopheles gambiae","level":3,"score":0.5119439363479614},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.48923277854919434},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.487131804227829},{"id":"https://openalex.org/C2778060650","wikidata":"https://www.wikidata.org/wiki/Q22964789","display_name":"Gene drive","level":4,"score":0.43537747859954834},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.42609700560569763},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4129732847213745},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.4128149151802063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3966146409511566},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37038418650627136},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.34789425134658813},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.29294997453689575},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.23963025212287903},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.15384787321090698},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.09383523464202881},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470015902.a0000561","doi":"https://doi.org/10.1002/9780470015902.a0000561","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470015902.a0000561","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Life Sciences","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W101651626","https://openalex.org/W1560792299","https://openalex.org/W1828818916","https://openalex.org/W1971515849","https://openalex.org/W1974769584","https://openalex.org/W1977178667","https://openalex.org/W1978157456","https://openalex.org/W1989322815","https://openalex.org/W1990027679","https://openalex.org/W1992098072","https://openalex.org/W1992925265","https://openalex.org/W1993827187","https://openalex.org/W1994528729","https://openalex.org/W1995648543","https://openalex.org/W1999402250","https://openalex.org/W1999664692","https://openalex.org/W2001488804","https://openalex.org/W2002439648","https://openalex.org/W2009441114","https://openalex.org/W2019349386","https://openalex.org/W2023609729","https://openalex.org/W2024523038","https://openalex.org/W2029416825","https://openalex.org/W2032817175","https://openalex.org/W2033454731","https://openalex.org/W2039062433","https://openalex.org/W2044931738","https://openalex.org/W2048652409","https://openalex.org/W2050178288","https://openalex.org/W2052112605","https://openalex.org/W2057150795","https://openalex.org/W2058816652","https://openalex.org/W2065589732","https://openalex.org/W2068466141","https://openalex.org/W2068948616","https://openalex.org/W2069271483","https://openalex.org/W2079491737","https://openalex.org/W2080094749","https://openalex.org/W2095299680","https://openalex.org/W2097255766","https://openalex.org/W2099193967","https://openalex.org/W2103080800","https://openalex.org/W2106013076","https://openalex.org/W2107327355","https://openalex.org/W2110643873","https://openalex.org/W2118638546","https://openalex.org/W2122132730","https://openalex.org/W2124492198","https://openalex.org/W2131802378","https://openalex.org/W2132170447","https://openalex.org/W2135163881","https://openalex.org/W2135544680","https://openalex.org/W2140231262","https://openalex.org/W2152032402","https://openalex.org/W2164460477"],"related_works":["https://openalex.org/W1483949175","https://openalex.org/W6968894116","https://openalex.org/W2788570944","https://openalex.org/W2021743398","https://openalex.org/W7166707584","https://openalex.org/W2975390929","https://openalex.org/W2166501543","https://openalex.org/W1564629725","https://openalex.org/W1799760597","https://openalex.org/W4239000178"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"historically":[2],"the":[3,7,11,78,195,214,242,249],"classical":[4],"model":[5,34,43,62],"for":[6,17,19,35,44,84,184,241],"understanding":[8,105,220,247],"of":[9,53,80,111,156,160,189,197,207,217,221],"development,":[10],"fruit\u2010fly":[12],"Drosophila":[13,128],"melanogaster":[14],"is":[15,98,224,244],"valuable":[16],"study":[18],"three":[20],"reasons:":[21],"as":[22,29,41,51],"an":[23,30,104,177],"organism":[24,109],"in":[25,73,77,172,176,201],"its":[26,208],"own":[27],"right,":[28],"inexpensive,":[31],"genetically":[32,81],"powerful":[33],"human":[36,190,199],"function":[37],"and":[38,40,69,76,113,119,148,151,153,158,162,252],"disease,":[39],"a":[42,107,123,130,136,143,233,258],"economically":[45],"important":[46],"or":[47,64,87],"harmful":[48],"insects,":[49],"such":[50],"vectors":[52],"disease.":[54],"The":[55,139,165],"sophisticated":[56],"genetic":[57,74,146,166],"tools":[58],"that":[59,117],"distinguishDrosophilafrom":[60],"other":[61],"organisms":[63],"insects":[65],"allow":[66],"great":[67],"spatial":[68],"temporal":[70],"precisions":[71],"both":[72],"intervention,":[75],"expression":[79],"encoded":[82],"sensors":[83],"second":[85],"messengers":[86],"intracellular":[88],"environmental":[89],"variables.":[90],"Combined":[91],"with":[92,135,210],"other,":[93],"novel":[94],"functional":[95,185,235,245],"readouts,":[96],"it":[97],"now":[99,225],"possible":[100],"to":[101,121,231,256],"move":[102],"towards":[103],"ofDrosophilaas":[106],"metazoan":[108],"composed":[110],"distinct":[112],"individually":[114],"tractable":[115],"tissues":[116,251],"interact":[118,255],"integrate":[120],"produce":[122],"functioning":[124],"whole.":[125],"Key":[126],"Concepts:":[127],"melanogasteris":[129],"small,":[131],"easily":[132],"reared":[133],"insect":[134],"short":[137],"lifecycle.":[138],"key":[140],"advantages":[141],"ofDrosophilaare":[142],"balance":[144],"between":[145],"power":[147],"biomedical":[149],"relevance,":[150],"rapidity":[152],"low":[154],"cost":[155],"generation":[157],"maintenance":[159],"mutant":[161],"transgenic":[163],"stocks.":[164],"toolbox":[167],"available":[168],"forDrosophilaallows":[169],"precise":[170],"intervention":[171],"specific,":[173],"defined":[174],"cells":[175],"otherwise":[178],"normal":[179],"organism,":[180],"opening":[181],"unique":[182],"opportunities":[183],"biology.":[186],"Approximately":[187],"70%":[188,206],"genes":[191,209],"have":[192],"clearDrosophilahomologues,":[193],"allowing":[194],"modelling":[196],"many":[198],"diseases":[200],"flies.":[202],"Drosophilaalso":[203],"shares":[204],"approximately":[205],"Anopheles":[211],"gambiae":[212],",":[213],"mosquito":[215],"vector":[216],"malaria.":[218],"Our":[219],"fly":[222],"development":[223],"mature:":[226],"new":[227],"phenotypes":[228],"are":[229],"required":[230],"provide":[232],"global":[234],"genomic":[236],"understanding.":[237],"An":[238],"exciting":[239],"challenge":[240],"future":[243],"biology;":[246],"how":[248],"different":[250],"control":[253],"systems":[254],"make":[257],"working,":[259],"successful":[260],"organism.":[261]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}