{"id":"https://openalex.org/W1887859305","doi":"https://doi.org/10.1074/jbc.m115.676700","title":"Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy","display_name":"Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy","publication_year":2015,"publication_date":"2015-09-02","ids":{"openalex":"https://openalex.org/W1887859305","doi":"https://doi.org/10.1074/jbc.m115.676700","mag":"1887859305","pmid":"https://pubmed.ncbi.nlm.nih.gov/26304121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646211"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m115.676700","doi":"https://doi.org/10.1074/jbc.m115.676700","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.676700","pdf_url":"http://www.jbc.org/article/S002192582044582X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582044582X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089734620","display_name":"Vera J. Goh","orcid":"https://orcid.org/0000-0001-5260-6280","observed_orcids":["https://orcid.org/0000-0001-5260-6280"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Vera J. Goh","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109482292","display_name":"Jolene S.Y. Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jolene S.Y. Tan","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036543705","display_name":"Bryan C. Tan","orcid":"https://orcid.org/0000-0001-6399-8814","observed_orcids":["https://orcid.org/0000-0001-6399-8814"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bryan C. Tan","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087354118","display_name":"Colin J.P. Seow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Colin Seow","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112273786","display_name":"Wei-Yi Ong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wei-Yi Ong","raw_affiliation_strings":["the Department of Anatomy and Neurobiology and Aging Research Programme, National University of Singapore, Singapore 119260, Singapore","Department of Anatomy, National University of Singapore, Singapore 119260, Singapore","Neurobiology and Aging Research Programme, National University of Singapore, Singapore 119260, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Anatomy and Neurobiology and Aging Research Programme, National University of Singapore, Singapore 119260, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Anatomy, National University of Singapore, Singapore 119260, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Neurobiology and Aging Research Programme, National University of Singapore, Singapore 119260, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020548114","display_name":"Yen Ching Lim","orcid":"https://orcid.org/0000-0002-5961-0159","observed_orcids":["https://orcid.org/0000-0002-5961-0159"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yen Ching Lim","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038880076","display_name":"Lei Sun","orcid":"https://orcid.org/0000-0003-3937-941X","observed_orcids":["https://orcid.org/0000-0003-3937-941X","https://orcid.org/0000-0002-5024-4164"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Sun","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078766702","display_name":"Sujoy Ghosh","orcid":"https://orcid.org/0000-0002-7601-165X","observed_orcids":["https://orcid.org/0000-0002-7601-165X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Sujoy Ghosh","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040798706","display_name":"David L. Silver","orcid":"https://orcid.org/0000-0002-7289-9890","observed_orcids":["https://orcid.org/0000-0002-7289-9890"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"David L. Silver","raw_affiliation_strings":["From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and david.silver@duke-nus.edu.sg","Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore and david.silver@duke-nus.edu.sg","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040798706"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.298,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.87202381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"290","issue":"42","first_page":"25686","last_page":"25699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8539999723434448},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-membrane-protein","display_name":"endoplasmic reticulum membrane protein","score":0.8769999742507935},{"id":"https://openalex.org/keywords/postnatal-lethality","display_name":"postnatal lethality","score":0.7419999837875366},{"id":"https://openalex.org/keywords/villous-atrophy","display_name":"villous atrophy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fat-absorption","display_name":"fat absorption","score":0.9139999747276306},{"id":"https://openalex.org/keywords/bile-acid-transporters","display_name":"bile acid transporters","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bile-acid-accumulation","display_name":"bile acid accumulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/enterocytes","display_name":"enterocytes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tamoxifen-inducible-knockout","display_name":"tamoxifen-inducible knockout","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2776924286","wikidata":"https://www.wikidata.org/wiki/Q284070","display_name":"Protein losing enteropathy","level":4,"score":0.5748943090438843},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5384500026702881},{"id":"https://openalex.org/C2778426112","wikidata":"https://www.wikidata.org/wiki/Q3055380","display_name":"Enteropathy","level":3,"score":0.532143771648407},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4174799621105194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36550426483154297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3058018088340759},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26080310344696045},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24629339575767517},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003643","descriptor_name":"Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m115.676700","doi":"https://doi.org/10.1074/jbc.m115.676700","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.676700","pdf_url":"http://www.jbc.org/article/S002192582044582X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4017281","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646211","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26304121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26304121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4646211","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4646211/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m115.676700","doi":"https://doi.org/10.1074/jbc.m115.676700","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.676700","pdf_url":"http://www.jbc.org/article/S002192582044582X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5226730507","display_name":null,"funder_award_id":"CBRG/0012/2012","funder_id":"https://openalex.org/F4320320697","funder_display_name":"Ministry of Health -Singapore"}],"funders":[{"id":"https://openalex.org/F4320320697","display_name":"Ministry of Health -Singapore","ror":"https://ror.org/00mrhvv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1887859305.pdf","grobid_xml":"https://content.openalex.org/works/W1887859305.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W20726012","https://openalex.org/W111805191","https://openalex.org/W1516972356","https://openalex.org/W1539287055","https://openalex.org/W1555526329","https://openalex.org/W1863992383","https://openalex.org/W1964081409","https://openalex.org/W1965506486","https://openalex.org/W1965664368","https://openalex.org/W1966374931","https://openalex.org/W1966892435","https://openalex.org/W1967844990","https://openalex.org/W1972744939","https://openalex.org/W1981640411","https://openalex.org/W1989086831","https://openalex.org/W1992335884","https://openalex.org/W1997238838","https://openalex.org/W1998448918","https://openalex.org/W2005016596","https://openalex.org/W2008688211","https://openalex.org/W2011910303","https://openalex.org/W2013123192","https://openalex.org/W2020294832","https://openalex.org/W2022316151","https://openalex.org/W2027926561","https://openalex.org/W2028890879","https://openalex.org/W2034781186","https://openalex.org/W2035187068","https://openalex.org/W2036953560","https://openalex.org/W2038714514","https://openalex.org/W2039303083","https://openalex.org/W2042082068","https://openalex.org/W2043880988","https://openalex.org/W2046409965","https://openalex.org/W2047140120","https://openalex.org/W2066362633","https://openalex.org/W2067954779","https://openalex.org/W2074134894","https://openalex.org/W2077293808","https://openalex.org/W2077389635","https://openalex.org/W2081471404","https://openalex.org/W2085387589","https://openalex.org/W2090434593","https://openalex.org/W2097961915","https://openalex.org/W2099067020","https://openalex.org/W2100413191","https://openalex.org/W2101951807","https://openalex.org/W2111214065","https://openalex.org/W2113411413","https://openalex.org/W2117387366","https://openalex.org/W2131463221","https://openalex.org/W2132780101","https://openalex.org/W2140065347","https://openalex.org/W2141778874","https://openalex.org/W2145875334","https://openalex.org/W2148403724","https://openalex.org/W2156073539","https://openalex.org/W2157010562","https://openalex.org/W2159318264","https://openalex.org/W2161215121","https://openalex.org/W2163138997","https://openalex.org/W2164015929","https://openalex.org/W2166040974","https://openalex.org/W2168623286","https://openalex.org/W2169492015","https://openalex.org/W2172455650"],"related_works":["https://openalex.org/W2047140120","https://openalex.org/W896315702","https://openalex.org/W2336809587","https://openalex.org/W4401830015","https://openalex.org/W3152872927","https://openalex.org/W4399193704","https://openalex.org/W2163138997","https://openalex.org/W2061894905","https://openalex.org/W2794763488","https://openalex.org/W4308542004"],"abstract_inverted_index":{"Lipid":[0],"droplets":[1],"(LDs)":[2],"are":[3],"phylogenetically":[4],"conserved":[5],"cytoplasmic":[6],"organelles":[7],"that":[8,44,60,96,187],"store":[9],"neutral":[10],"lipids":[11,18],"within":[12,134,160,180],"a":[13,35,101],"phospholipid":[14],"monolayer.":[15],"LDs":[16,146],"compartmentalize":[17],"and":[19,55,118,123,132,157,197],"may":[20],"help":[21],"to":[22,111,148,174],"prevent":[23],"cellular":[24,144],"damage":[25],"caused":[26],"by":[27],"their":[28],"excess":[29],"or":[30],"bioactive":[31],"forms.":[32],"FIT2":[33,61,75,87,98,105,188],"is":[34],"ubiquitously":[36],"expressed":[37],"transmembrane":[38],"endoplasmic":[39],"reticulum":[40],"(ER)":[41],"membrane":[42],"protein":[43],"has":[45],"previously":[46],"been":[47,91],"implicated":[48],"in":[49,52,66,69,71,150,170,193],"LD":[50],"formation":[51],"mammalian":[53],"cells":[54],"tissue.":[56],"Recent":[57],"data":[58,183],"indicate":[59],"plays":[62,189],"an":[63,70,190],"essential":[64,191],"role":[65,192],"fat":[67],"storage":[68],"vivo":[72],"constitutive":[73],"adipose":[74],"knock-out":[76,106],"mouse":[77,108],"model,":[78],"but":[79],"the":[80,138,143,161,175,185],"physiological":[81],"effects":[82],"of":[83,120,125,177],"postnatal":[84],"whole":[85,102],"body":[86,103],"depletion":[88],"have":[89],"never":[90],"studied.":[92],"Here,":[93],"we":[94],"show":[95],"tamoxifen-induced":[97],"deletion":[99],"using":[100],"ROSA26CreER(T2)-driven":[104],"(iF2KO)":[107],"model":[109],"leads":[110],"lethal":[112],"intestinal":[113,121,195],"pathology,":[114],"including":[115],"villus":[116],"blunting":[117],"death":[119],"crypts,":[122],"loss":[124],"lipid":[126],"absorption.":[127],"iF2KO":[128,151,171],"mice":[129],"lose":[130],"weight":[131],"die":[133],"2":[135],"weeks":[136],"after":[137,153],"first":[139],"tamoxifen":[140],"dose.":[141],"At":[142],"level,":[145],"failed":[147],"form":[149],"enterocytes":[152],"acute":[154],"oil":[155],"challenge":[156],"instead":[158],"accumulated":[159],"ER.":[162],"Intestinal":[163],"bile":[164,178],"acid":[165],"transporters":[166],"were":[167],"transcriptionally":[168],"dysregulated":[169],"mice,":[172],"leading":[173],"buildup":[176],"acids":[179],"enterocytes.":[181],"These":[182],"support":[184],"conclusion":[186],"regulating":[194],"health":[196],"survival":[198],"postnatally.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}