{"id":"https://openalex.org/W18924823","doi":null,"title":"Characterization of platelet-activating factor synthesized by normal and granulocyte-macrophage colony-stimulating factor-primed human eosinophils.","display_name":"Characterization of platelet-activating factor synthesized by normal and granulocyte-macrophage colony-stimulating factor-primed human eosinophils.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W18924823","mag":"18924823","pmid":"https://pubmed.ncbi.nlm.nih.gov/1493922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421661"},"language":"en","primary_location":{"id":"pmid:1493922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1493922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1421661/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049355810","display_name":"Massimo Triggiani","orcid":"https://orcid.org/0000-0001-7318-2093","observed_orcids":["https://orcid.org/0000-0001-7318-2093"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Triggiani","raw_affiliation_strings":["Division of Clinical Immunology, Johns Hopkins Asthma & Allergy Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Johns Hopkins Asthma & Allergy Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109905280","display_name":"RP Schleimer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Schleimer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052234120","display_name":"Kenichi Tomioka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tomioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067750098","display_name":"W C Hubbard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W C Hubbard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103377292","display_name":"F H Chilton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F H Chilton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7691,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.71500778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"4","first_page":"500","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9559999704360962},{"id":"https://openalex.org/keywords/paf-biosynthesis","display_name":"PAF biosynthesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8119999766349792},{"id":"https://openalex.org/keywords/f-met-leu-phe","display_name":"fMet-Leu-Phe","score":0.9409999847412109},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.6830000281333923},{"id":"https://openalex.org/keywords/eosinophil-infiltration","display_name":"eosinophil infiltration","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.9289613366127014},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7695372104644775},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.6056318283081055},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.49336352944374084},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.46927371621131897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46721068024635315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45788776874542236},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.43740034103393555},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4318329095840454},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.42837679386138916},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41373297572135925},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3896048069000244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3882313370704651},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3591024875640869},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:1493922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1493922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1421661","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1421661/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:18924823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1493922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1421661","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1421661/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2453319997","display_name":"PLATELET ACTIVATING FACTOR","funder_award_id":"R01AI026771","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5946025403","display_name":"GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE","funder_award_id":"5r01am031891-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1545377491","https://openalex.org/W1552451309","https://openalex.org/W1563717384","https://openalex.org/W1567247348","https://openalex.org/W1595478289","https://openalex.org/W1596169348","https://openalex.org/W1858845313","https://openalex.org/W1927551960","https://openalex.org/W1973436145","https://openalex.org/W1978972285","https://openalex.org/W1987409651","https://openalex.org/W1988181179","https://openalex.org/W1993618712","https://openalex.org/W1998455553","https://openalex.org/W2001682079","https://openalex.org/W2007248764","https://openalex.org/W2008403839","https://openalex.org/W2011658825","https://openalex.org/W2047539724","https://openalex.org/W2065851459","https://openalex.org/W2071000507","https://openalex.org/W2077114653","https://openalex.org/W2080119725","https://openalex.org/W2113434905","https://openalex.org/W2140547471","https://openalex.org/W2152311269","https://openalex.org/W2161752363","https://openalex.org/W2317007280","https://openalex.org/W2339378413","https://openalex.org/W2472018727"],"related_works":["https://openalex.org/W2161752363","https://openalex.org/W1927551960","https://openalex.org/W2411251903","https://openalex.org/W1630710446","https://openalex.org/W1566489422","https://openalex.org/W2014977968","https://openalex.org/W2015988224","https://openalex.org/W1963128175","https://openalex.org/W2019819679","https://openalex.org/W2037347279"],"abstract_inverted_index":{"Platelet-activating":[0],"factor":[1,153],"(PAF;":[2],"1-alkyl-2-acetyl-sn-glycero-3-":[3],"phosphocholine)":[4],"is":[5,87],"a":[6,157],"mediator":[7],"involved":[8],"in":[9,61,112,156,162,172,180],"the":[10,50,118,134,141,173,181,184],"pathogenesis":[11],"of":[12,82,106,133,144,175,183,187,200],"inflammatory":[13],"diseases":[14],"associated":[15,27],"with":[16,28,99,150,168],"tissue":[17],"eosinophil":[18],"infiltration.":[19],"Previous":[20],"studies":[21,45],"utilizing":[22],"bioassay":[23],"or":[24,179],"assaying":[25],"enzymes":[26],"PAF":[29,52,107,163,176,201],"biosynthesis":[30],"have":[31],"suggested":[32],"that":[33,73,192,203],"human":[34,59,193],"eosinophils":[35,60,75,139,166,194],"produce":[36,76,101,196],"PAF.":[37,83,145,188],"The":[38,84],"present":[39],"study":[40],"has":[41],"extended":[42],"these":[43],"initial":[44],"by":[46,58,91,138,210],"identifying":[47],"and":[48,55,65,94,116,131,202],"quantifying":[49],"different":[51],"molecular":[53,80,120,177,198],"species":[54,81,86,121,178,199],"analogues":[56],"synthesized":[57],"response":[62,113],"to":[63,109,114,159],"A23187":[64,115],"f-Met-Leu-Phe":[66],"(FMLP).":[67],"Gas":[68],"chromatography-mass":[69],"spectrometric":[70],"analysis":[71],"indicated":[72],"A23187-stimulated":[74],"at":[77],"least":[78],"three":[79],"predominant":[85],"1-hexadecyl-2-acetyl-GPC":[88],"(16:0)":[89],"followed":[90],"1-octadecyl-2-acetyl-GPC":[92,95],"(18:0)":[93],"(18:1).":[96],"Eosinophils":[97],"stimulated":[98,167],"FMLP":[100],"approximately":[102],"100-fold":[103],"smaller":[104],"quantities":[105],"relative":[108],"those":[110],"produced":[111,137],"only":[117],"16:0":[119],"could":[122],"be":[123,207],"measured.":[124],"A":[125],"small":[126],"percentage":[127,182],"(comprising":[128],"between":[129],"2":[130],"5%)":[132],"2-acetylated":[135],"phospholipids":[136],"was":[140],"1-acyl":[142,185],"analogue":[143,186],"Long-term":[146],"(72":[147],"hr)":[148],"incubation":[149],"granulocyte-macrophage":[151],"colony-stimulating":[152],"(GM-CSF)":[154],"resulted":[155],"three-":[158],"fourfold":[160],"increase":[161],"synthesis":[164],"from":[165],"FMLP,":[169],"without":[170],"changes":[171],"profile":[174],"These":[189],"data":[190],"indicate":[191],"can":[195,206],"various":[197],"this":[204],"process":[205],"quantitatively":[208],"enhanced":[209],"GM-CSF.":[211]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
