{"id":"https://openalex.org/W1893500905","doi":null,"title":"C\ud615 \uac04\uc5fc\ubc14\uc774\ub7ec\uc2a4(HCV)\uc758 NS5B RNA Replicase\uc5d0 \uc758\ud574 \uadf8 \ud65c\uc131\uc774 \uc870\uc808\ub418\ub294 HCV \uc9c0\ub188 \ud45c\uc801 Hammerhead \ub9ac\ubcf4\uc790\uc784 \uac1c\ubc1c","display_name":"C\ud615 \uac04\uc5fc\ubc14\uc774\ub7ec\uc2a4(HCV)\uc758 NS5B RNA Replicase\uc5d0 \uc758\ud574 \uadf8 \ud65c\uc131\uc774 \uc870\uc808\ub418\ub294 HCV \uc9c0\ub188 \ud45c\uc801 Hammerhead \ub9ac\ubcf4\uc790\uc784 \uac1c\ubc1c","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1893500905","mag":"1893500905"},"language":"en","primary_location":{"id":"mag:1893500905","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=MSMHBQ_2007_v43n3_159","pdf_url":null,"source":{"id":"https://openalex.org/S4210219379","display_name":"The Korean Journal of Microbiology","issn_l":"0440-2413","issn":["0440-2413","2383-9902"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Microbiology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100723876","display_name":"Chang-Ho Lee","orcid":"https://orcid.org/0000-0002-1039-1434","observed_orcids":["https://orcid.org/0000-0002-1039-1434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang-Ho Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1039-1434","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029669212","display_name":"Seong\u2010Wook Lee","orcid":"https://orcid.org/0000-0003-1718-7601","observed_orcids":["https://orcid.org/0000-0003-1718-7601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seong\u2010Wook Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1718-7601","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11368736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"3","first_page":"159","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.12520000338554382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hammerhead-ribozyme","display_name":"hammerhead ribozyme","score":0.878000020980835},{"id":"https://openalex.org/keywords/internal-ribosome-entry-site","display_name":"internal ribosome entry site","score":0.9440000057220459},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/rna-aptamers","display_name":"RNA aptamers","score":0.9089999794960022},{"id":"https://openalex.org/keywords/communication-module","display_name":"communication module","score":0.8059999942779541},{"id":"https://openalex.org/keywords/in-vitro-selection","display_name":"in vitro selection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/anti-hcv-agents","display_name":"anti-HCV agents","score":0.6629999876022339},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.8692063093185425},{"id":"https://openalex.org/C2781426373","wikidata":"https://www.wikidata.org/wiki/Q24766653","display_name":"NS5B","level":5,"score":0.8629575371742249},{"id":"https://openalex.org/C2779792011","wikidata":"https://www.wikidata.org/wiki/Q3817690","display_name":"Hammerhead ribozyme","level":5,"score":0.6871738433837891},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.6828629374504089},{"id":"https://openalex.org/C1342335","wikidata":"https://www.wikidata.org/wiki/Q6545871","display_name":"Ligase ribozyme","level":5,"score":0.6108232736587524},{"id":"https://openalex.org/C30951146","wikidata":"https://www.wikidata.org/wiki/Q6745754","display_name":"Mammalian CPEB3 ribozyme","level":5,"score":0.5876542329788208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5838455557823181},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.56547611951828},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5383760333061218},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5274688601493835},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5211615562438965},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.46317794919013977},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.46031755208969116},{"id":"https://openalex.org/C66144319","wikidata":"https://www.wikidata.org/wiki/Q7907583","display_name":"VS ribozyme","level":5,"score":0.42798614501953125},{"id":"https://openalex.org/C107745601","wikidata":"https://www.wikidata.org/wiki/Q3934265","display_name":"Hairpin ribozyme","level":5,"score":0.414569228887558},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3022605776786804},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.23951849341392517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21859771013259888},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.21222740411758423},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2101576328277588},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18248242139816284},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1165986955165863}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:1893500905","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=MSMHBQ_2007_v43n3_159","pdf_url":null,"source":{"id":"https://openalex.org/S4210219379","display_name":"The Korean Journal of Microbiology","issn_l":"0440-2413","issn":["0440-2413","2383-9902"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Microbiology","raw_type":null},{"id":"mag:1937196971","doi":null,"is_oa":false,"landing_page_url":"http://dspace.kci.go.kr/handle/kci/64435","pdf_url":null,"source":{"id":"https://openalex.org/S4306494981","display_name":"\ubbf8\uc0dd\ubb3c\ud559\ud68c\uc9c0","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ubbf8\uc0dd\ubb3c\ud559\ud68c\uc9c0","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W754140620","https://openalex.org/W1750797010","https://openalex.org/W1937196971","https://openalex.org/W2146009846","https://openalex.org/W1983688227","https://openalex.org/W1562725278","https://openalex.org/W1976794293","https://openalex.org/W2365188047","https://openalex.org/W2357123119","https://openalex.org/W1986561584"],"abstract_inverted_index":{"For":[0],"the":[1,89,110,123,129,135,142,152,166,169],"development":[2],"of":[3,16,53,65,67,93,98,137,144,158,168],"basic":[4],"genetic":[5],"materials":[6],"for":[7,81,182,189,196,201,204],"specific":[8,183],"and":[9,91,184,199],"effective":[10,185],"therapeutic":[11],"approach":[12],"to":[13,48,62,70,88,108,192],"suppress":[14],"multiplication":[15],"hepatitis":[17],"C":[18],"virus":[19],"(HCV),":[20],"HCV":[21,35,54,71,99,162,170,197,205],"internal":[22],"ribosome":[23],"entry":[24],"site":[25,52],"(IRES)-targeting":[26],"hammerhead":[27],"ribozyme":[28,44,59,83,94,119,130,154,175],"which":[29,76,116],"activity":[30,84,120,157],"is":[31],"allosterically":[32],"regulated":[33],"by":[34],"regulatory":[36],"protein,":[37],"NS5B":[38,87,171],"RNA":[39,68,164],"replicase,":[40],"was":[41,60,131],"developed.":[42],"The":[43,57],"targeted":[45],"most":[46,111],"effectively":[47],"+382":[49,96],"nucleotide":[50],"(nt)":[51],"IRES":[55,163],"RNA.":[56],"allosteric":[58,153,174],"designed":[61],"be":[63,177],"composed":[64],"sequence":[66,75,92,115],"aptamer":[69],"NS5B,":[72],"communication":[73,113],"module":[74,114],"can":[77,117,155,176],"transfer":[78],"structural":[79],"transition":[80],"inducing":[82],"upon":[85],"binding":[86],"aptamer,":[90],"targeting":[95],"nt":[97],"IRES.":[100],"Noticeably,":[101],"we":[102],"employed":[103],"in":[104,134,141,165],"vitro":[105],"selection":[106],"technology":[107],"identify":[109],"appropriate":[112],"induce":[118,156],"depending":[121],"on":[122],"US5B":[124],"protein.":[125,172],"We":[126],"demonstrated":[127],"that":[128],"nonfunctional":[132],"either":[133],"absence":[136],"any":[138],"proteins":[139],"or":[140],"presence":[143,167],"control":[145],"bovine":[146],"serum":[147],"albumin.":[148],"In":[149],"sharp":[150],"contrast,":[151],"cleavage":[159],"reaction":[160],"with":[161],"This":[173],"used":[178],"as":[179],"lead":[180,194],"compound":[181],"anti-HCV":[186],"agent,":[187],"tool":[188],"highthroughput":[190],"screening":[191],"isolate":[193],"chemicals":[195],"therapeutics,":[198],"ligand":[200],"biosensor":[202],"system":[203],"diagnosis.":[206]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
