{"id":"https://openalex.org/W189028045","doi":null,"title":"Lymphocyte DNA damage in rats challenged with a single bout of strenuous exercise.","display_name":"Lymphocyte DNA damage in rats challenged with a single bout of strenuous exercise.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W189028045","mag":"189028045","pmid":"https://pubmed.ncbi.nlm.nih.gov/17242495"},"language":"en","primary_location":{"id":"pmid:17242495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086458513","display_name":"Tomasz Henryk Wierzba","orcid":"https://orcid.org/0000-0003-4146-0487","observed_orcids":["https://orcid.org/0000-0003-4146-0487"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"T H Wierzba","raw_affiliation_strings":["Department of Physiology, Medical University of Gdansk, Gdansk, Poland. twierzba@amg.gda.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical University of Gdansk, Gdansk, Poland. twierzba@amg.gda.pl","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013495721","display_name":"Robert Antoni Olek","orcid":"https://orcid.org/0000-0002-3714-7386","observed_orcids":["https://orcid.org/0000-0002-3714-7386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Olek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038105619","display_name":"Donatella Fedeli","orcid":"https://orcid.org/0000-0002-3260-5288","observed_orcids":["https://orcid.org/0000-0002-3260-5288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Fedeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036414871","display_name":"Giancarlo Falcioni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Falcioni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1384,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7513615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"57 Suppl 10","issue":null,"first_page":"115","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphocyte-dna-damage","display_name":"lymphocyte DNA damage","score":0.8669999837875366},{"id":"https://openalex.org/keywords/single-bout-exercise","display_name":"single bout exercise","score":0.6610000133514404},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.734000027179718},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tempol","display_name":"tempol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/superoxide-dismutase-mimics","display_name":"superoxide dismutase mimetic","score":0.8500000238418579},{"id":"https://openalex.org/keywords/submaximal-running","display_name":"submaximal running","score":0.7020000219345093},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.7477121949195862},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7192270755767822},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7108782529830933},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7000396251678467},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6819638609886169},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6220558285713196},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5751191973686218},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5179547071456909},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5107941627502441},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.506367564201355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4390966296195984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35201403498649597},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3479984998703003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22364899516105652}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003497","descriptor_name":"Cyclic N-Oxides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053960","descriptor_name":"DNA Breaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:17242495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubblicazioni.unicam.it:11581/115834","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11581/115834","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:189028045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2027725425","https://openalex.org/W2167992089","https://openalex.org/W1968529406","https://openalex.org/W7061682378","https://openalex.org/W2325007983","https://openalex.org/W23678437","https://openalex.org/W140576477","https://openalex.org/W1848526864","https://openalex.org/W2044157989","https://openalex.org/W2062585797"],"abstract_inverted_index":{"Exercise":[0],"induces":[1],"extensive":[2],"generation":[3],"of":[4,31,52,56,102],"reactive":[5],"oxygen":[6],"species,":[7],"which":[8],"are":[9],"responsible":[10],"for":[11],"tissue":[12],"damage:":[13],"enzymes":[14,32],"inactivation,":[15],"lipid":[16],"peroxidation":[17],"and":[18,40,66],"single":[19,54],"strand":[20,64,107],"breaks":[21,65,108],"in":[22,109,141],"DNA.":[23],"Defense":[24],"system":[25],"against":[26],"free":[27],"radicals":[28],"is":[29],"consisting":[30],"such":[33],"as":[34],"superoxide":[35],"dismutase,":[36],"catalase,":[37],"glutathione":[38],"peroxidase,":[39],"numerous":[41],"non-enzymatic":[42],"antioxidants.":[43],"The":[44,105],"study":[45],"was":[46],"performed":[47],"to":[48,68,100,136],"evaluate":[49],"the":[50,61,81,132,155],"effect":[51],"a":[53,75,116],"bout":[55],"submaximal":[57],"running":[58,94],"exercise,":[59],"on":[60,95],"lymphocyte":[62,126],"DNA":[63,106,127,152],"also":[67],"test":[69],"how":[70],"supplementation":[71],"with":[72,90,144],"tempol":[73,147],"-":[74,120],"membrane-permeable":[76],"SOD-mimetic":[77],"(0.2":[78],"mmol/kg/day)":[79],"influences":[80],"eventually":[82],"evoked":[83],"damage.":[84],"Male,":[85],"Wistar":[86],"rats":[87,142],"were":[88,112],"challenged":[89,143],"graded":[91],"50":[92],"min.":[93,130],"treadmill":[96],"at":[97],"intensity":[98],"up":[99],"75-85%":[101],"predicted":[103],"VO(2)max.":[104],"individual":[110],"lymphocytes":[111],"determined":[113],"by":[114,148],"using":[115],"gel":[117],"electrophoretic":[118],"technique":[119],"\"comet\"":[121],"assay.":[122],"We":[123],"found":[124],"substantial":[125],"damage":[128,140,153],"60":[129],"after":[131],"exercise.":[133,145],"Tempol":[134],"failed":[135],"prevent":[137],"from":[138],"oxidative":[139],"Moreover":[146],"itself":[149],"induced":[150],"higher":[151],"than":[154],"exercise":[156],"bout.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
