{"id":"https://openalex.org/W1893396692","doi":null,"title":"Epstein-Barr virus-associated gastric adenocarcinoma.","display_name":"Epstein-Barr virus-associated gastric adenocarcinoma.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W1893396692","mag":"1893396692","pmid":"https://pubmed.ncbi.nlm.nih.gov/1314023","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886378"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026666281","display_name":"Darryl K. Shibata","orcid":"https://orcid.org/0000-0002-4567-1639","observed_orcids":["https://orcid.org/0000-0002-4567-1639"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Shibata","raw_affiliation_strings":["Department of Pathology, Los Angeles County, University of Southern California Medical Center 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Los Angeles County, University of Southern California Medical Center 90033","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430","https://openalex.org/I4210096972"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112182874","display_name":"Lawrence Martin Weiss","orcid":"https://orcid.org/0000-0002-2356-535X","observed_orcids":["https://orcid.org/0000-0002-2356-535X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7778,"has_fulltext":false,"cited_by_count":467,"citation_normalized_percentile":{"value":0.97396818,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"140","issue":"4","first_page":"769","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":1.0},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/viral-carcinogenesis","display_name":"viral oncogenesis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/lymphoepithelioma-like-carcinoma","display_name":"lymphoepithelioma-like carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gastric-dysplasia","display_name":"gastric dysplasia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/intestinal-metaplasia","display_name":"intestinal metaplasia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sex-differences-in-infection","display_name":"sex differences in infection","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.7545604705810547},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6976344585418701},{"id":"https://openalex.org/C2777048871","wikidata":"https://www.wikidata.org/wiki/Q17125282","display_name":"Lymphoepithelioma","level":4,"score":0.6412881016731262},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6368918418884277},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.6262235045433044},{"id":"https://openalex.org/C2780941775","wikidata":"https://www.wikidata.org/wiki/Q2897350","display_name":"Gastric lymphoma","level":3,"score":0.6034852862358093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5661916136741638},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.5344865322113037},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.523414134979248},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.5131943821907043},{"id":"https://openalex.org/C2776497702","wikidata":"https://www.wikidata.org/wiki/Q872095","display_name":"Intestinal metaplasia","level":3,"score":0.485883891582489},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.44735655188560486},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.43885284662246704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27751755714416504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21609407663345337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1798931062221527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11796540021896362},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.106117844581604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07621651887893677},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.05749678611755371},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1314023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1314023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8669808234","display_name":"EPIDEMIOLOGY OF HIV-RELATED LYMPHOMA","funder_award_id":"R01CA050850","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G91000648","display_name":"IN SITU HYBRIDIZATION IN HODGKINS DISEASE","funder_award_id":"R29CA050341","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W18139066","https://openalex.org/W126999521","https://openalex.org/W150741373","https://openalex.org/W194951695","https://openalex.org/W201131023","https://openalex.org/W273413991","https://openalex.org/W1877917243","https://openalex.org/W1967738350","https://openalex.org/W1969873417","https://openalex.org/W1980278926","https://openalex.org/W1993970743","https://openalex.org/W1996478245","https://openalex.org/W2001761244","https://openalex.org/W2045667595","https://openalex.org/W2050717506","https://openalex.org/W2052914540","https://openalex.org/W2057749060","https://openalex.org/W2064567786","https://openalex.org/W2081061847","https://openalex.org/W2081669022","https://openalex.org/W2104308668","https://openalex.org/W2159963304","https://openalex.org/W2160858666","https://openalex.org/W2193280530","https://openalex.org/W2261317767","https://openalex.org/W2327153404","https://openalex.org/W2329058715","https://openalex.org/W2338576041","https://openalex.org/W2411130816"],"related_works":["https://openalex.org/W2136045932","https://openalex.org/W1528967742","https://openalex.org/W2406713709","https://openalex.org/W204151003","https://openalex.org/W1506669504","https://openalex.org/W2406770182","https://openalex.org/W2467295604","https://openalex.org/W2082823816","https://openalex.org/W1986494540","https://openalex.org/W1983978762"],"abstract_inverted_index":{"The":[0,34,85,100,126],"Epstein-Barr":[1],"virus":[2],"(EBV)":[3],"has":[4],"been":[5],"detected":[6,64,141,148],"in":[7,24,46,57,65,80,96,106,113,129,149],"certain":[8],"types":[9],"of":[10,27,67,71,162],"lymphoma":[11],"and":[12,19,79,122],"some":[13,160],"epithelial":[14],"neoplasms":[15],"including":[16],"nasopharyngeal":[17,53],"lymphoepithelioma,":[18,54],"rare":[20,48],"lymphoepithelioma-like":[21],"carcinomas":[22],"occurring":[23],"a":[25],"variety":[26],"organs":[28],"including,":[29],"most":[30,146],"recently,":[31],"the":[32,37,47,92,130],"stomach.":[33],"authors":[35],"investigated":[36],"possibility":[38],"that":[39,51],"EBV":[40,61,86,101,127,138,144],"may":[41],"be":[42],"present":[43,90,105],"not":[44],"only":[45],"gastric":[49,59,73,93,124,132,150,163],"cancers":[50],"resemble":[52],"but":[55,110],"also":[56,104],"typical":[58,72],"adenocarcinoma.":[60],"sequences":[62],"were":[63,88,103,111],"22":[66],"138":[68],"(16%)":[69],"cases":[70,161],"adenocarcinoma":[74,164],"by":[75,142],"polymerase":[76],"chain":[77],"reaction":[78],"situ":[81],"hybridization":[82],"(ISH)":[83],"techniques.":[84],"genomes":[87,102,128],"specifically":[89],"within":[91],"carcinoma":[94,133],"cells":[95,134],"an":[97],"even":[98],"distribution.":[99],"adjacent":[107],"dysplastic":[108],"epithelium":[109],"absent":[112],"surrounding":[114],"lymphocytes,":[115],"other":[116],"normal":[117,123],"stromal":[118],"cells,":[119],"intestinal":[120],"metaplasia,":[121],"mucosa.":[125],"infected":[131],"are":[135,165],"expressed":[136],"as":[137],"RNA":[139],"was":[140,145],"ISH.":[143],"often":[147],"tumors":[151],"from":[152],"men":[153],"(21%)":[154],"compared":[155],"with":[156],"women":[157],"(3%).":[158],"Thus":[159],"EBV-associated.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}