{"id":"https://openalex.org/W1891981195","doi":"https://doi.org/10.1002/med.20214","title":"Prophylactic and therapeutic implications of toll\u2010like receptor ligands","display_name":"Prophylactic and therapeutic implications of toll\u2010like receptor ligands","publication_year":2010,"publication_date":"2010-10-25","ids":{"openalex":"https://openalex.org/W1891981195","doi":"https://doi.org/10.1002/med.20214","mag":"1891981195","pmid":"https://pubmed.ncbi.nlm.nih.gov/22383179"},"language":"en","primary_location":{"id":"doi:10.1002/med.20214","doi":"https://doi.org/10.1002/med.20214","is_oa":false,"landing_page_url":"https://doi.org/10.1002/med.20214","pdf_url":null,"source":{"id":"https://openalex.org/S22382660","display_name":"Medicinal Research Reviews","issn_l":"0198-6325","issn":["0198-6325","1098-1128"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Research Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028589118","display_name":"Mona Hedayat","orcid":"https://orcid.org/0009-0005-8125-5914","observed_orcids":["https://orcid.org/0009-0005-8125-5914"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mona Hedayat","raw_affiliation_strings":["Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068044071","display_name":"Kiyoshi Takeda","orcid":"https://orcid.org/0000-0002-1778-6332","observed_orcids":["https://orcid.org/0000-0002-1778-6332"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Takeda","raw_affiliation_strings":["Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan","WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028354492","display_name":"Nima Rezaei","orcid":"https://orcid.org/0000-0002-3836-1827","observed_orcids":["https://orcid.org/0000-0002-3836-1827"]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","IR"],"is_corresponding":true,"raw_author_name":"Nima Rezaei","raw_affiliation_strings":["Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, United Kingdom","Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran","Research Group for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]},{"raw_affiliation_string":"Research Group for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028354492"],"corresponding_institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408","https://openalex.org/I91136226"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":0.6088,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.56054795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"32","issue":"2","first_page":"294","last_page":"325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tlr-antagonists","display_name":"TLR antagonists","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.859000027179718},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chronic-viral-infection","display_name":"chronic viral infection","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9039999842643738},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.7549999952316284},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7359281182289124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6532064080238342},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6277014017105103},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.607912540435791},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6045170426368713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5434818267822266},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.480758398771286},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.37532249093055725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07001730799674988}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/med.20214","doi":"https://doi.org/10.1002/med.20214","is_oa":false,"landing_page_url":"https://doi.org/10.1002/med.20214","pdf_url":null,"source":{"id":"https://openalex.org/S22382660","display_name":"Medicinal Research Reviews","issn_l":"0198-6325","issn":["0198-6325","1098-1128"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Research Reviews","raw_type":"journal-article"},{"id":"pmid:22383179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22383179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal research reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":254,"referenced_works":["https://openalex.org/W92445081","https://openalex.org/W177423944","https://openalex.org/W1488196937","https://openalex.org/W1489842152","https://openalex.org/W1499635692","https://openalex.org/W1499978168","https://openalex.org/W1508362664","https://openalex.org/W1514540900","https://openalex.org/W1519633296","https://openalex.org/W1527612695","https://openalex.org/W1528669066","https://openalex.org/W1534378060","https://openalex.org/W1534699340","https://openalex.org/W1545754268","https://openalex.org/W1612465238","https://openalex.org/W1622088669","https://openalex.org/W1644577573","https://openalex.org/W1677119557","https://openalex.org/W1794516118","https://openalex.org/W1838162521","https://openalex.org/W1892684502","https://openalex.org/W1925757606","https://openalex.org/W1928414651","https://openalex.org/W1936135068","https://openalex.org/W1963552316","https://openalex.org/W1963966961","https://openalex.org/W1965325090","https://openalex.org/W1965417417","https://openalex.org/W1968287338","https://openalex.org/W1969072247","https://openalex.org/W1971521446","https://openalex.org/W1972230556","https://openalex.org/W1972776583","https://openalex.org/W1972964227","https://openalex.org/W1975654823","https://openalex.org/W1975785277","https://openalex.org/W1975974203","https://openalex.org/W1976416996","https://openalex.org/W1976623095","https://openalex.org/W1976927528","https://openalex.org/W1978962348","https://openalex.org/W1983882689","https://openalex.org/W1986178107","https://openalex.org/W1990065094","https://openalex.org/W1991236592","https://openalex.org/W1991636753","https://openalex.org/W1991731944","https://openalex.org/W1992913167","https://openalex.org/W1994391392","https://openalex.org/W1995866508","https://openalex.org/W1996096145","https://openalex.org/W1996671942","https://openalex.org/W1999064607","https://openalex.org/W1999468766","https://openalex.org/W2000659418","https://openalex.org/W2002109885","https://openalex.org/W2003494594","https://openalex.org/W2003581234","https://openalex.org/W2004107411","https://openalex.org/W2004465286","https://openalex.org/W2004657012","https://openalex.org/W2006246742","https://openalex.org/W2007375974","https://openalex.org/W2007701914","https://openalex.org/W2008152503","https://openalex.org/W2008793028","https://openalex.org/W2008902102","https://openalex.org/W2011185227","https://openalex.org/W2016862474","https://openalex.org/W2018920420","https://openalex.org/W2019840235","https://openalex.org/W2020888257","https://openalex.org/W2021427213","https://openalex.org/W2021803494","https://openalex.org/W2023699576","https://openalex.org/W2024238985","https://openalex.org/W2024849509","https://openalex.org/W2025345914","https://openalex.org/W2025412364","https://openalex.org/W2025980739","https://openalex.org/W2026282548","https://openalex.org/W2027632198","https://openalex.org/W2029157767","https://openalex.org/W2030029811","https://openalex.org/W2032082148","https://openalex.org/W2034160168","https://openalex.org/W2035145667","https://openalex.org/W2035327965","https://openalex.org/W2035490072","https://openalex.org/W2035816846","https://openalex.org/W2036726679","https://openalex.org/W2036970411","https://openalex.org/W2038207849","https://openalex.org/W2038910210","https://openalex.org/W2039378822","https://openalex.org/W2040459416","https://openalex.org/W2043948229","https://openalex.org/W2045807962","https://openalex.org/W2047054188","https://openalex.org/W2047366876","https://openalex.org/W2047376205","https://openalex.org/W2051026238","https://openalex.org/W2051511024","https://openalex.org/W2051940924","https://openalex.org/W2053429123","https://openalex.org/W2054015168","https://openalex.org/W2054170090","https://openalex.org/W2054732723","https://openalex.org/W2055659035","https://openalex.org/W2057858743","https://openalex.org/W2058916344","https://openalex.org/W2059638323","https://openalex.org/W2060916776","https://openalex.org/W2061163173","https://openalex.org/W2061626698","https://openalex.org/W2062274977","https://openalex.org/W2063755565","https://openalex.org/W2063780343","https://openalex.org/W2067046112","https://openalex.org/W2067359484","https://openalex.org/W2067828508","https://openalex.org/W2068273967","https://openalex.org/W2068750125","https://openalex.org/W2068933786","https://openalex.org/W2072393575","https://openalex.org/W2072464131","https://openalex.org/W2073565085","https://openalex.org/W2073802637","https://openalex.org/W2076361525","https://openalex.org/W2078524612","https://openalex.org/W2078844752","https://openalex.org/W2079545537","https://openalex.org/W2082669319","https://openalex.org/W2083682196","https://openalex.org/W2083831117","https://openalex.org/W2084229289","https://openalex.org/W2087413579","https://openalex.org/W2087747665","https://openalex.org/W2088091610","https://openalex.org/W2088571368","https://openalex.org/W2089910376","https://openalex.org/W2091418899","https://openalex.org/W2095224835","https://openalex.org/W2095833996","https://openalex.org/W2095842810","https://openalex.org/W2095881540","https://openalex.org/W2101189282","https://openalex.org/W2102571541","https://openalex.org/W2102578857","https://openalex.org/W2105125582","https://openalex.org/W2105191701","https://openalex.org/W2106023265","https://openalex.org/W2107181087","https://openalex.org/W2107182434","https://openalex.org/W2108022314","https://openalex.org/W2109231206","https://openalex.org/W2109445380","https://openalex.org/W2110161909","https://openalex.org/W2110768898","https://openalex.org/W2110834028","https://openalex.org/W2111200149","https://openalex.org/W2113445686","https://openalex.org/W2115583388","https://openalex.org/W2116763454","https://openalex.org/W2117684163","https://openalex.org/W2118011548","https://openalex.org/W2119885778","https://openalex.org/W2120211786","https://openalex.org/W2120290296","https://openalex.org/W2123109241","https://openalex.org/W2124438200","https://openalex.org/W2125430546","https://openalex.org/W2126659405","https://openalex.org/W2126953691","https://openalex.org/W2127934565","https://openalex.org/W2128897591","https://openalex.org/W2129319296","https://openalex.org/W2129708174","https://openalex.org/W2129783872","https://openalex.org/W2130186203","https://openalex.org/W2130452292","https://openalex.org/W2130655121","https://openalex.org/W2130679789","https://openalex.org/W2131660005","https://openalex.org/W2132177571","https://openalex.org/W2132802507","https://openalex.org/W2133369735","https://openalex.org/W2133690732","https://openalex.org/W2133972984","https://openalex.org/W2134557327","https://openalex.org/W2135680156","https://openalex.org/W2135876044","https://openalex.org/W2136236728","https://openalex.org/W2136395827","https://openalex.org/W2137059754","https://openalex.org/W2137729498","https://openalex.org/W2137773986","https://openalex.org/W2138167941","https://openalex.org/W2140644802","https://openalex.org/W2141021804","https://openalex.org/W2142275934","https://openalex.org/W2143895770","https://openalex.org/W2144350507","https://openalex.org/W2144787399","https://openalex.org/W2145584783","https://openalex.org/W2147038697","https://openalex.org/W2147903280","https://openalex.org/W2148172043","https://openalex.org/W2148579227","https://openalex.org/W2149697611","https://openalex.org/W2150025583","https://openalex.org/W2151777859","https://openalex.org/W2152842365","https://openalex.org/W2153328681","https://openalex.org/W2154130646","https://openalex.org/W2154933177","https://openalex.org/W2155706758","https://openalex.org/W2155860623","https://openalex.org/W2156445477","https://openalex.org/W2157339124","https://openalex.org/W2158113874","https://openalex.org/W2158614517","https://openalex.org/W2159576879","https://openalex.org/W2160063406","https://openalex.org/W2161577497","https://openalex.org/W2163816719","https://openalex.org/W2163861382","https://openalex.org/W2165181124","https://openalex.org/W2167286967","https://openalex.org/W2168064756","https://openalex.org/W2168165195","https://openalex.org/W2168383601","https://openalex.org/W2169958419","https://openalex.org/W2170819284","https://openalex.org/W2170858665","https://openalex.org/W2171594721","https://openalex.org/W2172168743","https://openalex.org/W2172232482","https://openalex.org/W2183162582","https://openalex.org/W2309076745","https://openalex.org/W2313658741","https://openalex.org/W2398096299","https://openalex.org/W2405904493","https://openalex.org/W2409493875","https://openalex.org/W2411549174","https://openalex.org/W2416069788","https://openalex.org/W2561010084","https://openalex.org/W2916433875","https://openalex.org/W3091948925","https://openalex.org/W4246077736","https://openalex.org/W4248217693","https://openalex.org/W4249688612","https://openalex.org/W4312314020","https://openalex.org/W6716407626"],"related_works":["https://openalex.org/W2025189524","https://openalex.org/W3202142733","https://openalex.org/W2096475036","https://openalex.org/W2046931618","https://openalex.org/W197610273","https://openalex.org/W2102268163","https://openalex.org/W2295353160","https://openalex.org/W1987113542","https://openalex.org/W2129036118","https://openalex.org/W1979580921"],"abstract_inverted_index":{"The":[0,32],"evolutionary":[1],"conserved":[2],"Toll-like":[3],"receptors":[4,15],"(TLRs)":[5],"are":[6],"the":[7,44,51,83,93,99,109,112,136],"first":[8],"identified":[9],"and":[10,25,77,105,114,132,139],"best":[11],"characterized":[12],"pattern":[13],"recognition":[14],"(PRRs)":[16],"which":[17],"discriminate":[18],"self":[19],"from":[20],"nonself,":[21],"providing":[22],"an":[23,151],"early":[24],"effective":[26],"immune":[27,52,68],"response":[28,53,69],"against":[29],"invading":[30],"pathogens.":[31],"ever":[33],"expanding":[34],"knowledge":[35],"of":[36,43,85,88,95,101,117],"TLR":[37,96],"signaling":[38,97],"network":[39],"make":[40],"it":[41],"one":[42],"most":[45],"promising":[46,143],"therapeutic":[47,133,148,158],"strategies":[48,60],"to":[49,70,153],"modulate":[50],"in":[54,98],"various":[55,146],"human":[56],"diseases.":[57],"Immune":[58],"modulating":[59],"based":[61],"on":[62,145],"TLR-specific":[63,118,124],"agonists":[64,125],"elicit":[65],"a":[66,122],"potent":[67],"adjuvant":[71],"vaccine":[72],"immunotherapy,":[73],"cancers,":[74],"allergic":[75],"diseases,":[76],"chronic":[78,102],"viral":[79],"infections":[80],"while":[81,135],"minimizing":[82],"risk":[84],"uncontrolled":[86],"provocation":[87],"systemic":[89],"inflammatory":[90,104],"response.":[91],"Moreover,":[92],"contribution":[94],"pathogenesis":[100],"noninfectious":[103],"autoimmune":[106],"diseases":[107],"provides":[108],"rationale":[110],"for":[111,129],"development":[113],"clinical":[115,140],"implementation":[116],"antagonists.":[119],"At":[120],"present,":[121],"few":[123],"have":[126],"been":[127],"approved":[128],"both":[130],"prophylactic":[131],"applications,":[134],"ongoing":[137],"preclinical":[138],"studies":[141],"show":[142],"results":[144],"novel":[147],"molecules":[149],"as":[150],"adjunctive":[152],"conventional":[154],"pharmacotherapy":[155],"or":[156],"stand-alone":[157],"strategy.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}