{"id":"https://openalex.org/W1893039775","doi":"https://doi.org/10.21775/cimb.008.097","title":"Drug Resistance inMycobacterium tuberculosis","display_name":"Drug Resistance inMycobacterium tuberculosis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1893039775","doi":"https://doi.org/10.21775/cimb.008.097","mag":"1893039775","pmid":"https://pubmed.ncbi.nlm.nih.gov/16878362"},"language":"en","primary_location":{"id":"doi:10.21775/cimb.008.097","doi":"https://doi.org/10.21775/cimb.008.097","is_oa":true,"landing_page_url":"https://doi.org/10.21775/cimb.008.097","pdf_url":"https://www.caister.com/cimb/v/v8/97.pdf","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.caister.com/cimb/v/v8/97.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037704297","display_name":"Rabia Johnson","orcid":"https://orcid.org/0000-0002-6328-0789","observed_orcids":["https://orcid.org/0000-0002-6328-0789"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Rabia Johnson","raw_affiliation_strings":["Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Science, Tygerberg, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Science, Tygerberg, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062490980","display_name":"Elizabeth Maria Streicher","orcid":"https://orcid.org/0000-0003-3901-1981","observed_orcids":["https://orcid.org/0000-0003-3901-1981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth M Streicher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113990441","display_name":"Gail Louw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gail E Louw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021801489","display_name":"Robin M. Warren","orcid":"https://orcid.org/0000-0001-5741-7358","observed_orcids":["https://orcid.org/0000-0001-5741-7358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin M Warren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026225819","display_name":"Paul D. van Helden","orcid":"https://orcid.org/0000-0002-1557-2496","observed_orcids":["https://orcid.org/0000-0002-1557-2496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul D van Helden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113665180","display_name":"Thomas C. Victor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas C Victor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":7.753,"has_fulltext":true,"cited_by_count":227,"citation_normalized_percentile":{"value":0.97806975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"2","first_page":"97","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/first-line-drug-resistance","display_name":"first-line drug resistance","score":0.675000011920929},{"id":"https://openalex.org/keywords/second-line-drug-resistance","display_name":"second-line drug resistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/resistance-mechanisms","display_name":"resistance mechanisms","score":0.7720000147819519},{"id":"https://openalex.org/keywords/resistance-gene-mutations","display_name":"resistance gene mutations","score":0.7730000019073486},{"id":"https://openalex.org/keywords/molecular-detection-of-drug-resistance","display_name":"molecular detection of drug resistance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tuberculosis-treatment-guidelines","display_name":"tuberculosis treatment guidelines","score":0.6850000023841858},{"id":"https://openalex.org/keywords/molecular-epidemiology","display_name":"molecular epidemiology","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tuberculosis-outbreak","display_name":"tuberculosis outbreak","score":0.7519999742507935},{"id":"https://openalex.org/keywords/transmission-prevention","display_name":"transmission prevention","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tuberculosis-control","display_name":"tuberculosis control","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8700610399246216},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.755418062210083},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7461691498756409},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.620774507522583},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.6182068586349487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5996161103248596},{"id":"https://openalex.org/C2777107064","wikidata":"https://www.wikidata.org/wiki/Q1040214","display_name":"Extensively drug-resistant tuberculosis","level":4,"score":0.4754450023174286},{"id":"https://openalex.org/C3020294253","wikidata":"https://www.wikidata.org/wiki/Q1189184","display_name":"Drug resistant tuberculosis","level":4,"score":0.42266055941581726},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41873544454574585},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39181697368621826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28936758637428284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2541951537132263},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.24495726823806763},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09276202321052551},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08054926991462708},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006287","descriptor_name":"Health Planning Guidelines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011159","descriptor_name":"Population Surveillance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D014944","descriptor_name":"World Health Organization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.21775/cimb.008.097","doi":"https://doi.org/10.21775/cimb.008.097","is_oa":true,"landing_page_url":"https://doi.org/10.21775/cimb.008.097","pdf_url":"https://www.caister.com/cimb/v/v8/97.pdf","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmid:16878362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16878362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21775/cimb.008.097","doi":"https://doi.org/10.21775/cimb.008.097","is_oa":true,"landing_page_url":"https://doi.org/10.21775/cimb.008.097","pdf_url":"https://www.caister.com/cimb/v/v8/97.pdf","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3459414100","display_name":"INH resistance in Beijing/W isolates of M tuberculosis","funder_award_id":"1r21ai055800-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5254287072","display_name":null,"funder_award_id":"R21 AI55800-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322679","display_name":"International Atomic Energy Agency","ror":"https://ror.org/02zt1gg83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1893039775.pdf","grobid_xml":"https://content.openalex.org/works/W1893039775.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W20893520","https://openalex.org/W77854182","https://openalex.org/W103235722","https://openalex.org/W128341503","https://openalex.org/W1552927766","https://openalex.org/W1599735915","https://openalex.org/W1779918428","https://openalex.org/W1788151071","https://openalex.org/W1906071890","https://openalex.org/W1916021332","https://openalex.org/W1922413122","https://openalex.org/W1930402573","https://openalex.org/W1941232375","https://openalex.org/W1966126698","https://openalex.org/W1966719805","https://openalex.org/W1971706644","https://openalex.org/W1977261026","https://openalex.org/W1981198757","https://openalex.org/W1984247669","https://openalex.org/W2001265073","https://openalex.org/W2001941396","https://openalex.org/W2003654629","https://openalex.org/W2005769920","https://openalex.org/W2007755754","https://openalex.org/W2011605425","https://openalex.org/W2017082286","https://openalex.org/W2022361934","https://openalex.org/W2023807749","https://openalex.org/W2027451272","https://openalex.org/W2032080946","https://openalex.org/W2036200174","https://openalex.org/W2039733501","https://openalex.org/W2042323404","https://openalex.org/W2048238824","https://openalex.org/W2052422622","https://openalex.org/W2054280858","https://openalex.org/W2058925610","https://openalex.org/W2060248414","https://openalex.org/W2064063117","https://openalex.org/W2064943876","https://openalex.org/W2065130119","https://openalex.org/W2072113124","https://openalex.org/W2072890880","https://openalex.org/W2075000963","https://openalex.org/W2075830613","https://openalex.org/W2077443707","https://openalex.org/W2079561839","https://openalex.org/W2082666408","https://openalex.org/W2087010421","https://openalex.org/W2087475619","https://openalex.org/W2089154924","https://openalex.org/W2089972364","https://openalex.org/W2091525541","https://openalex.org/W2093165547","https://openalex.org/W2093712250","https://openalex.org/W2094075600","https://openalex.org/W2098335911","https://openalex.org/W2102321517","https://openalex.org/W2104392898","https://openalex.org/W2106191613","https://openalex.org/W2107548203","https://openalex.org/W2107823707","https://openalex.org/W2107835859","https://openalex.org/W2107861076","https://openalex.org/W2109273367","https://openalex.org/W2112687806","https://openalex.org/W2119142977","https://openalex.org/W2119603196","https://openalex.org/W2120595078","https://openalex.org/W2120659509","https://openalex.org/W2121472688","https://openalex.org/W2124564317","https://openalex.org/W2125427123","https://openalex.org/W2128796998","https://openalex.org/W2129759335","https://openalex.org/W2130263042","https://openalex.org/W2130610060","https://openalex.org/W2132102084","https://openalex.org/W2132298285","https://openalex.org/W2135681003","https://openalex.org/W2137144551","https://openalex.org/W2138715011","https://openalex.org/W2140262510","https://openalex.org/W2140586560","https://openalex.org/W2141810514","https://openalex.org/W2142392294","https://openalex.org/W2144651829","https://openalex.org/W2148922378","https://openalex.org/W2151708720","https://openalex.org/W2152755899","https://openalex.org/W2152929618","https://openalex.org/W2153092680","https://openalex.org/W2153938082","https://openalex.org/W2155222297","https://openalex.org/W2161140573","https://openalex.org/W2164045886","https://openalex.org/W2165202203","https://openalex.org/W2166849360","https://openalex.org/W2169602677","https://openalex.org/W2170243611","https://openalex.org/W2171501019","https://openalex.org/W2173540289","https://openalex.org/W2183601760","https://openalex.org/W2286891786","https://openalex.org/W2315232969","https://openalex.org/W2327004351","https://openalex.org/W2398743953","https://openalex.org/W2402205561","https://openalex.org/W2418210342","https://openalex.org/W2992349401","https://openalex.org/W3021963619","https://openalex.org/W3145825357","https://openalex.org/W4241098070","https://openalex.org/W4249756873","https://openalex.org/W4252250457","https://openalex.org/W4254221699","https://openalex.org/W7073565043","https://openalex.org/W7073909734","https://openalex.org/W7074140350","https://openalex.org/W7074183902"],"related_works":["https://openalex.org/W7098373054","https://openalex.org/W1818704933","https://openalex.org/W3010355796","https://openalex.org/W2008256066","https://openalex.org/W7220781729","https://openalex.org/W1980108230","https://openalex.org/W2443422556","https://openalex.org/W2082666408","https://openalex.org/W7155748605","https://openalex.org/W7171930896"],"abstract_inverted_index":{"Anti-tuberculosis":[0],"drugs":[1,22,112],"are":[2,23],"a":[3,39],"two-edged":[4],"sword.":[5],"While":[6],"they":[7,12],"destroy":[8],"pathogenic":[9],"M.":[10],"tuberculosis":[11,42],"also":[13,72],"select":[14],"for":[15,88,142],"drug":[16,31,62,80,97,143,162],"resistant":[17,32,163],"bacteria":[18],"against":[19],"which":[20],"those":[21],"then":[24],"ineffective.":[25],"Global":[26],"surveillance":[27],"has":[28,56],"shown":[29],"that":[30,127,170],"Tuberculosis":[33,89],"is":[34,37,125],"widespread":[35],"and":[36,109,113,147],"now":[38],"threat":[40],"to":[41,74,92,106,118,134,139,149,184],"control":[43],"programs":[44],"in":[45,64,82,100,156,178],"many":[46],"countries.":[47],"Application":[48,66],"of":[49,61,67,77,79,104,115,161,173,181],"molecular":[50,68,116,128],"methods":[51,70,117],"during":[52],"the":[53,75,93,96,101,171,179],"last":[54],"decade":[55],"greatly":[57],"changed":[58],"our":[59],"understanding":[60],"resistance":[63,81,98,105,120],"tuberculosis.":[65],"epidemiological":[69],"was":[71],"central":[73],"description":[76],"outbreaks":[78],"Tuberculosis.":[83],"This":[84],"review":[85],"describes":[86],"recommendations":[87],"treatment":[90],"according":[91],"WHO":[94],"guidelines,":[95],"problem":[99],"world,":[102],"mechanisms":[103],"first":[107],"line":[108,111],"second":[110],"applications":[114],"detect":[119],"causing":[121],"gene":[122],"mutations.":[123],"It":[124],"envisaged":[126],"techniques":[129],"may":[130,152],"be":[131,153,176],"important":[132],"adjuncts":[133],"traditional":[135],"culture":[136],"based":[137],"procedures":[138],"rapidly":[140],"screen":[141],"resistance.":[144],"Prospective":[145],"analysis":[146],"intervention":[148],"prevent":[150],"transmission":[151,160],"particularly":[154],"helpful":[155],"areas":[157],"with":[158],"ongoing":[159],"strains":[164],"as":[165],"recent":[166],"mathematical":[167],"modeling":[168],"indicate":[169],"burden":[172],"MDR-TB":[174],"cannot":[175],"contained":[177],"absence":[180],"specific":[182],"efforts":[183],"limit":[185],"transmission.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}