{"id":"https://openalex.org/W1887619174","doi":"https://doi.org/10.3109/02699052.2015.1042053","title":"Flavonoids from Scutellaria attenuate okadaic acid-induced neuronal damage in rats","display_name":"Flavonoids from Scutellaria attenuate okadaic acid-induced neuronal damage in rats","publication_year":2015,"publication_date":"2015-06-17","ids":{"openalex":"https://openalex.org/W1887619174","doi":"https://doi.org/10.3109/02699052.2015.1042053","mag":"1887619174","pmid":"https://pubmed.ncbi.nlm.nih.gov/26083050"},"language":"en","primary_location":{"id":"doi:10.3109/02699052.2015.1042053","doi":"https://doi.org/10.3109/02699052.2015.1042053","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02699052.2015.1042053","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100613535","display_name":"Shufeng Zhang","orcid":"https://orcid.org/0000-0003-4125-7139","observed_orcids":["https://orcid.org/0000-0003-4125-7139"]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Feng Zhang","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041948549","display_name":"Yong-Cai Dong","orcid":"https://orcid.org/0000-0003-1230-8603","observed_orcids":["https://orcid.org/0000-0003-1230-8603"]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-Cai Dong","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","b Workers Hospital of Chengde Iron & Steel Group Co., Ltd , Chengde , Hebei , PR China","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","Workers Hospital of Chengde Iron & Steel Group Co., Ltd, Chengde, Hebei, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"b Workers Hospital of Chengde Iron & Steel Group Co., Ltd , Chengde , Hebei , PR China","institution_ids":[]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Workers Hospital of Chengde Iron & Steel Group Co., Ltd, Chengde, Hebei, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao-Feng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Feng Zhang","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101109217","display_name":"Xiao-Guang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Guang Wu","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian-Jun Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Jun Cheng","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Hua Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Hua Guan","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ya-Zhen Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ya-Zhen Shang","raw_affiliation_strings":["a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development , Chengde , Hebei , PR China and","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, PR China and","institution_ids":["https://openalex.org/I192578869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I192578869"],"apc_list":null,"apc_paid":null,"fwci":1.4376,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79272826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"29","issue":"11","first_page":"1376","last_page":"1382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.2054000049829483,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scutellaria-baicalensis","display_name":"Scutellaria baicalensis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuronal-damage","display_name":"neuronal injury","score":0.7879999876022339},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8289999961853027},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.718999981880188},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.921999990940094},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8960000276565552},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.8384261131286621},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6981447339057922},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6867324709892273},{"id":"https://openalex.org/C2778153525","wikidata":"https://www.wikidata.org/wiki/Q803769","display_name":"Scutellaria baicalensis","level":4,"score":0.6654453873634338},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6573994159698486},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.6363092064857483},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6003892421722412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5263144969940186},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47023528814315796},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.453615665435791},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.437228798866272},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3573057949542999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35586607456207275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3335634469985962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2583662271499634},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2412494719028473},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19415077567100525},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15203115344047546},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.10674399137496948},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09197095036506653},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.05511552095413208},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019319","descriptor_name":"Okadaic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020547","descriptor_name":"Lateral Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D031364","descriptor_name":"Scutellaria baicalensis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02699052.2015.1042053","doi":"https://doi.org/10.3109/02699052.2015.1042053","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02699052.2015.1042053","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},{"id":"pmid:26083050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26083050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain injury","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W133864801","https://openalex.org/W619926174","https://openalex.org/W1485288152","https://openalex.org/W1655159477","https://openalex.org/W1749352888","https://openalex.org/W1909811943","https://openalex.org/W1954244449","https://openalex.org/W1964825402","https://openalex.org/W1965839177","https://openalex.org/W1978293942","https://openalex.org/W1984159370","https://openalex.org/W1995509509","https://openalex.org/W1999473120","https://openalex.org/W2004777846","https://openalex.org/W2011485908","https://openalex.org/W2013629772","https://openalex.org/W2037079985","https://openalex.org/W2060929383","https://openalex.org/W2069513220","https://openalex.org/W2073776090","https://openalex.org/W2081758959","https://openalex.org/W2083412338","https://openalex.org/W2086526477","https://openalex.org/W2094333303","https://openalex.org/W2095380398","https://openalex.org/W2104973420","https://openalex.org/W2128635872","https://openalex.org/W2143019449","https://openalex.org/W2146425519","https://openalex.org/W2154973096","https://openalex.org/W2165821586","https://openalex.org/W2351703893","https://openalex.org/W2385474758","https://openalex.org/W2390880518","https://openalex.org/W2609857184","https://openalex.org/W4234332843","https://openalex.org/W4394347623"],"related_works":["https://openalex.org/W4312079451","https://openalex.org/W4391296189","https://openalex.org/W2379767786","https://openalex.org/W4390742501","https://openalex.org/W1012407344","https://openalex.org/W2375606883","https://openalex.org/W2383067951","https://openalex.org/W2086526477","https://openalex.org/W2362318717","https://openalex.org/W2021533121"],"abstract_inverted_index":{"PRIMARY":[0],"OBJECTIVE:":[1],"To":[2],"study":[3],"the":[4,34,71,94,143,157,161,192],"effect":[5],"of":[6,12,38,44,59,73,90,96,126,163,168,183,194],"flavonoids":[7],"isolated":[8],"from":[9],"aerial":[10],"parts":[11],"Scutellaria":[13],"baicalensis":[14],"Georgi":[15],"(SSF)":[16],"on":[17],"cerebral":[18,61],"damage":[19,121,171],"induced":[20],"by":[21,123],"okadaic":[22],"acid":[23],"(OA)":[24],"in":[25,142,160,172,191],"rats.":[26,164],"METHODS":[27],"AND":[28,110],"PROCEDURES:":[29],"OA":[30],"was":[31,65],"microinjected":[32],"into":[33],"right":[35],"lateral":[36],"ventricle":[37],"male":[39],"rats":[40,117,173],"at":[41,146],"a":[42,50,57,175,181],"dose":[43],"200":[45],"ng":[46],"kg(-1)":[47],"twice":[48],"with":[49,67],"3-day":[51],"interval":[52],"between":[53],"injections":[54],"to":[55,184],"establish":[56],"model":[58],"Alzheimer's-disease-like":[60],"damage.":[62],"Neuronal":[63],"morphology":[64],"observed":[66],"thionin":[68],"staining":[69],"and":[70,79,93,100,129,136,139,151,188],"expressions":[72],"glial":[74],"fibrillary":[75],"acidic":[76],"protein":[77,134],"(GFAP)":[78],"\u03b2-amyloid":[80],"peptide":[81,128],"1-40":[82],"(A\u03b21-40)":[83],"were":[84,104],"monitored":[85],"via":[86],"immunohistochemistry.":[87],"The":[88,112],"level":[89],"malondialdehyde":[91],"(MDA)":[92],"activities":[95],"glutathione":[97],"peroxidase":[98],"(GSH-Px)":[99],"lactate":[101],"dehydrogenase":[102],"(LDH)":[103],"measured":[105],"using":[106],"spectrophotometry.":[107],"MAIN":[108],"OUTCOMES":[109],"RESULTS:":[111],"results":[113],"showed":[114],"that":[115],"OA-treated":[116],"exhibited":[118],"marked":[119],"neuronal":[120,170],"accompanied":[122],"increased":[124],"levels":[125],"A\u03b21-40":[127],"MDA":[130],"accumulation,":[131],"decreased":[132],"GFAP":[133],"expression":[135,190],"reduced":[137],"GSH-Px":[138],"LDH":[140],"activity":[141],"brain.":[144],"SSF":[145,179],"three":[147],"doses":[148],"(25,":[149],"50":[150],"100":[152],"mg":[153],"kg(-1))":[154],"dramatically":[155],"reversed":[156],"OA-induced":[158,169],"changes":[159],"brains":[162],"CONCLUSION:":[165],"SSF-mediated":[166],"amelioration":[167],"provides":[174],"rationale":[176],"for":[177],"assessing":[178],"as":[180],"means":[182],"reducing":[185],"tau":[186],"hyperphosphorylation":[187],"A\u03b2":[189],"treatment":[193],"Alzheimer's":[195],"disease.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}