{"id":"https://openalex.org/W1891661735","doi":"https://doi.org/10.4049/jimmunol.174.1.464","title":"Activation of Cytokine Production by Secreted Phospholipase A2 in Human Lung Macrophages Expressing the M-Type Receptor","display_name":"Activation of Cytokine Production by Secreted Phospholipase A2 in Human Lung Macrophages Expressing the M-Type Receptor","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1891661735","doi":"https://doi.org/10.4049/jimmunol.174.1.464","mag":"1891661735","pmid":"https://pubmed.ncbi.nlm.nih.gov/15611272"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.174.1.464","doi":"https://doi.org/10.4049/jimmunol.174.1.464","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.1.464","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079235615","display_name":"Francescopaolo Granata","orcid":"https://orcid.org/0000-0002-2793-8889","observed_orcids":["https://orcid.org/0000-0002-2793-8889"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francescopaolo Granata","raw_affiliation_strings":["Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038256842","display_name":"Angelica Petraroli","orcid":"https://orcid.org/0000-0001-5700-7164","observed_orcids":["https://orcid.org/0000-0001-5700-7164"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Angelica Petraroli","raw_affiliation_strings":["Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","Division of Clinical Immunology and Allergy, University of Naples Federico II, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II, and","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042606678","display_name":"\u00c9ric Boilard","orcid":"https://orcid.org/0000-0001-6319-6432","observed_orcids":["https://orcid.org/0000-0001-6319-6432"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Boilard","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique , Valbonne ,","\u2021Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique , Valbonne ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]},{"raw_affiliation_string":"\u2021Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne, France; and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040786260","display_name":"Sofiane Bezzine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sofiane Bezzine","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique , Valbonne ,","\u2021Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique , Valbonne ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]},{"raw_affiliation_string":"\u2021Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne, France; and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108388252","display_name":"James Bollinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Bollinger","raw_affiliation_strings":["Departments of Chemistry and Biochemistry, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biochemistry, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110467480","display_name":"Luigi Del Vecchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Del Vecchio","raw_affiliation_strings":["Division of Hematology, A. Cardarelli Hospital , Naples ,","\u2020Division of Hematology, A. Cardarelli Hospital, Naples, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, A. Cardarelli Hospital , Naples ,","institution_ids":["https://openalex.org/I4210087768"]},{"raw_affiliation_string":"\u2020Division of Hematology, A. Cardarelli Hospital, Naples, Italy;","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054562365","display_name":"Michael H. Gelb","orcid":"https://orcid.org/0000-0001-7000-5219","observed_orcids":["https://orcid.org/0000-0001-7000-5219"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H Gelb","raw_affiliation_strings":["Departments of Chemistry and Biochemistry, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biochemistry, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082931018","display_name":"Gerard J. Lambeau","orcid":"https://orcid.org/0000-0002-9239-518X","observed_orcids":["https://orcid.org/0000-0002-9239-518X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gerard Lambeau","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique , Valbonne ,","\u2021Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique , Valbonne ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]},{"raw_affiliation_string":"\u2021Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne, France; and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089722463","display_name":"Gianni Marone","orcid":"https://orcid.org/0000-0002-9849-4701","observed_orcids":["https://orcid.org/0000-0002-9849-4701"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianni Marone","raw_affiliation_strings":["Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","Division of Clinical Immunology and Allergy, University of Naples Federico II, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II, and","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049355810","display_name":"Massimo Triggiani","orcid":"https://orcid.org/0000-0001-7318-2093","observed_orcids":["https://orcid.org/0000-0001-7318-2093"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Massimo Triggiani","raw_affiliation_strings":["Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","Division of Clinical Immunology and Allergy, University of Naples Federico II, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II , Naples ,","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, University of Naples Federico II, and","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5038256842","https://openalex.org/A5049355810","https://openalex.org/A5079235615","https://openalex.org/A5089722463"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":5.3023,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.96164008,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"174","issue":"1","first_page":"464","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-phospholipase-a2","display_name":"secretory phospholipase A2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-macrophages","display_name":"lung macrophages","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9390000104904175},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/arachidonic-acid-mobilization","display_name":"arachidonic acid mobilization","score":0.7300000190734863},{"id":"https://openalex.org/keywords/minoxidil","display_name":"minoxidil","score":0.492000013589859},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6985098123550415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6404215097427368},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.6257941126823425},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5888503193855286},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5719417333602905},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5695999264717102},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4960354268550873},{"id":"https://openalex.org/C2776888444","wikidata":"https://www.wikidata.org/wiki/Q7187515","display_name":"Phospholipase A","level":4,"score":0.45163094997406006},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4339669346809387},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4238389730453491},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.4116644263267517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3711584508419037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18591603636741638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15790531039237976}],"mesh":[{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054507","descriptor_name":"Receptors, Phospholipase A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.174.1.464","doi":"https://doi.org/10.4049/jimmunol.174.1.464","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.1.464","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15611272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15611272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.502.3848","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.502.3848","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://faculty.washington.edu/gelb/2005/granata-activation.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00091119v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00091119","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunology, 2005, 174, pp.464-474","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5282994943","display_name":null,"funder_award_id":"MH 36235","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1510691059","https://openalex.org/W1511525837","https://openalex.org/W1523990116","https://openalex.org/W1546540358","https://openalex.org/W1579289250","https://openalex.org/W1605781633","https://openalex.org/W1733040301","https://openalex.org/W1793847751","https://openalex.org/W1968008704","https://openalex.org/W1970898912","https://openalex.org/W1978414262","https://openalex.org/W1988458614","https://openalex.org/W1994395273","https://openalex.org/W1996242613","https://openalex.org/W2004152446","https://openalex.org/W2012667759","https://openalex.org/W2019790923","https://openalex.org/W2021661112","https://openalex.org/W2024288968","https://openalex.org/W2031198908","https://openalex.org/W2033834096","https://openalex.org/W2037814757","https://openalex.org/W2041003777","https://openalex.org/W2041981966","https://openalex.org/W2043817911","https://openalex.org/W2046956572","https://openalex.org/W2047072740","https://openalex.org/W2056026888","https://openalex.org/W2062643698","https://openalex.org/W2065952313","https://openalex.org/W2077065351","https://openalex.org/W2080550444","https://openalex.org/W2086854208","https://openalex.org/W2087408276","https://openalex.org/W2088025081","https://openalex.org/W2091980322","https://openalex.org/W2096326625","https://openalex.org/W2096436185","https://openalex.org/W2098960884","https://openalex.org/W2103592190","https://openalex.org/W2112463904","https://openalex.org/W2119586406","https://openalex.org/W2122117766","https://openalex.org/W2122887929","https://openalex.org/W2132305492","https://openalex.org/W2132509717","https://openalex.org/W2134416921","https://openalex.org/W2137474950","https://openalex.org/W2140182017","https://openalex.org/W2167935048","https://openalex.org/W2170022255","https://openalex.org/W2318077287","https://openalex.org/W2415298848","https://openalex.org/W2444063973","https://openalex.org/W2469578780","https://openalex.org/W2798643531","https://openalex.org/W4244311005"],"related_works":["https://openalex.org/W2017870178","https://openalex.org/W2338497937","https://openalex.org/W2096436185","https://openalex.org/W7217377956","https://openalex.org/W1590776570","https://openalex.org/W2086854208","https://openalex.org/W2066703775","https://openalex.org/W2051986345","https://openalex.org/W2060807189","https://openalex.org/W2083042942"],"abstract_inverted_index":{"Secreted":[0],"phospholipases":[1],"A(2)":[2],"(sPLA(2))":[3],"are":[4,22],"enzymes":[5],"released":[6],"in":[7,24,44,112,190,224],"plasma":[8],"and":[9,19,41,82,96,126,135,167,209],"extracellular":[10],"fluids":[11],"during":[12],"inflammatory":[13],"diseases.":[14],"Because":[15],"human":[16,33,94,192],"group":[17,89],"IB":[18,90],"X":[20],"sPLA(2)s":[21,38,66,111,122,160,188],"expressed":[23,117],"the":[25,63,97,101,108,118,148,159,177,191,213,218],"lung,":[26],"we":[27],"examined":[28],"their":[29,50,58,76,206],"effects":[30],"on":[31],"primary":[32],"lung":[34,193],"macrophages":[35],"(HLM).":[36],"Both":[37],"induced":[39],"TNF-alpha":[40],"IL-6":[42,180],"release":[43],"a":[45,168,200],"concentration-dependent":[46],"manner":[47],"by":[48,131,182,197],"increasing":[49],"mRNA":[51,125],"expression.":[52],"This":[53],"effect":[54],"was":[55,73,161],"independent":[56,204],"of":[57,65,88,100,156,165,171,179,205,212],"enzymatic":[59,207],"activity":[60,142,208],"because":[61],"1)":[62],"capacity":[64],"to":[67,75,78,147],"mobilize":[68],"arachidonic":[69],"acid":[70],"from":[71],"HLM":[72,116,157,198,216],"unrelated":[74],"ability":[77],"induce":[79],"cytokine":[80,114,153,195,226],"production;":[81],"2)":[83],"two":[84,186],"catalytically":[85,109],"inactive":[86],"isoforms":[87],"sPLA(2)":[91,95,141],"(bromophenacyl":[92],"bromide-inactivated":[93],"H48Q":[98],"mutant":[99],"porcine":[102],"sPLA(2))":[103],"were":[104],"as":[105,107,129,143,145],"effective":[106],"active":[110],"inducing":[113],"production.":[115,154],"M-type":[119,149,219],"receptor":[120],"for":[121],"at":[123],"both":[124],"protein":[127],"levels,":[128],"determined":[130],"RT-PCR,":[132],"immunoblotting,":[133],"immunoprecipitation,":[134],"flow":[136],"cytometry.":[137],"Me-indoxam,":[138],"which":[139],"decreases":[140],"well":[144],"binding":[146],"receptor,":[150,220],"suppressed":[151],"sPLA(2)-induced":[152],"Incubation":[155],"with":[158,163],"associated":[162],"phosphorylation":[164],"ERK1/2,":[166],"specific":[169],"inhibitor":[170],"this":[172],"pathway,":[173],"PD98059,":[174],"significantly":[175],"reduced":[176],"production":[178,196,227],"elicited":[181],"sPLA(2)s.":[183],"In":[184],"conclusion,":[185],"distinct":[187],"produced":[189],"stimulate":[194],"via":[199],"mechanism":[201],"that":[202],"is":[203],"involves":[210],"activation":[211],"ERK1/2":[214],"pathway.":[215],"express":[217],"but":[221],"its":[222],"involvement":[223],"eliciting":[225],"deserves":[228],"further":[229],"investigation.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
