{"id":"https://openalex.org/W1892809155","doi":null,"title":"Contemporary approaches for nonviral gene therapy.","display_name":"Contemporary approaches for nonviral gene therapy.","publication_year":2015,"publication_date":"2015-06-01","ids":{"openalex":"https://openalex.org/W1892809155","mag":"1892809155","pmid":"https://pubmed.ncbi.nlm.nih.gov/26175402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9892924"},"language":"en","primary_location":{"id":"pmid:26175402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26175402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9892924/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Charles H Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles H Jones","raw_affiliation_strings":["Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101513384","display_name":"Andrew B. Hill","orcid":"https://orcid.org/0000-0002-1784-0829","observed_orcids":["https://orcid.org/0000-0002-1784-0829"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Hill","raw_affiliation_strings":["McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090116471","display_name":"Mingfu Chen","orcid":"https://orcid.org/0000-0002-0169-613X","observed_orcids":["https://orcid.org/0000-0002-0169-613X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingfu Chen","raw_affiliation_strings":["Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079480513","display_name":"Blaine A. Pfeifer","orcid":"https://orcid.org/0000-0002-9338-2794","observed_orcids":["https://orcid.org/0000-0002-9338-2794","https://orcid.org/0000-0002-1784-0829"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaine A Pfeifer","raw_affiliation_strings":["Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1241,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.07664596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"19","issue":"107","first_page":"447","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-viral-gene-therapy","display_name":"non-viral gene therapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.8799999952316284},{"id":"https://openalex.org/keywords/nucleic-acid-chemistry","display_name":"nucleic acid chemistry","score":0.7720000147819519},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.6349999904632568},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/vector-design","display_name":"vector design","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.7232705354690552},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7192642688751221},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.6830438375473022},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6611582040786743},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.604527473449707},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5737250447273254},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5514642596244812},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.5495667457580566},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.54623943567276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48010897636413574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40749067068099976},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3388426601886749},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33337903022766113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22709649801254272},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14119583368301392},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1234743595123291},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10230231285095215}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:26175402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26175402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9892924","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9892924/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},{"id":"mag:1892809155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26175402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9892924","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9892924/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3544714208","display_name":"A Hybrid Biomaterial-biological Vector for Antigen Presenting Cell Gene Delivery","funder_award_id":"R03AI088485","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1963589190","https://openalex.org/W1965364831","https://openalex.org/W1966116207","https://openalex.org/W1974746401","https://openalex.org/W1977506341","https://openalex.org/W1978129709","https://openalex.org/W1980903345","https://openalex.org/W1982969769","https://openalex.org/W1983075730","https://openalex.org/W1985969431","https://openalex.org/W1992007086","https://openalex.org/W1998008475","https://openalex.org/W1998381734","https://openalex.org/W2003171404","https://openalex.org/W2003414091","https://openalex.org/W2008416020","https://openalex.org/W2015806699","https://openalex.org/W2020256361","https://openalex.org/W2021037505","https://openalex.org/W2024341039","https://openalex.org/W2024409869","https://openalex.org/W2025037761","https://openalex.org/W2031211461","https://openalex.org/W2039551908","https://openalex.org/W2043692200","https://openalex.org/W2045015558","https://openalex.org/W2049044362","https://openalex.org/W2054587076","https://openalex.org/W2058708049","https://openalex.org/W2072632544","https://openalex.org/W2073873559","https://openalex.org/W2076277381","https://openalex.org/W2076617713","https://openalex.org/W2078575618","https://openalex.org/W2079903460","https://openalex.org/W2080274229","https://openalex.org/W2088718964","https://openalex.org/W2089394717","https://openalex.org/W2090480442","https://openalex.org/W2091533570","https://openalex.org/W2093410766","https://openalex.org/W2095102812","https://openalex.org/W2096745064","https://openalex.org/W2111063482","https://openalex.org/W2112579649","https://openalex.org/W2119422370","https://openalex.org/W2123746851","https://openalex.org/W2123958837","https://openalex.org/W2131018316","https://openalex.org/W2134100064","https://openalex.org/W2141666604","https://openalex.org/W2147895630","https://openalex.org/W2151711712","https://openalex.org/W2153138904","https://openalex.org/W2160066921","https://openalex.org/W2167380395","https://openalex.org/W2317839986","https://openalex.org/W2321877594","https://openalex.org/W2328245805","https://openalex.org/W2413266975","https://openalex.org/W2433496323"],"related_works":["https://openalex.org/W3164524028","https://openalex.org/W2073026167","https://openalex.org/W4246074985","https://openalex.org/W4388043138","https://openalex.org/W4413776546","https://openalex.org/W4289133916","https://openalex.org/W2782611871","https://openalex.org/W3138769995","https://openalex.org/W4361296895","https://openalex.org/W3181865221"],"abstract_inverted_index":{"Gene":[0],"therapy":[1],"is":[2,20,45],"the":[3,23,34,42,48,53,62,89,116,128,138,147,170,182],"manipulation":[4,19],"of":[5,26,39,51,55,64,91,131,140,173,178],"gene":[6,84,104,194],"expression":[7],"patterns":[8],"in":[9,103,160],"specific":[10],"cells":[11],"to":[12,74,100,113,126],"treat":[13],"genetic":[14],"and":[15,36,80,82,122,163,189],"pathological":[16],"diseases.":[17],"This":[18,134],"accomplished":[21],"by":[22,47,97],"controlled":[24],"introduction":[25],"exogenous":[27],"nucleic":[28,164],"acids":[29],"into":[30,60],"target":[31],"cells.":[32],"Given":[33],"size":[35],"negative":[37],"charge":[38],"these":[40,107,179],"biomacromolecules,":[41],"delivery":[43,85,129],"process":[44],"driven":[46],"carrier":[49],"vector,":[50],"which":[52],"usage":[54],"viral":[56,65,132],"vectors":[57,93,110],"dominates.":[58],"Taking":[59],"account":[61],"limitations":[63],"vectors,":[66],"nonviral":[67,92,109,174],"alternatives":[68],"have":[69,111,124,146,168],"gained":[70],"significant":[71],"attention":[72],"due":[73],"their":[75,83],"flexible":[76],"design,":[77],"low":[78],"cytotoxicity":[79],"immunogenicity,":[81],"efficacy.":[86],"That":[87],"stated,":[88],"field":[90],"has":[94,135],"been":[95],"dominated":[96],"research":[98],"dedicated":[99],"overcoming":[101,187],"barriers":[102,117,191],"transfer.":[105],"Unfortunately,":[106],"traditional":[108],"failed":[112,125],"completely":[114],"overcome":[115],"required":[118],"for":[119,149,186],"clinical":[120,151],"translation":[121],"thus,":[123],"match":[127],"outcomes":[130],"vector.":[133],"consequently":[136],"encouraged":[137],"development":[139],"new,":[141],"more":[142],"radical":[143],"approaches":[144,180],"that":[145,167],"potential":[148],"higher":[150],"translation.":[152],"In":[153],"this":[154],"review,":[155],"we":[156],"discuss":[157],"recent":[158],"advances":[159],"vector":[161],"technology":[162],"acid":[165],"chemistry":[166],"challenged":[169],"current":[171],"understanding":[172],"systems.":[175],"The":[176],"diversity":[177],"highlights":[181],"numerous":[183],"alternative":[184],"avenues":[185],"innate":[188],"technical":[190],"associated":[192],"with":[193],"delivery.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}