{"id":"https://openalex.org/W1890728356","doi":"https://doi.org/10.1002/pbc.25340","title":"Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: A report from the Children's Oncology Group","display_name":"Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: A report from the Children's Oncology Group","publication_year":2014,"publication_date":"2014-12-02","ids":{"openalex":"https://openalex.org/W1890728356","doi":"https://doi.org/10.1002/pbc.25340","mag":"1890728356","pmid":"https://pubmed.ncbi.nlm.nih.gov/25464386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4376595"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.25340","doi":"https://doi.org/10.1002/pbc.25340","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.25340","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4376595","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010315088","display_name":"Daniel M. Lerman","orcid":"https://orcid.org/0000-0001-8079-0791","observed_orcids":["https://orcid.org/0000-0001-8079-0791"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Lerman","raw_affiliation_strings":["Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","Department of Orthopedics, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]},{"raw_affiliation_string":"Department of Orthopedics, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071618470","display_name":"Michael J. Monument","orcid":"https://orcid.org/0000-0002-9517-8308","observed_orcids":["https://orcid.org/0000-0002-9517-8308"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Monument","raw_affiliation_strings":["Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","Department of Orthopedics, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]},{"raw_affiliation_string":"Department of Orthopedics, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065772957","display_name":"Elizabeth J. McIlvaine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth McIlvaine","raw_affiliation_strings":["University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109066747","display_name":"Xiao\u2010qiong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao\u2010qiong Liu","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070193992","display_name":"Dali Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dali Huang","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074195068","display_name":"Laura Monovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Monovich","raw_affiliation_strings":["Children's Oncology Group Biopathology Center, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Oncology Group Biopathology Center, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035948901","display_name":"Natalie Beeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Beeler","raw_affiliation_strings":["Children's Oncology Group Biopathology Center, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Oncology Group Biopathology Center, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032743242","display_name":"Richard Greg Gorlick","orcid":"https://orcid.org/0000-0001-8995-2929","observed_orcids":["https://orcid.org/0000-0001-8995-2929"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Gorlick","raw_affiliation_strings":["Department of Pediatrics, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, New York","institution_ids":["https://openalex.org/I1335289525","https://openalex.org/I4210135976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085873078","display_name":"Neyssa M. Marina","orcid":"https://orcid.org/0000-0002-7195-8887","observed_orcids":["https://orcid.org/0000-0002-7195-8887"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neyssa M. Marina","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Stanford University, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Stanford University, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081072468","display_name":"Richard B. Womer","orcid":"https://orcid.org/0000-0002-4405-1200","observed_orcids":["https://orcid.org/0000-0002-4405-1200"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Womer","raw_affiliation_strings":["Division of Oncology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027642211","display_name":"Julia A. Bridge","orcid":"https://orcid.org/0000-0001-7489-9213","observed_orcids":["https://orcid.org/0000-0001-7489-9213"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia A. Bridge","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090325707","display_name":"Mark Krailo","orcid":"https://orcid.org/0000-0002-7608-0698","observed_orcids":["https://orcid.org/0000-0002-7608-0698"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D. Krailo","raw_affiliation_strings":["University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055040715","display_name":"Robert Lor Randall","orcid":"https://orcid.org/0000-0002-3660-774X","observed_orcids":["https://orcid.org/0000-0002-3660-774X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Lor Randall","raw_affiliation_strings":["Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","Department of Orthopedics, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]},{"raw_affiliation_string":"Department of Orthopedics, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101617262","display_name":"Stephen L. Lessnick","orcid":"https://orcid.org/0000-0001-8705-4682","observed_orcids":["https://orcid.org/0000-0001-8705-4682"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen L. Lessnick","raw_affiliation_strings":["Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","Department of Orthopedics, University of Utah, Salt Lake City, Utah","Division of Pediatric Hematology/Oncology and the Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]},{"raw_affiliation_string":"Department of Orthopedics, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology and the Department of Oncological Sciences, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5101617262"],"corresponding_institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":2.9358,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.90528156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"62","issue":"5","first_page":"759","last_page":"765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cdkn2a-deletion","display_name":"CDKN2A deletion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/localized-disease","display_name":"localized disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.5569999814033508},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.951215386390686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7691887617111206},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5585800409317017},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.49010881781578064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48639705777168274},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.46298515796661377},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41944658756256104},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4133918285369873},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3431699872016907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2904210686683655},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29008862376213074},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20433634519577026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15552258491516113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13072407245635986}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/pbc.25340","doi":"https://doi.org/10.1002/pbc.25340","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.25340","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},{"id":"pmid:25464386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25464386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Clinical Trial"},{"id":"pmh:oai:europepmc.org:3817342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4376595","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4376595","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4376595","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7fv184pz","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7fv184pz","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric Blood & Cancer, vol 62, iss 5","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3817342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4376595","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2638068995","display_name":"EWS/FLI AND ITS TARGETS IN EWING'S SARCOMA","funder_award_id":"R01CA140394","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4379540926","display_name":"Children's Oncology Group Statistics and Data Center","funder_award_id":"U10CA180899","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5094520579","display_name":"COG NCTN Network Group Operations Center","funder_award_id":"U10CA180886","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G77358762","display_name":"Children's Oncology Group Chair's Grant","funder_award_id":"U10CA098543","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000895596","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320312218","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W192608075","https://openalex.org/W1965651835","https://openalex.org/W1967488943","https://openalex.org/W1970008001","https://openalex.org/W1976829673","https://openalex.org/W1979767024","https://openalex.org/W1999330214","https://openalex.org/W2009113301","https://openalex.org/W2017678147","https://openalex.org/W2024482562","https://openalex.org/W2025989401","https://openalex.org/W2026853588","https://openalex.org/W2029578553","https://openalex.org/W2036463815","https://openalex.org/W2055280366","https://openalex.org/W2060387821","https://openalex.org/W2061474729","https://openalex.org/W2066056292","https://openalex.org/W2066848701","https://openalex.org/W2067708781","https://openalex.org/W2068402552","https://openalex.org/W2069351898","https://openalex.org/W2077033536","https://openalex.org/W2084891010","https://openalex.org/W2087404852","https://openalex.org/W2091151265","https://openalex.org/W2096113686","https://openalex.org/W2097489065","https://openalex.org/W2099907467","https://openalex.org/W2113168035","https://openalex.org/W2115581335","https://openalex.org/W2125547572","https://openalex.org/W2126563069","https://openalex.org/W2128628566","https://openalex.org/W2136182072","https://openalex.org/W2136422121","https://openalex.org/W2142256144","https://openalex.org/W2151526351","https://openalex.org/W2152190525","https://openalex.org/W2164263233","https://openalex.org/W2170407716","https://openalex.org/W2171223526","https://openalex.org/W2314097426","https://openalex.org/W2324307412","https://openalex.org/W2325098089","https://openalex.org/W2414340841","https://openalex.org/W2417778380","https://openalex.org/W2977606681","https://openalex.org/W4231148876"],"related_works":["https://openalex.org/W4415826647","https://openalex.org/W4408391946","https://openalex.org/W4416053864","https://openalex.org/W1994568630","https://openalex.org/W4399605487","https://openalex.org/W2908461496","https://openalex.org/W4416411992","https://openalex.org/W7151494229","https://openalex.org/W1979767024","https://openalex.org/W7166863478"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"growing":[2],"collection":[3],"of":[4,58,67,86,99,126],"retrospective":[5,154],"studies":[6,155],"have":[7,15,93,112],"suggested":[8],"that":[9],"TP53":[10,68,94,129,159],"mutations":[11,69,96,130],"and/or":[12,131,161],"CDKN2A":[13,75,105,132,162],"deletions":[14,133],"prognostic":[16,167],"significance":[17],"in":[18,27,81,115,123,169],"Ewing":[19,171],"sarcoma.":[20,172],"We":[21],"sought":[22],"to":[23,63,92,111,135],"evaluate":[24],"these":[25],"variables":[26],"patients":[28,45,127,136],"with":[29,128,137],"localized":[30,170],"disease":[31],"treated":[32],"prospectively":[33],"on":[34,47],"a":[35],"single":[36],"Children's":[37,48],"Oncology":[38,49],"Group":[39,50],"protocol.":[40],"PROCEDURE:":[41],"Of":[42],"the":[43],"568":[44],"enrolled":[46],"protocol":[51],"AEWS0031":[52],"(NCT00006734),":[53],"112":[54],"had":[55],"tumor":[56],"specimens":[57],"sufficient":[59],"quality":[60],"and":[61,74,97],"quantity":[62],"allow":[64],"for":[65],"analysis":[66],"status":[70],"by":[71,77,144],"DNA":[72],"sequencing,":[73],"deletion":[76,163],"dual":[78],"color":[79],"fluorescent":[80],"situ":[82],"hybridization.":[83],"RESULTS:":[84],"Eight":[85],"93":[87],"cases":[88,101,108],"(8.6%)":[89],"were":[90,109],"found":[91,110],"point":[95],"12":[98],"107":[100],"(11.2%)":[102],"demonstrated":[103,143],"homozygous":[104],"deletion.":[106],"Two":[107],"an":[113],"alteration":[114],"both":[116],"genes.":[117],"There":[118],"was":[119],"no":[120],"significant":[121],"difference":[122],"event-free":[124],"survival":[125],"compared":[134],"normal":[138],"TP53/CDKN2A":[139],"gene":[140],"status,":[141],"as":[142],"log":[145],"rank":[146],"test":[147],"(p":[148],"=":[149],"0.58).":[150],"CONCLUSIONS:":[151],"Although":[152],"previous":[153],"suggest":[156],"their":[157],"significance,":[158],"mutation":[160],"are":[164],"not":[165],"reliable":[166],"biomarkers":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}