{"id":"https://openalex.org/W1889176404","doi":"https://doi.org/10.1371/journal.ppat.1005063","title":"An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression","display_name":"An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression","publication_year":2015,"publication_date":"2015-07-30","ids":{"openalex":"https://openalex.org/W1889176404","doi":"https://doi.org/10.1371/journal.ppat.1005063","mag":"1889176404","pmid":"https://pubmed.ncbi.nlm.nih.gov/26225566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4520688"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1005063","doi":"https://doi.org/10.1371/journal.ppat.1005063","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005063","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005063&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005063&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022228517","display_name":"Gilles Darcis","orcid":"https://orcid.org/0000-0001-8192-1351","observed_orcids":["https://orcid.org/0000-0001-8192-1351"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Gilles Darcis","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium; Service des Maladies Infectieuses, Universit\u00e9 de Li\u00e8ge, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium","Service des Maladies Infectieuses, Universit\u00e9 de Li\u00e8ge, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium","Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium; Service des Maladies Infectieuses, Universit\u00e9 de Li\u00e8ge, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I157674565","https://openalex.org/I4210134544"]},{"raw_affiliation_string":"Service des Maladies Infectieuses, Universit\u00e9 de Li\u00e8ge, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]},{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101660501","display_name":"Anna Kula","orcid":"https://orcid.org/0000-0001-8404-2176","observed_orcids":["https://orcid.org/0000-0001-8404-2176"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anna Kula","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013301212","display_name":"Sophie Bouchat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sophie Bouchat","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026093084","display_name":"Koh Fujinaga","orcid":"https://orcid.org/0000-0003-4242-9078","observed_orcids":["https://orcid.org/0000-0003-4242-9078"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koh Fujinaga","raw_affiliation_strings":["Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006080143","display_name":"Francis Corazza","orcid":"https://orcid.org/0000-0001-9487-2712","observed_orcids":["https://orcid.org/0000-0001-9487-2712"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210102955","display_name":"Centre Hospitalier Universitaire Brugmann","ror":"https://ror.org/011apjk30","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210102955"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Francis Corazza","raw_affiliation_strings":["Laboratory of Immunology, Brugmann University Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Brugmann University Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210102955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009164410","display_name":"Amina A\u00eft-Ammar","orcid":"https://orcid.org/0000-0001-6862-0597","observed_orcids":["https://orcid.org/0000-0001-6862-0597"]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amina Ait-Ammar","raw_affiliation_strings":["Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014177138","display_name":"Nad\u00e8ge Delacourt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nad\u00e8ge Delacourt","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102963928","display_name":"Adeline M\u00e9lard","orcid":"https://orcid.org/0000-0003-1207-0201","observed_orcids":["https://orcid.org/0000-0003-1207-0201"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Adeline Melard","raw_affiliation_strings":["Service de Virologie, Universit\u00e9 Paris-Descartes, AP-HP, H\u00f4pital Necker-Enfants Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Virologie, Universit\u00e9 Paris-Descartes, AP-HP, H\u00f4pital Necker-Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080832138","display_name":"Kabamba Kabeya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kabamba Kabeya","raw_affiliation_strings":["Service des Maladies Infectieuses, CHU St-Pierre, ULB, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses, CHU St-Pierre, ULB, Bruxelles, Belgium","institution_ids":["https://openalex.org/I4210154425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112474211","display_name":"Caroline Vanhulle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Caroline Vanhulle","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041418222","display_name":"Beno\u00eet Van Driessche","orcid":"https://orcid.org/0000-0001-7051-5761","observed_orcids":["https://orcid.org/0000-0001-7051-5761"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Benoit Van Driessche","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005471754","display_name":"Jean\u2010St\u00e9phane Gatot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-St\u00e9phane Gatot","raw_affiliation_strings":["Service de G\u00e9n\u00e9tique, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de G\u00e9n\u00e9tique, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035701190","display_name":"Thomas Cherrier","orcid":"https://orcid.org/0000-0002-0707-9204","observed_orcids":["https://orcid.org/0000-0002-0707-9204"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Cherrier","raw_affiliation_strings":["IGBMC (Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire), Illkirch-Graffenstaden, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IGBMC (Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire), Illkirch-Graffenstaden, France","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060959306","display_name":"Luiz Francisco Pianowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luiz F. Pianowski","raw_affiliation_strings":["Kyolab, Rua Isaura Ap. Oliviera Barbosa Terini, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyolab, Rua Isaura Ap. Oliviera Barbosa Terini, Sao Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067136189","display_name":"L\u00facio Gama","orcid":"https://orcid.org/0000-0001-9511-012X","observed_orcids":["https://orcid.org/0000-0001-9511-012X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucio Gama","raw_affiliation_strings":["Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012915002","display_name":"Christian Schwartz","orcid":"https://orcid.org/0000-0002-7084-268X","observed_orcids":["https://orcid.org/0000-0002-7084-268X"]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Schwartz","raw_affiliation_strings":["Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105125143","display_name":"Jorge Vila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jorge Vila","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113457972","display_name":"Ars\u00e8ne Burny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ars\u00e8ne Burny","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109329435","display_name":"Nathan Clumeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nathan Clumeck","raw_affiliation_strings":["Service des Maladies Infectieuses, CHU St-Pierre, ULB, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses, CHU St-Pierre, ULB, Bruxelles, Belgium","institution_ids":["https://openalex.org/I4210154425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036459628","display_name":"Michel P. Moutschen","orcid":"https://orcid.org/0000-0002-6405-1785","observed_orcids":["https://orcid.org/0000-0002-6405-1785"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Michel Moutschen","raw_affiliation_strings":["Service des Maladies Infectieuses, Universit\u00e9 de Li\u00e8ge, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses, Universit\u00e9 de Li\u00e8ge, Centre Hospitalier Universitaire (CHU) de Li\u00e8ge, Domaine Universitaire du Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842158","display_name":"St\u00e9phane De Wit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"St\u00e9phane De Wit","raw_affiliation_strings":["Service des Maladies Infectieuses, CHU St-Pierre, ULB, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses, CHU St-Pierre, ULB, Bruxelles, Belgium","institution_ids":["https://openalex.org/I4210154425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070916977","display_name":"Boris Matija Peterlin","orcid":"https://orcid.org/0000-0003-3692-219X","observed_orcids":["https://orcid.org/0000-0003-3692-219X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Matija Peterlin","raw_affiliation_strings":["Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838912","display_name":"Christine Rouzioux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Rouzioux","raw_affiliation_strings":["Service de Virologie, Universit\u00e9 Paris-Descartes, AP-HP, H\u00f4pital Necker-Enfants Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Virologie, Universit\u00e9 Paris-Descartes, AP-HP, H\u00f4pital Necker-Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083249607","display_name":"Olivier Rohr","orcid":"https://orcid.org/0000-0001-8992-2025","observed_orcids":["https://orcid.org/0000-0001-8992-2025"]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Rohr","raw_affiliation_strings":["Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France; Institut de Parasitologie et de Pathologie Tropicale, EA7292, University of Strasbourg, University of Strasbourg, Strasbourg, France","Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France","Institut de Parasitologie et de Pathologie Tropicale, EA7292, University of Strasbourg, University of Strasbourg, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France; Institut de Parasitologie et de Pathologie Tropicale, EA7292, University of Strasbourg, University of Strasbourg, Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]},{"raw_affiliation_string":"Institut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Schiltigheim, France","institution_ids":["https://openalex.org/I68947357"]},{"raw_affiliation_string":"Institut de Parasitologie et de Pathologie Tropicale, EA7292, University of Strasbourg, University of Strasbourg, Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060863599","display_name":"Carine M. Van Lint","orcid":"https://orcid.org/0000-0002-2219-2862","observed_orcids":["https://orcid.org/0000-0002-2219-2862"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Carine Van Lint","raw_affiliation_strings":["Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Molecular Virology, Institut de Biologie et de M\u00e9decine Mol\u00e9culaires (IBMM), Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5060863599"],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":16.7998,"has_fulltext":true,"cited_by_count":290,"citation_normalized_percentile":{"value":0.99486521,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"7","first_page":"e1005063","last_page":"e1005063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latency-reversing-agents","display_name":"latency-reversing agents","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bryostatin-1","display_name":"bryostatin 1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/p-tefb","display_name":"P-TEFb","score":0.8899999856948853},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-kinase-c-agonists","display_name":"protein kinase C agonists","score":0.9670000076293945},{"id":"https://openalex.org/keywords/prostratin","display_name":"prostratin","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hexamethylene-bisacetamide","display_name":"hexamethylene bisacetamide","score":0.890999972820282},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.4880000054836273},{"id":"https://openalex.org/keywords/hiv-1-reservoir","display_name":"HIV-1 reservoir","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7149999737739563},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7420606017112732},{"id":"https://openalex.org/C2777841055","wikidata":"https://www.wikidata.org/wiki/Q15314917","display_name":"P-TEFb","level":5,"score":0.6657830476760864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5566965937614441},{"id":"https://openalex.org/C2910806222","wikidata":"https://www.wikidata.org/wiki/Q4981136","display_name":"Bryostatin 1","level":4,"score":0.5505757331848145},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.5393625497817993},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.4783696234226227},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.4125063419342041},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4021841287612915},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.37698614597320557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3341562747955322},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.3328391909599304},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3206349313259125},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3179618716239929},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18603411316871643},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.18177539110183716},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16846930980682373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16285067796707153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09232029318809509},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.08672523498535156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042925","descriptor_name":"Positive Transcriptional Elongation Factor B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054713","descriptor_name":"Bryostatins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":13,"locations":[{"id":"doi:10.1371/journal.ppat.1005063","doi":"https://doi.org/10.1371/journal.ppat.1005063","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005063","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005063&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3505715","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4520688","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26225566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26225566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:4520688","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4520688/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.775.9518","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.775.9518","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/37/ppat.1005063.PMC4520688.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-02268448v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02268448","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2015, 11 (7), pp.e1005063. ⟨10.1371/journal.ppat.1005063⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/205174","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/205174","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS pathogens, 11 (7","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:46911b3af13e4e1dbee7dd349246f43b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/46911b3af13e4e1dbee7dd349246f43b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 11, Iss 7, p e1005063 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1498922","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/An_In_Depth_Comparison_of_Latency_Reversing_Agent_Combinations_in_Various_In_Vitro_and_Ex_Vivo_HIV_1_Latency_Models_Identified_Bryostatin_1_JQ1_and_Ingenol_B_JQ1_to_Potently_Reactivate_Viral_Gene_Expression/1498922","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/185859","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/185859","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 11 (7), e1005063 (2015)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:univoak.eu:islandora_55321","doi":null,"is_oa":true,"landing_page_url":"https://univoak.eu/islandora/object/islandora%3A55321","pdf_url":null,"source":{"id":"https://openalex.org/S4306402449","display_name":"univOAK (4 institutions : Universit\u00e9 de Strasbourg, Universit\u00e9 de Haute Alsace, INSA Strasbourg, Biblioth\u00e8que Nationale et Universitaire de Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100283","host_organization_name":"Laboratoire des Sciences de l'Ing\u00e9nieur, de l'Informatique et de l'Imagerie","host_organization_lineage":["https://openalex.org/I4210100283"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:univoak.eu:islandora_61052","doi":null,"is_oa":true,"landing_page_url":"https://univoak.eu/islandora/object/islandora%3A61052","pdf_url":null,"source":{"id":"https://openalex.org/S4306402449","display_name":"univOAK (4 institutions : Universit\u00e9 de Strasbourg, Universit\u00e9 de Haute Alsace, INSA Strasbourg, Biblioth\u00e8que Nationale et Universitaire de Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100283","host_organization_name":"Laboratoire des Sciences de l'Ing\u00e9nieur, de l'Informatique et de l'Imagerie","host_organization_lineage":["https://openalex.org/I4210100283"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:univoak.eu:islandora_79837","doi":null,"is_oa":false,"landing_page_url":"https://univoak.eu/islandora/object/islandora%3A79837","pdf_url":null,"source":{"id":"https://openalex.org/S4306402449","display_name":"univOAK (4 institutions : Universit\u00e9 de Strasbourg, Universit\u00e9 de Haute Alsace, INSA Strasbourg, Biblioth\u00e8que Nationale et Universitaire de Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100283","host_organization_name":"Laboratoire des Sciences de l'Ing\u00e9nieur, de l'Informatique et de l'Imagerie","host_organization_lineage":["https://openalex.org/I4210100283"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1005063","doi":"https://doi.org/10.1371/journal.ppat.1005063","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005063","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005063&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6714156533","display_name":null,"funder_award_id":"HIV-1","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320317836","display_name":"Les Amis des Instituts Pasteur \u00e0 Bruxelles","ror":"https://ror.org/026wyqd33"},{"id":"https://openalex.org/F4320318621","display_name":"Waalse Gewest","ror":null},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320322893","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266"},{"id":"https://openalex.org/F4320323739","display_name":"Koning Boudewijnstichting","ror":"https://ror.org/02am44w88"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1889176404.pdf","grobid_xml":"https://content.openalex.org/works/W1889176404.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1549854676","https://openalex.org/W1582968384","https://openalex.org/W1878746864","https://openalex.org/W1964173449","https://openalex.org/W1966066354","https://openalex.org/W1967760633","https://openalex.org/W1974488636","https://openalex.org/W1980528204","https://openalex.org/W1980861325","https://openalex.org/W1982316892","https://openalex.org/W1982884889","https://openalex.org/W1983498205","https://openalex.org/W1991342850","https://openalex.org/W1994817306","https://openalex.org/W1999301226","https://openalex.org/W1999871051","https://openalex.org/W2004040286","https://openalex.org/W2006758510","https://openalex.org/W2011261958","https://openalex.org/W2013851631","https://openalex.org/W2014017310","https://openalex.org/W2015266566","https://openalex.org/W2020695410","https://openalex.org/W2026814484","https://openalex.org/W2028613789","https://openalex.org/W2033997792","https://openalex.org/W2038598840","https://openalex.org/W2047127491","https://openalex.org/W2048929371","https://openalex.org/W2051122335","https://openalex.org/W2055796578","https://openalex.org/W2061510891","https://openalex.org/W2074447021","https://openalex.org/W2075106941","https://openalex.org/W2077050840","https://openalex.org/W2078681578","https://openalex.org/W2081064241","https://openalex.org/W2082853636","https://openalex.org/W2083880346","https://openalex.org/W2084076352","https://openalex.org/W2089844574","https://openalex.org/W2090238266","https://openalex.org/W2091794992","https://openalex.org/W2094654932","https://openalex.org/W2100335940","https://openalex.org/W2100859269","https://openalex.org/W2103409409","https://openalex.org/W2111707367","https://openalex.org/W2114312013","https://openalex.org/W2114538357","https://openalex.org/W2115580899","https://openalex.org/W2115630982","https://openalex.org/W2116532772","https://openalex.org/W2117785982","https://openalex.org/W2120488252","https://openalex.org/W2122660117","https://openalex.org/W2124114936","https://openalex.org/W2124268946","https://openalex.org/W2127467277","https://openalex.org/W2128009957","https://openalex.org/W2130651313","https://openalex.org/W2132456440","https://openalex.org/W2137581249","https://openalex.org/W2140681504","https://openalex.org/W2140683149","https://openalex.org/W2143339498","https://openalex.org/W2145848202","https://openalex.org/W2147447587","https://openalex.org/W2149236270","https://openalex.org/W2150469988","https://openalex.org/W2151980311","https://openalex.org/W2157138119","https://openalex.org/W2160076049","https://openalex.org/W2168127928","https://openalex.org/W2332747917","https://openalex.org/W2793229524"],"related_works":["https://openalex.org/W7101044033","https://openalex.org/W2147447587","https://openalex.org/W2566550820","https://openalex.org/W4240851181","https://openalex.org/W3033442029","https://openalex.org/W2622181489","https://openalex.org/W1974488636","https://openalex.org/W2122952147","https://openalex.org/W3136278721","https://openalex.org/W3207834414"],"abstract_inverted_index":{"The":[0,246],"persistence":[1],"of":[2,29,72,117,145,162,179,191,215,249,266,281,285,295],"latently":[3,34],"infected":[4,35],"cells":[5,36,219],"in":[6,33,55,97,109,175,211],"patients":[7,187],"under":[8],"combinatory":[9,195],"antiretroviral":[10],"therapy":[11],"(cART)":[12],"is":[13,37],"a":[14,56,271,276,288],"major":[15],"hurdle":[16],"to":[17,21,51,85,142,159,200,235,238,291],"HIV-1":[18,111,146,298],"eradication.":[19],"Strategies":[20],"purge":[22],"these":[23,250],"reservoirs":[24],"are":[25,48,83],"needed":[26],"and":[27,42,80,103,119,127,137,152,164,230,274],"activation":[28,144],"viral":[30,150],"gene":[31],"expression":[32,147],"one":[38],"promising":[39],"strategy.":[40],"Bromodomain":[41],"Extraterminal":[43],"(BET)":[44],"bromodomain":[45],"inhibitors":[46],"(BETi)":[47],"compounds":[49],"able":[50],"reactivate":[52],"latent":[53,297],"proviruses":[54],"positive":[57,207,243],"transcription":[58],"elongation":[59],"factor":[60],"b":[61],"(P-TEFb)-dependent":[62],"manner.":[63],"In":[64],"this":[65],"study,":[66],"we":[67,122,173],"tested":[68],"the":[69,149,167,189,201,227,242,263,279,293,296],"reactivation":[70],"potential":[71,289],"protein":[73,153],"kinase":[74],"C":[75],"(PKC)":[76],"agonists":[77,126],"(prostratin,":[78],"bryostatin-1":[79],"ingenol-B),":[81],"which":[82],"known":[84],"activate":[86],"NF-\u03baB":[87,165],"signaling":[88],"pathway":[89],"as":[90,92,132,287],"well":[91],"P-TEFb,":[93],"used":[94],"alone":[95,130],"or":[96],"combination":[98,252],"with":[99,204,241],"P-TEFb-releasing":[100,128],"agents":[101,129,135],"(HMBA":[102],"BETi":[104],"(JQ1,":[105],"I-BET,":[106],"I-BET151)).":[107],"Using":[108],"vitro":[110],"post-integration":[112],"latency":[113],"model":[114],"cell":[115],"lines":[116],"T-lymphoid":[118],"myeloid":[120],"lineages,":[121],"demonstrated":[123],"that":[124,138,188,239],"PKC":[125],"acted":[131],"potent":[133,247,272],"latency-reversing":[134],"(LRAs)":[136],"their":[139],"combinations":[140,228,268],"led":[141,158],"synergistic":[143],"at":[148],"mRNA":[151],"levels.":[154],"Mechanistically,":[155],"combined":[156],"treatments":[157,253],"higher":[160],"activations":[161],"P-TEFb":[163],"than":[166],"corresponding":[168],"individual":[169],"drug":[170],"treatments.":[171],"Importantly,":[172],"observed":[174,203],"ex":[176,212],"vivo":[177,213],"cultures":[178,193,214],"CD8+-depleted":[180],"PBMCs":[181],"from":[182,221],"35":[183],"cART-treated":[184,224],"HIV-1+":[185,223],"aviremic":[186,225],"percentage":[190,202],"reactivated":[192],"following":[194],"bryostatin-1+JQ1":[196,229],"treatment":[197],"was":[198],"identical":[199],"anti-CD3+anti-CD28":[205],"antibodies":[206],"control":[208,244],"stimulation.":[209,245],"Remarkably,":[210],"resting":[216],"CD4+":[217],"T":[218],"isolated":[220],"15":[222],"patients,":[226],"ingenol-B+JQ1":[231],"released":[232],"infectious":[233],"viruses":[234],"levels":[236],"similar":[237],"obtained":[240],"effects":[248],"two":[251,282],"were":[254],"already":[255],"detected":[256],"24":[257],"hours":[258],"post-stimulation.":[259],"These":[260],"results":[261],"constitute":[262],"first":[264],"demonstration":[265],"LRA":[267],"exhibiting":[269],"such":[270],"effect":[273],"represent":[275],"proof-of-concept":[277],"for":[278],"co-administration":[280],"different":[283],"types":[284],"LRAs":[286],"strategy":[290],"reduce":[292],"size":[294],"reservoirs.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":43},{"year":2015,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}