{"id":"https://openalex.org/W1886924970","doi":null,"title":"Study of the mechanisms behind the additive effect of neoadjuvant castration on radiotherapy for prostate cancer","display_name":"Study of the mechanisms behind the additive effect of neoadjuvant castration on radiotherapy for prostate cancer","publication_year":2015,"publication_date":"2015-10-23","ids":{"openalex":"https://openalex.org/W1886924970","mag":"1886924970"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26911447","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Study_of_the_mechanisms_behind_the_additive_effect_of_neoadjuvant_castration_on_radiotherapy_for_prostate_cancer/26911447","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/44864","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007121525","display_name":"Firas Tarish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Firas Tarish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007121525"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.29809999465942383,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.29809999465942383,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.2361000031232834,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.906000018119812},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ku70","display_name":"Ku70","score":0.9789999723434448},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.949999988079071},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8769999742507935},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9660000205039978},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8420000076293945},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.5329999923706055},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8236703872680664},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.6084904670715332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6013861894607544},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.581595778465271},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5670642256736755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46238890290260315},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44375789165496826},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06512236595153809}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26911447","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Study_of_the_mechanisms_behind_the_additive_effect_of_neoadjuvant_castration_on_radiotherapy_for_prostate_cancer/26911447","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/44864","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/44864","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1886924970","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/handle/10616/44864","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/44864","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/44864","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1211637162","https://openalex.org/W1959049775","https://openalex.org/W1969098361","https://openalex.org/W1971261511","https://openalex.org/W1979327836","https://openalex.org/W1982508997","https://openalex.org/W1986356842","https://openalex.org/W1995150044","https://openalex.org/W1997414785","https://openalex.org/W2006001375","https://openalex.org/W2013559131","https://openalex.org/W2030575063","https://openalex.org/W2050164541","https://openalex.org/W2064293531","https://openalex.org/W2066944903","https://openalex.org/W2068140359","https://openalex.org/W2077892030","https://openalex.org/W2087688041","https://openalex.org/W2089579900","https://openalex.org/W2092577047","https://openalex.org/W2099324760","https://openalex.org/W2100343950","https://openalex.org/W2105537697","https://openalex.org/W2106285196","https://openalex.org/W2114005884","https://openalex.org/W2118494705","https://openalex.org/W2137996608","https://openalex.org/W2142359566","https://openalex.org/W2143956685","https://openalex.org/W2148643283","https://openalex.org/W2169637630","https://openalex.org/W2224374441"],"related_works":["https://openalex.org/W2157762086","https://openalex.org/W2155273968","https://openalex.org/W2103873217","https://openalex.org/W2138253517","https://openalex.org/W4295745228","https://openalex.org/W2295683284","https://openalex.org/W1999919666","https://openalex.org/W2007269128","https://openalex.org/W2091568189","https://openalex.org/W2101717355"],"abstract_inverted_index":{"Castration":[0,842,872,982],"improves":[1,455],"responses":[2,456,585],"to":[3,31,37,46,94,183,236,298,319,423,457,521,542,613,688,758,794,823],"radiotherapy":[4,458],"(RT)":[5,459],"in":[6,23,101,144,157,177,216,229,244,266,276,310,344,351,369,373,401,413,438,444,460,496,530,567,578,586,628,640,671,680,706,725,788,834,848,875,879,909,1018],"prostate":[7,24,65,125,132,178,267,314,345,370,387,414,449,461,492,579,602,631,730,790,845,984,1020],"cancer":[8,25,66,133,268,346,371,388,415,493,532,568,580,846,985],"with":[9,131,147,162,249,440,490,501,750],"unknown":[10],"mechanism.":[11],"An":[12],"understanding":[13],"of":[14,60,77,81,98,137,159,200,207,213,252,279,290,294,338,353,381,420,473,480,547,560,598,637,658,675,711,715,727,763,772,784,798,809,838,844,850],"what":[15],"happens":[16],"at":[17,512],"the":[18,48,78,82,184,223,250,330,548,591,604,634,672,689,709,760,766,782,795,835],"cellular":[19],"and":[20,33,50,71,96,107,118,342,390,398,427,515,518,527,556,594,600,648,663,713,717,722,745,765,804,905,977],"molecular":[21],"level":[22,255,559],"cells,":[26,347],"while":[27],"reducing":[28],"their":[29],"access":[30],"androgens":[32],"then":[34],"exposing":[35],"them":[36],"ionizing":[38],"radiation":[39],"(IR),":[40],"would":[41],"give":[42],"us":[43],"an":[44,86,441,737],"opportunity":[45],"optimize":[47],"treatment":[49,597],"may":[51,181,408],"also":[52,155],"inspire":[53],"novel":[54],"therapeutic":[55],"approaches.":[56],"Paper":[57,189,301,451,588,641],"I:":[58],"Growth":[59],"solid":[61],"tumours":[62],"such":[63],"as":[64,74,348,350,417,639,748],"is":[67,85,285,367,384,468,792],"characterized":[68],"by":[69,122,205,470,564,815,913,986],"neovascularization":[70],"increased":[72,185,299],"glycolysis":[73],"a":[75,292,326,359,393,418,557,734],"result":[76],"hypoxic":[79],"microenvironment":[80],"tumour.":[83],"HIF-1\u03b1":[84,123,138,150,152,165,851],"important":[87],"transcription":[88,97],"factor":[89],"that":[90,170,259,273,406,428,465,536,573,819],"regulates":[91,262],"cell":[92,103,175],"adaptation":[93],"hypoxia":[95,176],"genes":[99],"involved":[100],"angiogenesis,":[102],"survival,":[104,389],"glucose":[105],"metabolism,":[106],"tumour":[108,174,731],"invasion.":[109],"To":[110,485,776],"test":[111,486],"whether":[112,193,781],"any":[113],"connection":[114],"between":[115,329,396,742,902],"castration":[116,141,172,194,274,311,425,454,517,540,574,617,699,803],"therapy":[117,377,843],"intra-tumoural":[119,799],"hypoxia,":[120],"measured":[121,563],"expression,":[124],"biopsy":[126],"specimens":[127],"from":[128,234,645,651],"14":[129],"patients":[130,146,161,214,231,374,489,511,537,638,644,682],"were":[134,227,494,654,665],"investigated.":[135],"Downregulation":[136],"expression":[139,153,246,341],"after":[140,187,238,256,505,516],"was":[142,154,219,272,678,686,700,740],"observed":[143,679,741],"five":[145],"initial":[148,163],"high":[149,447,721,796],"expression.":[151,166,209],"reduced":[156,228,545,687],"two":[158,497],"three":[160],"low":[164],"These":[167,403],"data":[168,304,404],"suggest":[169],"neoadjuvant":[171,539],"reduces":[173],"cancer,":[179,462,603,791],"which":[180],"contribute":[182],"radiosensitivity":[186],"castration.":[188,508],"II:":[190],"We":[191,509,534],"investigated":[192],"impairs":[195,575],"non-homologous":[196],"end-joining":[197],"(NHEJ)":[198,478],"repair":[199,289,296,365,479,529,627],"DNA":[201,295,354,481,625,773,989],"double-strand":[202,482,990],"breaks":[203,483],"(DSBs)":[204],"downregulation":[206,293,849],"Ku70":[208,225,245,263,280,283,716,744,877],"The":[210,242,656,827],"same":[211,635],"cohort":[212,636],"used":[215],"paper":[217],"I":[218],"analysed.":[220,655],"After":[221],"castration,":[222,239,257],"nuclear":[224,676],"levels":[226,265,278,546,657,705,710,797],"12":[230],"(levels":[232],"varied":[233],"43%":[235],"97%":[237],"p":[240,695],"<0.001).":[241,696],"reduction":[243,670],"correlated":[247,669],"significantly":[248],"decrease":[251],"serum":[253,684,703],"PSA":[254,685],"suggesting":[258],"AR":[260,677,764],"activity":[261,343,383,555,577],"protein":[264,284,550],"tissue.":[269,533],"Our":[270],"conclusion":[271],"results":[275,847],"decreased":[277],"protein.":[281],"Since":[282,453],"necessary":[286],"for":[287,336,386],"NHEJ":[288,526,549,554,576],"DSBs,":[291,562],"leads":[297],"radiosensitivity.":[300],"III:":[302],"Emerging":[303],"demonstrate":[305,325,392,405,759],"homologous":[306,475],"recombination":[307],"(HR)":[308],"defects":[309],"resistant":[312],"malignant":[313],"tumours,":[315],"rendering":[316],"these":[317,707,785],"sensitive":[318],"PARP":[320,382,399,436,903],"inhibitor":[321],"treatments.":[322],"Here,":[323,610],"we":[324,361,391,463,611,755],"direct":[327],"link":[328],"androgen":[331,523,619,801,807],"receptor":[332,524,620],"(AR)":[333,621],"being":[334],"required":[335],"maintenance":[337,352],"HR":[339,407],"gene":[340],"well":[349],"damage":[355,626,774],"response":[356,771],"signalling.":[357],"As":[358],"consequence,":[360],"show":[362,535],"PARP-mediated":[363],"backup":[364],"pathway":[366],"upregulated":[368],"tissues":[372],"following":[375,802],"androgen-deprivation":[376],"(ADT).":[378],"Furthermore,":[379],"upregulation":[380],"essential":[385],"synthetic":[394],"lethality":[395],"ADT":[397,442],"inhibitors":[400,437],"vivo.":[402],"be":[409,432],"functionally":[410],"impaired":[411,552],"earlier":[412],"etiology":[416],"consequence":[419],"ADT;":[421],"prior":[422,541],"emerging":[424],"resistance":[426],"this":[429,466],"potentially":[430],"can":[431],"exploited":[433],"therapeutically":[434],"using":[435,702],"combination":[439],"upfront":[443,503],"advanced":[445],"or":[446,504,813],"risk":[448],"cancer.":[450,632,1021],"IV:":[452],"hypothesized":[464],"radiosensitization":[467],"caused":[469,814],"castration-mediated":[471],"down-regulation":[472],"non":[474],"end":[476],"joining":[477],"(DSBs).":[484],"this,":[487],"forty-eight":[488],"localized":[491],"enrolled":[495],"arms,":[498],"either":[499],"treating":[500],"RT":[502,519,543,584],"receiving":[506,538],"neo-adjuvant":[507],"biopsied":[510],"diagnosis,":[513],"before":[514],"treatments":[520],"monitor":[522],"(AR),":[525],"DSB":[528],"verified":[531],"had":[544],"Ku70,":[551,660],"RTinduced":[553],"higher":[558],"unrepaired":[561],"\u03b3-H2AX":[565],"foci":[566],"tissues.":[569],"This":[570],"study":[571],"demonstrates":[572],"tissue,":[581],"explaining":[582],"improved":[583],"tumours.":[587],"V:":[589],"Despite":[590],"early":[592],"diagnosis":[593],"subsequently":[595],"effective":[596],"intermediate":[599],"high-risk":[601],"recurrence":[605],"rate":[606],"remains":[607,779],"regrettably":[608],"high.":[609],"wanted":[612],"investigate":[614],"how":[615],"effectively":[616],"suppresses":[618],"signalling,":[622],"thereby":[623],"affecting":[624],"primary":[629],"hormone-na\u00efve":[630,789,1019],"From":[633],"IV,":[642],"four":[643,681],"arm":[646,652],"1":[647],"one":[649],"patient":[650],"2":[653],"AR,":[659,712,743],"phosphorylated":[661,718,746],"DNA-PKcs":[662,747],"PAR":[664],"measured.":[666],"A":[667],"significant":[668],"mean":[673],"intensity":[674],"whose":[683],"greatest":[690],"extent,":[691],"about":[692],"90%":[693],"(\u03c1=1,":[694],"Although":[697],"complete":[698],"obtained":[701],"testosterone":[704],"patients,":[708],"consequently":[714,805],"DNAPKcs":[719],"remained":[720],"positively":[723],"co-varied":[724,770],"clusters":[726],"cells":[728,787,812,818],"throughout":[729],"areas.":[732],"Meanwhile,":[733],"tendency":[735],"towards":[736],"inverse":[738],"correlation":[739],"compared":[749],"PARP-1":[751],"activity.":[752],"In":[753],"conclusion,":[754],"are":[756],"first":[757],"heterogeneous":[761],"landscape":[762],"consequent":[767],"divergent":[768],"although":[769],"repair.":[775,992],"date,":[777],"it":[778],"unclear":[780],"emergence":[783],"castration-resistant":[786,817],"due":[793],"residual":[800],"suboptimal":[806],"suppression":[808],"otherwise":[810],"androgen-dependent":[811],"quiescent":[816],"promote":[820],"progression":[821],"according":[822],"clonal":[824],"selection":[825],"pressure.":[826],"current":[828],"finding":[829],"certainly":[830],"warrants":[831],"further":[832],"investigation":[833],"future.":[836],"List":[837],"scientific":[839],"papers":[840],"I.":[841],"levels.":[852],"Al-Ubaidi":[853,882],"FL,":[854,883],"Schultz":[855,884],"N,":[856,885],"Egevad":[857,888],"L,":[858,889],"Granfors":[859,890],"T,":[860,891],"Helleday":[861,892,976],"T.":[862,893],"Int":[863],"J":[864],"Radiat":[865],"Oncol":[866],"Biol":[867],"Phys.":[868],"2012;82(3):1243-8.":[869],"https://doi.org/10.1016/j.ijrobp.2011.10.038":[870],"II.":[871],"Therapy":[873,908],"Results":[874],"Decreased":[876],"Levels":[878],"Prostate":[880,910],"Cancer.":[881],"Loseva":[886],"O,":[887],"Clin":[894],"Cancer":[895],"Res.":[896],"2013;19(6):1547-56.":[897],"https://doi.org/10.1158/1078-0432.CCR-12-2795":[898],"III.":[899],"Synthetic":[900],"Lethality":[901],"inhibition":[904],"Androgen":[906,914,1015],"Deprivation":[907],"Cancer,":[911],"explained":[912],"Receptor":[915,1016],"driving":[916],"Homologous":[917],"Recombination.":[918],"Mohammad":[919],"Asim,":[920],"Heather":[921],"Ireland":[922],"Zecchini,":[923,960],"Firas":[924,993,1022],"L.":[925,994,1023],"Tarish,":[926,995,1024],"Charles":[927],"E.":[928],"Massie,":[929],"Ajoeb":[930],"Baridi,":[931],"Anne":[932],"Y.":[933],"Warren,":[934],"Wanfeng":[935],"Zhao,":[936],"Leigh-Anne":[937],"McDuffus,":[938],"Patrice":[939],"Mascalchi,":[940],"Harveer":[941],"Dev,":[942],"Karan":[943],"Wadhwa,":[944],"Paul":[945,961],"Wijnhoven,":[946],"Josep":[947],"Forment,":[948],"Scott":[949],"Lyons,":[950],"Roslin":[951],"Russell,":[952],"Andy":[953],"G.":[954,969],"Lynch,":[955],"Cormac":[956],"O\u2019Neill,":[957],"Vincent":[958],"R.":[959],"S.":[962],"Rennie,":[963],"Aria":[964],"Baniahmad,":[965],"Simon":[966],"Tavar\u00e9,":[967],"Ian":[968],"Mills,":[970],"Niklas":[971,996,1025],"Schultz,":[972,997,1026],"Yaron":[973],"Galanty,":[974],"Thomas":[975,1010,1039],"David":[978],"Neal.":[979],"[Manuscript]":[980,1041],"IV.":[981],"radiosensitizes":[983],"impairing":[987],"DNA-PKmediated":[988],"break":[991],"Anna":[998,1027],"Tanoglidi,":[999,1028],"Hans":[1000,1029],"Hamberg,":[1001,1030],"Henry":[1002,1031],"Letocha,":[1003,1032],"Katalin":[1004,1033],"Karaszi,":[1005,1034],"Freddie":[1006,1035],"Hamdy,":[1007,1036],"Torvald":[1008,1037],"Granfors,":[1009,1038],"Helleday.":[1011,1040],"[Accepted]":[1012],"https://doi.org/10.1126/scitranslmed.aac5671":[1013],"V.":[1014],"Heterogeneity":[1017]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}