{"id":"https://openalex.org/W1887859818","doi":"https://doi.org/10.1016/s1054-3589(08)60731-0","title":"Single Photon Emission Computed Tomography Imaging of Dopaminergic Function: Presynaptic Transporter, Postsynaptic Receptor, and \u201cIntrasynaptic\u201d Transmitter","display_name":"Single Photon Emission Computed Tomography Imaging of Dopaminergic Function: Presynaptic Transporter, Postsynaptic Receptor, and \u201cIntrasynaptic\u201d Transmitter","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1887859818","doi":"https://doi.org/10.1016/s1054-3589(08)60731-0","mag":"1887859818","pmid":"https://pubmed.ncbi.nlm.nih.gov/9327882"},"language":"en","primary_location":{"id":"doi:10.1016/s1054-3589(08)60731-0","doi":"https://doi.org/10.1016/s1054-3589(08)60731-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1054-3589(08)60731-0","pdf_url":null,"source":{"id":"https://openalex.org/S2764403048","display_name":"Advances in pharmacology","issn_l":"1054-3589","issn":["1054-3589","1557-8925"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4253836996","display_name":null},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s1054-3589(08)60731-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079125204","display_name":"Robert B. Innis","orcid":"https://orcid.org/0000-0003-1238-7209","observed_orcids":["https://orcid.org/0000-0003-1238-7209"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R B Innis","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079125204"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":1.3586,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78087649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":null,"first_page":"215","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.3662000000476837,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.13920000195503235,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.5410000085830688},{"id":"https://openalex.org/keywords/123i-beta-cit","display_name":"[123I]beta-CIT","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.765999972820282},{"id":"https://openalex.org/keywords/123i-ibzm","display_name":"[123I]IBZM","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.6069999933242798},{"id":"https://openalex.org/keywords/amphetamine-challenge","display_name":"amphetamine challenge","score":0.8949999809265137},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.777999997138977},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7770000100135803},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.7419999837875366},{"id":"https://openalex.org/keywords/neuroreceptor-imaging","display_name":"neuroreceptor imaging","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6661427021026611},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5808905363082886},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5051327347755432},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.44005799293518066},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36017516255378723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2294788956642151},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.211170494556427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15440523624420166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13094326853752136},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0919751226902008}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1054-3589(08)60731-0","doi":"https://doi.org/10.1016/s1054-3589(08)60731-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1054-3589(08)60731-0","pdf_url":null,"source":{"id":"https://openalex.org/S2764403048","display_name":"Advances in pharmacology","issn_l":"1054-3589","issn":["1054-3589","1557-8925"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Pharmacology","raw_type":"book-chapter"},{"id":"pmid:9327882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9327882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in pharmacology (San Diego, Calif.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1054-3589(08)60731-0","doi":"https://doi.org/10.1016/s1054-3589(08)60731-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1054-3589(08)60731-0","pdf_url":null,"source":{"id":"https://openalex.org/S2764403048","display_name":"Advances in pharmacology","issn_l":"1054-3589","issn":["1054-3589","1557-8925"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Pharmacology","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1993253047","https://openalex.org/W1996327177","https://openalex.org/W2007510516","https://openalex.org/W2058691511","https://openalex.org/W2411550141"],"related_works":["https://openalex.org/W2046816122","https://openalex.org/W2046432427","https://openalex.org/W1969967069","https://openalex.org/W2030970694","https://openalex.org/W2411550141","https://openalex.org/W2086514194","https://openalex.org/W19616920","https://openalex.org/W2398747235","https://openalex.org/W2110626227","https://openalex.org/W2020619932"],"abstract_inverted_index":{"Publisher":[0],"Summary":[1],"A":[4,189],"promising":[5],"single":[6],"photon":[7],"emission":[8],"computed":[9],"tomography":[10],"(SPECT)":[11],"radiotracer\u2014[":[12],"123":[13,68,201,227],"I]":[14,69],"\u03b2":[15,18,20,70],"-CIT":[16],"(2":[17],"-carbomethoxy-3":[19],"-(4-iodophenyl)":[21],"tropane\u2014have":[22],"been":[23,184],"developed":[24],"that":[25,56],"labels":[26],"DA":[27,37,169,237],"transporters":[28],"(DATs),":[29],"which":[30,72,158],"are":[31],"located":[32],"on":[33],"the":[34,41,45,54,94,105,114,125,137,143,150,180,197,214,222],"terminals":[35],"of":[36,93,117,129,142,149,163,179,196,213,224,250],"neuronal":[38],"projections":[39],"from":[40],"substantia":[42],"nigra":[43],"to":[44,77,88,103,110,134,205,234,245],"striatum.":[46,95],"Thus,":[47],"this":[48],"tracer":[49],"is":[50,75,159],"a":[51,79,82,130,140,207],"marker":[52],"for":[53,210],"neurons":[55],"degenerate":[57],"in":[58,113,136,152,167,174,186],"Parkinson's":[59],"disease":[60],"(PD).":[61],"This":[62,122],"chapter":[63,123],"reviews":[64,124],"studies":[65,173,220],"with":[66,176],"[":[67,200,226],"-CIT,":[71],"suggest":[73],"it":[74],"likely":[76],"be":[78,99],"useful":[80],"as":[81],"research":[83],"and":[84,127,148,231,244],"potential":[85,146],"clinical":[86],"imaging":[87,97,178,233],"measure":[89,141,162,235],"dopaminergic":[90],"terminal":[91],"innervation":[92],"Neuroreceptor":[96],"can":[98],"used":[100,204],"not":[101],"only":[102],"quantify":[104],"target":[106],"receptor,":[107],"but":[108],"also":[109],"assess":[111],"changes":[112],"synaptic":[115,168],"concentration":[116],"neurotransmitter":[118],"following":[119],"pharmacological":[120],"challenges.":[121],"development":[126],"validation":[128],"SPECT":[131,177,232],"paradigm":[132],"designed":[133],"provide,":[135],"same":[138],"experiment,":[139],"baseline":[144,209],"D2-binding":[145],"(BP)":[147],"reduction":[151],"D2":[153,181],"BP":[154],"induced":[155],"by":[156],"amphetamine,":[157],"an":[160,164],"indirect":[161],"amphetamine-induced":[165],"increase":[166],"concentration.":[170],"D-Amphetamine":[171],"challenge":[172,243],"conjunction":[175],"receptor":[182],"have":[183],"performed":[185],"human":[187],"subjects.":[188],"bolus":[190],"plus":[191],"constant":[192],"infusion":[193,230],"administration":[194],"schedule":[195],"D2-receptor":[198],"radiotracer":[199],"I]IBZM":[202,228],"was":[203],"obtain":[206],"stable":[208],"reliable":[211],"quantitation":[212],"d":[216,241],"-amphetamine":[217,242],"effect.":[218],"These":[219],"show":[221],"feasibility":[223],"using":[225],"programmed":[229],"endogenous":[236],"release":[238],"after":[239],"study":[246],"brain":[247],"neurochemical":[248],"correlates":[249],"emotions.":[251]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
