{"id":"https://openalex.org/W1891304457","doi":null,"title":"Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.","display_name":"Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W1891304457","mag":"1891304457","pmid":"https://pubmed.ncbi.nlm.nih.gov/10397243"},"language":"en","primary_location":{"id":"pmid:10397243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10397243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005383718","display_name":"Chuanshu Huang","orcid":"https://orcid.org/0000-0003-4133-5096","observed_orcids":["https://orcid.org/0000-0003-4133-5096"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Huang","raw_affiliation_strings":["The Hormel Institute, University of Minnesota, Austin 55912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hormel Institute, University of Minnesota, Austin 55912, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105522617","display_name":"W Y Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Y Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103175333","display_name":"Jingxia Li","orcid":"https://orcid.org/0000-0001-7909-5310","observed_orcids":["https://orcid.org/0000-0001-7909-5310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108748274","display_name":"Z Dong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.8145,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.97891242,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"13","first_page":"3053","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.15860000252723694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.10209999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic","display_name":"arsenic","score":0.9869999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/c-jun-nh2-terminal-kinase","display_name":"c-Jun NH2-terminal kinase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/jnk1","display_name":"JNK1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/p53-independent-pathway","display_name":"p53-independent pathway","score":0.8849999904632568},{"id":"https://openalex.org/keywords/p53-transactivation","display_name":"p53 transactivation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/jb6-cells","display_name":"JB6 cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7897025346755981},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7358869314193726},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.685356855392456},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6029338240623474},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.5791338086128235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5650922656059265},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49987173080444336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46401581168174744},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4447585940361023},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42799198627471924},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4142567813396454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39415794610977173},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.375916987657547},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3643048107624054},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27236878871917725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22919723391532898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2072264552116394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1778492033481598},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14920324087142944},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.04949641227722168},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10397243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10397243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.312.1061","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.312.1061","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/59/13/3053.full.pdf","raw_type":"text"},{"id":"mag:1891304457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10397243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2965793526","display_name":"MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTION","funder_award_id":"R29CA074916","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W12339002","https://openalex.org/W20902001","https://openalex.org/W192794212","https://openalex.org/W614157604","https://openalex.org/W1530284699","https://openalex.org/W1600706591","https://openalex.org/W1767150122","https://openalex.org/W1853068488","https://openalex.org/W1972305678","https://openalex.org/W1973769612","https://openalex.org/W1979319210","https://openalex.org/W1979595147","https://openalex.org/W1990232793","https://openalex.org/W1991701837","https://openalex.org/W1992630084","https://openalex.org/W1993358791","https://openalex.org/W2005542290","https://openalex.org/W2011823088","https://openalex.org/W2019872464","https://openalex.org/W2022297125","https://openalex.org/W2038939403","https://openalex.org/W2051562393","https://openalex.org/W2055349083","https://openalex.org/W2060836077","https://openalex.org/W2063580337","https://openalex.org/W2069148122","https://openalex.org/W2074114480","https://openalex.org/W2074169536","https://openalex.org/W2093294267","https://openalex.org/W2100964039","https://openalex.org/W2126679757","https://openalex.org/W2133935930","https://openalex.org/W2143047856","https://openalex.org/W2148200419","https://openalex.org/W2156211746","https://openalex.org/W2166185936","https://openalex.org/W2174418452","https://openalex.org/W2184391500","https://openalex.org/W2318612270","https://openalex.org/W2321676059","https://openalex.org/W2332935893","https://openalex.org/W2487425302"],"related_works":["https://openalex.org/W2022553472","https://openalex.org/W7095486578","https://openalex.org/W7099850847","https://openalex.org/W2045020804","https://openalex.org/W2374884302","https://openalex.org/W2809988456","https://openalex.org/W2073504917","https://openalex.org/W2172221058","https://openalex.org/W2061049714","https://openalex.org/W2060947663"],"abstract_inverted_index":{"Arsenic":[0],"has":[1],"been":[2],"used":[3],"as":[4,14],"an":[5],"effective":[6],"chemotherapy":[7],"agent":[8,140],"for":[9,37,141],"some":[10],"human":[11,118],"cancers,":[12],"such":[13],"acute":[15],"promyelocytic":[16],"leukemia.":[17],"In":[18,44,71],"this":[19],"study,":[20],"we":[21,46,132],"found":[22,47],"that":[23,48,90,108,134],"arsenic":[24,49,135],"induces":[25],"activation":[26,92],"of":[27,39,81,85,93,100,116,144],"c-Jun":[28],"NH2-terminal":[29],"kinases":[30],"(JNKs)":[31],"at":[32],"a":[33,82,138],"similar":[34],"dose":[35],"range":[36],"induction":[38,62],"apoptosis":[40,61,74,99],"in":[41,60,97,113],"JB6":[42,101],"cells.":[43,102],"addition,":[45],"did":[50],"not":[51],"induce":[52],"p53-dependent":[53],"transactivation.":[54],"Similarly,":[55],"there":[56],"was":[57,75],"no":[58],"difference":[59],"between":[63],"cells":[64,127],"with":[65,105,146],"p53":[66,69,109,147],"+/+":[67],"or":[68],"-/-.":[70],"contrast,":[72],"arsenic-induced":[73,98],"almost":[76],"totally":[77],"blocked":[78],"by":[79,129],"expression":[80],"dominant-negative":[83],"mutant":[84],"JNK1.":[86],"These":[87],"results":[88],"suggest":[89,133],"the":[91,142],"JNKs":[94],"is":[95],"involved":[96,112],"Taken":[103],"together":[104],"previous":[106],"findings":[107],"mutations":[110],"are":[111],"approximately":[114],"50%":[115],"all":[117,122],"cancers":[119,145],"and":[120],"nearly":[121],"chemotherapeutic":[123],"agents":[124],"kill":[125],"cancer":[126],"mainly":[128],"apoptotic":[130],"induction,":[131],"may":[136],"be":[137],"useful":[139],"treatment":[143],"mutation.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}