{"id":"https://openalex.org/W188697491","doi":"https://doi.org/10.1097/wnf.0b013e3181c46f61","title":"Prospective, Randomized, Double-Blind Study, Comparing Botulinum Toxins Type A Botox and Prosigne for Blepharospasm and Hemifacial Spasm Treatment","display_name":"Prospective, Randomized, Double-Blind Study, Comparing Botulinum Toxins Type A Botox and Prosigne for Blepharospasm and Hemifacial Spasm Treatment","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W188697491","doi":"https://doi.org/10.1097/wnf.0b013e3181c46f61","mag":"188697491","pmid":"https://pubmed.ncbi.nlm.nih.gov/20124784"},"language":"en","primary_location":{"id":"doi:10.1097/wnf.0b013e3181c46f61","doi":"https://doi.org/10.1097/wnf.0b013e3181c46f61","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnf.0b013e3181c46f61","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110433727","display_name":"Elizabeth Maria Aparecida Barasnevicius Quagliato","orcid":"https://orcid.org/0009-0009-9380-238X","observed_orcids":["https://orcid.org/0009-0009-9380-238X"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Elizabeth Maria Aparecida Barasnevicius Quagliato","raw_affiliation_strings":["Neurology Department, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil","E-mail: [email\u00a0protected]","reprint requests to Elizabeth Maria Aparecida Barasnevicius Quagliato, MD, PhD, Rua Alfredo Calil 187, Jardim das Palmeiras, Campinas, CEP 13101-507, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"reprint requests to Elizabeth Maria Aparecida Barasnevicius Quagliato, MD, PhD, Rua Alfredo Calil 187, Jardim das Palmeiras, Campinas, CEP 13101-507, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006199525","display_name":"Edmur Franco Carelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edmur Franco Carelli","raw_affiliation_strings":["Neurology Department, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026697013","display_name":"Maura Aparecida Viana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maura Aparecida Viana","raw_affiliation_strings":["Neurology Department, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110433727"],"corresponding_institution_ids":["https://openalex.org/I181391015"],"apc_list":null,"apc_paid":null,"fwci":2.108,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.85964781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"1","first_page":"27","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12625","display_name":"Sympathectomy and Hyperhidrosis Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9369999766349792},{"id":"https://openalex.org/keywords/onabotulinumtoxina","display_name":"onabotulinumtoxinA","score":0.9020000100135803},{"id":"https://openalex.org/keywords/blepharospasm","display_name":"blepharospasm","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hemifacial-spasm","display_name":"hemifacial spasm","score":1.0},{"id":"https://openalex.org/keywords/formulation-comparison","display_name":"formulation comparison","score":0.621999979019165},{"id":"https://openalex.org/keywords/dose-equivalence","display_name":"dose equivalence","score":0.8220000267028809},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6809999942779541},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8690000176429749},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2778817116","wikidata":"https://www.wikidata.org/wiki/Q883863","display_name":"Blepharospasm","level":3,"score":0.9670246243476868},{"id":"https://openalex.org/C2781344935","wikidata":"https://www.wikidata.org/wiki/Q1568480","display_name":"Hemifacial spasm","level":3,"score":0.9484869241714478},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7390825152397156},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.6759463548660278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6622772216796875},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.568318247795105},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5369213819503784},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47341448068618774},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3679828643798828},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3652908504009247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1467808187007904},{"id":"https://openalex.org/C2778987478","wikidata":"https://www.wikidata.org/wiki/Q242160","display_name":"Facial nerve","level":2,"score":0.13196679949760437}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001764","descriptor_name":"Blepharospasm","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001764","descriptor_name":"Blepharospasm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019569","descriptor_name":"Hemifacial Spasm","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019569","descriptor_name":"Hemifacial Spasm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/wnf.0b013e3181c46f61","doi":"https://doi.org/10.1097/wnf.0b013e3181c46f61","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnf.0b013e3181c46f61","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:20124784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20124784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1504251620","https://openalex.org/W1918147071","https://openalex.org/W1979511972","https://openalex.org/W1997402247","https://openalex.org/W1999838039","https://openalex.org/W2020743866","https://openalex.org/W2027882596","https://openalex.org/W2049052738","https://openalex.org/W2065211181","https://openalex.org/W2090606556","https://openalex.org/W2103608653","https://openalex.org/W2365024437"],"related_works":["https://openalex.org/W2103608653","https://openalex.org/W2067119511","https://openalex.org/W2140698472","https://openalex.org/W2015921773","https://openalex.org/W1982050085","https://openalex.org/W156824020","https://openalex.org/W2171409921","https://openalex.org/W117490009","https://openalex.org/W2152009000","https://openalex.org/W2351453403"],"abstract_inverted_index":{"Botulinum":[0],"toxin":[1],"A":[2],"(BTA)":[3],"is":[4],"considered":[5,244],"an":[6],"effective":[7],"treatment":[8,124,213],"of":[9,23,36,47,102,122,214,240],"blepharospasm":[10,54,66,159,180,246],"and":[11,45,55,74,78,88,105,114,119,136,145,165,173,210,226,232,247],"hemifacial":[12,56,80,166,216,248],"spasm,":[13],"but":[14],"there":[15],"are":[16],"few":[17],"studies":[18],"to":[19,41],"permit":[20],"a":[21,34,237],"comparison":[22],"its":[24],"different":[25],"formulations.":[26],"This":[27],"prospective,":[28],"randomized,":[29],"double-blind":[30],"study":[31],"compared":[32],"Prosigne,":[33],"BTA":[35,111],"Chinese":[37],"origin,":[38],"with":[39,72,76,86,90,142],"Botox":[40,172,225],"establish":[42],"safety,":[43,231],"efficacy,":[44,230],"equivalence":[46,239],"doses":[48],"between":[49,202],"those":[50],"2":[51],"formulations":[52],"in":[53,62,96,127],"spasm":[57,81,167,217,249],"treatment.":[58],"Fifty-seven":[59],"patients":[60,82,93,168],"participated":[61],"this":[63],"study:":[64],"21":[65],"(from":[67],"whom":[68],"11":[69],"were":[70,84,94,125,131,140,199],"treated":[71,85],"Botox;":[73,87],"10,":[75],"Prosigne)":[77],"36":[79],"(17":[83],"19,":[89],"Prosigne).":[91,177],"All":[92],"similar":[95,126,143,156,229],"age,":[97],"disease":[98],"time":[99,106,153],"span,":[100],"number":[101],"previous":[103],"shots,":[104],"elapsed":[107],"since":[108],"the":[109,117,120,123,137,183,203,212],"last":[110],"application.":[112],"Pain":[113],"burning":[115],"during":[116],"injection":[118],"result":[121],"both":[128,148,158,163,179],"groups.":[129,149],"There":[130,198],"no":[132,200],"systemic":[133],"adverse":[134],"events,":[135],"local":[138],"ones":[139],"observed":[141],"intensity":[144],"frequency":[146],"for":[147,157,162,171,176,245],"The":[150],"mean":[151],"effect":[152],"length":[154],"was":[155],"(11.3":[160],"weeks":[161,170,175],"toxins)":[164],"(12.8":[169],"12.9":[174],"In":[178],"groups,":[181],"only":[182],"36-Item":[184,204],"Short-Form":[185,205],"Health":[186,206],"Survey":[187,207],"emotional":[188],"aspects":[189],"domain":[190],"showed":[191],"improvement":[192],"from":[193],"baseline":[194],"after":[195,211],"16":[196],"weeks.":[197],"differences":[201],"scores":[208],"before":[209],"all":[215],"patients.":[218],"Therefore,":[219],"it":[220],"has":[221],"been":[222],"concluded":[223],"that":[224,236],"Prosigne":[227],"have":[228],"tolerability":[233],"profiles,":[234],"so":[235],"dose":[238],"1:1":[241],"may":[242],"be":[243],"treatments.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
