{"id":"https://openalex.org/W1886771640","doi":"https://doi.org/10.1186/s12943-015-0395-0","title":"GLIPR1-\u0394TM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells","display_name":"GLIPR1-\u0394TM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells","publication_year":2015,"publication_date":"2015-06-19","ids":{"openalex":"https://openalex.org/W1886771640","doi":"https://doi.org/10.1186/s12943-015-0395-0","mag":"1886771640","pmid":"https://pubmed.ncbi.nlm.nih.gov/26084402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4484888"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-015-0395-0","doi":"https://doi.org/10.1186/s12943-015-0395-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0395-0","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-015-0395-0","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-015-0395-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091895470","display_name":"Styliani Karanika","orcid":"https://orcid.org/0000-0003-2387-6075","observed_orcids":["https://orcid.org/0000-0003-2387-6075"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Styliani Karanika","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. stelakara@hotmail.com","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. stelakara@hotmail.com","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039216029","display_name":"Theodoros Karantanos","orcid":"https://orcid.org/0000-0002-6792-8298","observed_orcids":["https://orcid.org/0000-0002-6792-8298"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodoros Karantanos","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. theodoroskarantanosmd@gmail.com","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. theodoroskarantanosmd@gmail.com","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088393329","display_name":"Shinji Kurosaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Kurosaka","raw_affiliation_strings":["Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. kurosaka969696@yahoo.co.jp","Kitasato University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. kurosaka969696@yahoo.co.jp","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Kitasato University","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086214965","display_name":"Jianxiang Wang","orcid":"https://orcid.org/0000-0001-9437-9151","observed_orcids":["https://orcid.org/0000-0001-9437-9151"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianxiang Wang","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. JWang@mdanderson.org","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. JWang@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068893767","display_name":"Takahiro Hirayama","orcid":"https://orcid.org/0000-0002-3841-4036","observed_orcids":["https://orcid.org/0000-0002-3841-4036"]},"institutions":[{"id":"https://openalex.org/I4210111955","display_name":"Kitasato University Hospital","ror":"https://ror.org/02b3e2815","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111955"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Hirayama","raw_affiliation_strings":["Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. thirayam@med.kitasato-u.ac.jp","Kitasato University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. thirayam@med.kitasato-u.ac.jp","institution_ids":["https://openalex.org/I4210111955","https://openalex.org/I64189623"]},{"raw_affiliation_string":"Kitasato University","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074265065","display_name":"Guang Yang","orcid":"https://orcid.org/0000-0003-1688-515X","observed_orcids":["https://orcid.org/0000-0003-1688-515X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang Yang","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. GYang@mdanderson.org","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. GYang@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675558","display_name":"Sanghee Park","orcid":"https://orcid.org/0000-0003-0532-906X","observed_orcids":["https://orcid.org/0000-0003-0532-906X","https://orcid.org/0000-0003-3263-3323"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanghee Park","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. Spark@mdanderson.org","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. Spark@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000560636","display_name":"Alexei A. Golstov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexei A. Golstov","raw_affiliation_strings":["Department of Thoracic & Cardio Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. agoltsov@mdanderson.org","Department of Thoracic & Cardio Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic & Cardio Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. agoltsov@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Thoracic & Cardio Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000431579","display_name":"Ryuta Tanimoto","orcid":"https://orcid.org/0000-0003-4583-8387","observed_orcids":["https://orcid.org/0000-0003-4583-8387"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryuta Tanimoto","raw_affiliation_strings":["Department of Urology, Thomas Jefferson University Hospital, Philadelphia, PA, USA. ryuta.tanimoto@jeffersonhospital.org","Thomas Jefferson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Thomas Jefferson University Hospital, Philadelphia, PA, USA. ryuta.tanimoto@jeffersonhospital.org","institution_ids":["https://openalex.org/I2799360765"]},{"raw_affiliation_string":"Thomas Jefferson University","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103233838","display_name":"Likun Li","orcid":"https://orcid.org/0000-0002-1027-1352","observed_orcids":["https://orcid.org/0000-0002-1027-1352"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Likun Li","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. LLi@mdanderson.org","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. LLi@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042000405","display_name":"Timothy C. Thompson","orcid":"https://orcid.org/0000-0003-1424-3831","observed_orcids":["https://orcid.org/0000-0003-1424-3831"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy C. Thompson","raw_affiliation_strings":["Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. timthomp@mdanderson.org","Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology - Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA. timthomp@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genitourinary Medical Oncology \u2013 Research, Unit 18-3, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042000405"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":0.9454,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.70182624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"122","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9879999756813049},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9179999828338623},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7770000100135803},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8730000257492065},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.843999981880188},{"id":"https://openalex.org/keywords/vcap-xenograft","display_name":"VCaP xenograft","score":0.7829999923706055},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9573290348052979},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6435023546218872},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.602818489074707},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5977110862731934},{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.5151368379592896},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.503980815410614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43538522720336914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4044114351272583},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4018837809562683},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35086047649383545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3310067653656006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20993655920028687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05235058069229126}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12943-015-0395-0","doi":"https://doi.org/10.1186/s12943-015-0395-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0395-0","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-015-0395-0","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4484888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4484888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:26084402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26084402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12943-015-0395-0","doi":"https://doi.org/10.1186/s12943-015-0395-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0395-0","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-015-0395-0","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G132965223","display_name":null,"funder_award_id":"#CA16672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G1343882066","display_name":null,"funder_award_id":"R0150588","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1422072807","display_name":null,"funder_award_id":"P50140388","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G2770569025","display_name":null,"funder_award_id":"R0150588","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G3891701891","display_name":null,"funder_award_id":"RO150588","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5565782708","display_name":null,"funder_award_id":"CA # 16672","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6042238479","display_name":null,"funder_award_id":"P50140388","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7054595596","display_name":null,"funder_award_id":"PC093932","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320307689","display_name":"Prostate Cancer Research & Education Foundation","ror":"https://ror.org/02w6b8q27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1886771640.pdf","grobid_xml":"https://content.openalex.org/works/W1886771640.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1911989431","https://openalex.org/W1949969406","https://openalex.org/W1963569255","https://openalex.org/W1976385326","https://openalex.org/W2026894807","https://openalex.org/W2029074172","https://openalex.org/W2036449946","https://openalex.org/W2039008831","https://openalex.org/W2052233102","https://openalex.org/W2086269831","https://openalex.org/W2096931514","https://openalex.org/W2106498871","https://openalex.org/W2107392093","https://openalex.org/W2108679313","https://openalex.org/W2110560370","https://openalex.org/W2113938742","https://openalex.org/W2118873545","https://openalex.org/W2120292596","https://openalex.org/W2122907368","https://openalex.org/W2123526148","https://openalex.org/W2128628205","https://openalex.org/W2137293812","https://openalex.org/W2137467802","https://openalex.org/W2138645583","https://openalex.org/W2141970041","https://openalex.org/W2148643283","https://openalex.org/W2148806906","https://openalex.org/W2152673858","https://openalex.org/W2153197580","https://openalex.org/W2157104445","https://openalex.org/W2168401998","https://openalex.org/W2169700609","https://openalex.org/W6639871308"],"related_works":["https://openalex.org/W3015945042","https://openalex.org/W7143820610","https://openalex.org/W2049112283","https://openalex.org/W2178537302","https://openalex.org/W2137293812","https://openalex.org/W1556552411","https://openalex.org/W1998396158","https://openalex.org/W3183642437","https://openalex.org/W3132302069","https://openalex.org/W2324344351"],"abstract_inverted_index":{"BACKGROUND:":[0],"Docetaxel":[1],"is":[2,35,46],"the":[3,22,38,49,65,68,83,102,124,142,164,214,218,232,239,281,288],"first":[4],"chemotherapy":[5],"agent":[6],"approved":[7],"for":[8,300],"treatment":[9,70,248,276],"of":[10,25,37,40,51,55,59,85,89,101,123,151,199,205,217,234,241,274,283,290,297],"metastatic":[11,90,258],"castration-resistant":[12],"prostate":[13,93],"cancer":[14,94],"(mCRPC).":[15],"The":[16,57,98,121,149,246],"limited":[17],"survival":[18],"benefit":[19],"associated":[20],"with":[21,71,108,133,160,186,249,302],"quick":[23],"emergence":[24,84,289],"resistance":[26,52,86],"and":[27,53,73,81,87,104,113,118,128,138,146,153,193,202,221,243,251,256,285],"systemic":[28,306],"toxicity":[29],"diminished":[30],"its":[31,226,305],"efficacy.":[32,227],"JNK-mediated":[33],"apoptosis":[34,190],"one":[36],"mechanisms":[39],"docetaxel":[41,72,103,152,187,237,250,284,298],"activity":[42],"whereas":[43],"ERK1/2-c-Myc-CXCR4":[44,129,206],"signaling":[45,130,201],"implicated":[47],"in":[48,92,173,191,260,277],"development":[50,88],"induction":[54,198],"migration.":[56],"aim":[58],"this":[60],"study":[61],"was":[62,171],"to":[63,188,236],"evaluate":[64],"hypothesis":[66,170],"that":[67,183,210,222,231,272],"combination":[69,155,220,247],"GLIPR1-\u0394TM":[74,105,154,252,275],"will":[75],"synergistically":[76],"induce":[77,189],"greater":[78],"cell":[79],"death":[80],"inhibit":[82,287],"potential":[91,259],"(PCa)":[95],"cells.":[96,245],"METHODS:":[97],"synergistic":[99],"effects":[100,122,216],"were":[106,131,158],"evaluated":[107,132],"DNA":[109,136],"fragmentation,":[110,137],"DAPI":[111],"staining":[112],"MTS":[114,139],"using":[115,141,163,175],"paired":[116],"t-test":[117],"isobologram":[119],"study.":[120],"drugs":[125],"on":[126,156],"JNK":[127,143,200,211],"Western":[134],"blot,":[135],"assays":[140],"inhibitor":[144,166],"SP600125,":[145],"CXCR4":[147,165,223],"siRNA.":[148],"results":[150],"migration":[157,240],"examined":[159,172],"scratch":[161],"assay":[162],"AMD3100":[167],"while":[168],"our":[169],"vivo":[174],"VCaP":[176,192,242,261],"orthotopic":[177],"xenograft":[178],"model.":[179],"RESULTS:":[180],"We":[181,208,228],"found":[182,230],"GLIPR1-\u0394\u03a4\u039c":[184,235],"synergized":[185],"PC-3":[194,244],"PCa":[195,278],"cells":[196,279],"through":[197],"concomitant":[203],"inhibition":[204],"signaling.":[207],"showed":[209],"activation":[212],"mediates":[213],"apoptotic":[215],"drug":[219,291],"knockdown":[224],"increases":[225,280],"also":[229],"addition":[233,273],"decreases":[238],"inhibited":[253],"tumor":[254],"growth":[255],"decreased":[257],"xenografts":[262],"more":[263],"than":[264],"single":[265],"agents":[266],"did.":[267],"CONCLUSIONS:":[268],"Our":[269],"data":[270],"suggested":[271],"efficacy":[282],"may":[286],"resistance;":[292],"potentially":[293],"permitting":[294],"a":[295],"decrease":[296],"dose":[299],"patients":[301],"mCRPC":[303],"eliminating":[304],"toxicities.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
