{"id":"https://openalex.org/W1886852946","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","title":"T cell therapies-are T memory stem cells the answer?","display_name":"T cell therapies-are T memory stem cells the answer?","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W1886852946","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","mag":"1886852946","pmid":"https://pubmed.ncbi.nlm.nih.gov/26605297","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620096"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3625348","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620096","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072165806","display_name":"Jacqueline K. Flynn","orcid":"https://orcid.org/0000-0002-3822-294X","observed_orcids":["https://orcid.org/0000-0002-3822-294X"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacqueline K Flynn","raw_affiliation_strings":["1 School of Applied Sciences and Program in Metabolism, Exercise and Disease, Health Initiatives Research Institute, RMIT University, Melbourne, Australia ; 2 Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia ; 3 Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia ; 4 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Applied Sciences and Program in Metabolism, Exercise and Disease, Health Initiatives Research Institute, RMIT University, Melbourne, Australia ; 2 Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia ; 3 Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia ; 4 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I145902186","https://openalex.org/I165779595","https://openalex.org/I56590836","https://openalex.org/I82951845"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091208578","display_name":"Paul R. Gorry","orcid":"https://orcid.org/0000-0001-5407-7124","observed_orcids":["https://orcid.org/0000-0001-5407-7124"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul R Gorry","raw_affiliation_strings":["1 School of Applied Sciences and Program in Metabolism, Exercise and Disease, Health Initiatives Research Institute, RMIT University, Melbourne, Australia ; 2 Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia ; 3 Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia ; 4 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Applied Sciences and Program in Metabolism, Exercise and Disease, Health Initiatives Research Institute, RMIT University, Melbourne, Australia ; 2 Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia ; 3 Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia ; 4 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I145902186","https://openalex.org/I165779595","https://openalex.org/I56590836","https://openalex.org/I82951845"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3287,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60594359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"3","issue":"17","first_page":"251","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.07159999758005142,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-immunotherapy","display_name":"T cell therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.6830000281333923},{"id":"https://openalex.org/keywords/central-memory-t-cells","display_name":"central memory T cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7444556951522827},{"id":"https://openalex.org/C2991763054","wikidata":"https://www.wikidata.org/wiki/Q38103695","display_name":"Immunological memory","level":4,"score":0.4825800955295563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.426763653755188},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4235060214996338},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39096713066101074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.387405127286911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3832016587257385},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1743866503238678},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17354053258895874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15577763319015503},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.08393988013267517}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:europepmc.org:3625348","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4620096","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620096","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Transl Med","raw_type":"Text"},{"id":"pmid:26605297","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26605297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:alma61RMIT.INST:11247950470001341","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":false,"landing_page_url":"http://doi.org/10.3978/j.issn.2305-5839.2015.08.13","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27481140","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/T_cell_therapies_-_are_T_memory_stem_cells_the_answer_/27481140","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"mag:1886852946","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26605297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3625348","doi":"https://doi.org/10.3978/j.issn.2305-5839.2015.08.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1761214387","https://openalex.org/W1904663047","https://openalex.org/W1963522404","https://openalex.org/W1965247885","https://openalex.org/W1967420347","https://openalex.org/W1977450164","https://openalex.org/W1987655663","https://openalex.org/W1993331347","https://openalex.org/W1994456685","https://openalex.org/W1995046740","https://openalex.org/W2002013266","https://openalex.org/W2005336458","https://openalex.org/W2018311892","https://openalex.org/W2020604513","https://openalex.org/W2025690693","https://openalex.org/W2030099809","https://openalex.org/W2039333435","https://openalex.org/W2044273929","https://openalex.org/W2051582044","https://openalex.org/W2060838652","https://openalex.org/W2066271426","https://openalex.org/W2069873682","https://openalex.org/W2071548401","https://openalex.org/W2091246599","https://openalex.org/W2101190252","https://openalex.org/W2106863865","https://openalex.org/W2124513722","https://openalex.org/W2130011407","https://openalex.org/W2144796561","https://openalex.org/W2161080156","https://openalex.org/W4211067214"],"related_works":["https://openalex.org/W3199387848","https://openalex.org/W2570323108","https://openalex.org/W3032709499","https://openalex.org/W2060838652","https://openalex.org/W2069873682","https://openalex.org/W3195238290","https://openalex.org/W2115734161","https://openalex.org/W2286931303","https://openalex.org/W3000268866","https://openalex.org/W4285500716"],"abstract_inverted_index":{"T":[0,12,29],"memory":[1,11,27],"stem":[2,15],"cells":[3],"(TSCM)":[4],"are":[5],"the":[6,71,91,94],"earliest":[7],"developmental":[8],"stage":[9],"of":[10,73,84,96],"cells,":[13],"displaying":[14],"cell-like":[16],"properties":[17],"and":[18,25,36,43,62,88],"exhibiting":[19],"a":[20],"gene":[21],"profile":[22],"between":[23],"naive":[24],"central":[26],"(CM)":[28],"cells.":[30],"Their":[31],"long-lifespan,":[32],"robust":[33],"proliferative":[34],"potential":[35],"self-renewal":[37],"capacity":[38],"has":[39],"generated":[40],"much":[41],"research":[42],"clinical":[44],"interest":[45],"particularly":[46],"for":[47,70,77,93],"therapeutic":[48],"use.":[49],"Here,":[50],"we":[51,89],"discuss":[52],"recent":[53],"findings":[54],"published":[55],"in":[56,75],"Science":[57],"Translational":[58],"Medicine":[59],"by":[60],"Biasco":[61],"colleagues":[63],"[2015":[64],"Feb":[65],"4;7(273):273ra13],":[66],"which":[67],"provided":[68],"evidence":[69],"persistence":[72],"TSCM":[74],"humans":[76],"up":[78],"to":[79],"12":[80],"years":[81],"after":[82],"infusion":[83],"genetically":[85],"modified":[86],"lymphocytes,":[87],"examine":[90],"implications":[92],"development":[95],"novel":[97],"immunotherapies":[98],"using":[99],"TSCM.":[100]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
