{"id":"https://openalex.org/W1892467251","doi":"https://doi.org/10.1073/pnas.1517584112","title":"Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells","display_name":"Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells","publication_year":2015,"publication_date":"2015-11-02","ids":{"openalex":"https://openalex.org/W1892467251","doi":"https://doi.org/10.1073/pnas.1517584112","mag":"1892467251","pmid":"https://pubmed.ncbi.nlm.nih.gov/26575629"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1517584112","doi":"https://doi.org/10.1073/pnas.1517584112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1517584112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4679042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080953874","display_name":"Antoine J. Tanne","orcid":"https://orcid.org/0000-0002-0164-775X","observed_orcids":["https://orcid.org/0000-0002-0164-775X"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antoine Tanne","raw_affiliation_strings":["Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109056111","display_name":"Luciana Ribeiro Muniz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciana R. Muniz","raw_affiliation_strings":["Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","aTisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"raw_affiliation_string":"aTisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050364723","display_name":"Anna M. Puzio\u2010Kuter","orcid":"https://orcid.org/0009-0008-3298-8152","observed_orcids":["https://orcid.org/0009-0008-3298-8152"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Puzio-Kuter","raw_affiliation_strings":["Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;","Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027765728","display_name":"Katerina I. Leonova","orcid":"https://orcid.org/0000-0001-5068-5341","observed_orcids":["https://orcid.org/0000-0001-5068-5341"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katerina I. Leonova","raw_affiliation_strings":["Roswell Park Cancer Institute, Buffalo, NY 14263;","Roswell Park Cancer Institute; Buffalo; NY; 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute, Buffalo, NY 14263;","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Roswell Park Cancer Institute; Buffalo; NY; 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069808553","display_name":"Andrei V. Gudkov","orcid":"https://orcid.org/0000-0003-2548-0154","observed_orcids":["https://orcid.org/0000-0003-2548-0154"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrei V. Gudkov","raw_affiliation_strings":["Roswell Park Cancer Institute, Buffalo, NY 14263;","cRoswell Park Cancer Institute, Buffalo, NY 14263;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute, Buffalo, NY 14263;","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"cRoswell Park Cancer Institute, Buffalo, NY 14263;","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012704679","display_name":"David Tsai Ting","orcid":"https://orcid.org/0000-0002-3261-2322","observed_orcids":["https://orcid.org/0000-0002-3261-2322"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Ting","raw_affiliation_strings":["Massachusetts General Hospital, Charlestown, MA 02129;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Charlestown, MA 02129;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016002177","display_name":"R\u00e9mi Monasson","orcid":"https://orcid.org/0000-0002-4459-0204","observed_orcids":["https://orcid.org/0000-0002-4459-0204"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Monasson","raw_affiliation_strings":["Laboratoire de Physique Th\u00e9orique, CNRS and Ecole Normale Sup\u00e9rieure, 75005 Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physique Th\u00e9orique, CNRS and Ecole Normale Sup\u00e9rieure, 75005 Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002693245","display_name":"Simona Cocco","orcid":"https://orcid.org/0000-0002-1852-7789","observed_orcids":["https://orcid.org/0000-0002-1852-7789"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Simona Cocco","raw_affiliation_strings":["Laboratoire de Physique Statistique, CNRS and Ecole Normale Sup\u00e9rieure, 75005 Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physique Statistique, CNRS and Ecole Normale Sup\u00e9rieure, 75005 Paris, France;","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089778846","display_name":"Arnold J. Levine","orcid":"https://orcid.org/0000-0002-1871-6387","observed_orcids":["https://orcid.org/0000-0002-1871-6387"]},"institutions":[{"id":"https://openalex.org/I40036882","display_name":"Institute for Advanced Study","ror":"https://ror.org/00f809463","country_code":"US","type":"facility","lineage":["https://openalex.org/I40036882"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold J. Levine","raw_affiliation_strings":["Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;","The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;","bRutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;","gThe Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;","institution_ids":["https://openalex.org/I40036882"]},{"raw_affiliation_string":"bRutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"gThe Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;","institution_ids":["https://openalex.org/I40036882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055358847","display_name":"Nina Bhardwaj","orcid":"https://orcid.org/0000-0003-1865-4187","observed_orcids":["https://orcid.org/0000-0003-1865-4187"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Bhardwaj","raw_affiliation_strings":["Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","aTisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"raw_affiliation_string":"aTisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063215100","display_name":"Benjamin D. Greenbaum","orcid":"https://orcid.org/0000-0001-6153-8793","observed_orcids":["https://orcid.org/0000-0001-6153-8793"]},"institutions":[{"id":"https://openalex.org/I40036882","display_name":"Institute for Advanced Study","ror":"https://ror.org/00f809463","country_code":"US","type":"facility","lineage":["https://openalex.org/I40036882"]},{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D. Greenbaum","raw_affiliation_strings":["Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029","The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;","Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","gThe Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;","institution_ids":["https://openalex.org/I40036882"]},{"raw_affiliation_string":"Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"raw_affiliation_string":"gThe Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540;","institution_ids":["https://openalex.org/I40036882"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4335,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.92895969,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"112","issue":"49","first_page":"15154","last_page":"15159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.12139999866485596,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9589999914169312},{"id":"https://openalex.org/keywords/immunostimulatory-rna","display_name":"immunostimulatory RNA","score":0.6660000085830688},{"id":"https://openalex.org/keywords/rna-motifs","display_name":"RNA motifs","score":0.47999998927116394},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.8510000109672546},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.6600000262260437},{"id":"https://openalex.org/keywords/repetitive-elements","display_name":"repetitive elements","score":0.6629999876022339},{"id":"https://openalex.org/keywords/reticuloendothelial-system","display_name":"reticuloendothelial system","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.810173749923706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6896810531616211},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.682572066783905},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5882872939109802},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5706710815429688},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.48967960476875305},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3737689256668091},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34677261114120483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3089815676212311},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2535448670387268}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1517584112","doi":"https://doi.org/10.1073/pnas.1517584112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1517584112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:26575629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26575629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4679042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4679042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4679042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4679042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1900324703","display_name":null,"funder_award_id":"P01 CA087497","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2591309862","display_name":"From sequences to structure: statistical-physics methods to infer co-evolutionary constraints in proteins and RNAs","funder_award_id":"ANR-13-BS04-0012","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2614035065","display_name":null,"funder_award_id":"5P01CA087497-13","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3250253619","display_name":null,"funder_award_id":"1R01CA180913-01A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4052264009","display_name":null,"funder_award_id":"W81XWH-13-1-0237","funder_id":"https://openalex.org/F4320332447","funder_display_name":"U.S. Army"},{"id":"https://openalex.org/G4457048514","display_name":null,"funder_award_id":"R01CA180913","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5257709500","display_name":null,"funder_award_id":"R01 AI081848","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G814575136","display_name":null,"funder_award_id":"5R01AI081848-05","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8676180397","display_name":null,"funder_award_id":"1010968.01","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G9000897310","display_name":"Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology","funder_award_id":"K12CA087723","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320332447","display_name":"U.S. Army","ror":"https://ror.org/00afsp483"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1492294511","https://openalex.org/W1538376111","https://openalex.org/W1866437440","https://openalex.org/W1971620413","https://openalex.org/W1971899779","https://openalex.org/W1973659410","https://openalex.org/W1977852460","https://openalex.org/W1983438661","https://openalex.org/W1984595502","https://openalex.org/W1987410025","https://openalex.org/W1989652106","https://openalex.org/W1995586746","https://openalex.org/W2001674944","https://openalex.org/W2001904356","https://openalex.org/W2008760127","https://openalex.org/W2028584099","https://openalex.org/W2036564362","https://openalex.org/W2042699075","https://openalex.org/W2043033879","https://openalex.org/W2056925335","https://openalex.org/W2057088297","https://openalex.org/W2063701006","https://openalex.org/W2065854688","https://openalex.org/W2071501400","https://openalex.org/W2077046530","https://openalex.org/W2078028724","https://openalex.org/W2080827095","https://openalex.org/W2084241014","https://openalex.org/W2084733358","https://openalex.org/W2085185449","https://openalex.org/W2085939060","https://openalex.org/W2096465161","https://openalex.org/W2100019645","https://openalex.org/W2105349784","https://openalex.org/W2120426523","https://openalex.org/W2120866805","https://openalex.org/W2121646171","https://openalex.org/W2121982897","https://openalex.org/W2128016314","https://openalex.org/W2137053907","https://openalex.org/W2146680808","https://openalex.org/W2146706147","https://openalex.org/W2153268494","https://openalex.org/W2161167739","https://openalex.org/W2166810745","https://openalex.org/W2168168927","https://openalex.org/W2169777381","https://openalex.org/W2255688436","https://openalex.org/W2259938310"],"related_works":["https://openalex.org/W2057980850","https://openalex.org/W2046151756","https://openalex.org/W2777142390","https://openalex.org/W2187207551","https://openalex.org/W2069184423","https://openalex.org/W2114216755","https://openalex.org/W2810367383","https://openalex.org/W1603543036","https://openalex.org/W3140535742","https://openalex.org/W3195667928"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2,48,112],"demonstrated":[3],"abundant":[4],"transcription":[5],"of":[6,9,60,64,75,104,122,133,175,198,212],"a":[7,119,190,196],"set":[8,197],"noncoding":[10],"RNAs":[11],"(ncRNAs)":[12],"preferentially":[13],"within":[14],"tumors":[15,168],"as":[16,126],"opposed":[17],"to":[18,37,114,138,195,220],"normal":[19],"tissue.":[20],"Using":[21],"an":[22,57],"approach":[23],"from":[24,145,172],"statistical":[25],"physics,":[26],"we":[27,80],"quantify":[28],"global":[29],"transcriptome-wide":[30],"motif":[31,49,69],"use":[32,50,70],"for":[33],"the":[34,53,83,105,134,164,210,221],"first":[35],"time,":[36],"our":[38],"knowledge,":[39],"in":[40,94,99,159,167,179,215],"human":[41,85,87,106,109],"and":[42,108,129,187,217],"murine":[43],"ncRNAs,":[44,62],"determining":[45],"that":[46,71,82,102,118,149,163],"most":[47,103],"consistent":[51],"with":[52,182],"coding":[54],"genome.":[55],"However,":[56],"outlier":[58],"subset":[59,121],"tumor-associated":[61,84],"typically":[63],"recent":[65],"evolutionary":[66],"origin,":[67],"has":[68],"is":[72,92],"often":[73,155],"indicative":[74],"pathogen-associated":[76],"RNA.":[77],"For":[78],"instance,":[79],"show":[81],"repeat":[86,89],"satellite":[88],"II":[90],"(HSATII)":[91],"enriched":[93],"motifs":[95],"containing":[96],"CpG":[97],"dinucleotides":[98],"AU-rich":[100],"contexts":[101],"genome":[107],"adapted":[110],"viruses":[111],"evolved":[113],"avoid.":[115],"We":[116,161],"demonstrate":[117],"key":[120],"these":[123],"ncRNAs":[124,143,177],"functions":[125],"immunostimulatory":[127],"\"self-agonists\"":[128],"directly":[130],"activates":[131],"cells":[132,181],"mononuclear":[135],"phagocytic":[136],"system":[137],"produce":[139],"proinflammatory":[140],"cytokines.":[141],"These":[142,203],"arise":[144],"endogenous":[146],"repetitive":[147,201],"elements":[148],"are":[150,154],"normally":[151],"silenced,":[152],"yet":[153],"very":[156],"highly":[157],"expressed":[158,178],"cancers.":[160],"propose":[162],"innate":[165,183],"response":[166],"may":[169],"partially":[170],"originate":[171],"direct":[173],"interaction":[174],"immunogenic":[176],"cancer":[180],"pattern":[184],"recognition":[185],"receptors,":[186],"thereby":[188],"assign":[189],"previously":[191],"unidentified":[192],"danger-associated":[193],"function":[194],"dark":[199],"matter":[200],"elements.":[202],"findings":[204],"potentially":[205],"reconcile":[206],"several":[207],"observations":[208],"concerning":[209],"role":[211],"ncRNA":[213],"expression":[214],"cancers":[216],"their":[218],"relationship":[219],"tumor":[222],"microenvironment.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
