{"id":"https://openalex.org/W1885585690","doi":"https://doi.org/10.1176/ajp.161.10.1848","title":"Reduced Spinophilin But Not Microtubule-Associated Protein 2 Expression in the Hippocampal Formation in Schizophrenia and Mood Disorders: Molecular Evidence for a Pathology of Dendritic Spines","display_name":"Reduced Spinophilin But Not Microtubule-Associated Protein 2 Expression in the Hippocampal Formation in Schizophrenia and Mood Disorders: Molecular Evidence for a Pathology of Dendritic Spines","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W1885585690","doi":"https://doi.org/10.1176/ajp.161.10.1848","mag":"1885585690","pmid":"https://pubmed.ncbi.nlm.nih.gov/15465982"},"language":"en","primary_location":{"id":"doi:10.1176/ajp.161.10.1848","doi":"https://doi.org/10.1176/ajp.161.10.1848","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.161.10.1848","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090144860","display_name":"Amanda J. Law","orcid":"https://orcid.org/0000-0002-2574-1564","observed_orcids":["https://orcid.org/0000-0002-2574-1564"]},"institutions":[{"id":"https://openalex.org/I2803066836","display_name":"Warneford Hospital","ror":"https://ror.org/03we1zb10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802171185","https://openalex.org/I2803066836"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda J. Law","raw_affiliation_strings":["University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK. amanda.law@psych.ox.ac.uk","University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK. amanda.law@psych.ox.ac.uk","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]},{"raw_affiliation_string":"University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091548535","display_name":"Cynthia Shannon Weickert","orcid":"https://orcid.org/0000-0002-4560-0259","observed_orcids":["https://orcid.org/0000-0002-4560-0259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia Shannon Weickert","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056413476","display_name":"Thomas M. Hyde","orcid":"https://orcid.org/0000-0002-8746-3037","observed_orcids":["https://orcid.org/0000-0002-8746-3037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Hyde","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020523652","display_name":"Joel E. Kleinman","orcid":"https://orcid.org/0000-0002-4210-6052","observed_orcids":["https://orcid.org/0000-0002-4210-6052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel E. Kleinman","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050681797","display_name":"Paul J. Harrison","orcid":"https://orcid.org/0000-0002-6719-1126","observed_orcids":["https://orcid.org/0000-0002-6719-1126","https://orcid.org/0000-0001-8328-1722","https://orcid.org/0000-0001-8769-5615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul J. Harrison","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0083,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.96127352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"161","issue":"10","first_page":"1848","last_page":"1855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinophilin","display_name":"spinophilin","score":0.906000018119812},{"id":"https://openalex.org/keywords/map2","display_name":"MAP2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7210000157356262},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.953000009059906},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9860000014305115},{"id":"https://openalex.org/keywords/synaptic-connectivity","display_name":"synaptic connectivity","score":0.6570000052452087},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cyclophilin","display_name":"cyclophilin","score":0.7039999961853027},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.7973979711532593},{"id":"https://openalex.org/C2778499278","wikidata":"https://www.wikidata.org/wiki/Q1499420","display_name":"Subiculum","level":4,"score":0.7694960832595825},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.690066933631897},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6290667653083801},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5939648747444153},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5894472599029541},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.5399466156959534},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4675257205963135},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.45517802238464355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3929734230041504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3417004942893982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2639044225215912},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19781526923179626},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.16209223866462708},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099273","descriptor_name":"Neurabins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021983","descriptor_name":"Cyclophilins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021983","descriptor_name":"Cyclophilins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1176/ajp.161.10.1848","doi":"https://doi.org/10.1176/ajp.161.10.1848","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.161.10.1848","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},{"id":"doi:10.1176/appi.ajp.161.10.1848","doi":"https://doi.org/10.1176/appi.ajp.161.10.1848","is_oa":false,"landing_page_url":"https://doi.org/10.1176/appi.ajp.161.10.1848","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:15465982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15465982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1523740207","https://openalex.org/W1564190433","https://openalex.org/W1907092125","https://openalex.org/W1960099260","https://openalex.org/W1963490696","https://openalex.org/W1969141861","https://openalex.org/W1971696611","https://openalex.org/W1974262619","https://openalex.org/W1980574091","https://openalex.org/W1982304401","https://openalex.org/W1990483753","https://openalex.org/W1993646796","https://openalex.org/W1994517931","https://openalex.org/W1995673433","https://openalex.org/W2004899233","https://openalex.org/W2007742115","https://openalex.org/W2011209444","https://openalex.org/W2012316488","https://openalex.org/W2014643424","https://openalex.org/W2015268580","https://openalex.org/W2021366646","https://openalex.org/W2022390548","https://openalex.org/W2025011978","https://openalex.org/W2026696795","https://openalex.org/W2028669852","https://openalex.org/W2033345409","https://openalex.org/W2037749055","https://openalex.org/W2041317465","https://openalex.org/W2042626704","https://openalex.org/W2049147617","https://openalex.org/W2051420506","https://openalex.org/W2051948526","https://openalex.org/W2056429179","https://openalex.org/W2058387509","https://openalex.org/W2059549202","https://openalex.org/W2060642455","https://openalex.org/W2063987862","https://openalex.org/W2065918017","https://openalex.org/W2066877235","https://openalex.org/W2070017293","https://openalex.org/W2081020873","https://openalex.org/W2084017889","https://openalex.org/W2084749198","https://openalex.org/W2084772141","https://openalex.org/W2088793971","https://openalex.org/W2088804493","https://openalex.org/W2091612053","https://openalex.org/W2093937489","https://openalex.org/W2094936308","https://openalex.org/W2098391962","https://openalex.org/W2101494517","https://openalex.org/W2105575850","https://openalex.org/W2116679423","https://openalex.org/W2119804742","https://openalex.org/W2129167450","https://openalex.org/W2130718539","https://openalex.org/W2134624334","https://openalex.org/W2146264275","https://openalex.org/W2168334242","https://openalex.org/W2284323937","https://openalex.org/W2886587096"],"related_works":["https://openalex.org/W2013603018","https://openalex.org/W2030004690","https://openalex.org/W1969141861","https://openalex.org/W2048571739","https://openalex.org/W2608154434","https://openalex.org/W2015268580","https://openalex.org/W1986563644","https://openalex.org/W7039267902","https://openalex.org/W2021366646","https://openalex.org/W4248498866"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Aberrant":[1],"synaptic":[2],"connectivity":[3],"may":[4,202],"underlie":[5],"the":[6,9,26,32,77,80,120,123,128,140,151,176,181,187,190],"involvement":[7],"of":[8,25,50,82,93,113,183],"hippocampus":[10],"in":[11,41,45,48,116,153,171,205],"schizophrenia.":[12,42],"There":[13],"is":[14,38],"reasonable":[15],"neuropathological":[16],"evidence":[17,165,191],"for":[18,166],"a":[19,91,167],"presynaptic":[20],"pathology":[21,37,170,201],"but":[22,159],"few":[23],"studies":[24],"postsynaptic":[27],"component.":[28],"This":[29],"study":[30],"tested":[31],"hypothesis":[33],"that":[34,173,192],"hippocampal":[35,51,168],"dendritic":[36,85,94,103,169,199],"also":[39,203],"present":[40],"METHOD:":[43],"Using":[44],"situ":[46],"hybridization":[47],"sections":[49],"formation":[52],"from":[53,139],"10":[54,58,73],"patients":[55,59,107],"with":[56,60,64,69,108],"schizophrenia,":[57],"mood":[61,133,206],"disorders":[62],"(three":[63],"bipolar":[65],"disorder":[66,134],"and":[67,72,96,122,144],"seven":[68],"major":[70],"depression),":[71],"healthy":[74],"comparison":[75,130,141],"subjects,":[76],"authors":[78],"examined":[79],"expression":[81,162],"two":[83],"important":[84],"genes:":[86],"spinophilin,":[87],"which":[88],"serves":[89],"as":[90],"marker":[92],"spines,":[95],"microtubule-associated":[97],"protein":[98],"2":[99],"(MAP2),":[100],"an":[101],"overall":[102],"marker.":[104],"RESULTS:":[105],"The":[106,132],"schizophrenia":[109,172],"had":[110],"lower":[111],"levels":[112],"spinophilin":[114,158],"mRNA":[115,146],"CA4":[117],"(hilus),":[118],"CA3,":[119],"subiculum,":[121],"entorhinal":[124],"cortex":[125],"than":[126],"did":[127,147],"normal":[129],"subjects.":[131],"group":[135],"showed":[136],"similar":[137],"differences":[138],"group.":[142],"MAP2":[143,161],"cyclophilin":[145],"not":[148],"differ":[149],"between":[150],"groups":[152],"any":[154],"subfield.":[155],"CONCLUSIONS:":[156],"Decreased":[157],"unchanged":[160],"provides":[163],"molecular":[164],"preferentially":[174],"affects":[175],"spines.":[177],"As":[178],"spines":[179],"are":[180,195],"target":[182],"most":[184],"glutamatergic":[185],"synapses,":[186],"data":[188],"extend":[189],"excitatory":[193],"synapses":[194],"particularly":[196],"affected.":[197],"Similar":[198],"spine":[200],"occur":[204],"disorders.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}