{"id":"https://openalex.org/W1887312232","doi":"https://doi.org/10.1152/ajpregu.1991.261.3.r690","title":"Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans","display_name":"Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W1887312232","doi":"https://doi.org/10.1152/ajpregu.1991.261.3.r690","mag":"1887312232","pmid":"https://pubmed.ncbi.nlm.nih.gov/1887957"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.1991.261.3.r690","doi":"https://doi.org/10.1152/ajpregu.1991.261.3.r690","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1991.261.3.r690","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T. Matsukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Matsukawa","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083099888","display_name":"Eiji Gotoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E. Gotoh","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113511094","display_name":"Kosuke Minamisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Minamisawa","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025521503","display_name":"Minoru Kihara","orcid":"https://orcid.org/0000-0003-1778-5177","observed_orcids":["https://orcid.org/0000-0003-1778-5177"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Kihara","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075058891","display_name":"Shinichiro Ueda","orcid":"https://orcid.org/0000-0003-0456-0841","observed_orcids":["https://orcid.org/0000-0003-0456-0841"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Ueda","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113889153","display_name":"Hiroshi Shionoiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Shionoiri","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061825004","display_name":"Masao Ishii","orcid":"https://orcid.org/0000-0002-7328-4599","observed_orcids":["https://orcid.org/0000-0002-7328-4599"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ishii","raw_affiliation_strings":["Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Yokohama City UniversitySchool of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I89630735"],"apc_list":null,"apc_paid":null,"fwci":2.475,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.88586552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"261","issue":"3","first_page":"R690","last_page":"R696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0568000003695488,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/muscle-sympathetic-nerve-activity","display_name":"muscle sympathetic nerve activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sympathetic-outflow","display_name":"sympathetic outflow","score":0.8529999852180481},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.878000020980835},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.921999990940094},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pressor-agents","display_name":"pressor agents","score":0.7429999709129333},{"id":"https://openalex.org/keywords/central-venous-pressure","display_name":"central venous pressure","score":0.6259999871253967},{"id":"https://openalex.org/keywords/autonomic-regulation","display_name":"autonomic regulation","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.8532296419143677},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.7687155604362488},{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.7404902577400208},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6170563697814941},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6032547950744629},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5485133528709412},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4948064684867859},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.4550940692424774},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.4482578635215759},{"id":"https://openalex.org/C2911027401","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous Infusions","level":2,"score":0.4408867359161377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4325277507305145},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36298707127571106},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25639158487319946}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.1991.261.3.r690","doi":"https://doi.org/10.1152/ajpregu.1991.261.3.r690","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1991.261.3.r690","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:1887957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1887957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2327966529","https://openalex.org/W2417535704","https://openalex.org/W1989012292","https://openalex.org/W3141573261","https://openalex.org/W2289870436","https://openalex.org/W2410296038","https://openalex.org/W2410322632","https://openalex.org/W2891789771","https://openalex.org/W2003244144","https://openalex.org/W7097425035"],"abstract_inverted_index":{"The":[0,16,53],"effect":[1],"of":[2,33,78,85,107,120,130],"angiotensin":[3],"II":[4,41,80,109,146],"(ANG":[5],"II)":[6],"on":[7],"the":[8,57,60,67,76,83,98,105,118,131,148],"sympathetic":[9,22,149],"outflow":[10,150],"was":[11,71,89],"examined":[12],"in":[13,62,69,133,155],"normal":[14],"humans.":[15,156],"mean":[17,63],"arterial":[18,64,134],"pressure":[19,65,96,135],"and":[20,29,36,44,66],"muscle":[21],"nerve":[23],"activity":[24],"(MSNA)":[25],"were":[26],"measured":[27],"before":[28],"during":[30,75,82,104,117],"intravenous":[31],"infusions":[32,77,84,106,119],"phenylephrine":[34,121],"(0.5":[35],"1.0":[37],"micrograms.kg-1.min-1)":[38],"or":[39],"ANG":[40,79,108,145],"(5,":[42],"10,":[43],"20":[45],"ng.kg-1.min-1)":[46],"for":[47,56,112,124],"15":[48,113,125],"min":[49],"at":[50,97],"30-min":[51],"intervals.":[52],"baroreflex":[54],"slope":[55],"relationship":[58],"between":[59],"increases":[61],"reductions":[68],"MSNA":[70,101],"significantly":[72,102],"less":[73],"acute":[74],"than":[81],"phenylephrine.":[86],"When":[87],"nitroprusside":[88],"infused":[90],"simultaneously":[91],"to":[92],"maintain":[93],"central":[94],"venous":[95],"basal":[99],"level,":[100],"increased":[103],"(5":[110],"ng.kg-1.min-1":[111],"min)":[114],"but":[115],"not":[116],"(1.0":[122],"micrograms.kg-1.min-1":[123],"min),":[126],"with":[127],"accompanying":[128],"attenuation":[129],"elevation":[132],"induced":[136],"by":[137],"these":[138],"pressor":[139],"agents.":[140],"These":[141],"findings":[142],"suggest":[143],"that":[144],"stimulates":[147],"without":[151],"mediating":[152],"baroreceptor":[153],"reflexes":[154]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}