{"id":"https://openalex.org/W1887289367","doi":null,"title":"An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole.","display_name":"An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole.","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W1887289367","mag":"1887289367","pmid":"https://pubmed.ncbi.nlm.nih.gov/15248163"},"language":"en","primary_location":{"id":"pmid:15248163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15248163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International microbiology : the official journal of the Spanish Society for Microbiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://revistes.iec.cat/index.php/IM/article/download/4c457c6245f75.002/9456","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022906688","display_name":"\u00d8ystein Brorson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802281627","display_name":"Sykehuset i Vestfold","ror":"https://ror.org/04a0aep16","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2802281627"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Oystein Brorson","raw_affiliation_strings":["Department of Microbiology, Vestfold Sentralsykehus, T\u00f8nsberg, Norway","Vestfold Sentralsykehus, T\u00f8nsberg, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Vestfold Sentralsykehus, T\u00f8nsberg, Norway","institution_ids":["https://openalex.org/I2802281627"]},{"raw_affiliation_string":"Vestfold Sentralsykehus, T\u00f8nsberg, Norway","institution_ids":["https://openalex.org/I2802281627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108437722","display_name":"Sverre-Henning Brorson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sverre-Henning A Brorson","raw_affiliation_strings":["Ullev\u00e5l Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ullev\u00e5l Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4385,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.86379449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"2","first_page":"139","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":1.0},{"id":"https://openalex.org/keywords/tinidazole","display_name":"tinidazole","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cystic-forms","display_name":"cystic forms","score":0.6679999828338623},{"id":"https://openalex.org/keywords/minimum-bactericidal-concentration","display_name":"minimum bactericidal concentration","score":0.8809999823570251},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lyme-disease","display_name":"Lyme disease","score":0.4410000145435333},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4860000014305115},{"id":"https://openalex.org/keywords/rna-degradation","display_name":"RNA degradation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/macrolide-combination-therapy","display_name":"macrolide combination therapy","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.7178449630737305},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6964143514633179},{"id":"https://openalex.org/C2780626017","wikidata":"https://www.wikidata.org/wiki/Q1321320","display_name":"Tinidazole","level":4,"score":0.4711928367614746},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4549840986728668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.452095091342926},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4459991157054901},{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.4427139163017273},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41944241523742676},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.38442569971084595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33910614252090454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17085912823677063},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008860","descriptor_name":"Microscopy, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014011","descriptor_name":"Tinidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":6,"locations":[{"id":"pmid:15248163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15248163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International microbiology : the official journal of the Spanish Society for Microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:hispana.mcu.es:4283663","doi":null,"is_oa":false,"landing_page_url":"http://revistes.iec.cat/revistes/index.php/IM/article/view/5888","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Microbiology; Vol. 7, N\u00fam. 2 (2004); 139\u2013142","raw_type":null},{"id":"pmh:oai:ojs.revistes.iec.cat:article/9459","doi":null,"is_oa":true,"landing_page_url":"https://revistes.iec.cat/index.php/IM/article/view/4c457c6245f75.002","pdf_url":"https://revistes.iec.cat/index.php/IM/article/download/4c457c6245f75.002/9456","source":{"id":"https://openalex.org/S4306402040","display_name":"Estudis Rom\u00e0nics (Institut d'Estudis Catalans)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59493104","host_organization_name":"Institut d'Estudis Catalans","host_organization_lineage":["https://openalex.org/I59493104"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1139-6709","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hispana.mcu.es:6001623","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1139-67092004000200009","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:scielo:S1139-67092004000200009","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1139-67092004000200009","pdf_url":null,"source":{"id":"https://openalex.org/S4306402135","display_name":"Scientific Electronic library online (Sciences Carlos III Health Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801357902","host_organization_name":"Instituto de Salud Carlos III","host_organization_lineage":["https://openalex.org/I2801357902"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Microbiology v.7 n.2 2004","raw_type":"journal article"},{"id":"mag:1887289367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15248163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs.revistes.iec.cat:article/9459","doi":null,"is_oa":true,"landing_page_url":"https://revistes.iec.cat/index.php/IM/article/view/4c457c6245f75.002","pdf_url":"https://revistes.iec.cat/index.php/IM/article/download/4c457c6245f75.002/9456","source":{"id":"https://openalex.org/S4306402040","display_name":"Estudis Rom\u00e0nics (Institut d'Estudis Catalans)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59493104","host_organization_name":"Institut d'Estudis Catalans","host_organization_lineage":["https://openalex.org/I59493104"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1139-6709","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1887289367.pdf","grobid_xml":"https://content.openalex.org/works/W1887289367.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2136047088","https://openalex.org/W2105630621","https://openalex.org/W2061126046","https://openalex.org/W2087174674","https://openalex.org/W2079234029","https://openalex.org/W2089178664","https://openalex.org/W2099632189","https://openalex.org/W2392289676","https://openalex.org/W2387524630","https://openalex.org/W2109607406"],"abstract_inverted_index":{"The":[0,15,54],"susceptibility":[1],"of":[2,7,20,46,92,101,119,146,159,171,184],"mobile":[3,24,47,182],"and":[4,83,116,136,143,166,173,181],"cystic":[5,50,180],"forms":[6,51,183],"Borrelia":[8],"burgdorferi":[9],"to":[10,49,130],"tinidazole":[11],"(TZ)":[12],"was":[13,26,68,94,148],"examined.":[14],"minimal":[16],"bactericidal":[17],"concentration":[18,91],"(MBC)":[19],"TZ":[21,41,93,172],"against":[22],"the":[23,44,90,99,102,113,117,133,140,144,157],"spirochetes":[25,48],">128":[27],"microg/ml":[28,73],"at":[29,60],"37":[30,61],"degrees":[31,62],"C":[32,63],"in":[33,64,121,156],"micro-oxic":[34,66],"atmosphere":[35,67],"when":[36,89],"incubated":[37],"for":[38,56,74],"14":[39],"days.":[40],"significantly":[42,149],"reduced":[43],"conversion":[45],"during":[52],"incubation.":[53],"MBC":[55],"older":[57],"(10-months-old)":[58],"cysts":[59,103,123,127,141],"a":[65,169,174],">0.5":[69],"microg/ml,":[70],"but":[71],">0.125":[72],"young":[75,114],"(1-day-old)":[76],"cysts.":[77],"Acridine":[78],"orange":[79],"staining,":[80],"dark-field":[81],"microscopy":[82,86],"transmission":[84],"electron":[85],"revealed":[87],"that,":[88],">":[95],"or":[96],"=":[97],"MBC,":[98],"contents":[100],"were":[104,128],"partly":[105],"degraded,":[106],"core":[107,137],"structures":[108,135,138],"did":[109],"not":[110],"develop":[111],"inside":[112,139],"cysts,":[115],"amount":[118],"RNA":[120],"these":[122],"decreased":[124],"significantly.":[125],"When":[126],"exposed":[129],"TZ,":[131],"both":[132,179],"spirochetal":[134],"dissolved,":[142],"production":[145],"blebs":[147],"reduced.":[150],"These":[151],"observations":[152],"may":[153],"be":[154],"valuable":[155],"treatment":[158],"resistant":[160],"infections":[161],"caused":[162],"by":[163],"B.":[164,185],"burgdorferi,":[165],"suggest":[167],"that":[168],"combination":[170],"macrolide":[175],"antibiotic":[176],"could":[177],"eradicate":[178],"burgdorferi.":[186]},"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}